Introduction

library("limma")
library("plyr")
library("edgeR")
library("dplyr")
library("tidyr")
library("ashr")
library("ggplot2")
library("cowplot")
library("VennDiagram")
library("RUVSeq")
library("topGO")

#load in filtered count data, RUVs output
filt_counts <- readRDS("data/filtered_counts.rds")
filt_counts <- filt_counts$counts
RUVsOut <- readRDS("data/RUVsOut.rds")

# load gene annotations
gene_anno <- read.delim("data/gene-annotation.txt",
                        sep = "\t")

# load in reordered sample information
sampleinfo <- readRDS("data/Sample.info.RNAseq.reordered.csv")

Limma doesn’t deal with technical replicates, so here I randomly sample 1 replicate for each of the 6 individualxcondition

# #randomly sample 1 replicate from each set of 3 replicates
# individuals <- c("18855", "18856", "19160")
# treatments <- c("S", "U")
# 
# set.seed(1234)
# selected_samples <- c()
# for(i in c("18856", "18855")){
#      for(t in treatments){
#           sample_num <- base::sample(c(1:3), 1)
#           selected_samples <- c(selected_samples, paste0(i, sep = "_", sample_num, sep = "_", t))
#      }
# }
# 
# sample_num <- base::sample(c(2:3), 1)
# selected_samples <- c(selected_samples, paste0("19160", sep = "_", sample_num, sep = "_", "U"))
# sample_num <- base::sample(c(1:3), 1)
# selected_samples <- c(selected_samples, paste0("19160", sep = "_", sample_num, sep = "_", "S"))
# 
# selected_samples
# randomly_sampled_indices <- match(selected_samples, colnames(filt_counts))
# 
# single_filt_counts <- filt_counts[,randomly_sampled_indices]
# anno <- pData(RUVsOut)[randomly_sampled_indices,]

single_filt_counts <- filt_counts
anno <- pData(RUVsOut)
x <- paste0(anno$Individual, anno$treatment)

anno$LibraryPrepBatch <- factor(anno$LibraryPrepBatch, levels = c("1", "2"))
anno$Replicate <- factor(anno$Replicate, levels = c("1", "2", "3"))

design <- model.matrix(~treatment + Sex + Individual + W_1 + W_2 + RIN,
                       data = anno)
colnames(design) <- gsub("treatment", "", colnames(design))
colnames(design)

[1] "(Intercept)"        "Unstrain"           "SexM"              
[4] "IndividualNA18856 " "IndividualNA19160 " "W_1"               
[7] "W_2"                "RIN"               

# Model individual as a random effect (use duplicate correlation function); treatment as a fixed effect, covariates = RUV factors
     # Because of issues with duplicateCorrelation with the number of covariates I include in the design matrix, I elect intead to include all samples (all technical replicates) and use duplicateCorrelation for technical replicates and instead include Individual as a fixed effect in the linear model
# Recommended to run both voom and duplicateCorrelation twice.
# https://support.bioconductor.org/p/59700/#67620

#TMM Normalization
y <- DGEList(single_filt_counts)
y <- calcNormFactors(y, method = "TMM")
#Voom for differential expression
v1 <- voom(y, design)

Coefficients not estimable: IndividualNA19160  

Warning: Partial NA coefficients for 10517 probe(s)

corfit1 <- duplicateCorrelation(v1, design, block = x)

Coefficients not estimable: IndividualNA19160  

Warning in glmgam.fit(dx, dy, coef.start = start, tol = tol, maxit =
maxit, : Too much damping - convergence tolerance not achievable

corfit1$consensus.correlation

[1] 0.3330516

v2 <- voom(y, design, block = x, correlation = corfit1$consensus.correlation)

Coefficients not estimable: IndividualNA19160  

Warning: Partial NA coefficients for 10517 probe(s)

corfit2 <- duplicateCorrelation(v2, design, block = x)

Coefficients not estimable: IndividualNA19160  

Warning in glmgam.fit(dx, dy, coef.start = start, tol = tol, maxit =
maxit, : Too much damping - convergence tolerance not achievable

Warning in glmgam.fit(dx, dy, coef.start = start, tol = tol, maxit =
maxit, : Too much damping - convergence tolerance not achievable

corfit2$consensus.correlation

[1] 0.3331473

fit <- lmFit(v2, design, block = x,
             correlation = corfit2$consensus.correlation)

Coefficients not estimable: IndividualNA19160  

Warning: Partial NA coefficients for 10517 probe(s)

fit <- eBayes(fit)

Warning in .ebayes(fit = fit, proportion = proportion, stdev.coef.lim =
stdev.coef.lim, : Estimation of var.prior failed - set to default value

saveRDS(v2, "output/voom_results.rds")

get_results <- function(x, number = nrow(x$coefficients), sort.by = "none",
                        ...) {
  # x - object MArrayLM from eBayes output
  # ... - additional arguments passed to topTable
  stopifnot(class(x) == "MArrayLM")
  results <- topTable(x, number = number, sort.by = sort.by, ...)
  return(results)
}

top_treatment <- get_results(fit, coef = "Unstrain", sort.by = "B")
head(top_treatment)

                     logFC  AveExpr         t      P.Value    adj.P.Val
ENSG00000102317  0.9987454 6.675008  9.623281 1.524391e-08 0.0001603202
ENSG00000104368 -3.0460584 3.590530 -8.010949 2.308420e-07 0.0012138827
ENSG00000100292 -1.0889277 5.415850 -7.351254 7.722353e-07 0.0027071997
ENSG00000181019 -0.7867957 5.816648 -6.684738 2.776203e-06 0.0049479401
ENSG00000005102  1.1806718 2.864059  6.669238 2.862102e-06 0.0049479401
ENSG00000080824 -0.5223356 8.869466 -6.453824 4.386006e-06 0.0049479401
                       B
ENSG00000102317 9.815807
ENSG00000104368 6.715829
ENSG00000100292 6.075909
ENSG00000181019 4.870571
ENSG00000005102 4.446004
ENSG00000080824 4.428583

results_treatment <- get_results(fit, coef = "Unstrain",
                              number = nrow(filt_counts), sort = "none")
ma_treatment <- ggplot(data.frame(Amean = fit$Amean, logFC = fit$coef[, "Unstrain"]),
                       aes(x = Amean, y = logFC)) +
  geom_point() +
  labs(x = "Average expression level", y = "Log fold change",
       title = "Treatment effect")
ma_treatment

hist_treatment <- ggplot(results_treatment, aes(x = P.Value)) +
  geom_histogram(binwidth = 0.01) +
  labs(x = "p-value", y = "Number of genes", title = "Treatment effect")
hist_treatment

plot_gene <- function(v, g) {
  # v - An EList object containing log2 counts per million
  # g - character vector of a single gene
  stopifnot(class(v) == "EList",
            is.character(g), length(g) == 1)
  library("tidyr")
  single_gene <- v$E[g, ]
  single_gene_long <- as.data.frame(single_gene)
  colnames(single_gene_long) <- "log2cpm"
  single_gene_long$sample <- rownames(single_gene_long)
  single_gene_long <- separate(single_gene_long, col = "sample", sep = "_",
                                into = c("Individual", "Replicate", "Treatment"))
  single_gene_long$Treatment <- factor(single_gene_long$Treatment, levels = c("S", "U"))
  single_gene_long$Treatment <- revalue(single_gene_long$Treatment, c("S"="Strain", "U"="No Strain"))
  
  ggplot(single_gene_long, aes(x = Treatment, y = log2cpm, fill = Treatment)) +
       labs(title = g, x = "Treatment", y = expression("Expression level (" * log[2] * " cpm)")) + 
       geom_dotplot(binaxis = "y", stackdir = "center") + 
       stat_summary(fun.data = "mean_sdl", fun.args = list(mult=1))
  
}

#rename top_treatment genes to gene symbols for easier interpretation
top_treatment_top4 <- gene_anno$external_gene_name[match(head(rownames(top_treatment), n=4), gene_anno$ensembl_gene_id)]
top_treatment_top4

[1] RBM3  PLAT  HMOX1 NQO1 
56858 Levels: A1BG A1BG-AS1 A1CF A2M A2M-AS1 A2ML1 A2ML1-AS1 ... ZZEF1

p_treatment_1 <- plot_gene(v2, rownames(top_treatment)[1])
p_treatment_2 <- plot_gene(v2, rownames(top_treatment)[2]) 
p_treatment_3 <- plot_gene(v2, rownames(top_treatment)[3]) 
p_treatment_4 <- plot_gene(v2, rownames(top_treatment)[4]) 
ggsave("fig-limma-treatment-hit-1.eps", plot = p_treatment_1,
       width = 7, height = 7, units = "in")

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

plot_grid(p_treatment_1, p_treatment_2, p_treatment_3, p_treatment_4)

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.
`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.
`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.
`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

run_ash <- function(x, coef) {
  # Perform multiple testing correction with adaptive shrinkage (ASH)
  #
  # x - object MArrayLM from eBayes output
  # coef - coefficient tested by eBayes
  stopifnot(class(x) == "MArrayLM", coef %in% colnames(x$coefficients))
  result <- ash(betahat = x$coefficients[, coef],
                sebetahat = x$stdev.unscaled[, coef] * sqrt(x$s2.post),
                df = x$df.total[1])
  return(result)
}

ash_treatment <- run_ash(fit, "Unstrain")
class(ash_treatment)

[1] "ash"

names(ash_treatment)

[1] "fitted_g" "loglik"   "logLR"    "data"     "result"   "call"    

sum(ash_treatment$result$svalue < .05)

[1] 917

hist(ash_treatment$result$svalue)

Plots

plot_ma <- function(x, qval) {
  # Create MA plot.
  #
  # x - data frame with topTable and ASH output
  #     (columns logFC, AveExpr, and qvalue)
  # qval - qvalue cutoff for calling a gene DE
  #
  stopifnot(is.data.frame(x), c("logFC", "AveExpr", "qvalue") %in% colnames(x),
            is.numeric(qval), qval <= 1, qval >= 0)
  x$highlight <- ifelse(x$qvalue < qval, "darkred", "gray75")
  x$highlight <- factor(x$highlight, levels = c("darkred", "gray75"))
  ggplot(x, aes(x = AveExpr, y = logFC, color = highlight, shape = highlight)) +
    geom_point() +
    labs(x = "Average expression level", y = "Log fold change") +
    scale_color_identity(drop = FALSE) +
    scale_shape_manual(values = c(16, 1), drop = FALSE) +
    theme(legend.position = "none")
#   scale_color_gradient(low = "red", high = "white", limits = c(0, 0.25))
}

plot_volcano <- function(x, qval) {
  # Create volcano plot.
  #
  # x - data frame with topTable and ASH output
  #     (columns logFC, P.Value, and qvalue)
  # qval - qvalue cutoff for calling a gene DE
  #
  stopifnot(is.data.frame(x), c("logFC", "P.Value", "qvalue") %in% colnames(x),
            is.numeric(qval), qval <= 1, qval >= 0)
  x$highlight <- ifelse(x$qvalue < qval, "darkred", "gray75")
  x$highlight <- factor(x$highlight, levels = c("darkred", "gray75"))
  ggplot(x, aes(x = logFC, y = -log10(P.Value), color = highlight)) +
    geom_point(shape = 1) +
    labs(x = "Log fold change",
         y = expression(-log[10] * " p-value")) +
    scale_color_identity(drop = FALSE) +
    theme(legend.position = "none")
}

plot_pval_hist <- function(x, qval) {
  # Create histogram of p-values.
  #
  # x - data frame with topTable and ash output (columns P.Value and qvalue)
  # qval - qvalue cutoff for calling a gene DE
  #
  stopifnot(is.data.frame(x), c("P.Value", "qvalue") %in% colnames(x))
  x$highlight <- ifelse(x$qvalue < qval, "darkred", "gray75")
  x$highlight <- factor(x$highlight, levels = c("darkred", "gray75"))
  ggplot(x, aes(x = P.Value, fill = highlight)) +
    geom_histogram(position = "stack", binwidth = 0.01) +
    scale_fill_identity(drop = FALSE) +
    labs(x = "p-value", y = "Number of genes")
}

tests <- colnames(fit$coefficients)
results <- vector(length = length(tests), mode = "list")
names(results) <- tests

for (test in tests[c(1:4, 6:8)]) {
  # Extract limma results
     print(test)
  results[[test]] <- get_results(fit, coef = test)
  # Add mutliple testing correction with ASH
  output_ash <- run_ash(fit, coef = test)$result
  results[[test]] <- cbind(results[[test]], lfsr = output_ash$lfsr,
                           lfdr = output_ash$lfdr, qvalue = output_ash$qvalue,
                           svalue = output_ash$svalue)
}

[1] "(Intercept)"
[1] "Unstrain"
[1] "SexM"
[1] "IndividualNA18856 "
[1] "W_1"
[1] "W_2"
[1] "RIN"

#FDR 0.1
plot_ma(results[["Unstrain"]], 0.1)

Past versions of “use Functions-1.png”

plot_volcano(results[["Unstrain"]], 0.1)

Past versions of “use Functions-2.png”

plot_pval_hist(results[["Unstrain"]], 0.1)

Past versions of “use Functions-3.png”

table(results[["Unstrain"]]$qvalue < 0.1)

FALSE  TRUE 
 8000  2517 

significant_genes_10 <- row.names(results[["Unstrain"]])[results[["Unstrain"]]$qvalue < 0.1]
significant_symbols_10 <- gene_anno$external_gene_name[match(significant_genes_10, gene_anno$ensembl_gene_id)]
head(significant_symbols_10)

[1] LINC01128  AGRN       DVL1       MXRA8      AURKAIP1   AL391244.1
56858 Levels: A1BG A1BG-AS1 A1CF A2M A2M-AS1 A2ML1 A2ML1-AS1 ... ZZEF1

significant_anno_10 <- gene_anno[match(significant_genes_10, gene_anno$ensembl_gene_id),]


#FDR 0.05
plot_ma(results[["Unstrain"]], 0.05)

Past versions of “use Functions-4.png”

plot_volcano(results[["Unstrain"]], 0.05)

Past versions of “use Functions-5.png”

plot_pval_hist(results[["Unstrain"]], 0.05)

Past versions of “use Functions-6.png”

table(results[["Unstrain"]]$qvalue < 0.05)

FALSE  TRUE 
 9363  1154 

significant_genes_05 <- row.names(results[["Unstrain"]])[results[["Unstrain"]]$qvalue < 0.05]
significant_symbols_05 <- gene_anno$external_gene_name[match(significant_genes_05, gene_anno$ensembl_gene_id)]
head(significant_symbols_05)

[1] DVL1   MRPL20 ATAD3A MMP23B PEX10  CEP104
56858 Levels: A1BG A1BG-AS1 A1CF A2M A2M-AS1 A2ML1 A2ML1-AS1 ... ZZEF1

significant_anno_05 <- gene_anno[match(significant_genes_05, gene_anno$ensembl_gene_id),]
save(significant_genes_05, file="data/DEgenes_FDR05.rda")

#FDR 0.01
plot_ma(results[["Unstrain"]], 0.01)

Past versions of “use Functions-7.png”

plot_volcano(results[["Unstrain"]], 0.01)

Past versions of “use Functions-8.png”

plot_pval_hist(results[["Unstrain"]], 0.01)

Past versions of “use Functions-9.png”

table(results[["Unstrain"]]$qvalue < 0.01)

FALSE  TRUE 
10347   170 

significant_genes_01 <- row.names(results[["Unstrain"]])[results[["Unstrain"]]$qvalue < 0.01]
significant_symbols_01 <- gene_anno$external_gene_name[match(significant_genes_01, gene_anno$ensembl_gene_id)]
head(significant_symbols_01)

[1] TENT5B EYA3   RCC1   SLC6A9 PLK3   PRDX1 
56858 Levels: A1BG A1BG-AS1 A1CF A2M A2M-AS1 A2ML1 A2ML1-AS1 ... ZZEF1

significant_anno_01 <- gene_anno[match(significant_genes_01, gene_anno$ensembl_gene_id),]

#abs(logFC) > 1
significant_genes_05_FC1 <- row.names(results[["Unstrain"]])[results[["Unstrain"]]$qvalue < 0.05 & abs(results[["Unstrain"]]$logFC) > 1]
significant_symbols_05_FC1 <- gene_anno$external_gene_name[match(significant_genes_05_FC1, gene_anno$ensembl_gene_id)]
significant_anno_05_FC1 <- gene_anno[match(significant_genes_05_FC1, gene_anno$ensembl_gene_id),]

significant_anno_05_FC1

      ensembl_gene_id external_gene_name chromosome_name
31021 ENSG00000232679          LINC01705               1
4381  ENSG00000115221              ITGB6               2
7662  ENSG00000138411              HECW2               2
28538 ENSG00000229056         AC020571.1               2
8570  ENSG00000144485               HES6               2
5175  ENSG00000121577             POPDC2               3
934   ENSG00000065534               MYLK               3
13727 ENSG00000174640            SLCO2A1               3
15279 ENSG00000182585               EPGN               4
4845  ENSG00000118785               SPP1               4
14924 ENSG00000180801               ARSJ               4
13297 ENSG00000172403             SYNPO2               4
9313  ENSG00000150630              VEGFC               4
11274 ENSG00000164171              ITGA2               5
13332 ENSG00000172548             NIPAL4               5
7450  ENSG00000137309              HMGA1               6
28168 ENSG00000228495          LINC01013               6
3341  ENSG00000106631               MYL7               7
10067 ENSG00000157168               NRG1               8
2910  ENSG00000104368               PLAT               8
457   ENSG00000026508               CD44              11
46915 ENSG00000261578         AP003119.3              11
3449  ENSG00000107796              ACTA2              10
7759  ENSG00000139044           B4GALNT3              12
3928  ENSG00000111674               ENO2              12
11706 ENSG00000165891               E2F7              12
10325 ENSG00000159251              ACTC1              15
81    ENSG00000005102              MEOX1              17
5642  ENSG00000125398               SOX9              17
14020 ENSG00000176170              SPHK1              17
2562  ENSG00000101670               LIPG              18
2157  ENSG00000100003            SEC14L2              22
2248  ENSG00000100292              HMOX1              22
                                                                                              description
31021                     long intergenic non-protein coding RNA 1705 [Source:HGNC Symbol;Acc:HGNC:52493]
4381                                           integrin subunit beta 6 [Source:HGNC Symbol;Acc:HGNC:6161]
7662  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:29853]
28538                                                                                                    
8570                           hes family bHLH transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:18254]
5175                                       popeye domain containing 2 [Source:HGNC Symbol;Acc:HGNC:17648]
934                                          myosin light chain kinase [Source:HGNC Symbol;Acc:HGNC:7590]
13727      solute carrier organic anion transporter family member 2A1 [Source:HGNC Symbol;Acc:HGNC:10955]
15279                                              epithelial mitogen [Source:HGNC Symbol;Acc:HGNC:17470]
4845                                        secreted phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:11255]
14924                                   arylsulfatase family member J [Source:HGNC Symbol;Acc:HGNC:26286]
13297                                                  synaptopodin 2 [Source:HGNC Symbol;Acc:HGNC:17732]
9313                             vascular endothelial growth factor C [Source:HGNC Symbol;Acc:HGNC:12682]
11274                                         integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137]
13332                                   NIPA like domain containing 4 [Source:HGNC Symbol;Acc:HGNC:28018]
7450                                     high mobility group AT-hook 1 [Source:HGNC Symbol;Acc:HGNC:5010]
28168                     long intergenic non-protein coding RNA 1013 [Source:HGNC Symbol;Acc:HGNC:48987]
3341                                             myosin light chain 7 [Source:HGNC Symbol;Acc:HGNC:21719]
10067                                                     neuregulin 1 [Source:HGNC Symbol;Acc:HGNC:7997]
2910                                plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051]
457                                 CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681]
46915                                                                                                    
3449                               actin, alpha 2, smooth muscle, aorta [Source:HGNC Symbol;Acc:HGNC:130]
7759                    beta-1,4-N-acetyl-galactosaminyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:24137]
3928                                                         enolase 2 [Source:HGNC Symbol;Acc:HGNC:3353]
11706                                      E2F transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:23820]
10325                                    actin, alpha, cardiac muscle 1 [Source:HGNC Symbol;Acc:HGNC:143]
81                                               mesenchyme homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7013]
5642                                                        SRY-box 9 [Source:HGNC Symbol;Acc:HGNC:11204]
14020                                            sphingosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11240]
2562                                        lipase G, endothelial type [Source:HGNC Symbol;Acc:HGNC:6623]
2157                                       SEC14 like lipid binding 2 [Source:HGNC Symbol;Acc:HGNC:10699]
2248                                                  heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013]
      start_position end_position
31021      222041705    222064763
4381       160099666    160200313
7662       196189099    196593692
28538      196260024    196264204
8570       238238267    238240662
5175       119636457    119665324
934        123610049    123884331
13727      133932696    134052184
15279       74308473     74315307
4845        87975650     87983426
14924      113900284    113979727
13297      118850688    119061247
9313       176683538    176792727
11274       52989326     53094779
13332      157460019    157474717
7450        34236873     34246231
28168      132131915    132169374
3341        44138864     44141332
10067       31639386     32767959
2910        42175233     42207724
457         35138870     35232402
46915       76800364     76804555
3449        88935074     88991339
7759          460364       563509
3928         6913745      6923698
11706       77021247     77065580
10325       34788096     34796139
81          43640388     43661954
5642        72121020     72126420
14020       76376584     76387860
2562        49560699     49599182
2157        30396857     30425317
2248        35380361     35394214
                                                                                                                                                                                                                                                       phenotype
31021                                                                                                                                                                                                                                                           
4381                                                                                                         Alopecia-intellectual disability syndrome;Hypocalcified amelogenesis imperfecta;Hypoplastic amelogenesis imperfecta;AMELOGENESIS IMPERFECTA TYPE IH
7662                                                                                                                                                                               HECW2;NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA SEIZURES AND ABSENT LANGUAGE
28538                                                                                                                                                                                                                                                           
8570                                                                                                                                                                                                                                                            
5175                                                                                                                                                                                                                                                            
934                                                                                                        Megacystis-microcolon-intestinal hypoperistalsis syndrome;Familial thoracic aortic aneurysm and aortic dissection;AORTIC ANEURYSM FAMILIAL THORACIC 7
13727                                                                                                                         Chronic enteropathy associated with SLCO2A1 gene;Pachydermoperiostosis;HYPERTROPHIC OSTEOARTHROPATHY PRIMARY AUTOSOMAL RECESSIVE 2
15279                                                                                                                                                                                                                                                           
4845                                                                                                                                                                                                                      Pediatric systemic lupus erythematosus
14924                                                                                                                                                                                                                                                           
13297                                                                                                                                                                                                                                                           
9313                                                                                                                                                                                                                     Milroy Disease;Lymphedema hereditary id
11274                                                                                                                                                                           Fetal and neonatal alloimmune thrombocytopenia;BLEEDING DISORDER PLATELET-TYPE 9
13332                                                                                                                                           Congenital nonbullous ichthyosiform erythroderma;Lamellar ichthyosis;ICHTHYOSIS CONGENITAL AUTOSOMAL RECESSIVE 6
7450                                                                                                                                                                                                                      DIABETES MELLITUS NONINSULIN-DEPENDENT
28168                                                                                                                                                                                                                                                           
3341                                                                                                                                                                                                                                                            
10067                                                                                                                                                                                                                                            SCHIZOPHRENIA 6
2910                                                                                                                         Lethal hydranencephaly-diaphragmatic hernia syndrome;THROMBOPHILIA FAMILIAL DUE TO DECREASED RELEASE OF TISSUE PLASMINOGENACTIVATOR
457                                                                                                                                                                                                                                    BLOOD GROUP INDIAN SYSTEM
46915                                                                                                                                                                                                                                                           
3449                                                                            AORTIC ANEURYSM FAMILIAL THORACIC 6;Moyamoya disease 5;Familial thoracic aortic aneurysm and aortic dissection;Moyamoya disease;MULTISYSTEMIC SMOOTH MUSCLE DYSFUNCTION SYNDROME
7759                                                                                                                                                                                                                                                            
3928                                                                                                                                                                                                                                                            
11706                                                                                                                                                                                                                                                           
10325                                                 Atrial septal defect ostium secundum type;Familial isolated dilated cardiomyopathy;Left ventricular noncompaction;ATRIAL SEPTAL DEFECT 5;Cardiomyopathy dilated 1R;CARDIOMYOPATHY FAMILIAL HYPERTROPHIC 11
81                                                                                                                                                               Klippel-Feil Anomaly;Isolated Klippel-Feil syndrome;KLIPPEL-FEIL SYNDROME 2 AUTOSOMAL RECESSIVE
5642  CAMPOMELIC DYSPLASIA;PIERRE ROBIN SEQUENCE;46XX ovotesticular disorder of sex development;46XX testicular disorder of sex development;46XY complete gonadal dysgenesis;46XY partial gonadal dysgenesis;Isolated Pierre Robin syndrome;46XY SEX REVERSAL 10
14020                                                                                                                                                                                                                                                           
2562                                                                                                                                                                                                                                                            
2157                                                                                                                                                                                                                                                            
2248                                                                                                                                                                                           HEME OXYGENASE 1 DEFICIENCY;PULMONARY DISEASE CHRONIC OBSTRUCTIVE
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                go_id
31021                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
4381                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0016020;GO:0016021;GO:0005813;GO:0005654;GO:0007155;GO:0030054;GO:0005515;GO:0007229;GO:0007160;GO:0008305;GO:0046718;GO:0005925;GO:0005886;GO:0038023;GO:0005178;GO:0016032;GO:0030198;GO:0001618;GO:0043235;GO:0033627;GO:0006954;GO:0038044;GO:0009897;GO:0034685;
7662                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        ;GO:0005737;GO:0016740;GO:0016567;GO:0004842;GO:0005856;GO:0005819;GO:0061630;GO:0043161;GO:0005515;GO:0072686;GO:0030071
28538                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
8570                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005634;GO:0046983;GO:0006355;GO:0006351;GO:0003677;GO:0007275;GO:0030154;GO:0000981;GO:0008134;GO:0003700;GO:0003712;GO:0005667;GO:0000977;GO:0001227;GO:0000122;GO:0006357;GO:0007399;
5175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    ;GO:0016020;GO:0016021;GO:0005886;GO:0003674;GO:0008150;GO:0042383;GO:0002027
934                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0060414;GO:0005737;GO:0046872;GO:0000166;GO:0004672;GO:0004674;GO:0005524;GO:0006468;GO:0016740;GO:0016301;GO:0016310;GO:0003779;GO:0005886;GO:0015629;GO:0005856;GO:0042995;GO:0005515;GO:0005516;GO:0005829;GO:0030027;GO:0001725;GO:0032154;GO:0030335;GO:0051928;GO:0006936;GO:0006939;GO:0090303;GO:0032060;GO:0004687;GO:0014820;GO:0071476;
13727                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0016020;GO:0016021;GO:0005215;GO:0055085;GO:0005886;GO:0015347;GO:0043252;GO:0005887;GO:0005319;GO:0006869;GO:0015132;GO:0015732;GO:0006811;
15279                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GO:0005622;GO:0016020;GO:0016021;GO:0008083;GO:0005576;GO:0005615;GO:0008284;GO:0005887;GO:0005154;GO:0001525;GO:0043406;GO:0045741;GO:0045840;GO:0000187;GO:0050679;GO:0000165;
4845                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 ;GO:0005794;GO:0007155;GO:0001503;GO:0005615;GO:0007566;GO:0010469;GO:0005515;GO:0005576;GO:0005125;GO:0070062;GO:0031214;GO:0044267;GO:0043687;GO:0005788;GO:0030198;GO:0045893;GO:0033280;GO:0046697;GO:0050840;GO:0001649;GO:0006710;GO:0045780;GO:0071394;GO:2000866;GO:0006954;GO:0010033;GO:0030154;GO:0048545;GO:0048685;GO:0031982;GO:0042995;GO:0048471
14924                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0046872;GO:0016787;GO:0003824;GO:0008152;GO:0005576;GO:0008484;GO:0005788;GO:0004065;GO:0016020;GO:0016021;
13297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               GO:0005634;GO:0005737;GO:0043231;GO:0005829;GO:0003779;GO:0015629;GO:0005856;GO:0005515;GO:0030054;GO:0005925;GO:0001725;GO:0030018;GO:0071889;GO:0031005;GO:0032233;GO:0051393;GO:0051371;GO:0000045;GO:0099023;
9313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GO:0016020;GO:0008083;GO:0010469;GO:0005515;GO:0005576;GO:0007275;GO:0030154;GO:0005615;GO:0050918;GO:0001525;GO:0051781;GO:0007165;GO:0002576;GO:0031093;GO:0048010;GO:0042056;GO:0043185;GO:0001666;GO:0001938;GO:0008284;GO:0045766;GO:0050930;GO:0060754;GO:0001954;GO:0002052;GO:0006929;GO:0008285;GO:0009887;GO:0016331;GO:0030947;GO:0031954;GO:0042493;GO:0043536;GO:0045776;GO:0050679;GO:0050714;GO:0050731;GO:1901492;GO:1990830;
11274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0016020;GO:0016021;GO:0046872;GO:0007155;GO:0005515;GO:0009986;GO:0007229;GO:0008305;GO:0046718;GO:0005925;GO:0005886;GO:0016032;GO:0007596;GO:0030198;GO:0044877;GO:0009887;GO:0007160;GO:0001618;GO:0005518;GO:0031589;GO:0001540;GO:0098639;GO:0033627;GO:0048333;GO:0034666;GO:0005178;GO:0038064;GO:0043236;GO:0043395;GO:0046982;GO:0001666;GO:0002687;GO:0006929;GO:0006971;GO:0007565;GO:0008283;GO:0010634;GO:0010694;GO:0014070;GO:0014075;GO:0014850;GO:0014911;GO:0030879;GO:0031346;GO:0032967;GO:0033343;GO:0033591;GO:0038065;GO:0042060;GO:0042493;GO:0043388;GO:0043589;GO:0045184;GO:0045727;GO:0045785;GO:0045987;GO:0048041;GO:0048661;GO:0050729;GO:0050927;GO:0050966;GO:0051971;GO:0060100;GO:0070365;GO:0071107;GO:0071260;GO:0071392;GO:0071407;GO:0005634;GO:0009897;GO:0030424;GO:0042995;GO:0043679;GO:0045178;GO:0048471;
13332                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0016020;GO:0016021;GO:0006811;GO:0015095;GO:0015693;GO:1903830;
7450                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   GO:0045944;GO:0005634;GO:0006355;GO:0006366;GO:0006351;GO:0003677;GO:0005694;GO:0000785;GO:0005515;GO:0030374;GO:0045893;GO:0005925;GO:0003700;GO:0000981;GO:0005654;GO:0005829;GO:0008285;GO:0042974;GO:0009615;GO:0006284;GO:0019899;GO:0008134;GO:0045892;GO:0003682;GO:0090575;GO:0065003;GO:0005667;GO:0051169;GO:0075713;GO:0001205;GO:0006337;GO:0046965;GO:0001158;GO:0003680;GO:0003906;GO:0042975;GO:0006268;GO:0031936;GO:0035986;GO:0090402;GO:2000774;GO:0035985;
28168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
3341                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005509;GO:0046872;GO:0016459;GO:0005515;GO:0005829;GO:0006936;GO:0031672;GO:0043197;
10067                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0016020;GO:0016021;GO:0005654;GO:0005102;GO:0009790;GO:0005634;GO:0018108;GO:0008083;GO:0010469;GO:0005886;GO:0005576;GO:0005615;GO:0046854;GO:0007171;GO:0008284;GO:0005178;GO:0046934;GO:0051897;GO:0005088;GO:0000165;GO:0030971;GO:0005125;GO:0004713;GO:0038128;GO:2000145;GO:0032148;GO:0055007;GO:0000187;GO:0014032;GO:0045892;GO:0007399;GO:0030297;GO:0051048;GO:0042060;GO:0030879;GO:0003222;GO:0043125;GO:0038127;GO:0060956;GO:0003712;GO:0007154;GO:0038129;GO:0043496;GO:0043497;GO:0051155;GO:0060379;;GO:0005176;GO:0045499;GO:0000902;GO:0001964;GO:0003161;GO:0007416;GO:0007420;GO:0007422;GO:0007507;GO:0007517;GO:0007626;GO:0008366;GO:0010001;GO:0010628;GO:0014068;GO:0016477;GO:0021781;GO:0021842;GO:0022008;GO:0031643;GO:0042177;GO:0045213;GO:0045595;GO:0045773;GO:0045860;GO:0045944;GO:0046579;GO:0048663;GO:0048709;GO:0048738;GO:0050731;GO:0060999;GO:0070886;GO:2000010;GO:2000727;GO:2001223;GO:0005737;GO:0005887;GO:0009897;GO:0030424;GO:0030425;GO:0030673;GO:0031594;GO:0044297;GO:0045202
2910                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GO:0005737;GO:0016787;GO:0005576;GO:0008233;GO:0006508;GO:0004252;GO:0005615;GO:0008236;GO:0005515;GO:0070062;GO:0005102;GO:0031639;GO:0009986;GO:0007596;GO:0006464;GO:0045861;GO:0042730;GO:0051219;GO:0001666;GO:0014909;GO:0048008;GO:0030141;GO:0045177;
457                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0070374;GO:0016020;GO:0016021;GO:0005794;GO:0005829;GO:0007155;GO:0005886;GO:0042995;GO:0005515;GO:0005540;GO:0051216;GO:0009986;GO:0005925;GO:0050900;GO:0005887;GO:0070062;GO:0005902;GO:0043312;GO:0016324;GO:0033138;GO:0043066;GO:0050731;GO:0030667;GO:0030198;GO:0043154;GO:0060333;GO:0044319;GO:0022617;GO:0007160;GO:0044344;GO:0098609;GO:0005518;GO:0043518;GO:1902166;GO:0030214;GO:0034116;GO:0070487;GO:0004896;GO:0035692;GO:0031258;GO:2000392;GO:1900625;;GO:0033674
46915                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
3449                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005737;GO:0000166;GO:0005524;GO:0005856;GO:0005615;GO:0005829;GO:0070062;GO:0009615;GO:0032991;GO:0010628;GO:0019901;GO:0008217;GO:0014829;GO:0090131;GO:0015629;GO:0030027;GO:0030175;GO:0030485;GO:0044297;GO:0006936;GO:0072144;
7759                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GO:0016020;GO:0016021;GO:0016740;GO:0005794;GO:0008376;GO:0032580;GO:0033842;
3928                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000287;GO:0006096;GO:0004634;GO:0000015;GO:0005737;GO:0016020;GO:0046872;GO:0005829;GO:0016829;GO:0005886;GO:0005515;GO:0005615;GO:0070062;GO:0006094;GO:0061621;;GO:0001917;GO:0005622;GO:0043025;GO:0043204;GO:0043209
11706                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GO:0005634;GO:0016607;GO:0006355;GO:0006351;GO:0003677;GO:0003700;GO:0005515;GO:0006974;GO:0007049;GO:0005667;GO:0042802;GO:0000122;GO:0000981;GO:0000987;GO:0003714;GO:0001890;GO:0002040;GO:0006977;GO:0032466;GO:0032877;GO:0045944;GO:0060707;GO:0060718;GO:0070365;GO:0005654;GO:0008285;GO:0030330;GO:2000134;GO:0000977;GO:0000978;GO:0001227;GO:0071930;
10325                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005737;GO:0016020;GO:0000166;GO:0005524;GO:0005856;GO:0005615;GO:0005925;GO:0005829;GO:0070062;GO:0016887;GO:0072562;GO:0031674;GO:0010628;GO:0090131;GO:0030027;GO:0030175;GO:0044297;GO:0005884;GO:0017022;GO:0030049;GO:0030017;GO:0030048;GO:0060047;GO:0055003;GO:0055008;GO:0031032;GO:0030240;GO:0033275;GO:0042493;GO:0043066;GO:0045471;GO:0060048;GO:0070252;GO:0042643;
81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0005634;GO:0005737;GO:0006355;GO:0006366;GO:0006351;GO:0003677;GO:0003700;GO:0043565;GO:0005515;GO:0007275;GO:0000981;GO:0045944;GO:0003674;GO:0008150;GO:0001077;GO:0061053;GO:0000978;GO:0003682;GO:0071837;GO:0001757;GO:0060218;GO:0061056
5642  GO:0045944;GO:0005634;GO:0005654;GO:0006355;GO:0006351;GO:0003677;GO:0003700;GO:0006334;GO:0000981;GO:0005515;GO:0007165;GO:0051216;GO:0045893;GO:0007283;GO:0001934;GO:0001501;GO:0090090;GO:0003682;GO:0008584;GO:0032991;GO:0071347;GO:0071260;GO:0008284;GO:0042127;GO:0042981;GO:0043066;GO:0070371;GO:0001502;GO:0032332;GO:0045892;GO:0006367;GO:0004672;GO:0019933;GO:0071560;GO:0007173;GO:0045662;GO:0060041;GO:0000978;GO:0002062;GO:1902894;GO:0071300;GO:0065003;GO:0050680;GO:0006338;GO:0001158;GO:0001077;GO:0030850;GO:0010634;GO:0050679;GO:0014068;GO:0034236;GO:0001708;GO:0002053;GO:0090103;GO:0060008;GO:0001894;GO:0071364;GO:0030279;GO:0070168;GO:0071504;GO:0003705;GO:0001837;GO:0090190;GO:0001942;GO:0003203;GO:0090184;GO:2000020;GO:0030916;GO:0061036;GO:2000741;GO:0032331;GO:0035019;GO:0000976;GO:0001228;GO:0008013;GO:0035326;GO:0043425;GO:0043565;GO:0044212;GO:0046982;GO:0097157;GO:0000122;GO:0001503;GO:0001658;GO:0002063;GO:0002683;GO:0003170;GO:0003179;GO:0003188;GO:0003413;GO:0003415;GO:0006357;GO:0007010;GO:0007219;GO:0007417;GO:0007507;GO:0008285;GO:0010564;GO:0010628;GO:0010629;GO:0014032;GO:0014036;GO:0019100;GO:0030154;GO:0030155;GO:0030198;GO:0030238;GO:0030502;GO:0030857;GO:0030858;GO:0030879;GO:0030903;GO:0031018;GO:0032808;GO:0034504;GO:0035622;GO:0043491;GO:0045165;GO:0045595;GO:0045732;GO:0046533;GO:0048709;GO:0048873;GO:0060009;GO:0060018;GO:0060174;GO:0060221;GO:0060350;GO:0060441;GO:0060487;GO:0060512;GO:0060517;GO:0060532;GO:0060534;GO:0060729;GO:0060784;GO:0061046;GO:0061138;GO:0061145;GO:0070384;GO:0071599;GO:0071773;GO:0072034;GO:0072170;GO:0072189;GO:0072190;GO:0072193;GO:0072197;GO:0072289;GO:0097065;GO:0098609;GO:1901203;GO:2000138;GO:2000794;GO:2001054;GO:0005667;GO:0044798;
14020                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           ;GO:0005737;GO:0005634;GO:0016020;GO:0000166;GO:0005524;GO:0005829;GO:0016740;GO:0016301;GO:0016310;GO:0005886;GO:0008152;GO:0003951;GO:0005515;GO:0000287;GO:0046834;GO:0003376;GO:0005516;GO:0010800;GO:0030335;GO:0031398;GO:0006457;GO:0043066;GO:0007165;GO:0051092;GO:1901224;GO:0003677;GO:0030307;GO:0035556;GO:0030148;GO:0045766;GO:0019722;GO:0045931;GO:0038036;GO:0045987;GO:0048146;GO:0046512;GO:0051721;GO:0010803;GO:0006670;GO:0008481;GO:0017050;GO:0046521;GO:0001568;GO:0006954;GO:0007420;GO:0008284;GO:0032651
2562                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0006629;GO:0005576;GO:0004465;GO:0052689;;GO:0005615;GO:0042632;GO:0016787;GO:0016042;GO:0004620;GO:0007584;GO:0008283;GO:0050746;GO:0004806;GO:0008201;GO:0005794;GO:0005769;GO:0034375;GO:0043691;GO:0055091;GO:0009395;GO:0009986;GO:0032376;GO:0008970;GO:0010983
2157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GO:0005634;GO:0005737;GO:0005829;GO:0006351;GO:0006355;GO:0045893;GO:0008289;GO:0070062;GO:0005543;GO:0008431;GO:0045540;
2248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0046872;GO:0055114;GO:0004392;GO:0006788;GO:0005615;GO:0045766;GO:1903589;GO:0090050;GO:0005634;GO:0016020;GO:0016021;GO:0016491;GO:0005783;GO:0005789;GO:0042803;GO:0005515;GO:0006915;GO:0048471;GO:0043231;GO:0051260;GO:0043123;GO:0019221;GO:0019899;GO:0001525;GO:0048661;GO:0071456;GO:1902042;GO:0020037;GO:0034605;GO:0045765;GO:0008219;GO:0035556;GO:0048662;GO:0006979;GO:0006879;GO:0042542;GO:0034383;GO:0045080;GO:0055072;GO:0004630;GO:0001666;GO:0001935;GO:0002246;GO:0002686;GO:0007264;GO:0007588;GO:0008217;GO:0008285;GO:0008630;GO:0010656;GO:0014806;GO:0016239;GO:0016242;GO:0031670;GO:0032764;GO:0034101;GO:0034395;GO:0035094;GO:0042167;GO:0042168;GO:0043065;GO:0043305;GO:0043392;GO:0043433;GO:0043524;GO:0043619;GO:0043627;GO:0051090;GO:0071243;GO:0071276;GO:0072719;GO:0097421;GO:0097755;GO:1904036;GO:1904706;GO:0005730;GO:0005829;GO:0005901;
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  go_descrip
31021                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
4381                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 membrane;integral component of membrane;centrosome;nucleoplasm;cell adhesion;cell junction;protein binding;integrin-mediated signaling pathway;cell-matrix adhesion;integrin complex;viral entry into host cell;focal adhesion;plasma membrane;signaling receptor activity;integrin binding;viral process;extracellular matrix organization;virus receptor activity;receptor complex;cell adhesion mediated by integrin;inflammatory response;transforming growth factor-beta secretion;external side of plasma membrane;integrin alphav-beta6 complex;
7662                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ;cytoplasm;transferase activity;protein ubiquitination;ubiquitin-protein transferase activity;cytoskeleton;spindle;ubiquitin protein ligase activity;proteasome-mediated ubiquitin-dependent protein catabolic process;protein binding;mitotic spindle;regulation of mitotic metaphase/anaphase transition
28538                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
8570                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       nucleus;protein dimerization activity;regulation of transcription, DNA-templated;transcription, DNA-templated;DNA binding;multicellular organism development;cell differentiation;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcription factor binding;DNA binding transcription factor activity;transcription cofactor activity;transcription factor complex;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;negative regulation of transcription by RNA polymerase II;regulation of transcription by RNA polymerase II;nervous system development;
5175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ;membrane;integral component of membrane;plasma membrane;molecular_function;biological_process;sarcolemma;regulation of heart rate
934                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 aorta smooth muscle tissue morphogenesis;cytoplasm;metal ion binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;ATP binding;protein phosphorylation;transferase activity;kinase activity;phosphorylation;actin binding;plasma membrane;actin cytoskeleton;cytoskeleton;cell projection;protein binding;calmodulin binding;cytosol;lamellipodium;stress fiber;cleavage furrow;positive regulation of cell migration;positive regulation of calcium ion transport;muscle contraction;smooth muscle contraction;positive regulation of wound healing;bleb assembly;myosin light chain kinase activity;tonic smooth muscle contraction;cellular hypotonic response;
13727                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           membrane;integral component of membrane;transporter activity;transmembrane transport;plasma membrane;sodium-independent organic anion transmembrane transporter activity;sodium-independent organic anion transport;integral component of plasma membrane;lipid transporter activity;lipid transport;prostaglandin transmembrane transporter activity;prostaglandin transport;ion transport;
15279                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       intracellular;membrane;integral component of membrane;growth factor activity;extracellular region;extracellular space;positive regulation of cell proliferation;integral component of plasma membrane;epidermal growth factor receptor binding;angiogenesis;positive regulation of MAP kinase activity;positive regulation of epidermal growth factor-activated receptor activity;positive regulation of mitotic nuclear division;activation of MAPK activity;positive regulation of epithelial cell proliferation;MAPK cascade;
4845                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               ;Golgi apparatus;cell adhesion;ossification;extracellular space;embryo implantation;regulation of signaling receptor activity;protein binding;extracellular region;cytokine activity;extracellular exosome;biomineral tissue development;cellular protein metabolic process;post-translational protein modification;endoplasmic reticulum lumen;extracellular matrix organization;positive regulation of transcription, DNA-templated;response to vitamin D;decidualization;extracellular matrix binding;osteoblast differentiation;androgen catabolic process;positive regulation of bone resorption;cellular response to testosterone stimulus;positive regulation of estradiol secretion;inflammatory response;response to organic substance;cell differentiation;response to steroid hormone;negative regulation of collateral sprouting of intact axon in response to injury;vesicle;cell projection;perinuclear region of cytoplasm
14924                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           metal ion binding;hydrolase activity;catalytic activity;metabolic process;extracellular region;sulfuric ester hydrolase activity;endoplasmic reticulum lumen;arylsulfatase activity;membrane;integral component of membrane;
13297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            nucleus;cytoplasm;intracellular membrane-bounded organelle;cytosol;actin binding;actin cytoskeleton;cytoskeleton;protein binding;cell junction;focal adhesion;stress fiber;Z disc;14-3-3 protein binding;filamin binding;positive regulation of actin filament bundle assembly;alpha-actinin binding;muscle alpha-actinin binding;autophagosome assembly;tethering complex;
9313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              membrane;growth factor activity;regulation of signaling receptor activity;protein binding;extracellular region;multicellular organism development;cell differentiation;extracellular space;positive chemotaxis;angiogenesis;positive regulation of cell division;signal transduction;platelet degranulation;platelet alpha granule lumen;vascular endothelial growth factor receptor signaling pathway;chemoattractant activity;vascular endothelial growth factor receptor 3 binding;response to hypoxia;positive regulation of endothelial cell proliferation;positive regulation of cell proliferation;positive regulation of angiogenesis;induction of positive chemotaxis;positive regulation of mast cell chemotaxis;positive regulation of cell-matrix adhesion;positive regulation of neuroblast proliferation;substrate-dependent cell migration;negative regulation of cell proliferation;animal organ morphogenesis;morphogenesis of embryonic epithelium;regulation of vascular endothelial growth factor receptor signaling pathway;positive regulation of protein autophosphorylation;response to drug;positive regulation of blood vessel endothelial cell migration;negative regulation of blood pressure;positive regulation of epithelial cell proliferation;positive regulation of protein secretion;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of lymphangiogenesis;cellular response to leukemia inhibitory factor;
11274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              membrane;integral component of membrane;metal ion binding;cell adhesion;protein binding;cell surface;integrin-mediated signaling pathway;integrin complex;viral entry into host cell;focal adhesion;plasma membrane;viral process;blood coagulation;extracellular matrix organization;protein-containing complex binding;animal organ morphogenesis;cell-matrix adhesion;virus receptor activity;collagen binding;cell-substrate adhesion;amyloid-beta binding;collagen binding involved in cell-matrix adhesion;cell adhesion mediated by integrin;mesodermal cell differentiation;integrin alpha2-beta1 complex;integrin binding;collagen receptor activity;laminin binding;heparan sulfate proteoglycan binding;protein heterodimerization activity;response to hypoxia;positive regulation of leukocyte migration;substrate-dependent cell migration;hypotonic response;female pregnancy;cell proliferation;positive regulation of epithelial cell migration;positive regulation of alkaline phosphatase activity;response to organic cyclic compound;response to amine;response to muscle activity;positive regulation of smooth muscle cell migration;mammary gland development;positive regulation of cell projection organization;positive regulation of collagen biosynthetic process;positive regulation of collagen binding;response to L-ascorbic acid;collagen-activated signaling pathway;wound healing;response to drug;positive regulation of DNA binding;skin morphogenesis;establishment of protein localization;positive regulation of translation;positive regulation of cell adhesion;positive regulation of smooth muscle contraction;focal adhesion assembly;positive regulation of smooth muscle cell proliferation;positive regulation of inflammatory response;positive regulation of positive chemotaxis;detection of mechanical stimulus involved in sensory perception of pain;positive regulation of transmission of nerve impulse;positive regulation of phagocytosis, engulfment;hepatocyte differentiation;response to parathyroid hormone;cellular response to mechanical stimulus;cellular response to estradiol stimulus;cellular response to organic cyclic compound;nucleus;external side of plasma membrane;axon;cell projection;axon terminus;basal part of cell;perinuclear region of cytoplasm;
13332                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  membrane;integral component of membrane;ion transport;magnesium ion transmembrane transporter activity;magnesium ion transport;magnesium ion transmembrane transport;
7450                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        positive regulation of transcription by RNA polymerase II;nucleus;regulation of transcription, DNA-templated;transcription by RNA polymerase II;transcription, DNA-templated;DNA binding;chromosome;chromatin;protein binding;ligand-dependent nuclear receptor transcription coactivator activity;positive regulation of transcription, DNA-templated;focal adhesion;DNA binding transcription factor activity;RNA polymerase II transcription factor activity, sequence-specific DNA binding;nucleoplasm;cytosol;negative regulation of cell proliferation;retinoic acid receptor binding;response to virus;base-excision repair;enzyme binding;transcription factor binding;negative regulation of transcription, DNA-templated;chromatin binding;RNA polymerase II transcription factor complex;protein-containing complex assembly;transcription factor complex;nuclear transport;establishment of integrated proviral latency;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding;nucleosome disassembly;retinoid X receptor binding;enhancer sequence-specific DNA binding;AT DNA binding;DNA-(apurinic or apyrimidinic site) endonuclease activity;peroxisome proliferator activated receptor binding;DNA unwinding involved in DNA replication;negative regulation of chromatin silencing;senescence-associated heterochromatin focus assembly;oncogene-induced cell senescence;positive regulation of cellular senescence;senescence-associated heterochromatin focus;
28168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
3341                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 calcium ion binding;metal ion binding;myosin complex;protein binding;cytosol;muscle contraction;A band;dendritic spine;
10067                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     membrane;integral component of membrane;nucleoplasm;signaling receptor binding;embryo development;nucleus;peptidyl-tyrosine phosphorylation;growth factor activity;regulation of signaling receptor activity;plasma membrane;extracellular region;extracellular space;phosphatidylinositol phosphorylation;activation of transmembrane receptor protein tyrosine kinase activity;positive regulation of cell proliferation;integrin binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;positive regulation of protein kinase B signaling;Ras guanyl-nucleotide exchange factor activity;MAPK cascade;receptor tyrosine kinase binding;cytokine activity;protein tyrosine kinase activity;ERBB2 signaling pathway;regulation of cell motility;activation of protein kinase B activity;cardiac muscle cell differentiation;activation of MAPK activity;neural crest cell development;negative regulation of transcription, DNA-templated;nervous system development;transmembrane receptor protein tyrosine kinase activator activity;negative regulation of secretion;wound healing;mammary gland development;ventricular trabecula myocardium morphogenesis;ErbB-3 class receptor binding;ERBB signaling pathway;endocardial cell differentiation;transcription cofactor activity;cell communication;ERBB3 signaling pathway;regulation of protein homodimerization activity;regulation of protein heterodimerization activity;positive regulation of striated muscle cell differentiation;cardiac muscle cell myoblast differentiation;;ErbB-2 class receptor binding;chemorepellent activity;cell morphogenesis;startle response;cardiac conduction system development;synapse assembly;brain development;peripheral nervous system development;heart development;muscle organ development;locomotory behavior;axon ensheathment;glial cell differentiation;positive regulation of gene expression;positive regulation of phosphatidylinositol 3-kinase signaling;cell migration;glial cell fate commitment;chemorepulsion involved in interneuron migration from the subpallium to the cortex;neurogenesis;positive regulation of myelination;negative regulation of protein catabolic process;neurotransmitter receptor metabolic process;regulation of cell differentiation;positive regulation of axon extension;positive regulation of protein kinase activity;positive regulation of transcription by RNA polymerase II;positive regulation of Ras protein signal transduction;neuron fate commitment;oligodendrocyte differentiation;cardiac muscle tissue development;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of dendritic spine development;positive regulation of calcineurin-NFAT signaling cascade;positive regulation of protein localization to cell surface;positive regulation of cardiac muscle cell differentiation;negative regulation of neuron migration;cytoplasm;integral component of plasma membrane;external side of plasma membrane;axon;dendrite;axolemma;neuromuscular junction;cell body;synapse
2910                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cytoplasm;hydrolase activity;extracellular region;peptidase activity;proteolysis;serine-type endopeptidase activity;extracellular space;serine-type peptidase activity;protein binding;extracellular exosome;signaling receptor binding;plasminogen activation;cell surface;blood coagulation;cellular protein modification process;negative regulation of proteolysis;fibrinolysis;phosphoprotein binding;response to hypoxia;smooth muscle cell migration;platelet-derived growth factor receptor signaling pathway;secretory granule;apical part of cell;
457                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       positive regulation of ERK1 and ERK2 cascade;membrane;integral component of membrane;Golgi apparatus;cytosol;cell adhesion;plasma membrane;cell projection;protein binding;hyaluronic acid binding;cartilage development;cell surface;focal adhesion;leukocyte migration;integral component of plasma membrane;extracellular exosome;microvillus;neutrophil degranulation;apical plasma membrane;positive regulation of peptidyl-serine phosphorylation;negative regulation of apoptotic process;positive regulation of peptidyl-tyrosine phosphorylation;secretory granule membrane;extracellular matrix organization;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;interferon-gamma-mediated signaling pathway;wound healing, spreading of cells;extracellular matrix disassembly;cell-matrix adhesion;cellular response to fibroblast growth factor stimulus;cell-cell adhesion;collagen binding;negative regulation of DNA damage response, signal transduction by p53 class mediator;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;hyaluronan catabolic process;positive regulation of heterotypic cell-cell adhesion;monocyte aggregation;cytokine receptor activity;macrophage migration inhibitory factor receptor complex;lamellipodium membrane;regulation of lamellipodium morphogenesis;positive regulation of monocyte aggregation;;positive regulation of kinase activity
46915                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
3449                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 cytoplasm;nucleotide binding;ATP binding;cytoskeleton;extracellular space;cytosol;extracellular exosome;response to virus;protein-containing complex;positive regulation of gene expression;protein kinase binding;regulation of blood pressure;vascular smooth muscle contraction;mesenchyme migration;actin cytoskeleton;lamellipodium;filopodium;smooth muscle contractile fiber;cell body;muscle contraction;glomerular mesangial cell development;
7759                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                membrane;integral component of membrane;transferase activity;Golgi apparatus;acetylgalactosaminyltransferase activity;Golgi cisterna membrane;N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity;
3928                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         magnesium ion binding;glycolytic process;phosphopyruvate hydratase activity;phosphopyruvate hydratase complex;cytoplasm;membrane;metal ion binding;cytosol;lyase activity;plasma membrane;protein binding;extracellular space;extracellular exosome;gluconeogenesis;canonical glycolysis;;photoreceptor inner segment;intracellular;neuronal cell body;perikaryon;myelin sheath
11706                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          nucleus;nuclear speck;regulation of transcription, DNA-templated;transcription, DNA-templated;DNA binding;DNA binding transcription factor activity;protein binding;cellular response to DNA damage stimulus;cell cycle;transcription factor complex;identical protein binding;negative regulation of transcription by RNA polymerase II;RNA polymerase II transcription factor activity, sequence-specific DNA binding;proximal promoter sequence-specific DNA binding;transcription corepressor activity;placenta development;sprouting angiogenesis;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;negative regulation of cytokinesis;positive regulation of DNA endoreduplication;positive regulation of transcription by RNA polymerase II;trophoblast giant cell differentiation;chorionic trophoblast cell differentiation;hepatocyte differentiation;nucleoplasm;negative regulation of cell proliferation;DNA damage response, signal transduction by p53 class mediator;negative regulation of G1/S transition of mitotic cell cycle;RNA polymerase II regulatory region sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;negative regulation of transcription involved in G1/S transition of mitotic cell cycle;
10325                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    cytoplasm;membrane;nucleotide binding;ATP binding;cytoskeleton;extracellular space;focal adhesion;cytosol;extracellular exosome;ATPase activity;blood microparticle;I band;positive regulation of gene expression;mesenchyme migration;lamellipodium;filopodium;cell body;actin filament;myosin binding;muscle filament sliding;sarcomere;actin filament-based movement;heart contraction;cardiac myofibril assembly;cardiac muscle tissue morphogenesis;actomyosin structure organization;skeletal muscle thin filament assembly;actin-myosin filament sliding;response to drug;negative regulation of apoptotic process;response to ethanol;cardiac muscle contraction;actin-mediated cell contraction;actomyosin, actin portion;
81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                nucleus;cytoplasm;regulation of transcription, DNA-templated;transcription by RNA polymerase II;transcription, DNA-templated;DNA binding;DNA binding transcription factor activity;sequence-specific DNA binding;protein binding;multicellular organism development;RNA polymerase II transcription factor activity, sequence-specific DNA binding;positive regulation of transcription by RNA polymerase II;molecular_function;biological_process;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;somite development;RNA polymerase II proximal promoter sequence-specific DNA binding;chromatin binding;HMG box domain binding;somite specification;hematopoietic stem cell differentiation;sclerotome development
5642  positive regulation of transcription by RNA polymerase II;nucleus;nucleoplasm;regulation of transcription, DNA-templated;transcription, DNA-templated;DNA binding;DNA binding transcription factor activity;nucleosome assembly;RNA polymerase II transcription factor activity, sequence-specific DNA binding;protein binding;signal transduction;cartilage development;positive regulation of transcription, DNA-templated;spermatogenesis;positive regulation of protein phosphorylation;skeletal system development;negative regulation of canonical Wnt signaling pathway;chromatin binding;male gonad development;protein-containing complex;cellular response to interleukin-1;cellular response to mechanical stimulus;positive regulation of cell proliferation;regulation of cell proliferation;regulation of apoptotic process;negative regulation of apoptotic process;ERK1 and ERK2 cascade;cartilage condensation;positive regulation of chondrocyte differentiation;negative regulation of transcription, DNA-templated;transcription initiation from RNA polymerase II promoter;protein kinase activity;cAMP-mediated signaling;cellular response to transforming growth factor beta stimulus;epidermal growth factor receptor signaling pathway;negative regulation of myoblast differentiation;retina development in camera-type eye;RNA polymerase II proximal promoter sequence-specific DNA binding;chondrocyte differentiation;negative regulation of pri-miRNA transcription by RNA polymerase II;cellular response to retinoic acid;protein-containing complex assembly;negative regulation of epithelial cell proliferation;chromatin remodeling;enhancer sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;prostate gland development;positive regulation of epithelial cell migration;positive regulation of epithelial cell proliferation;positive regulation of phosphatidylinositol 3-kinase signaling;protein kinase A catalytic subunit binding;cell fate specification;positive regulation of mesenchymal cell proliferation;cochlea morphogenesis;Sertoli cell differentiation;tissue homeostasis;cellular response to epidermal growth factor stimulus;negative regulation of ossification;negative regulation of biomineral tissue development;cellular response to heparin;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;epithelial to mesenchymal transition;positive regulation of branching involved in ureteric bud morphogenesis;hair follicle development;endocardial cushion morphogenesis;positive regulation of kidney development;positive regulation of male gonad development;otic vesicle formation;positive regulation of cartilage development;positive regulation of mesenchymal stem cell differentiation;negative regulation of chondrocyte differentiation;somatic stem cell population maintenance;transcription regulatory region sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;beta-catenin binding;enhancer binding;bHLH transcription factor binding;sequence-specific DNA binding;transcription regulatory region DNA binding;protein heterodimerization activity;pre-mRNA intronic binding;negative regulation of transcription by RNA polymerase II;ossification;branching involved in ureteric bud morphogenesis;chondrocyte development;negative regulation of immune system process;heart valve development;heart valve morphogenesis;heart valve formation;chondrocyte differentiation involved in endochondral bone morphogenesis;chondrocyte hypertrophy;regulation of transcription by RNA polymerase II;cytoskeleton organization;Notch signaling pathway;central nervous system development;heart development;negative regulation of cell proliferation;regulation of cell cycle process;positive regulation of gene expression;negative regulation of gene expression;neural crest cell development;neural crest cell fate specification;male germ-line sex determination;cell differentiation;regulation of cell adhesion;extracellular matrix organization;male sex determination;negative regulation of bone mineralization;negative regulation of epithelial cell differentiation;positive regulation of epithelial cell differentiation;mammary gland development;notochord development;endocrine pancreas development;lacrimal gland development;protein localization to nucleus;intrahepatic bile duct development;protein kinase B signaling;cell fate commitment;regulation of cell differentiation;positive regulation of protein catabolic process;negative regulation of photoreceptor cell differentiation;oligodendrocyte differentiation;homeostasis of number of cells within a tissue;Sertoli cell development;astrocyte fate commitment;limb bud formation;retinal rod cell differentiation;endochondral bone morphogenesis;epithelial tube branching involved in lung morphogenesis;lung epithelial cell differentiation;prostate gland morphogenesis;epithelial cell proliferation involved in prostatic bud elongation;bronchus cartilage development;trachea cartilage development;intestinal epithelial structure maintenance;regulation of cell proliferation involved in tissue homeostasis;regulation of branching involved in lung morphogenesis;morphogenesis of a branching epithelium;lung smooth muscle development;Harderian gland development;otic vesicle development;cellular response to BMP stimulus;renal vesicle induction;metanephric tubule development;ureter development;ureter urothelium development;ureter smooth muscle cell differentiation;ureter morphogenesis;metanephric nephron tubule formation;anterior head development;cell-cell adhesion;positive regulation of extracellular matrix assembly;positive regulation of cell proliferation involved in heart morphogenesis;regulation of epithelial cell proliferation involved in lung morphogenesis;negative regulation of mesenchymal cell apoptotic process;transcription factor complex;nuclear transcription factor complex;
14020                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ;cytoplasm;nucleus;membrane;nucleotide binding;ATP binding;cytosol;transferase activity;kinase activity;phosphorylation;plasma membrane;metabolic process;NAD+ kinase activity;protein binding;magnesium ion binding;lipid phosphorylation;sphingosine-1-phosphate signaling pathway;calmodulin binding;positive regulation of peptidyl-threonine phosphorylation;positive regulation of cell migration;positive regulation of protein ubiquitination;protein folding;negative regulation of apoptotic process;signal transduction;positive regulation of NF-kappaB transcription factor activity;positive regulation of NIK/NF-kappaB signaling;DNA binding;positive regulation of cell growth;intracellular signal transduction;sphingolipid biosynthetic process;positive regulation of angiogenesis;calcium-mediated signaling;positive regulation of mitotic cell cycle;sphingosine-1-phosphate receptor activity;positive regulation of smooth muscle contraction;positive regulation of fibroblast proliferation;sphingosine biosynthetic process;protein phosphatase 2A binding;regulation of tumor necrosis factor-mediated signaling pathway;sphingosine metabolic process;sphinganine kinase activity;D-erythro-sphingosine kinase activity;sphingoid catabolic process;blood vessel development;inflammatory response;brain development;positive regulation of cell proliferation;regulation of interleukin-1 beta production
2562                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                lipid metabolic process;extracellular region;lipoprotein lipase activity;carboxylic ester hydrolase activity;;extracellular space;cholesterol homeostasis;hydrolase activity;lipid catabolic process;phospholipase activity;response to nutrient;cell proliferation;regulation of lipoprotein metabolic process;triglyceride lipase activity;heparin binding;Golgi apparatus;early endosome;high-density lipoprotein particle remodeling;reverse cholesterol transport;phospholipid homeostasis;phospholipid catabolic process;cell surface;positive regulation of cholesterol transport;phosphatidylcholine 1-acylhydrolase activity;positive regulation of high-density lipoprotein particle clearance
2157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        nucleus;cytoplasm;cytosol;transcription, DNA-templated;regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;lipid binding;extracellular exosome;phospholipid binding;vitamin E binding;regulation of cholesterol biosynthetic process;
2248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    metal ion binding;oxidation-reduction process;heme oxygenase (decyclizing) activity;heme oxidation;extracellular space;positive regulation of angiogenesis;positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;positive regulation of cell migration involved in sprouting angiogenesis;nucleus;membrane;integral component of membrane;oxidoreductase activity;endoplasmic reticulum;endoplasmic reticulum membrane;protein homodimerization activity;protein binding;apoptotic process;perinuclear region of cytoplasm;intracellular membrane-bounded organelle;protein homooligomerization;positive regulation of I-kappaB kinase/NF-kappaB signaling;cytokine-mediated signaling pathway;enzyme binding;angiogenesis;positive regulation of smooth muscle cell proliferation;cellular response to hypoxia;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;heme binding;cellular response to heat;regulation of angiogenesis;cell death;intracellular signal transduction;negative regulation of smooth muscle cell proliferation;response to oxidative stress;cellular iron ion homeostasis;response to hydrogen peroxide;low-density lipoprotein particle clearance;positive regulation of chemokine biosynthetic process;iron ion homeostasis;phospholipase D activity;response to hypoxia;endothelial cell proliferation;wound healing involved in inflammatory response;negative regulation of leukocyte migration;small GTPase mediated signal transduction;excretion;regulation of blood pressure;negative regulation of cell proliferation;intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of muscle cell apoptotic process;smooth muscle hyperplasia;positive regulation of macroautophagy;negative regulation of macroautophagy;cellular response to nutrient;negative regulation of mast cell cytokine production;erythrocyte homeostasis;regulation of transcription from RNA polymerase II promoter in response to iron;response to nicotine;heme catabolic process;heme metabolic process;positive regulation of apoptotic process;negative regulation of mast cell degranulation;negative regulation of DNA binding;negative regulation of DNA binding transcription factor activity;negative regulation of neuron apoptotic process;regulation of transcription from RNA polymerase II promoter in response to oxidative stress;response to estrogen;regulation of DNA binding transcription factor activity;cellular response to arsenic-containing substance;cellular response to cadmium ion;cellular response to cisplatin;liver regeneration;positive regulation of blood vessel diameter;negative regulation of epithelial cell apoptotic process;negative regulation of vascular smooth muscle cell proliferation;nucleolus;cytosol;caveola;

#separate into up and downregulated
# upregulated
#logFC > 1
significant_genes_05_FC1_up <- row.names(results[["Unstrain"]])[results[["Unstrain"]]$qvalue < 0.05 & results[["Unstrain"]]$logFC > 1]
significant_symbols_05_FC1_up <- gene_anno$external_gene_name[match(significant_genes_05_FC1_up, gene_anno$ensembl_gene_id)]
significant_anno_05_FC1_up <- gene_anno[match(significant_genes_05_FC1_up, gene_anno$ensembl_gene_id),]

significant_anno_05_FC1_up

      ensembl_gene_id external_gene_name chromosome_name
5175  ENSG00000121577             POPDC2               3
934   ENSG00000065534               MYLK               3
15279 ENSG00000182585               EPGN               4
14924 ENSG00000180801               ARSJ               4
13297 ENSG00000172403             SYNPO2               4
13332 ENSG00000172548             NIPAL4               5
28168 ENSG00000228495          LINC01013               6
3341  ENSG00000106631               MYL7               7
10067 ENSG00000157168               NRG1               8
3449  ENSG00000107796              ACTA2              10
10325 ENSG00000159251              ACTC1              15
81    ENSG00000005102              MEOX1              17
                                                                          description
5175                   popeye domain containing 2 [Source:HGNC Symbol;Acc:HGNC:17648]
934                      myosin light chain kinase [Source:HGNC Symbol;Acc:HGNC:7590]
15279                          epithelial mitogen [Source:HGNC Symbol;Acc:HGNC:17470]
14924               arylsulfatase family member J [Source:HGNC Symbol;Acc:HGNC:26286]
13297                              synaptopodin 2 [Source:HGNC Symbol;Acc:HGNC:17732]
13332               NIPA like domain containing 4 [Source:HGNC Symbol;Acc:HGNC:28018]
28168 long intergenic non-protein coding RNA 1013 [Source:HGNC Symbol;Acc:HGNC:48987]
3341                         myosin light chain 7 [Source:HGNC Symbol;Acc:HGNC:21719]
10067                                 neuregulin 1 [Source:HGNC Symbol;Acc:HGNC:7997]
3449           actin, alpha 2, smooth muscle, aorta [Source:HGNC Symbol;Acc:HGNC:130]
10325                actin, alpha, cardiac muscle 1 [Source:HGNC Symbol;Acc:HGNC:143]
81                           mesenchyme homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7013]
      start_position end_position
5175       119636457    119665324
934        123610049    123884331
15279       74308473     74315307
14924      113900284    113979727
13297      118850688    119061247
13332      157460019    157474717
28168      132131915    132169374
3341        44138864     44141332
10067       31639386     32767959
3449        88935074     88991339
10325       34788096     34796139
81          43640388     43661954
                                                                                                                                                                                                       phenotype
5175                                                                                                                                                                                                            
934                                                        Megacystis-microcolon-intestinal hypoperistalsis syndrome;Familial thoracic aortic aneurysm and aortic dissection;AORTIC ANEURYSM FAMILIAL THORACIC 7
15279                                                                                                                                                                                                           
14924                                                                                                                                                                                                           
13297                                                                                                                                                                                                           
13332                                                                                           Congenital nonbullous ichthyosiform erythroderma;Lamellar ichthyosis;ICHTHYOSIS CONGENITAL AUTOSOMAL RECESSIVE 6
28168                                                                                                                                                                                                           
3341                                                                                                                                                                                                            
10067                                                                                                                                                                                            SCHIZOPHRENIA 6
3449                            AORTIC ANEURYSM FAMILIAL THORACIC 6;Moyamoya disease 5;Familial thoracic aortic aneurysm and aortic dissection;Moyamoya disease;MULTISYSTEMIC SMOOTH MUSCLE DYSFUNCTION SYNDROME
10325 Atrial septal defect ostium secundum type;Familial isolated dilated cardiomyopathy;Left ventricular noncompaction;ATRIAL SEPTAL DEFECT 5;Cardiomyopathy dilated 1R;CARDIOMYOPATHY FAMILIAL HYPERTROPHIC 11
81                                                                                                               Klippel-Feil Anomaly;Isolated Klippel-Feil syndrome;KLIPPEL-FEIL SYNDROME 2 AUTOSOMAL RECESSIVE
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          go_id
5175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ;GO:0016020;GO:0016021;GO:0005886;GO:0003674;GO:0008150;GO:0042383;GO:0002027
934                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0060414;GO:0005737;GO:0046872;GO:0000166;GO:0004672;GO:0004674;GO:0005524;GO:0006468;GO:0016740;GO:0016301;GO:0016310;GO:0003779;GO:0005886;GO:0015629;GO:0005856;GO:0042995;GO:0005515;GO:0005516;GO:0005829;GO:0030027;GO:0001725;GO:0032154;GO:0030335;GO:0051928;GO:0006936;GO:0006939;GO:0090303;GO:0032060;GO:0004687;GO:0014820;GO:0071476;
15279                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005622;GO:0016020;GO:0016021;GO:0008083;GO:0005576;GO:0005615;GO:0008284;GO:0005887;GO:0005154;GO:0001525;GO:0043406;GO:0045741;GO:0045840;GO:0000187;GO:0050679;GO:0000165;
14924                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GO:0046872;GO:0016787;GO:0003824;GO:0008152;GO:0005576;GO:0008484;GO:0005788;GO:0004065;GO:0016020;GO:0016021;
13297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005634;GO:0005737;GO:0043231;GO:0005829;GO:0003779;GO:0015629;GO:0005856;GO:0005515;GO:0030054;GO:0005925;GO:0001725;GO:0030018;GO:0071889;GO:0031005;GO:0032233;GO:0051393;GO:0051371;GO:0000045;GO:0099023;
13332                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GO:0016020;GO:0016021;GO:0006811;GO:0015095;GO:0015693;GO:1903830;
28168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
3341                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   GO:0005509;GO:0046872;GO:0016459;GO:0005515;GO:0005829;GO:0006936;GO:0031672;GO:0043197;
10067 GO:0016020;GO:0016021;GO:0005654;GO:0005102;GO:0009790;GO:0005634;GO:0018108;GO:0008083;GO:0010469;GO:0005886;GO:0005576;GO:0005615;GO:0046854;GO:0007171;GO:0008284;GO:0005178;GO:0046934;GO:0051897;GO:0005088;GO:0000165;GO:0030971;GO:0005125;GO:0004713;GO:0038128;GO:2000145;GO:0032148;GO:0055007;GO:0000187;GO:0014032;GO:0045892;GO:0007399;GO:0030297;GO:0051048;GO:0042060;GO:0030879;GO:0003222;GO:0043125;GO:0038127;GO:0060956;GO:0003712;GO:0007154;GO:0038129;GO:0043496;GO:0043497;GO:0051155;GO:0060379;;GO:0005176;GO:0045499;GO:0000902;GO:0001964;GO:0003161;GO:0007416;GO:0007420;GO:0007422;GO:0007507;GO:0007517;GO:0007626;GO:0008366;GO:0010001;GO:0010628;GO:0014068;GO:0016477;GO:0021781;GO:0021842;GO:0022008;GO:0031643;GO:0042177;GO:0045213;GO:0045595;GO:0045773;GO:0045860;GO:0045944;GO:0046579;GO:0048663;GO:0048709;GO:0048738;GO:0050731;GO:0060999;GO:0070886;GO:2000010;GO:2000727;GO:2001223;GO:0005737;GO:0005887;GO:0009897;GO:0030424;GO:0030425;GO:0030673;GO:0031594;GO:0044297;GO:0045202
3449                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GO:0005737;GO:0000166;GO:0005524;GO:0005856;GO:0005615;GO:0005829;GO:0070062;GO:0009615;GO:0032991;GO:0010628;GO:0019901;GO:0008217;GO:0014829;GO:0090131;GO:0015629;GO:0030027;GO:0030175;GO:0030485;GO:0044297;GO:0006936;GO:0072144;
10325                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GO:0005737;GO:0016020;GO:0000166;GO:0005524;GO:0005856;GO:0005615;GO:0005925;GO:0005829;GO:0070062;GO:0016887;GO:0072562;GO:0031674;GO:0010628;GO:0090131;GO:0030027;GO:0030175;GO:0044297;GO:0005884;GO:0017022;GO:0030049;GO:0030017;GO:0030048;GO:0060047;GO:0055003;GO:0055008;GO:0031032;GO:0030240;GO:0033275;GO:0042493;GO:0043066;GO:0045471;GO:0060048;GO:0070252;GO:0042643;
81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GO:0005634;GO:0005737;GO:0006355;GO:0006366;GO:0006351;GO:0003677;GO:0003700;GO:0043565;GO:0005515;GO:0007275;GO:0000981;GO:0045944;GO:0003674;GO:0008150;GO:0001077;GO:0061053;GO:0000978;GO:0003682;GO:0071837;GO:0001757;GO:0060218;GO:0061056
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              go_descrip
5175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  ;membrane;integral component of membrane;plasma membrane;molecular_function;biological_process;sarcolemma;regulation of heart rate
934                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             aorta smooth muscle tissue morphogenesis;cytoplasm;metal ion binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;ATP binding;protein phosphorylation;transferase activity;kinase activity;phosphorylation;actin binding;plasma membrane;actin cytoskeleton;cytoskeleton;cell projection;protein binding;calmodulin binding;cytosol;lamellipodium;stress fiber;cleavage furrow;positive regulation of cell migration;positive regulation of calcium ion transport;muscle contraction;smooth muscle contraction;positive regulation of wound healing;bleb assembly;myosin light chain kinase activity;tonic smooth muscle contraction;cellular hypotonic response;
15279                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   intracellular;membrane;integral component of membrane;growth factor activity;extracellular region;extracellular space;positive regulation of cell proliferation;integral component of plasma membrane;epidermal growth factor receptor binding;angiogenesis;positive regulation of MAP kinase activity;positive regulation of epidermal growth factor-activated receptor activity;positive regulation of mitotic nuclear division;activation of MAPK activity;positive regulation of epithelial cell proliferation;MAPK cascade;
14924                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       metal ion binding;hydrolase activity;catalytic activity;metabolic process;extracellular region;sulfuric ester hydrolase activity;endoplasmic reticulum lumen;arylsulfatase activity;membrane;integral component of membrane;
13297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        nucleus;cytoplasm;intracellular membrane-bounded organelle;cytosol;actin binding;actin cytoskeleton;cytoskeleton;protein binding;cell junction;focal adhesion;stress fiber;Z disc;14-3-3 protein binding;filamin binding;positive regulation of actin filament bundle assembly;alpha-actinin binding;muscle alpha-actinin binding;autophagosome assembly;tethering complex;
13332                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              membrane;integral component of membrane;ion transport;magnesium ion transmembrane transporter activity;magnesium ion transport;magnesium ion transmembrane transport;
28168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
3341                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             calcium ion binding;metal ion binding;myosin complex;protein binding;cytosol;muscle contraction;A band;dendritic spine;
10067 membrane;integral component of membrane;nucleoplasm;signaling receptor binding;embryo development;nucleus;peptidyl-tyrosine phosphorylation;growth factor activity;regulation of signaling receptor activity;plasma membrane;extracellular region;extracellular space;phosphatidylinositol phosphorylation;activation of transmembrane receptor protein tyrosine kinase activity;positive regulation of cell proliferation;integrin binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;positive regulation of protein kinase B signaling;Ras guanyl-nucleotide exchange factor activity;MAPK cascade;receptor tyrosine kinase binding;cytokine activity;protein tyrosine kinase activity;ERBB2 signaling pathway;regulation of cell motility;activation of protein kinase B activity;cardiac muscle cell differentiation;activation of MAPK activity;neural crest cell development;negative regulation of transcription, DNA-templated;nervous system development;transmembrane receptor protein tyrosine kinase activator activity;negative regulation of secretion;wound healing;mammary gland development;ventricular trabecula myocardium morphogenesis;ErbB-3 class receptor binding;ERBB signaling pathway;endocardial cell differentiation;transcription cofactor activity;cell communication;ERBB3 signaling pathway;regulation of protein homodimerization activity;regulation of protein heterodimerization activity;positive regulation of striated muscle cell differentiation;cardiac muscle cell myoblast differentiation;;ErbB-2 class receptor binding;chemorepellent activity;cell morphogenesis;startle response;cardiac conduction system development;synapse assembly;brain development;peripheral nervous system development;heart development;muscle organ development;locomotory behavior;axon ensheathment;glial cell differentiation;positive regulation of gene expression;positive regulation of phosphatidylinositol 3-kinase signaling;cell migration;glial cell fate commitment;chemorepulsion involved in interneuron migration from the subpallium to the cortex;neurogenesis;positive regulation of myelination;negative regulation of protein catabolic process;neurotransmitter receptor metabolic process;regulation of cell differentiation;positive regulation of axon extension;positive regulation of protein kinase activity;positive regulation of transcription by RNA polymerase II;positive regulation of Ras protein signal transduction;neuron fate commitment;oligodendrocyte differentiation;cardiac muscle tissue development;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of dendritic spine development;positive regulation of calcineurin-NFAT signaling cascade;positive regulation of protein localization to cell surface;positive regulation of cardiac muscle cell differentiation;negative regulation of neuron migration;cytoplasm;integral component of plasma membrane;external side of plasma membrane;axon;dendrite;axolemma;neuromuscular junction;cell body;synapse
3449                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytoplasm;nucleotide binding;ATP binding;cytoskeleton;extracellular space;cytosol;extracellular exosome;response to virus;protein-containing complex;positive regulation of gene expression;protein kinase binding;regulation of blood pressure;vascular smooth muscle contraction;mesenchyme migration;actin cytoskeleton;lamellipodium;filopodium;smooth muscle contractile fiber;cell body;muscle contraction;glomerular mesangial cell development;
10325                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cytoplasm;membrane;nucleotide binding;ATP binding;cytoskeleton;extracellular space;focal adhesion;cytosol;extracellular exosome;ATPase activity;blood microparticle;I band;positive regulation of gene expression;mesenchyme migration;lamellipodium;filopodium;cell body;actin filament;myosin binding;muscle filament sliding;sarcomere;actin filament-based movement;heart contraction;cardiac myofibril assembly;cardiac muscle tissue morphogenesis;actomyosin structure organization;skeletal muscle thin filament assembly;actin-myosin filament sliding;response to drug;negative regulation of apoptotic process;response to ethanol;cardiac muscle contraction;actin-mediated cell contraction;actomyosin, actin portion;
81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            nucleus;cytoplasm;regulation of transcription, DNA-templated;transcription by RNA polymerase II;transcription, DNA-templated;DNA binding;DNA binding transcription factor activity;sequence-specific DNA binding;protein binding;multicellular organism development;RNA polymerase II transcription factor activity, sequence-specific DNA binding;positive regulation of transcription by RNA polymerase II;molecular_function;biological_process;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;somite development;RNA polymerase II proximal promoter sequence-specific DNA binding;chromatin binding;HMG box domain binding;somite specification;hematopoietic stem cell differentiation;sclerotome development

# downregulated
#logFC < -1
significant_genes_05_FC1_down <- row.names(results[["Unstrain"]])[results[["Unstrain"]]$qvalue < 0.05 & results[["Unstrain"]]$logFC < -1]
significant_symbols_05_FC1_down <- gene_anno$external_gene_name[match(significant_genes_05_FC1_down, gene_anno$ensembl_gene_id)]
significant_anno_05_FC1_down <- gene_anno[match(significant_genes_05_FC1_down, gene_anno$ensembl_gene_id),]

significant_anno_05_FC1_down

      ensembl_gene_id external_gene_name chromosome_name
31021 ENSG00000232679          LINC01705               1
4381  ENSG00000115221              ITGB6               2
7662  ENSG00000138411              HECW2               2
28538 ENSG00000229056         AC020571.1               2
8570  ENSG00000144485               HES6               2
13727 ENSG00000174640            SLCO2A1               3
4845  ENSG00000118785               SPP1               4
9313  ENSG00000150630              VEGFC               4
11274 ENSG00000164171              ITGA2               5
7450  ENSG00000137309              HMGA1               6
2910  ENSG00000104368               PLAT               8
457   ENSG00000026508               CD44              11
46915 ENSG00000261578         AP003119.3              11
7759  ENSG00000139044           B4GALNT3              12
3928  ENSG00000111674               ENO2              12
11706 ENSG00000165891               E2F7              12
5642  ENSG00000125398               SOX9              17
14020 ENSG00000176170              SPHK1              17
2562  ENSG00000101670               LIPG              18
2157  ENSG00000100003            SEC14L2              22
2248  ENSG00000100292              HMOX1              22
                                                                                              description
31021                     long intergenic non-protein coding RNA 1705 [Source:HGNC Symbol;Acc:HGNC:52493]
4381                                           integrin subunit beta 6 [Source:HGNC Symbol;Acc:HGNC:6161]
7662  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:29853]
28538                                                                                                    
8570                           hes family bHLH transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:18254]
13727      solute carrier organic anion transporter family member 2A1 [Source:HGNC Symbol;Acc:HGNC:10955]
4845                                        secreted phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:11255]
9313                             vascular endothelial growth factor C [Source:HGNC Symbol;Acc:HGNC:12682]
11274                                         integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137]
7450                                     high mobility group AT-hook 1 [Source:HGNC Symbol;Acc:HGNC:5010]
2910                                plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051]
457                                 CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681]
46915                                                                                                    
7759                    beta-1,4-N-acetyl-galactosaminyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:24137]
3928                                                         enolase 2 [Source:HGNC Symbol;Acc:HGNC:3353]
11706                                      E2F transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:23820]
5642                                                        SRY-box 9 [Source:HGNC Symbol;Acc:HGNC:11204]
14020                                            sphingosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11240]
2562                                        lipase G, endothelial type [Source:HGNC Symbol;Acc:HGNC:6623]
2157                                       SEC14 like lipid binding 2 [Source:HGNC Symbol;Acc:HGNC:10699]
2248                                                  heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013]
      start_position end_position
31021      222041705    222064763
4381       160099666    160200313
7662       196189099    196593692
28538      196260024    196264204
8570       238238267    238240662
13727      133932696    134052184
4845        87975650     87983426
9313       176683538    176792727
11274       52989326     53094779
7450        34236873     34246231
2910        42175233     42207724
457         35138870     35232402
46915       76800364     76804555
7759          460364       563509
3928         6913745      6923698
11706       77021247     77065580
5642        72121020     72126420
14020       76376584     76387860
2562        49560699     49599182
2157        30396857     30425317
2248        35380361     35394214
                                                                                                                                                                                                                                                       phenotype
31021                                                                                                                                                                                                                                                           
4381                                                                                                         Alopecia-intellectual disability syndrome;Hypocalcified amelogenesis imperfecta;Hypoplastic amelogenesis imperfecta;AMELOGENESIS IMPERFECTA TYPE IH
7662                                                                                                                                                                               HECW2;NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA SEIZURES AND ABSENT LANGUAGE
28538                                                                                                                                                                                                                                                           
8570                                                                                                                                                                                                                                                            
13727                                                                                                                         Chronic enteropathy associated with SLCO2A1 gene;Pachydermoperiostosis;HYPERTROPHIC OSTEOARTHROPATHY PRIMARY AUTOSOMAL RECESSIVE 2
4845                                                                                                                                                                                                                      Pediatric systemic lupus erythematosus
9313                                                                                                                                                                                                                     Milroy Disease;Lymphedema hereditary id
11274                                                                                                                                                                           Fetal and neonatal alloimmune thrombocytopenia;BLEEDING DISORDER PLATELET-TYPE 9
7450                                                                                                                                                                                                                      DIABETES MELLITUS NONINSULIN-DEPENDENT
2910                                                                                                                         Lethal hydranencephaly-diaphragmatic hernia syndrome;THROMBOPHILIA FAMILIAL DUE TO DECREASED RELEASE OF TISSUE PLASMINOGENACTIVATOR
457                                                                                                                                                                                                                                    BLOOD GROUP INDIAN SYSTEM
46915                                                                                                                                                                                                                                                           
7759                                                                                                                                                                                                                                                            
3928                                                                                                                                                                                                                                                            
11706                                                                                                                                                                                                                                                           
5642  CAMPOMELIC DYSPLASIA;PIERRE ROBIN SEQUENCE;46XX ovotesticular disorder of sex development;46XX testicular disorder of sex development;46XY complete gonadal dysgenesis;46XY partial gonadal dysgenesis;Isolated Pierre Robin syndrome;46XY SEX REVERSAL 10
14020                                                                                                                                                                                                                                                           
2562                                                                                                                                                                                                                                                            
2157                                                                                                                                                                                                                                                            
2248                                                                                                                                                                                           HEME OXYGENASE 1 DEFICIENCY;PULMONARY DISEASE CHRONIC OBSTRUCTIVE
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                go_id
31021                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
4381                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0016020;GO:0016021;GO:0005813;GO:0005654;GO:0007155;GO:0030054;GO:0005515;GO:0007229;GO:0007160;GO:0008305;GO:0046718;GO:0005925;GO:0005886;GO:0038023;GO:0005178;GO:0016032;GO:0030198;GO:0001618;GO:0043235;GO:0033627;GO:0006954;GO:0038044;GO:0009897;GO:0034685;
7662                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        ;GO:0005737;GO:0016740;GO:0016567;GO:0004842;GO:0005856;GO:0005819;GO:0061630;GO:0043161;GO:0005515;GO:0072686;GO:0030071
28538                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
8570                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005634;GO:0046983;GO:0006355;GO:0006351;GO:0003677;GO:0007275;GO:0030154;GO:0000981;GO:0008134;GO:0003700;GO:0003712;GO:0005667;GO:0000977;GO:0001227;GO:0000122;GO:0006357;GO:0007399;
13727                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0016020;GO:0016021;GO:0005215;GO:0055085;GO:0005886;GO:0015347;GO:0043252;GO:0005887;GO:0005319;GO:0006869;GO:0015132;GO:0015732;GO:0006811;
4845                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 ;GO:0005794;GO:0007155;GO:0001503;GO:0005615;GO:0007566;GO:0010469;GO:0005515;GO:0005576;GO:0005125;GO:0070062;GO:0031214;GO:0044267;GO:0043687;GO:0005788;GO:0030198;GO:0045893;GO:0033280;GO:0046697;GO:0050840;GO:0001649;GO:0006710;GO:0045780;GO:0071394;GO:2000866;GO:0006954;GO:0010033;GO:0030154;GO:0048545;GO:0048685;GO:0031982;GO:0042995;GO:0048471
9313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GO:0016020;GO:0008083;GO:0010469;GO:0005515;GO:0005576;GO:0007275;GO:0030154;GO:0005615;GO:0050918;GO:0001525;GO:0051781;GO:0007165;GO:0002576;GO:0031093;GO:0048010;GO:0042056;GO:0043185;GO:0001666;GO:0001938;GO:0008284;GO:0045766;GO:0050930;GO:0060754;GO:0001954;GO:0002052;GO:0006929;GO:0008285;GO:0009887;GO:0016331;GO:0030947;GO:0031954;GO:0042493;GO:0043536;GO:0045776;GO:0050679;GO:0050714;GO:0050731;GO:1901492;GO:1990830;
11274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0016020;GO:0016021;GO:0046872;GO:0007155;GO:0005515;GO:0009986;GO:0007229;GO:0008305;GO:0046718;GO:0005925;GO:0005886;GO:0016032;GO:0007596;GO:0030198;GO:0044877;GO:0009887;GO:0007160;GO:0001618;GO:0005518;GO:0031589;GO:0001540;GO:0098639;GO:0033627;GO:0048333;GO:0034666;GO:0005178;GO:0038064;GO:0043236;GO:0043395;GO:0046982;GO:0001666;GO:0002687;GO:0006929;GO:0006971;GO:0007565;GO:0008283;GO:0010634;GO:0010694;GO:0014070;GO:0014075;GO:0014850;GO:0014911;GO:0030879;GO:0031346;GO:0032967;GO:0033343;GO:0033591;GO:0038065;GO:0042060;GO:0042493;GO:0043388;GO:0043589;GO:0045184;GO:0045727;GO:0045785;GO:0045987;GO:0048041;GO:0048661;GO:0050729;GO:0050927;GO:0050966;GO:0051971;GO:0060100;GO:0070365;GO:0071107;GO:0071260;GO:0071392;GO:0071407;GO:0005634;GO:0009897;GO:0030424;GO:0042995;GO:0043679;GO:0045178;GO:0048471;
7450                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   GO:0045944;GO:0005634;GO:0006355;GO:0006366;GO:0006351;GO:0003677;GO:0005694;GO:0000785;GO:0005515;GO:0030374;GO:0045893;GO:0005925;GO:0003700;GO:0000981;GO:0005654;GO:0005829;GO:0008285;GO:0042974;GO:0009615;GO:0006284;GO:0019899;GO:0008134;GO:0045892;GO:0003682;GO:0090575;GO:0065003;GO:0005667;GO:0051169;GO:0075713;GO:0001205;GO:0006337;GO:0046965;GO:0001158;GO:0003680;GO:0003906;GO:0042975;GO:0006268;GO:0031936;GO:0035986;GO:0090402;GO:2000774;GO:0035985;
2910                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GO:0005737;GO:0016787;GO:0005576;GO:0008233;GO:0006508;GO:0004252;GO:0005615;GO:0008236;GO:0005515;GO:0070062;GO:0005102;GO:0031639;GO:0009986;GO:0007596;GO:0006464;GO:0045861;GO:0042730;GO:0051219;GO:0001666;GO:0014909;GO:0048008;GO:0030141;GO:0045177;
457                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0070374;GO:0016020;GO:0016021;GO:0005794;GO:0005829;GO:0007155;GO:0005886;GO:0042995;GO:0005515;GO:0005540;GO:0051216;GO:0009986;GO:0005925;GO:0050900;GO:0005887;GO:0070062;GO:0005902;GO:0043312;GO:0016324;GO:0033138;GO:0043066;GO:0050731;GO:0030667;GO:0030198;GO:0043154;GO:0060333;GO:0044319;GO:0022617;GO:0007160;GO:0044344;GO:0098609;GO:0005518;GO:0043518;GO:1902166;GO:0030214;GO:0034116;GO:0070487;GO:0004896;GO:0035692;GO:0031258;GO:2000392;GO:1900625;;GO:0033674
46915                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
7759                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    GO:0016020;GO:0016021;GO:0016740;GO:0005794;GO:0008376;GO:0032580;GO:0033842;
3928                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000287;GO:0006096;GO:0004634;GO:0000015;GO:0005737;GO:0016020;GO:0046872;GO:0005829;GO:0016829;GO:0005886;GO:0005515;GO:0005615;GO:0070062;GO:0006094;GO:0061621;;GO:0001917;GO:0005622;GO:0043025;GO:0043204;GO:0043209
11706                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GO:0005634;GO:0016607;GO:0006355;GO:0006351;GO:0003677;GO:0003700;GO:0005515;GO:0006974;GO:0007049;GO:0005667;GO:0042802;GO:0000122;GO:0000981;GO:0000987;GO:0003714;GO:0001890;GO:0002040;GO:0006977;GO:0032466;GO:0032877;GO:0045944;GO:0060707;GO:0060718;GO:0070365;GO:0005654;GO:0008285;GO:0030330;GO:2000134;GO:0000977;GO:0000978;GO:0001227;GO:0071930;
5642  GO:0045944;GO:0005634;GO:0005654;GO:0006355;GO:0006351;GO:0003677;GO:0003700;GO:0006334;GO:0000981;GO:0005515;GO:0007165;GO:0051216;GO:0045893;GO:0007283;GO:0001934;GO:0001501;GO:0090090;GO:0003682;GO:0008584;GO:0032991;GO:0071347;GO:0071260;GO:0008284;GO:0042127;GO:0042981;GO:0043066;GO:0070371;GO:0001502;GO:0032332;GO:0045892;GO:0006367;GO:0004672;GO:0019933;GO:0071560;GO:0007173;GO:0045662;GO:0060041;GO:0000978;GO:0002062;GO:1902894;GO:0071300;GO:0065003;GO:0050680;GO:0006338;GO:0001158;GO:0001077;GO:0030850;GO:0010634;GO:0050679;GO:0014068;GO:0034236;GO:0001708;GO:0002053;GO:0090103;GO:0060008;GO:0001894;GO:0071364;GO:0030279;GO:0070168;GO:0071504;GO:0003705;GO:0001837;GO:0090190;GO:0001942;GO:0003203;GO:0090184;GO:2000020;GO:0030916;GO:0061036;GO:2000741;GO:0032331;GO:0035019;GO:0000976;GO:0001228;GO:0008013;GO:0035326;GO:0043425;GO:0043565;GO:0044212;GO:0046982;GO:0097157;GO:0000122;GO:0001503;GO:0001658;GO:0002063;GO:0002683;GO:0003170;GO:0003179;GO:0003188;GO:0003413;GO:0003415;GO:0006357;GO:0007010;GO:0007219;GO:0007417;GO:0007507;GO:0008285;GO:0010564;GO:0010628;GO:0010629;GO:0014032;GO:0014036;GO:0019100;GO:0030154;GO:0030155;GO:0030198;GO:0030238;GO:0030502;GO:0030857;GO:0030858;GO:0030879;GO:0030903;GO:0031018;GO:0032808;GO:0034504;GO:0035622;GO:0043491;GO:0045165;GO:0045595;GO:0045732;GO:0046533;GO:0048709;GO:0048873;GO:0060009;GO:0060018;GO:0060174;GO:0060221;GO:0060350;GO:0060441;GO:0060487;GO:0060512;GO:0060517;GO:0060532;GO:0060534;GO:0060729;GO:0060784;GO:0061046;GO:0061138;GO:0061145;GO:0070384;GO:0071599;GO:0071773;GO:0072034;GO:0072170;GO:0072189;GO:0072190;GO:0072193;GO:0072197;GO:0072289;GO:0097065;GO:0098609;GO:1901203;GO:2000138;GO:2000794;GO:2001054;GO:0005667;GO:0044798;
14020                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           ;GO:0005737;GO:0005634;GO:0016020;GO:0000166;GO:0005524;GO:0005829;GO:0016740;GO:0016301;GO:0016310;GO:0005886;GO:0008152;GO:0003951;GO:0005515;GO:0000287;GO:0046834;GO:0003376;GO:0005516;GO:0010800;GO:0030335;GO:0031398;GO:0006457;GO:0043066;GO:0007165;GO:0051092;GO:1901224;GO:0003677;GO:0030307;GO:0035556;GO:0030148;GO:0045766;GO:0019722;GO:0045931;GO:0038036;GO:0045987;GO:0048146;GO:0046512;GO:0051721;GO:0010803;GO:0006670;GO:0008481;GO:0017050;GO:0046521;GO:0001568;GO:0006954;GO:0007420;GO:0008284;GO:0032651
2562                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0006629;GO:0005576;GO:0004465;GO:0052689;;GO:0005615;GO:0042632;GO:0016787;GO:0016042;GO:0004620;GO:0007584;GO:0008283;GO:0050746;GO:0004806;GO:0008201;GO:0005794;GO:0005769;GO:0034375;GO:0043691;GO:0055091;GO:0009395;GO:0009986;GO:0032376;GO:0008970;GO:0010983
2157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        GO:0005634;GO:0005737;GO:0005829;GO:0006351;GO:0006355;GO:0045893;GO:0008289;GO:0070062;GO:0005543;GO:0008431;GO:0045540;
2248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0046872;GO:0055114;GO:0004392;GO:0006788;GO:0005615;GO:0045766;GO:1903589;GO:0090050;GO:0005634;GO:0016020;GO:0016021;GO:0016491;GO:0005783;GO:0005789;GO:0042803;GO:0005515;GO:0006915;GO:0048471;GO:0043231;GO:0051260;GO:0043123;GO:0019221;GO:0019899;GO:0001525;GO:0048661;GO:0071456;GO:1902042;GO:0020037;GO:0034605;GO:0045765;GO:0008219;GO:0035556;GO:0048662;GO:0006979;GO:0006879;GO:0042542;GO:0034383;GO:0045080;GO:0055072;GO:0004630;GO:0001666;GO:0001935;GO:0002246;GO:0002686;GO:0007264;GO:0007588;GO:0008217;GO:0008285;GO:0008630;GO:0010656;GO:0014806;GO:0016239;GO:0016242;GO:0031670;GO:0032764;GO:0034101;GO:0034395;GO:0035094;GO:0042167;GO:0042168;GO:0043065;GO:0043305;GO:0043392;GO:0043433;GO:0043524;GO:0043619;GO:0043627;GO:0051090;GO:0071243;GO:0071276;GO:0072719;GO:0097421;GO:0097755;GO:1904036;GO:1904706;GO:0005730;GO:0005829;GO:0005901;
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  go_descrip
31021                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
4381                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 membrane;integral component of membrane;centrosome;nucleoplasm;cell adhesion;cell junction;protein binding;integrin-mediated signaling pathway;cell-matrix adhesion;integrin complex;viral entry into host cell;focal adhesion;plasma membrane;signaling receptor activity;integrin binding;viral process;extracellular matrix organization;virus receptor activity;receptor complex;cell adhesion mediated by integrin;inflammatory response;transforming growth factor-beta secretion;external side of plasma membrane;integrin alphav-beta6 complex;
7662                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ;cytoplasm;transferase activity;protein ubiquitination;ubiquitin-protein transferase activity;cytoskeleton;spindle;ubiquitin protein ligase activity;proteasome-mediated ubiquitin-dependent protein catabolic process;protein binding;mitotic spindle;regulation of mitotic metaphase/anaphase transition
28538                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
8570                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       nucleus;protein dimerization activity;regulation of transcription, DNA-templated;transcription, DNA-templated;DNA binding;multicellular organism development;cell differentiation;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcription factor binding;DNA binding transcription factor activity;transcription cofactor activity;transcription factor complex;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;negative regulation of transcription by RNA polymerase II;regulation of transcription by RNA polymerase II;nervous system development;
13727                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           membrane;integral component of membrane;transporter activity;transmembrane transport;plasma membrane;sodium-independent organic anion transmembrane transporter activity;sodium-independent organic anion transport;integral component of plasma membrane;lipid transporter activity;lipid transport;prostaglandin transmembrane transporter activity;prostaglandin transport;ion transport;
4845                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               ;Golgi apparatus;cell adhesion;ossification;extracellular space;embryo implantation;regulation of signaling receptor activity;protein binding;extracellular region;cytokine activity;extracellular exosome;biomineral tissue development;cellular protein metabolic process;post-translational protein modification;endoplasmic reticulum lumen;extracellular matrix organization;positive regulation of transcription, DNA-templated;response to vitamin D;decidualization;extracellular matrix binding;osteoblast differentiation;androgen catabolic process;positive regulation of bone resorption;cellular response to testosterone stimulus;positive regulation of estradiol secretion;inflammatory response;response to organic substance;cell differentiation;response to steroid hormone;negative regulation of collateral sprouting of intact axon in response to injury;vesicle;cell projection;perinuclear region of cytoplasm
9313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              membrane;growth factor activity;regulation of signaling receptor activity;protein binding;extracellular region;multicellular organism development;cell differentiation;extracellular space;positive chemotaxis;angiogenesis;positive regulation of cell division;signal transduction;platelet degranulation;platelet alpha granule lumen;vascular endothelial growth factor receptor signaling pathway;chemoattractant activity;vascular endothelial growth factor receptor 3 binding;response to hypoxia;positive regulation of endothelial cell proliferation;positive regulation of cell proliferation;positive regulation of angiogenesis;induction of positive chemotaxis;positive regulation of mast cell chemotaxis;positive regulation of cell-matrix adhesion;positive regulation of neuroblast proliferation;substrate-dependent cell migration;negative regulation of cell proliferation;animal organ morphogenesis;morphogenesis of embryonic epithelium;regulation of vascular endothelial growth factor receptor signaling pathway;positive regulation of protein autophosphorylation;response to drug;positive regulation of blood vessel endothelial cell migration;negative regulation of blood pressure;positive regulation of epithelial cell proliferation;positive regulation of protein secretion;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of lymphangiogenesis;cellular response to leukemia inhibitory factor;
11274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              membrane;integral component of membrane;metal ion binding;cell adhesion;protein binding;cell surface;integrin-mediated signaling pathway;integrin complex;viral entry into host cell;focal adhesion;plasma membrane;viral process;blood coagulation;extracellular matrix organization;protein-containing complex binding;animal organ morphogenesis;cell-matrix adhesion;virus receptor activity;collagen binding;cell-substrate adhesion;amyloid-beta binding;collagen binding involved in cell-matrix adhesion;cell adhesion mediated by integrin;mesodermal cell differentiation;integrin alpha2-beta1 complex;integrin binding;collagen receptor activity;laminin binding;heparan sulfate proteoglycan binding;protein heterodimerization activity;response to hypoxia;positive regulation of leukocyte migration;substrate-dependent cell migration;hypotonic response;female pregnancy;cell proliferation;positive regulation of epithelial cell migration;positive regulation of alkaline phosphatase activity;response to organic cyclic compound;response to amine;response to muscle activity;positive regulation of smooth muscle cell migration;mammary gland development;positive regulation of cell projection organization;positive regulation of collagen biosynthetic process;positive regulation of collagen binding;response to L-ascorbic acid;collagen-activated signaling pathway;wound healing;response to drug;positive regulation of DNA binding;skin morphogenesis;establishment of protein localization;positive regulation of translation;positive regulation of cell adhesion;positive regulation of smooth muscle contraction;focal adhesion assembly;positive regulation of smooth muscle cell proliferation;positive regulation of inflammatory response;positive regulation of positive chemotaxis;detection of mechanical stimulus involved in sensory perception of pain;positive regulation of transmission of nerve impulse;positive regulation of phagocytosis, engulfment;hepatocyte differentiation;response to parathyroid hormone;cellular response to mechanical stimulus;cellular response to estradiol stimulus;cellular response to organic cyclic compound;nucleus;external side of plasma membrane;axon;cell projection;axon terminus;basal part of cell;perinuclear region of cytoplasm;
7450                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        positive regulation of transcription by RNA polymerase II;nucleus;regulation of transcription, DNA-templated;transcription by RNA polymerase II;transcription, DNA-templated;DNA binding;chromosome;chromatin;protein binding;ligand-dependent nuclear receptor transcription coactivator activity;positive regulation of transcription, DNA-templated;focal adhesion;DNA binding transcription factor activity;RNA polymerase II transcription factor activity, sequence-specific DNA binding;nucleoplasm;cytosol;negative regulation of cell proliferation;retinoic acid receptor binding;response to virus;base-excision repair;enzyme binding;transcription factor binding;negative regulation of transcription, DNA-templated;chromatin binding;RNA polymerase II transcription factor complex;protein-containing complex assembly;transcription factor complex;nuclear transport;establishment of integrated proviral latency;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding;nucleosome disassembly;retinoid X receptor binding;enhancer sequence-specific DNA binding;AT DNA binding;DNA-(apurinic or apyrimidinic site) endonuclease activity;peroxisome proliferator activated receptor binding;DNA unwinding involved in DNA replication;negative regulation of chromatin silencing;senescence-associated heterochromatin focus assembly;oncogene-induced cell senescence;positive regulation of cellular senescence;senescence-associated heterochromatin focus;
2910                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cytoplasm;hydrolase activity;extracellular region;peptidase activity;proteolysis;serine-type endopeptidase activity;extracellular space;serine-type peptidase activity;protein binding;extracellular exosome;signaling receptor binding;plasminogen activation;cell surface;blood coagulation;cellular protein modification process;negative regulation of proteolysis;fibrinolysis;phosphoprotein binding;response to hypoxia;smooth muscle cell migration;platelet-derived growth factor receptor signaling pathway;secretory granule;apical part of cell;
457                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       positive regulation of ERK1 and ERK2 cascade;membrane;integral component of membrane;Golgi apparatus;cytosol;cell adhesion;plasma membrane;cell projection;protein binding;hyaluronic acid binding;cartilage development;cell surface;focal adhesion;leukocyte migration;integral component of plasma membrane;extracellular exosome;microvillus;neutrophil degranulation;apical plasma membrane;positive regulation of peptidyl-serine phosphorylation;negative regulation of apoptotic process;positive regulation of peptidyl-tyrosine phosphorylation;secretory granule membrane;extracellular matrix organization;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;interferon-gamma-mediated signaling pathway;wound healing, spreading of cells;extracellular matrix disassembly;cell-matrix adhesion;cellular response to fibroblast growth factor stimulus;cell-cell adhesion;collagen binding;negative regulation of DNA damage response, signal transduction by p53 class mediator;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;hyaluronan catabolic process;positive regulation of heterotypic cell-cell adhesion;monocyte aggregation;cytokine receptor activity;macrophage migration inhibitory factor receptor complex;lamellipodium membrane;regulation of lamellipodium morphogenesis;positive regulation of monocyte aggregation;;positive regulation of kinase activity
46915                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
7759                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                membrane;integral component of membrane;transferase activity;Golgi apparatus;acetylgalactosaminyltransferase activity;Golgi cisterna membrane;N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity;
3928                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         magnesium ion binding;glycolytic process;phosphopyruvate hydratase activity;phosphopyruvate hydratase complex;cytoplasm;membrane;metal ion binding;cytosol;lyase activity;plasma membrane;protein binding;extracellular space;extracellular exosome;gluconeogenesis;canonical glycolysis;;photoreceptor inner segment;intracellular;neuronal cell body;perikaryon;myelin sheath
11706                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          nucleus;nuclear speck;regulation of transcription, DNA-templated;transcription, DNA-templated;DNA binding;DNA binding transcription factor activity;protein binding;cellular response to DNA damage stimulus;cell cycle;transcription factor complex;identical protein binding;negative regulation of transcription by RNA polymerase II;RNA polymerase II transcription factor activity, sequence-specific DNA binding;proximal promoter sequence-specific DNA binding;transcription corepressor activity;placenta development;sprouting angiogenesis;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;negative regulation of cytokinesis;positive regulation of DNA endoreduplication;positive regulation of transcription by RNA polymerase II;trophoblast giant cell differentiation;chorionic trophoblast cell differentiation;hepatocyte differentiation;nucleoplasm;negative regulation of cell proliferation;DNA damage response, signal transduction by p53 class mediator;negative regulation of G1/S transition of mitotic cell cycle;RNA polymerase II regulatory region sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;negative regulation of transcription involved in G1/S transition of mitotic cell cycle;
5642  positive regulation of transcription by RNA polymerase II;nucleus;nucleoplasm;regulation of transcription, DNA-templated;transcription, DNA-templated;DNA binding;DNA binding transcription factor activity;nucleosome assembly;RNA polymerase II transcription factor activity, sequence-specific DNA binding;protein binding;signal transduction;cartilage development;positive regulation of transcription, DNA-templated;spermatogenesis;positive regulation of protein phosphorylation;skeletal system development;negative regulation of canonical Wnt signaling pathway;chromatin binding;male gonad development;protein-containing complex;cellular response to interleukin-1;cellular response to mechanical stimulus;positive regulation of cell proliferation;regulation of cell proliferation;regulation of apoptotic process;negative regulation of apoptotic process;ERK1 and ERK2 cascade;cartilage condensation;positive regulation of chondrocyte differentiation;negative regulation of transcription, DNA-templated;transcription initiation from RNA polymerase II promoter;protein kinase activity;cAMP-mediated signaling;cellular response to transforming growth factor beta stimulus;epidermal growth factor receptor signaling pathway;negative regulation of myoblast differentiation;retina development in camera-type eye;RNA polymerase II proximal promoter sequence-specific DNA binding;chondrocyte differentiation;negative regulation of pri-miRNA transcription by RNA polymerase II;cellular response to retinoic acid;protein-containing complex assembly;negative regulation of epithelial cell proliferation;chromatin remodeling;enhancer sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;prostate gland development;positive regulation of epithelial cell migration;positive regulation of epithelial cell proliferation;positive regulation of phosphatidylinositol 3-kinase signaling;protein kinase A catalytic subunit binding;cell fate specification;positive regulation of mesenchymal cell proliferation;cochlea morphogenesis;Sertoli cell differentiation;tissue homeostasis;cellular response to epidermal growth factor stimulus;negative regulation of ossification;negative regulation of biomineral tissue development;cellular response to heparin;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;epithelial to mesenchymal transition;positive regulation of branching involved in ureteric bud morphogenesis;hair follicle development;endocardial cushion morphogenesis;positive regulation of kidney development;positive regulation of male gonad development;otic vesicle formation;positive regulation of cartilage development;positive regulation of mesenchymal stem cell differentiation;negative regulation of chondrocyte differentiation;somatic stem cell population maintenance;transcription regulatory region sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;beta-catenin binding;enhancer binding;bHLH transcription factor binding;sequence-specific DNA binding;transcription regulatory region DNA binding;protein heterodimerization activity;pre-mRNA intronic binding;negative regulation of transcription by RNA polymerase II;ossification;branching involved in ureteric bud morphogenesis;chondrocyte development;negative regulation of immune system process;heart valve development;heart valve morphogenesis;heart valve formation;chondrocyte differentiation involved in endochondral bone morphogenesis;chondrocyte hypertrophy;regulation of transcription by RNA polymerase II;cytoskeleton organization;Notch signaling pathway;central nervous system development;heart development;negative regulation of cell proliferation;regulation of cell cycle process;positive regulation of gene expression;negative regulation of gene expression;neural crest cell development;neural crest cell fate specification;male germ-line sex determination;cell differentiation;regulation of cell adhesion;extracellular matrix organization;male sex determination;negative regulation of bone mineralization;negative regulation of epithelial cell differentiation;positive regulation of epithelial cell differentiation;mammary gland development;notochord development;endocrine pancreas development;lacrimal gland development;protein localization to nucleus;intrahepatic bile duct development;protein kinase B signaling;cell fate commitment;regulation of cell differentiation;positive regulation of protein catabolic process;negative regulation of photoreceptor cell differentiation;oligodendrocyte differentiation;homeostasis of number of cells within a tissue;Sertoli cell development;astrocyte fate commitment;limb bud formation;retinal rod cell differentiation;endochondral bone morphogenesis;epithelial tube branching involved in lung morphogenesis;lung epithelial cell differentiation;prostate gland morphogenesis;epithelial cell proliferation involved in prostatic bud elongation;bronchus cartilage development;trachea cartilage development;intestinal epithelial structure maintenance;regulation of cell proliferation involved in tissue homeostasis;regulation of branching involved in lung morphogenesis;morphogenesis of a branching epithelium;lung smooth muscle development;Harderian gland development;otic vesicle development;cellular response to BMP stimulus;renal vesicle induction;metanephric tubule development;ureter development;ureter urothelium development;ureter smooth muscle cell differentiation;ureter morphogenesis;metanephric nephron tubule formation;anterior head development;cell-cell adhesion;positive regulation of extracellular matrix assembly;positive regulation of cell proliferation involved in heart morphogenesis;regulation of epithelial cell proliferation involved in lung morphogenesis;negative regulation of mesenchymal cell apoptotic process;transcription factor complex;nuclear transcription factor complex;
14020                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ;cytoplasm;nucleus;membrane;nucleotide binding;ATP binding;cytosol;transferase activity;kinase activity;phosphorylation;plasma membrane;metabolic process;NAD+ kinase activity;protein binding;magnesium ion binding;lipid phosphorylation;sphingosine-1-phosphate signaling pathway;calmodulin binding;positive regulation of peptidyl-threonine phosphorylation;positive regulation of cell migration;positive regulation of protein ubiquitination;protein folding;negative regulation of apoptotic process;signal transduction;positive regulation of NF-kappaB transcription factor activity;positive regulation of NIK/NF-kappaB signaling;DNA binding;positive regulation of cell growth;intracellular signal transduction;sphingolipid biosynthetic process;positive regulation of angiogenesis;calcium-mediated signaling;positive regulation of mitotic cell cycle;sphingosine-1-phosphate receptor activity;positive regulation of smooth muscle contraction;positive regulation of fibroblast proliferation;sphingosine biosynthetic process;protein phosphatase 2A binding;regulation of tumor necrosis factor-mediated signaling pathway;sphingosine metabolic process;sphinganine kinase activity;D-erythro-sphingosine kinase activity;sphingoid catabolic process;blood vessel development;inflammatory response;brain development;positive regulation of cell proliferation;regulation of interleukin-1 beta production
2562                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                lipid metabolic process;extracellular region;lipoprotein lipase activity;carboxylic ester hydrolase activity;;extracellular space;cholesterol homeostasis;hydrolase activity;lipid catabolic process;phospholipase activity;response to nutrient;cell proliferation;regulation of lipoprotein metabolic process;triglyceride lipase activity;heparin binding;Golgi apparatus;early endosome;high-density lipoprotein particle remodeling;reverse cholesterol transport;phospholipid homeostasis;phospholipid catabolic process;cell surface;positive regulation of cholesterol transport;phosphatidylcholine 1-acylhydrolase activity;positive regulation of high-density lipoprotein particle clearance
2157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        nucleus;cytoplasm;cytosol;transcription, DNA-templated;regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;lipid binding;extracellular exosome;phospholipid binding;vitamin E binding;regulation of cholesterol biosynthetic process;
2248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    metal ion binding;oxidation-reduction process;heme oxygenase (decyclizing) activity;heme oxidation;extracellular space;positive regulation of angiogenesis;positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;positive regulation of cell migration involved in sprouting angiogenesis;nucleus;membrane;integral component of membrane;oxidoreductase activity;endoplasmic reticulum;endoplasmic reticulum membrane;protein homodimerization activity;protein binding;apoptotic process;perinuclear region of cytoplasm;intracellular membrane-bounded organelle;protein homooligomerization;positive regulation of I-kappaB kinase/NF-kappaB signaling;cytokine-mediated signaling pathway;enzyme binding;angiogenesis;positive regulation of smooth muscle cell proliferation;cellular response to hypoxia;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;heme binding;cellular response to heat;regulation of angiogenesis;cell death;intracellular signal transduction;negative regulation of smooth muscle cell proliferation;response to oxidative stress;cellular iron ion homeostasis;response to hydrogen peroxide;low-density lipoprotein particle clearance;positive regulation of chemokine biosynthetic process;iron ion homeostasis;phospholipase D activity;response to hypoxia;endothelial cell proliferation;wound healing involved in inflammatory response;negative regulation of leukocyte migration;small GTPase mediated signal transduction;excretion;regulation of blood pressure;negative regulation of cell proliferation;intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of muscle cell apoptotic process;smooth muscle hyperplasia;positive regulation of macroautophagy;negative regulation of macroautophagy;cellular response to nutrient;negative regulation of mast cell cytokine production;erythrocyte homeostasis;regulation of transcription from RNA polymerase II promoter in response to iron;response to nicotine;heme catabolic process;heme metabolic process;positive regulation of apoptotic process;negative regulation of mast cell degranulation;negative regulation of DNA binding;negative regulation of DNA binding transcription factor activity;negative regulation of neuron apoptotic process;regulation of transcription from RNA polymerase II promoter in response to oxidative stress;response to estrogen;regulation of DNA binding transcription factor activity;cellular response to arsenic-containing substance;cellular response to cadmium ion;cellular response to cisplatin;liver regeneration;positive regulation of blood vessel diameter;negative regulation of epithelial cell apoptotic process;negative regulation of vascular smooth muscle cell proliferation;nucleolus;cytosol;caveola;

boxplot of expression levels of the top DE genes separated by individual x treatment

plot_gene <- function(v, g) {
  # v - An EList object containing log2 counts per million
  # g - character vector of a single gene
  stopifnot(class(v) == "EList",
            is.character(g), length(g) == 1)
  library("tidyr")
  single_gene <- v$E[g, ]
  single_gene_long <- as.data.frame(single_gene)
  colnames(single_gene_long) <- "log2cpm"
  single_gene_long$sample <- rownames(single_gene_long)
  single_gene_long <- separate(single_gene_long, col = "sample", sep = "_",
                                into = c("Individual", "Replicate", "Treatment"))

  single_gene_long$Treatment <- gsub('S', 'Strain', single_gene_long$Treatment)
  single_gene_long$Treatment <- gsub('U', 'Control', single_gene_long$Treatment)
  single_gene_long$Treatment <- factor(single_gene_long$Treatment, levels(factor(single_gene_long$Treatment))[c(1,2)])
  
  return(ggplot(single_gene_long, aes(x = Individual, y = log2cpm, fill = Individual)) +
              labs(title = g, y = expression("Expression level (" * log[2] * " cpm)")) + 
              geom_dotplot(binaxis = "y", stackdir = "center", key_glyph = 'rect', dotsize = 0.75) + 
              facet_wrap(~Treatment, strip.position = 'bottom') + 
              stat_summary(fun.data = "mean_sdl", fun.args = list(mult=1)) +
              theme(axis.title.x=element_blank())
              )
}

#all top genes
for (gene in 1:length(significant_anno_05_FC1[,1])) {
     print(plot_gene(v2, as.character(significant_anno_05_FC1[gene,1])))
}

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-1.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-2.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-3.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-4.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-5.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-6.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-7.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-8.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-9.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-10.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-11.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-12.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-13.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-14.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-15.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-16.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-17.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-18.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-19.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-20.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-21.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-22.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-23.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-24.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-25.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-26.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-27.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-28.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-29.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-30.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-31.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-32.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-33.png

#SOX9
plot_gene(v2, "ENSG00000125398")

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-34.png

#all top upregulated

for (gene in 1:length(significant_anno_05_FC1_up[,1])) {
     print(plot_gene(v2, as.character(significant_anno_05_FC1_up[gene,1])))
}

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-35.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-36.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-37.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-38.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-39.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-40.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-41.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-42.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-43.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-44.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-45.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-46.png

#all top downregulated

for (gene in 1:length(significant_anno_05_FC1_down[,1])) {
     print(plot_gene(v2, as.character(significant_anno_05_FC1_down[gene,1])))
}

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-47.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-48.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-49.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-50.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-51.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-52.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-53.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-54.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-55.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-56.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-57.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-58.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-59.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-60.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-61.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-62.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-63.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-64.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-65.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-66.png

`stat_bindot()` using `bins = 30`. Pick better value with `binwidth`.

Past versions of unnamed-chunk-1-67.png

saveRDS(results, "data/DE_results.rds")
threshold <- 0.05
gene_universe <- as.numeric(results[["Unstrain"]]$qvalue < threshold)
gene_universe <- factor(gene_universe)
names(gene_universe) <- rownames(results[["Unstrain"]])
head(gene_universe)

ENSG00000225972 ENSG00000225630 ENSG00000237973 ENSG00000248527 
              0               0               0               0 
ENSG00000198744 ENSG00000228794 
              0               0 
Levels: 0 1

go_data <- new("topGOdata",
               ontology = "BP",
               allGenes = gene_universe,
               nodeSize = 5,
               annotationFun = annFUN.org,
               mapping = "org.Hs.eg.db",
               ID = "ensembl")

Building most specific GOs .....

Loading required package: org.Hs.eg.db

    ( 9790 GO terms found. )

Build GO DAG topology ..........

    ( 13875 GO terms and 32681 relations. )

Annotating nodes ...............

    ( 9223 genes annotated to the GO terms. )

go_test <- runTest(go_data, algorithm = "weight01", statistic = "fisher")

             -- Weight01 Algorithm -- 

         the algorithm is scoring 6032 nontrivial nodes
         parameters: 
             test statistic: fisher

     Level 19:  1 nodes to be scored    (0 eliminated genes)

     Level 18:  3 nodes to be scored    (0 eliminated genes)

     Level 17:  7 nodes to be scored    (11 eliminated genes)

     Level 16:  20 nodes to be scored   (17 eliminated genes)

     Level 15:  51 nodes to be scored   (51 eliminated genes)

     Level 14:  108 nodes to be scored  (199 eliminated genes)

     Level 13:  175 nodes to be scored  (574 eliminated genes)

     Level 12:  295 nodes to be scored  (1404 eliminated genes)

     Level 11:  496 nodes to be scored  (2930 eliminated genes)

     Level 10:  677 nodes to be scored  (4305 eliminated genes)

     Level 9:   807 nodes to be scored  (5435 eliminated genes)

     Level 8:   845 nodes to be scored  (6766 eliminated genes)

     Level 7:   903 nodes to be scored  (7583 eliminated genes)

     Level 6:   782 nodes to be scored  (8202 eliminated genes)

     Level 5:   476 nodes to be scored  (8583 eliminated genes)

     Level 4:   252 nodes to be scored  (8827 eliminated genes)

     Level 3:   111 nodes to be scored  (8980 eliminated genes)

     Level 2:   22 nodes to be scored   (9028 eliminated genes)

     Level 1:   1 nodes to be scored    (9091 eliminated genes)

go_table <- GenTable(go_data, weightFisher = go_test,
                     orderBy = "weightFisher", ranksOf = "weightFisher",
                     topNodes = sum(score(go_test) < .01))
go_table

        GO.ID                                        Term Annotated
1  GO:0055114                 oxidation-reduction process       605
2  GO:0030198           extracellular matrix organization       208
3  GO:0045454                      cell redox homeostasis        47
4  GO:0001568                    blood vessel development       434
5  GO:0046364         monosaccharide biosynthetic process        63
6  GO:0050927 positive regulation of positive chemotax...        10
7  GO:0034135 regulation of toll-like receptor 2 signa...         7
8  GO:0006027         glycosaminoglycan catabolic process        40
9  GO:0006986                response to unfolded protein       141
10 GO:0051085 chaperone cofactor-dependent protein ref...        11
11 GO:1903364 positive regulation of cellular protein ...       108
12 GO:0048842 positive regulation of axon extension in...         5
13 GO:0002576                      platelet degranulation        72
14 GO:0002063                     chondrocyte development        21
15 GO:0033627          cell adhesion mediated by integrin        38
16 GO:0021955 central nervous system neuron axonogenes...        25
17 GO:0035987             endodermal cell differentiation        31
18 GO:0006695            cholesterol biosynthetic process        56
19 GO:0051897 positive regulation of protein kinase B ...        77
20 GO:0030223                  neutrophil differentiation         6
21 GO:0006516              glycoprotein catabolic process        14
22 GO:0045214                      sarcomere organization        19
23 GO:0060390 regulation of SMAD protein signal transd...        18
24 GO:0019321                   pentose metabolic process         7
25 GO:0043589                          skin morphogenesis         7
26 GO:0036499     PERK-mediated unfolded protein response        16
27 GO:0051693                      actin filament capping        18
28 GO:0001895                          retina homeostasis        27
29 GO:0030335       positive regulation of cell migration       300
30 GO:0051702                   interaction with symbiont        53
31 GO:0060047                           heart contraction       113
32 GO:0045056                                transcytosis        11
33 GO:0048708                   astrocyte differentiation        36
34 GO:0031346 positive regulation of cell projection o...       245
35 GO:0044267          cellular protein metabolic process      3279
36 GO:0007275          multicellular organism development      2843
37 GO:0034329                      cell junction assembly       151
38 GO:0006098                     pentose-phosphate shunt        12
39 GO:1901700      response to oxygen-containing compound       904
40 GO:0060706 cell differentiation involved in embryon...        15
41 GO:0032964               collagen biosynthetic process        29
42 GO:0033692 cellular polysaccharide biosynthetic pro...        39
43 GO:0008360                    regulation of cell shape        81
   Significant Expected weightFisher
1          101    68.68      3.0e-07
2           50    23.61      1.6e-05
3           16     5.34      3.3e-05
4           72    49.27      0.00014
5           13     7.15      0.00016
6            6     1.14      0.00030
7            5     0.79      0.00032
8           11     4.54      0.00039
9           32    16.01      0.00048
10           6     1.25      0.00059
11          21    12.26      0.00063
12           4     0.57      0.00075
13          18     8.17      0.00089
14           8     2.38      0.00141
15          10     4.31      0.00158
16           6     2.84      0.00159
17          10     3.52      0.00161
18          16     6.36      0.00161
19          18     8.74      0.00203
20           4     0.68      0.00205
21           6     1.59      0.00283
22           7     2.16      0.00350
23           7     2.04      0.00433
24           4     0.79      0.00436
25           4     0.79      0.00436
26           5     1.82      0.00436
27           5     2.04      0.00436
28           6     3.07      0.00481
29          51    34.06      0.00528
30          10     6.02      0.00532
31          16    12.83      0.00533
32           4     1.25      0.00534
33           6     4.09      0.00535
34          29    27.81      0.00536
35         365   372.23      0.00619
36         374   322.74      0.00664
37          21    17.14      0.00745
38           5     1.36      0.00746
39         115   102.62      0.00765
40           6     1.70      0.00790
41           6     3.29      0.00794
42           7     4.43      0.00795
43          17     9.20      0.00850

go_table[,-1]

                                          Term Annotated Significant
1                  oxidation-reduction process       605         101
2            extracellular matrix organization       208          50
3                       cell redox homeostasis        47          16
4                     blood vessel development       434          72
5          monosaccharide biosynthetic process        63          13
6  positive regulation of positive chemotax...        10           6
7  regulation of toll-like receptor 2 signa...         7           5
8          glycosaminoglycan catabolic process        40          11
9                 response to unfolded protein       141          32
10 chaperone cofactor-dependent protein ref...        11           6
11 positive regulation of cellular protein ...       108          21
12 positive regulation of axon extension in...         5           4
13                      platelet degranulation        72          18
14                     chondrocyte development        21           8
15          cell adhesion mediated by integrin        38          10
16 central nervous system neuron axonogenes...        25           6
17             endodermal cell differentiation        31          10
18            cholesterol biosynthetic process        56          16
19 positive regulation of protein kinase B ...        77          18
20                  neutrophil differentiation         6           4
21              glycoprotein catabolic process        14           6
22                      sarcomere organization        19           7
23 regulation of SMAD protein signal transd...        18           7
24                   pentose metabolic process         7           4
25                          skin morphogenesis         7           4
26     PERK-mediated unfolded protein response        16           5
27                      actin filament capping        18           5
28                          retina homeostasis        27           6
29       positive regulation of cell migration       300          51
30                   interaction with symbiont        53          10
31                           heart contraction       113          16
32                                transcytosis        11           4
33                   astrocyte differentiation        36           6
34 positive regulation of cell projection o...       245          29
35          cellular protein metabolic process      3279         365
36          multicellular organism development      2843         374
37                      cell junction assembly       151          21
38                     pentose-phosphate shunt        12           5
39      response to oxygen-containing compound       904         115
40 cell differentiation involved in embryon...        15           6
41               collagen biosynthetic process        29           6
42 cellular polysaccharide biosynthetic pro...        39           7
43                    regulation of cell shape        81          17
   Expected weightFisher
1     68.68      3.0e-07
2     23.61      1.6e-05
3      5.34      3.3e-05
4     49.27      0.00014
5      7.15      0.00016
6      1.14      0.00030
7      0.79      0.00032
8      4.54      0.00039
9     16.01      0.00048
10     1.25      0.00059
11    12.26      0.00063
12     0.57      0.00075
13     8.17      0.00089
14     2.38      0.00141
15     4.31      0.00158
16     2.84      0.00159
17     3.52      0.00161
18     6.36      0.00161
19     8.74      0.00203
20     0.68      0.00205
21     1.59      0.00283
22     2.16      0.00350
23     2.04      0.00433
24     0.79      0.00436
25     0.79      0.00436
26     1.82      0.00436
27     2.04      0.00436
28     3.07      0.00481
29    34.06      0.00528
30     6.02      0.00532
31    12.83      0.00533
32     1.25      0.00534
33     4.09      0.00535
34    27.81      0.00536
35   372.23      0.00619
36   322.74      0.00664
37    17.14      0.00745
38     1.36      0.00746
39   102.62      0.00765
40     1.70      0.00790
41     3.29      0.00794
42     4.43      0.00795
43     9.20      0.00850

write.csv(go_table, "output/GO_terms_enriched.csv")

# k-s test making use of ranked based on p-values
genes <- results[["Unstrain"]]$qvalue
names(genes) <- rownames(results[["Unstrain"]])

selection <- function(allScore){ return(allScore < 0.05)} # function that returns TRUE/FALSE for p-values<0.05
allGO2genes <- annFUN.org(whichOnto="BP", feasibleGenes=NULL, mapping="org.Hs.eg.db", ID="ensembl")
GOdata <- new("topGOdata",
  ontology="BP",
  allGenes=genes,
  annot=annFUN.GO2genes,
  GO2genes=allGO2genes,
  geneSel=selection,
  nodeSize=10)

Building most specific GOs .....

    ( 9790 GO terms found. )

Build GO DAG topology ..........

    ( 13875 GO terms and 32681 relations. )

Annotating nodes ...............

    ( 9223 genes annotated to the GO terms. )

results.ks <- runTest(GOdata, algorithm="classic", statistic="ks")

             -- Classic Algorithm -- 

         the algorithm is scoring 5184 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

goEnrichment <- GenTable(GOdata, KS=results.ks, orderBy="KS", topNodes=20)
goEnrichment <- goEnrichment %>% 
     mutate(KS = ifelse(grepl("<", KS), 1e-30, KS))
goEnrichment$KS <- as.numeric(goEnrichment$KS)
goEnrichment <- goEnrichment[goEnrichment$KS<0.05,]
goEnrichment <- goEnrichment[,c("GO.ID","Term","KS")]
goEnrichment$Term <- gsub(" [a-z]*\\.\\.\\.$", "", goEnrichment$Term)
goEnrichment$Term <- gsub("\\.\\.\\.$", "", goEnrichment$Term)
goEnrichment$Term <- paste(goEnrichment$GO.ID, goEnrichment$Term, sep=", ")
goEnrichment$Term <- factor(goEnrichment$Term, levels=rev(goEnrichment$Term))
goEnrichment$KS <- as.numeric(goEnrichment$KS)

require(ggplot2)
ggplot(goEnrichment, aes(x=Term, y=-log10(KS))) +
    stat_summary(geom = "bar", fun = mean, position = "dodge") +
    xlab("Biological process") +
    ylab("Enrichment") +
    ggtitle("Title") +
    scale_y_continuous(breaks = round(seq(0, max(-log10(goEnrichment$KS)), by = 2), 1)) +
    theme_bw(base_size=24) +
    theme(
        legend.position='none',
        legend.background=element_rect(),
        plot.title=element_text(angle=0, size=24, face="bold", vjust=1),
        axis.text.x=element_text(angle=0, size=18, face="bold", hjust=1.10),
        axis.text.y=element_text(angle=0, size=18, face="bold", vjust=0.5),
        axis.title=element_text(size=24, face="bold"),
        legend.key=element_blank(),     #removes the border
        legend.key.size=unit(1, "cm"),      #Sets overall area/size of the legend
        legend.text=element_text(size=18),  #Text size
        title=element_text(size=18)) +
    guides(colour=guide_legend(override.aes=list(size=2.5))) +
    coord_flip()

Pathway enrichment

Use pathfindR to perform enrichment analysis of pathways enriched amongst DE genes

# library(pathfindR)
# #Get data in corrrect format: DF with "gene symbols", "change values" (optional), "associated p values"
# results_df <- results[["Unstrain"]] %>% 
#      dplyr::select(logFC, qvalue) %>% 
#      tibble::rownames_to_column()
# 
# results_df$rowname <- gene_anno$external_gene_name[match(results_df$rowname, gene_anno$ensembl_gene_id)]
# results_df <- results_df %>% 
#      dplyr::mutate(Gene.symbol = rowname) %>% 
#      dplyr::select(Gene.symbol, logFC, qvalue)
# results_df$Gene.symbol <- as.character(results_df$Gene.symbol)
# 
# Unstrain_processed <- input_processing(input = results_df, # the input: in this case, differential expression results
#                                  p_val_threshold = 0.05, # p value threshold to filter significant genes
#                                  pin_name_path  = "Biogrid", # the name of the PIN to use for active subnetwork search
#                                  convert2alias = TRUE) # boolean indicating whether or not to convert missing symbols to alias symbols in the PIN
# 
# # using "BioCarta" as our gene sets for enrichment
# biocarta_list <- fetch_gene_set(gene_sets = "BioCarta",
#                                 min_gset_size = 10,
#                                 max_gset_size = 300)
# biocarta_gsets <- biocarta_list[[1]]
# biocarta_descriptions <- biocarta_list[[2]]
# 
# # using "KEGG" as our gene sets for enrichment
# KEGG_list <- fetch_gene_set(gene_sets = "KEGG",
#                                 min_gset_size = 10,
#                                 max_gset_size = 300)
# KEGG_gsets <- KEGG_list[[1]]
# KEGG_descriptions <- KEGG_list[[2]]
# 
# n_iter <- 15 ## number of iterations
# combined_res <- NULL ## to store the result of each iteration
# 
# for (i in 1:n_iter) {
#   
#   ###### Active Subnetwork Search
#   snws_file <- paste0("active_snws_", i) # Name of output file
#   active_snws <- active_snw_search(input_for_search = Unstrain_processed, 
#                                    pin_name_path = "Biogrid", 
#                                    snws_file = snws_file,
#                                    score_quan_thr = 0.8, # you may tweak these arguments for optimal filtering of subnetworks
#                                    sig_gene_thr = 0.02, # you may tweak these arguments for optimal filtering of subnetworks
#                                    search_method = "GR")
#   
#   ###### Enrichment Analyses
#   current_res <- enrichment_analyses(snws = active_snws,
#                                      sig_genes_vec = Unstrain_processed$GENE,
#                                      pin_name_path = "Biogrid", 
#                                      genes_by_term = KEGG_gsets,
#                                      term_descriptions = KEGG_descriptions,
#                                      adj_method = "bonferroni",
#                                      enrichment_threshold = 0.05,
#                                      list_active_snw_genes = TRUE) # listing the non-input active snw genes in output
#   
#   ###### Combine results via `rbind`
#   combined_res <- rbind(combined_res, current_res)
# }
# 
# 
# 
# ###### Summarize Combined Enrichment Results
# summarized_df <- summarize_enrichment_results(combined_res, 
#                                               list_active_snw_genes = TRUE)
# 
# ###### Annotate Affected Genes Involved in Each Enriched Term
# final_res <- annotate_term_genes(result_df = summarized_df, 
#                                  input_processed = Unstrain_processed, 
#                                  genes_by_term = KEGG_gsets)
# 
# #visualization
# visualize_terms(result_df = final_res, 
#                 hsa_KEGG = FALSE, # boolean to indicate whether human KEGG gene sets were used for enrichment analysis or not
#                 pin_name_path = "Biogrid")
# 
# enrichment_chart(final_res, top_terms = 10)

threshold <- 0.05
gene_universe_up <- as.numeric(results[["Unstrain"]]$qvalue < threshold & results[["Unstrain"]]$logFC > 0)
gene_universe_up <- factor(gene_universe_up)
names(gene_universe_up) <- rownames(results[["Unstrain"]])
head(gene_universe_up)

ENSG00000225972 ENSG00000225630 ENSG00000237973 ENSG00000248527 
              0               0               0               0 
ENSG00000198744 ENSG00000228794 
              0               0 
Levels: 0 1

go_data <- new("topGOdata",
               ontology = "BP",
               allGenes = gene_universe_up,
               nodeSize = 5,
               annotationFun = annFUN.org,
               mapping = "org.Hs.eg.db",
               ID = "ensembl")

Building most specific GOs .....

    ( 9790 GO terms found. )

Build GO DAG topology ..........

    ( 13875 GO terms and 32681 relations. )

Annotating nodes ...............

    ( 9223 genes annotated to the GO terms. )

go_test <- runTest(go_data, algorithm = "weight01", statistic = "fisher")

             -- Weight01 Algorithm -- 

         the algorithm is scoring 4723 nontrivial nodes
         parameters: 
             test statistic: fisher

     Level 19:  1 nodes to be scored    (0 eliminated genes)

     Level 18:  2 nodes to be scored    (0 eliminated genes)

     Level 17:  6 nodes to be scored    (11 eliminated genes)

     Level 16:  14 nodes to be scored   (16 eliminated genes)

     Level 15:  27 nodes to be scored   (51 eliminated genes)

     Level 14:  58 nodes to be scored   (166 eliminated genes)

     Level 13:  116 nodes to be scored  (451 eliminated genes)

     Level 12:  207 nodes to be scored  (1157 eliminated genes)

     Level 11:  354 nodes to be scored  (2713 eliminated genes)

     Level 10:  515 nodes to be scored  (4137 eliminated genes)

     Level 9:   635 nodes to be scored  (5269 eliminated genes)

     Level 8:   651 nodes to be scored  (6604 eliminated genes)

     Level 7:   715 nodes to be scored  (7458 eliminated genes)

     Level 6:   657 nodes to be scored  (8140 eliminated genes)

     Level 5:   419 nodes to be scored  (8544 eliminated genes)

     Level 4:   222 nodes to be scored  (8816 eliminated genes)

     Level 3:   101 nodes to be scored  (8974 eliminated genes)

     Level 2:   22 nodes to be scored   (9025 eliminated genes)

     Level 1:   1 nodes to be scored    (9091 eliminated genes)

go_table <- GenTable(go_data, weightFisher = go_test,
                     orderBy = "weightFisher", ranksOf = "weightFisher",
                     topNodes = sum(score(go_test) < .01))
go_table

        GO.ID                                        Term Annotated
1  GO:0030198           extracellular matrix organization       208
2  GO:0030199                collagen fibril organization        31
3  GO:0006027         glycosaminoglycan catabolic process        40
4  GO:0032964               collagen biosynthetic process        29
5  GO:0006768                    biotin metabolic process         9
6  GO:0031643          positive regulation of myelination         9
7  GO:0001503                                ossification       246
8  GO:0006024      glycosaminoglycan biosynthetic process        75
9  GO:0045454                      cell redox homeostasis        47
10 GO:0044267          cellular protein metabolic process      3279
11 GO:0035987             endodermal cell differentiation        31
12 GO:0060972                left/right pattern formation        14
13 GO:0060638       mesenchymal-epithelial cell signaling         5
14 GO:0070208                 protein heterotrimerization        11
15 GO:0042362    fat-soluble vitamin biosynthetic process         8
16 GO:0010838 positive regulation of keratinocyte prol...         6
17 GO:0098974 postsynaptic actin cytoskeleton organiza...         6
18 GO:0048709             oligodendrocyte differentiation        55
19 GO:0034329                      cell junction assembly       151
20 GO:0003009                 skeletal muscle contraction        13
21 GO:0060390 regulation of SMAD protein signal transd...        18
22 GO:0051764                   actin crosslink formation         7
23 GO:0060346                    bone trabecula formation         7
24 GO:0001649                  osteoblast differentiation       150
25 GO:0033692 cellular polysaccharide biosynthetic pro...        39
26 GO:0009058                        biosynthetic process      3911
27 GO:0042476                               odontogenesis        77
28 GO:0048592                           eye morphogenesis        84
29 GO:0085029               extracellular matrix assembly        16
30 GO:2000345      regulation of hepatocyte proliferation         8
   Significant Expected weightFisher
1           39    12.02      6.1e-06
2            8     1.79      0.00028
3            9     2.31      0.00030
4            5     1.68      0.00064
5            4     0.52      0.00110
6            4     0.52      0.00110
7           27    14.22      0.00121
8           13     4.33      0.00126
9            9     2.72      0.00127
10         166   189.49      0.00142
11           7     1.79      0.00161
12           4     0.81      0.00175
13           3     0.29      0.00176
14           4     0.64      0.00263
15           3     0.46      0.00333
16           3     0.35      0.00337
17           3     0.35      0.00337
18          10     3.18      0.00367
19          12     8.73      0.00376
20           4     0.75      0.00519
21           6     1.04      0.00557
22           3     0.40      0.00564
23           3     0.40      0.00564
24          14     8.67      0.00735
25           6     2.25      0.00858
26         178   226.02      0.00863
27           9     4.45      0.00887
28          10     4.85      0.00950
29           4     0.92      0.00957
30           3     0.46      0.00959

go_table[,-1]

                                          Term Annotated Significant
1            extracellular matrix organization       208          39
2                 collagen fibril organization        31           8
3          glycosaminoglycan catabolic process        40           9
4                collagen biosynthetic process        29           5
5                     biotin metabolic process         9           4
6           positive regulation of myelination         9           4
7                                 ossification       246          27
8       glycosaminoglycan biosynthetic process        75          13
9                       cell redox homeostasis        47           9
10          cellular protein metabolic process      3279         166
11             endodermal cell differentiation        31           7
12                left/right pattern formation        14           4
13       mesenchymal-epithelial cell signaling         5           3
14                 protein heterotrimerization        11           4
15    fat-soluble vitamin biosynthetic process         8           3
16 positive regulation of keratinocyte prol...         6           3
17 postsynaptic actin cytoskeleton organiza...         6           3
18             oligodendrocyte differentiation        55          10
19                      cell junction assembly       151          12
20                 skeletal muscle contraction        13           4
21 regulation of SMAD protein signal transd...        18           6
22                   actin crosslink formation         7           3
23                    bone trabecula formation         7           3
24                  osteoblast differentiation       150          14
25 cellular polysaccharide biosynthetic pro...        39           6
26                        biosynthetic process      3911         178
27                               odontogenesis        77           9
28                           eye morphogenesis        84          10
29               extracellular matrix assembly        16           4
30      regulation of hepatocyte proliferation         8           3
   Expected weightFisher
1     12.02      6.1e-06
2      1.79      0.00028
3      2.31      0.00030
4      1.68      0.00064
5      0.52      0.00110
6      0.52      0.00110
7     14.22      0.00121
8      4.33      0.00126
9      2.72      0.00127
10   189.49      0.00142
11     1.79      0.00161
12     0.81      0.00175
13     0.29      0.00176
14     0.64      0.00263
15     0.46      0.00333
16     0.35      0.00337
17     0.35      0.00337
18     3.18      0.00367
19     8.73      0.00376
20     0.75      0.00519
21     1.04      0.00557
22     0.40      0.00564
23     0.40      0.00564
24     8.67      0.00735
25     2.25      0.00858
26   226.02      0.00863
27     4.45      0.00887
28     4.85      0.00950
29     0.92      0.00957
30     0.46      0.00959

threshold <- 0.05
gene_universe_down <- as.numeric(results[["Unstrain"]]$qvalue < threshold & results[["Unstrain"]]$logFC < 0)
gene_universe_down <- factor(gene_universe_down)
names(gene_universe_down) <- rownames(results[["Unstrain"]])
head(gene_universe_down)

ENSG00000225972 ENSG00000225630 ENSG00000237973 ENSG00000248527 
              0               0               0               0 
ENSG00000198744 ENSG00000228794 
              0               0 
Levels: 0 1

go_data <- new("topGOdata",
               ontology = "BP",
               allGenes = gene_universe_down,
               nodeSize = 5,
               annotationFun = annFUN.org,
               mapping = "org.Hs.eg.db",
               ID = "ensembl")

Building most specific GOs .....

    ( 9790 GO terms found. )

Build GO DAG topology ..........

    ( 13875 GO terms and 32681 relations. )

Annotating nodes ...............

    ( 9223 genes annotated to the GO terms. )

go_test <- runTest(go_data, algorithm = "weight01", statistic = "fisher")

             -- Weight01 Algorithm -- 

         the algorithm is scoring 5175 nontrivial nodes
         parameters: 
             test statistic: fisher

     Level 19:  1 nodes to be scored    (0 eliminated genes)

     Level 18:  3 nodes to be scored    (0 eliminated genes)

     Level 17:  6 nodes to be scored    (11 eliminated genes)

     Level 16:  17 nodes to be scored   (17 eliminated genes)

     Level 15:  47 nodes to be scored   (48 eliminated genes)

     Level 14:  97 nodes to be scored   (188 eliminated genes)

     Level 13:  151 nodes to be scored  (516 eliminated genes)

     Level 12:  239 nodes to be scored  (1339 eliminated genes)

     Level 11:  385 nodes to be scored  (2797 eliminated genes)

     Level 10:  552 nodes to be scored  (4127 eliminated genes)

     Level 9:   677 nodes to be scored  (5231 eliminated genes)

     Level 8:   699 nodes to be scored  (6639 eliminated genes)

     Level 7:   800 nodes to be scored  (7483 eliminated genes)

     Level 6:   697 nodes to be scored  (8110 eliminated genes)

     Level 5:   439 nodes to be scored  (8539 eliminated genes)

     Level 4:   238 nodes to be scored  (8808 eliminated genes)

     Level 3:   105 nodes to be scored  (8979 eliminated genes)

     Level 2:   21 nodes to be scored   (9026 eliminated genes)

     Level 1:   1 nodes to be scored    (9091 eliminated genes)

go_table <- GenTable(go_data, weightFisher = go_test,
                     orderBy = "weightFisher", ranksOf = "weightFisher",
                     topNodes = sum(score(go_test) < .01))
go_table

        GO.ID                                        Term Annotated
1  GO:0055114                 oxidation-reduction process       605
2  GO:0046364         monosaccharide biosynthetic process        63
3  GO:0051085 chaperone cofactor-dependent protein ref...        11
4  GO:0006695            cholesterol biosynthetic process        56
5  GO:0030223                  neutrophil differentiation         6
6  GO:1900034     regulation of cellular response to heat        73
7  GO:0006986                response to unfolded protein       141
8  GO:0036499     PERK-mediated unfolded protein response        16
9  GO:0034135 regulation of toll-like receptor 2 signa...         7
10 GO:0019321                   pentose metabolic process         7
11 GO:1903364 positive regulation of cellular protein ...       108
12 GO:0045540 regulation of cholesterol biosynthetic p...        39
13 GO:0032874 positive regulation of stress-activated ...        95
14 GO:0021955 central nervous system neuron axonogenes...        25
15 GO:0050927 positive regulation of positive chemotax...        10
16 GO:0034144 negative regulation of toll-like recepto...         5
17 GO:0098712 L-glutamate import across plasma membran...         5
18 GO:0071500     cellular response to nitrosative stress         5
19 GO:0006793                phosphorus metabolic process      2036
20 GO:0030852 regulation of granulocyte differentiatio...         6
21 GO:1905323      telomerase holoenzyme complex assembly         6
22 GO:0060402          calcium ion transport into cytosol        66
23 GO:2000106 regulation of leukocyte apoptotic proces...        35
24 GO:0006098                     pentose-phosphate shunt        12
25 GO:0050771         negative regulation of axonogenesis        26
26 GO:2001020 regulation of response to DNA damage sti...       157
27 GO:0002063                     chondrocyte development        21
28 GO:0043066    negative regulation of apoptotic process       535
29 GO:0045104 intermediate filament cytoskeleton organ...        22
30 GO:0051131 chaperone-mediated protein complex assem...        14
31 GO:0036151 phosphatidylcholine acyl-chain remodelin...        14
32 GO:0002446                neutrophil mediated immunity       309
33 GO:0061052 negative regulation of cell growth invol...         8
34 GO:0035973                                  aggrephagy         8
35 GO:0090650 cellular response to oxygen-glucose depr...         8
36 GO:0048638          regulation of developmental growth       174
37 GO:0035336 long-chain fatty-acyl-CoA metabolic proc...        14
   Significant Expected weightFisher
1           51    33.72      5.8e-06
2            8     3.51      9.5e-06
3            6     0.61      1.1e-05
4           16     3.12      1.7e-05
5            4     0.33      0.00013
6           13     4.07      0.00017
7           22     7.86      0.00025
8            5     0.89      0.00029
9            4     0.39      0.00029
10           4     0.39      0.00029
11          14     6.02      0.00041
12           9     2.17      0.00044
13          13     5.29      0.00093
14           5     1.39      0.00096
15           4     0.56      0.00153
16           3     0.28      0.00158
17           3     0.28      0.00158
18           3     0.28      0.00158
19         138   113.47      0.00270
20           3     0.33      0.00303
21           3     0.33      0.00303
22           9     3.68      0.00306
23           5     1.95      0.00309
24           4     0.67      0.00330
25           7     1.45      0.00448
26          18     8.75      0.00490
27           5     1.17      0.00509
28          51    29.82      0.00580
29           5     1.23      0.00607
30           4     0.78      0.00610
31           4     0.78      0.00610
32          20    17.22      0.00779
33           3     0.45      0.00781
34           3     0.45      0.00781
35           3     0.45      0.00781
36          16     9.70      0.00880
37           3     0.78      0.00894

go_table[,-1]

                                          Term Annotated Significant
1                  oxidation-reduction process       605          51
2          monosaccharide biosynthetic process        63           8
3  chaperone cofactor-dependent protein ref...        11           6
4             cholesterol biosynthetic process        56          16
5                   neutrophil differentiation         6           4
6      regulation of cellular response to heat        73          13
7                 response to unfolded protein       141          22
8      PERK-mediated unfolded protein response        16           5
9  regulation of toll-like receptor 2 signa...         7           4
10                   pentose metabolic process         7           4
11 positive regulation of cellular protein ...       108          14
12 regulation of cholesterol biosynthetic p...        39           9
13 positive regulation of stress-activated ...        95          13
14 central nervous system neuron axonogenes...        25           5
15 positive regulation of positive chemotax...        10           4
16 negative regulation of toll-like recepto...         5           3
17 L-glutamate import across plasma membran...         5           3
18     cellular response to nitrosative stress         5           3
19                phosphorus metabolic process      2036         138
20 regulation of granulocyte differentiatio...         6           3
21      telomerase holoenzyme complex assembly         6           3
22          calcium ion transport into cytosol        66           9
23 regulation of leukocyte apoptotic proces...        35           5
24                     pentose-phosphate shunt        12           4
25         negative regulation of axonogenesis        26           7
26 regulation of response to DNA damage sti...       157          18
27                     chondrocyte development        21           5
28    negative regulation of apoptotic process       535          51
29 intermediate filament cytoskeleton organ...        22           5
30 chaperone-mediated protein complex assem...        14           4
31 phosphatidylcholine acyl-chain remodelin...        14           4
32                neutrophil mediated immunity       309          20
33 negative regulation of cell growth invol...         8           3
34                                  aggrephagy         8           3
35 cellular response to oxygen-glucose depr...         8           3
36          regulation of developmental growth       174          16
37 long-chain fatty-acyl-CoA metabolic proc...        14           3
   Expected weightFisher
1     33.72      5.8e-06
2      3.51      9.5e-06
3      0.61      1.1e-05
4      3.12      1.7e-05
5      0.33      0.00013
6      4.07      0.00017
7      7.86      0.00025
8      0.89      0.00029
9      0.39      0.00029
10     0.39      0.00029
11     6.02      0.00041
12     2.17      0.00044
13     5.29      0.00093
14     1.39      0.00096
15     0.56      0.00153
16     0.28      0.00158
17     0.28      0.00158
18     0.28      0.00158
19   113.47      0.00270
20     0.33      0.00303
21     0.33      0.00303
22     3.68      0.00306
23     1.95      0.00309
24     0.67      0.00330
25     1.45      0.00448
26     8.75      0.00490
27     1.17      0.00509
28    29.82      0.00580
29     1.23      0.00607
30     0.78      0.00610
31     0.78      0.00610
32    17.22      0.00779
33     0.45      0.00781
34     0.45      0.00781
35     0.45      0.00781
36     9.70      0.00880
37     0.78      0.00894

Volcano plots broken down by individual

single_filt_counts <- filt_counts
anno <- pData(RUVsOut)

NA18855_index <- which(anno$Individual == "NA18855 ")
NA18855 <- single_filt_counts[, NA18855_index]
NA18855_anno <- anno[NA18855_index, ]
     
NA18856_index <- which(anno$Individual == "NA18856 ")
NA18856 <- single_filt_counts[, NA18856_index]
NA18856_anno <- anno[NA18856_index, ]
     
NA19160_index <- which(anno$Individual == "NA19160 ")
NA19160 <- single_filt_counts[, NA19160_index]
NA19160_anno <- anno[NA19160_index, ]


plot_volcano <- function(x, qval) {
  # Create volcano plot.
  #
  # x - data frame with topTable and ASH output
  #     (columns logFC, P.Value, and qvalue)
  # qval - qvalue cutoff for calling a gene DE
  #
  stopifnot(is.data.frame(x), c("logFC", "P.Value", "qvalue") %in% colnames(x),
            is.numeric(qval), qval <= 1, qval >= 0)
  x$highlight <- ifelse(x$qvalue < qval, "darkred", "gray75")
  x$highlight <- factor(x$highlight, levels = c("darkred", "gray75"))
  ggplot(x, aes(x = logFC, y = -log10(P.Value), color = highlight)) +
    geom_point(shape = 1) +
    labs(x = "Log fold change",
         y = expression(-log[10] * " p-value")) +
    scale_color_identity(drop = FALSE) +
    theme(legend.position = "none")
}

volcano_plot_ind <- function(annotation, filtered_counts){
     design <- model.matrix(~treatment + W_1 + W_2 + RIN,
                            data = annotation)
     colnames(design) <- gsub("treatment", "", colnames(design))
     
     #TMM Normalization
     y <- DGEList(filtered_counts)
     y <- calcNormFactors(y, method = "TMM")
     #Voom for differential expression
     v1 <- voom(y, design)
     fit <- lmFit(v1, design, block = annotation$treatment,
                  correlation = corfit2$consensus.correlation)
     fit <- eBayes(fit)
     
     #extract results and run ash
     tests <- colnames(fit$coefficients)
     results <- vector(length = length(tests), mode = "list")
     names(results) <- tests
     
     for (test in tests) {
          # Extract limma results
          results[[test]] <- get_results(fit, coef = test)
          # Add mutliple testing correction with ASH
          output_ash <- run_ash(fit, coef = test)$result
          results[[test]] <- cbind(results[[test]], lfsr = output_ash$lfsr,
                                   lfdr = output_ash$lfdr, qvalue = output_ash$qvalue,
                                   svalue = output_ash$svalue)
          }

     #FDR 0.05
     print(plot_volcano(results[["Unstrain"]], 0.05))
     
     print(table(results[["Unstrain"]]$logFC > 0))
     print(table(results[["Unstrain"]]$logFC > 0.25))
     print(table(results[["Unstrain"]]$logFC < -0.25))
}


#make plots
volcano_plot_ind(NA18855_anno, NA18855)

Past versions of “individual volcano plots-1.png”

FALSE  TRUE 
 5229  5288 

FALSE  TRUE 
 9478  1039 

FALSE  TRUE 
 9591   926 

volcano_plot_ind(NA18856_anno, NA18856)

Past versions of “individual volcano plots-2.png”

FALSE  TRUE 
 5566  4951 

FALSE  TRUE 
 7792  2725 

FALSE  TRUE 
 7515  3002 

#volcano_plot_ind(NA19160_anno, NA19160)

#19160
design <- model.matrix(~treatment + W_1 + W_2,
                            data = NA19160_anno)
colnames(design) <- gsub("treatment", "", colnames(design))
     
#TMM Normalization
y <- DGEList(NA19160)
y <- calcNormFactors(y, method = "TMM")
#Voom for differential expression
v1 <- voom(y, design)
fit <- lmFit(v1, design, block = NA19160_anno$treatment,
                  correlation = corfit2$consensus.correlation)
fit <- eBayes(fit)
     
#extract results and run ash
tests <- colnames(fit$coefficients)
results <- vector(length = length(tests), mode = "list")
names(results) <- tests
     
for (test in tests) {
     # Extract limma results
     results[[test]] <- get_results(fit, coef = test)
     # Add mutliple testing correction with ASH
     output_ash <- run_ash(fit, coef = test)$result
     results[[test]] <- cbind(results[[test]], lfsr = output_ash$lfsr,
                              lfdr = output_ash$lfdr, qvalue = output_ash$qvalue,
                              svalue = output_ash$svalue)
     }

#FDR 0.05
plot_volcano(results[["Unstrain"]], 0.05)

Past versions of “individual volcano plots-3.png”

table(results[["Unstrain"]]$logFC > 0)

FALSE  TRUE 
 5309  5208 

table(results[["Unstrain"]]$logFC > 0.25)

FALSE  TRUE 
 9458  1059 

table(results[["Unstrain"]]$logFC < -0.25)

FALSE  TRUE 
 9530   987 

Additional analysis permuting samples:

From Ben Fair: “i have a suggestion for an analysis as a check that all your DE results (like the GO analysis, the enrichment for DE genes from published datasets) are robust… i’m not sure this is statistically perfect but its something that I think makes sense to try, for my own sanity: if you randomly reassign control and treatment labels and re-attampt DE testing, do all of those interesting results go away? the worry i am trying to address, is that you have some enrichment of DE genes in interesting GO categories for example, but is that just because you have more DE power for detecting highly expressed genes in this cell type (even if they are only modestly or not truly DE), and that is what drives the GO enrichment.”

#scramble treatment labels (x3) and store the DE genes (each time, randomly assign 9 samples to be strain)
# permuted_results <- vector("list", 12)
# for(time in 1:6){
#      #set up DE and scramble labels
#      anno <- pData(RUVsOut)
#      x <- paste0(anno$Individual, anno$treatment)
# 
#      anno$LibraryPrepBatch <- factor(anno$LibraryPrepBatch, levels = c("1", "2"))
#      anno$Replicate <- factor(anno$Replicate, levels = c("1", "2", "3"))
# 
#      strain_indices <- sample(nrow(anno), 9)
#      anno$treatment <- "Unstrain"
#      anno$treatment[strain_indices] <- "Strain"
#      design <- model.matrix(~treatment + Sex + Individual + W_1 + W_2 + RIN,
#                        data = anno)
#      colnames(design) <- gsub("treatment", "", colnames(design))
# 
#      permuted_results[[time]] <- anno
# 
#      #perform DE
#      #TMM Normalization
#      y <- DGEList(single_filt_counts)
#      y <- calcNormFactors(y, method = "TMM")
#      #Voom for differential expression
#      v1 <- voom(y, design)
#      corfit1 <- duplicateCorrelation(v1, design, block = x)
#      corfit1$consensus.correlation
#      v2 <- voom(y, design, block = x, correlation = corfit1$consensus.correlation)
#      corfit2 <- duplicateCorrelation(v2, design, block = x)
#      corfit2$consensus.correlation
#      fit <- lmFit(v2, design, block = x,
#              correlation = corfit2$consensus.correlation)
#      fit <- eBayes(fit)
# 
#      tests <- colnames(fit$coefficients)
#      results <- vector(length = length(tests), mode = "list")
#      names(results) <- tests
# 
#      for (test in tests[c(1:4, 6:8)]) {
#      # Extract limma results
#       results[[test]] <- get_results(fit, coef = test)
#      # Add mutliple testing correction with ASH
#      output_ash <- run_ash(fit, coef = test)$result
#      results[[test]] <- cbind(results[[test]], lfsr = output_ash$lfsr,
#                               lfdr = output_ash$lfdr, qvalue = output_ash$qvalue,
#                               svalue = output_ash$svalue)
#      }
# 
#      #store results
#      permuted_results[[6+time]] <- results[["Unstrain"]]
# }
# saveRDS(permuted_results, "output/permuted_results_DE.rds")
permuted_results <- readRDS("output/permuted_results_DE.rds")
permuted_results

[[1]]
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3  Unstrain 10.0
19160_3_S 19160_3_S   NA19160    M         3    Strain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2    Strain 10.0
18856_2_S 18856_2_S   NA18856    M         2  Unstrain  9.6
19160_3_U 19160_3_U   NA19160    M         3  Unstrain 10.0
18855_2_U 18855_2_U   NA18855    F         2    Strain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1  Unstrain  9.9
18856_1_S 18856_1_S   NA18856    M         1  Unstrain  8.5
19160_1_S 19160_1_S   NA19160    M         1    Strain  9.9
19160_2_U 19160_2_U   NA19160    M         2    Strain 10.0
18855_1_U 18855_1_U   NA18855    F         1    Strain 10.0
18856_3_S 18856_3_S   NA18856    M         3    Strain  9.6
18856_2_U 18856_2_U   NA18856    M         2    Strain  9.5
18855_3_U 18855_3_U   NA18855    F         3  Unstrain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295

[[2]]
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3    Strain 10.0
19160_3_S 19160_3_S   NA19160    M         3    Strain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2  Unstrain 10.0
18856_2_S 18856_2_S   NA18856    M         2    Strain  9.6
19160_3_U 19160_3_U   NA19160    M         3    Strain 10.0
18855_2_U 18855_2_U   NA18855    F         2    Strain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1    Strain  9.9
18856_1_S 18856_1_S   NA18856    M         1    Strain  8.5
19160_1_S 19160_1_S   NA19160    M         1  Unstrain  9.9
19160_2_U 19160_2_U   NA19160    M         2  Unstrain 10.0
18855_1_U 18855_1_U   NA18855    F         1    Strain 10.0
18856_3_S 18856_3_S   NA18856    M         3  Unstrain  9.6
18856_2_U 18856_2_U   NA18856    M         2  Unstrain  9.5
18855_3_U 18855_3_U   NA18855    F         3  Unstrain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295

[[3]]
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3    Strain 10.0
19160_3_S 19160_3_S   NA19160    M         3    Strain 10.0
18856_3_U 18856_3_U   NA18856    M         3    Strain 10.0
18856_1_U 18856_1_U   NA18856    M         1    Strain  9.9
18855_2_S 18855_2_S   NA18855    F         2  Unstrain 10.0
18856_2_S 18856_2_S   NA18856    M         2  Unstrain  9.6
19160_3_U 19160_3_U   NA19160    M         3  Unstrain 10.0
18855_2_U 18855_2_U   NA18855    F         2    Strain 10.0
19160_2_S 19160_2_S   NA19160    M         2  Unstrain 10.0
18855_1_S 18855_1_S   NA18855    F         1    Strain  9.9
18856_1_S 18856_1_S   NA18856    M         1    Strain  8.5
19160_1_S 19160_1_S   NA19160    M         1    Strain  9.9
19160_2_U 19160_2_U   NA19160    M         2  Unstrain 10.0
18855_1_U 18855_1_U   NA18855    F         1  Unstrain 10.0
18856_3_S 18856_3_S   NA18856    M         3  Unstrain  9.6
18856_2_U 18856_2_U   NA18856    M         2  Unstrain  9.5
18855_3_U 18855_3_U   NA18855    F         3    Strain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295

[[4]]
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3  Unstrain 10.0
19160_3_S 19160_3_S   NA19160    M         3  Unstrain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2    Strain 10.0
18856_2_S 18856_2_S   NA18856    M         2  Unstrain  9.6
19160_3_U 19160_3_U   NA19160    M         3    Strain 10.0
18855_2_U 18855_2_U   NA18855    F         2    Strain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1    Strain  9.9
18856_1_S 18856_1_S   NA18856    M         1    Strain  8.5
19160_1_S 19160_1_S   NA19160    M         1  Unstrain  9.9
19160_2_U 19160_2_U   NA19160    M         2  Unstrain 10.0
18855_1_U 18855_1_U   NA18855    F         1    Strain 10.0
18856_3_S 18856_3_S   NA18856    M         3    Strain  9.6
18856_2_U 18856_2_U   NA18856    M         2  Unstrain  9.5
18855_3_U 18855_3_U   NA18855    F         3    Strain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295

[[5]]
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3  Unstrain 10.0
19160_3_S 19160_3_S   NA19160    M         3  Unstrain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2  Unstrain 10.0
18856_2_S 18856_2_S   NA18856    M         2    Strain  9.6
19160_3_U 19160_3_U   NA19160    M         3    Strain 10.0
18855_2_U 18855_2_U   NA18855    F         2  Unstrain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1  Unstrain  9.9
18856_1_S 18856_1_S   NA18856    M         1  Unstrain  8.5
19160_1_S 19160_1_S   NA19160    M         1    Strain  9.9
19160_2_U 19160_2_U   NA19160    M         2    Strain 10.0
18855_1_U 18855_1_U   NA18855    F         1    Strain 10.0
18856_3_S 18856_3_S   NA18856    M         3    Strain  9.6
18856_2_U 18856_2_U   NA18856    M         2    Strain  9.5
18855_3_U 18855_3_U   NA18855    F         3    Strain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295

[[6]]
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3  Unstrain 10.0
19160_3_S 19160_3_S   NA19160    M         3    Strain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2  Unstrain 10.0
18856_2_S 18856_2_S   NA18856    M         2    Strain  9.6
19160_3_U 19160_3_U   NA19160    M         3    Strain 10.0
18855_2_U 18855_2_U   NA18855    F         2  Unstrain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1  Unstrain  9.9
18856_1_S 18856_1_S   NA18856    M         1    Strain  8.5
19160_1_S 19160_1_S   NA19160    M         1    Strain  9.9
19160_2_U 19160_2_U   NA19160    M         2    Strain 10.0
18855_1_U 18855_1_U   NA18855    F         1  Unstrain 10.0
18856_3_S 18856_3_S   NA18856    M         3    Strain  9.6
18856_2_U 18856_2_U   NA18856    M         2  Unstrain  9.5
18855_3_U 18855_3_U   NA18855    F         3    Strain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295

[[7]]
                        logFC      AveExpr             t      P.Value
ENSG00000225972 -6.767991e-01  3.439734306 -6.034212e+00 1.534683e-05
ENSG00000225630 -3.459833e-01  5.259763521 -4.409907e+00 4.107725e-04
ENSG00000237973 -2.340504e-01  5.765427761 -2.309679e+00 3.416705e-02
ENSG00000248527 -4.122446e-01  7.291375670 -5.647351e+00 3.262286e-05
ENSG00000198744 -6.027311e-02  1.692163426 -4.425191e-01 6.638701e-01
ENSG00000228794 -9.625710e-03  2.429990051 -6.846823e-02 9.462373e-01
ENSG00000223764  2.363846e-02  1.604113326  1.326653e-01 8.960655e-01
ENSG00000187634  1.311432e-01  2.774428967  1.057727e+00 3.054482e-01
ENSG00000188976 -1.271284e-01  5.602324306 -2.108812e+00 5.059980e-02
ENSG00000187961  1.325594e-01  3.205023751  1.151909e+00 2.658059e-01
ENSG00000187608 -1.051588e-01  3.515541854 -7.393004e-01 4.701314e-01
ENSG00000188157 -1.687196e-01  8.438003633 -1.784618e+00 9.275392e-02
ENSG00000131591 -4.326563e-02  2.698849622 -3.570313e-01 7.256019e-01
ENSG00000078808 -4.598536e-02  8.404430472 -6.825496e-01 5.043794e-01
ENSG00000176022 -8.386179e-03  5.315643527 -9.096719e-02 9.286159e-01
ENSG00000160087 -5.342404e-02  5.574117382 -9.565097e-01 3.526456e-01
ENSG00000131584 -1.248551e-01  5.338644789 -1.663437e+00 1.151346e-01
ENSG00000169972 -1.044143e-01  3.649507997 -1.293766e+00 2.135966e-01
ENSG00000127054 -8.861510e-02  5.813712471 -1.763807e+00 9.630361e-02
ENSG00000224051 -6.153466e-02  4.433660580 -7.176686e-01 4.830178e-01
ENSG00000107404 -9.239766e-02  5.541314411 -1.051471e+00 3.082262e-01
ENSG00000162576 -6.629820e-02  5.643016003 -6.556034e-01 5.211330e-01
ENSG00000175756 -2.330514e-02  5.949578662 -4.729930e-01 6.424261e-01
ENSG00000221978  1.246176e-01  6.117640537  1.075522e+00 2.976451e-01
ENSG00000224870 -5.212137e-02  4.193043833 -5.941803e-01 5.604655e-01
ENSG00000242485  1.097271e-02  5.474356677  1.767409e-01 8.618671e-01
ENSG00000160072 -2.606481e-02  4.020742816 -3.344057e-01 7.422941e-01
ENSG00000197785 -3.986811e-02  4.667370310 -4.901177e-01 6.305156e-01
ENSG00000160075  2.570885e-02  6.698987873  5.165866e-01 6.123117e-01
ENSG00000228594  5.667969e-02  3.231082811  4.613645e-01 6.505719e-01
ENSG00000197530 -1.670145e-01  6.011139637 -1.761902e+00 9.663438e-02
ENSG00000189409 -3.120851e-02  4.590321361 -2.866829e-01 7.779303e-01
ENSG00000248333 -2.539609e-01  3.904469734 -3.419798e+00 3.390157e-03
ENSG00000189339 -7.889013e-02  5.329578573 -1.410645e+00 1.769582e-01
ENSG00000008130 -3.467566e-02  5.472226379 -6.601556e-01 5.182809e-01
ENSG00000078369 -1.471033e-02  8.804321589 -3.445650e-01 7.347820e-01
ENSG00000162585 -9.614789e-02  4.754428869 -1.030171e+00 3.178221e-01
ENSG00000157933 -4.170617e-02  6.562145698 -7.895748e-01 4.409961e-01
ENSG00000157916 -2.380030e-02  7.002652621 -5.097098e-01 6.170168e-01
ENSG00000157911 -3.042208e-02  3.826112744 -2.880426e-01 7.769075e-01
ENSG00000157881 -1.948416e-02  4.048444809 -2.771334e-01 7.851259e-01
ENSG00000157870 -1.437396e-01  3.237377913 -1.318839e+00 2.052679e-01
ENSG00000158109 -8.364271e-02  6.732297019 -1.675515e+00 1.127121e-01
ENSG00000116213 -5.916146e-02  4.048572327 -8.210028e-01 4.233698e-01
ENSG00000227372  1.980463e-02  3.931432132  2.682032e-01 7.918732e-01
ENSG00000130764 -5.846816e-02  5.498222486 -9.254604e-01 3.680892e-01
ENSG00000116198 -6.409805e-02  4.799410870 -9.560501e-01 3.528709e-01
ENSG00000198912  1.108725e-02  4.517142545  1.609528e-01 8.740883e-01
ENSG00000131697  2.015576e-02  3.217207294  2.340496e-01 8.178311e-01
ENSG00000116251  1.021006e-01  6.491595851  1.685462e+00 1.107501e-01
ENSG00000116237 -1.106385e-02  7.144503644 -2.259333e-01 8.240333e-01
ENSG00000158292 -6.737194e-02  2.850382649 -5.631747e-01 5.809029e-01
ENSG00000097021 -3.972663e-02  4.963811963 -2.813111e-01 7.819755e-01
ENSG00000215788 -4.169332e-02  2.224832337 -2.081042e-01 8.376993e-01
ENSG00000171680 -4.813704e-02  4.816276482 -3.674191e-01 7.179852e-01
ENSG00000162408  1.623993e-01  3.954485497  1.817428e+00 8.739087e-02
ENSG00000204859 -4.964338e-02  3.319571732 -4.614250e-01 6.505294e-01
ENSG00000162413 -8.689368e-02  6.835844141 -1.626095e+00 1.229090e-01
ENSG00000116273  4.720304e-02  5.018894856  6.256304e-01 5.401309e-01
ENSG00000041988  9.402484e-02  3.387269004  1.034978e+00 3.156378e-01
ENSG00000007923 -1.393499e-01  5.116929638 -1.903423e+00 7.461167e-02
ENSG00000171735  1.790563e-02  3.971476593  1.489784e-01 8.833796e-01
ENSG00000049245  7.444088e-02  6.747961733  1.702935e+00 1.073750e-01
ENSG00000116288 -6.315667e-02  7.469041111 -1.303922e+00 2.101914e-01
ENSG00000116285 -3.437070e-02  6.567378923 -2.050315e-01 8.400601e-01
ENSG00000142599 -3.149498e-01  6.882232369 -5.493637e+00 4.425887e-05
ENSG00000074800  7.995019e-03  9.240103588  1.314682e-01 8.969975e-01
ENSG00000142583  8.556524e-02  2.154021950  4.111849e-01 6.862377e-01
ENSG00000180758  1.316956e-01  2.520571933  1.375868e+00 1.872857e-01
ENSG00000228526 -1.147713e-01  3.111024724 -6.291662e-01 5.378702e-01
ENSG00000049239  4.506518e-02  5.843277506  5.021609e-01 6.222015e-01
ENSG00000171621  6.160367e-02  7.640791271  7.922669e-01 4.394685e-01
ENSG00000171612  1.213680e-01  2.962339532  1.017418e+00 3.236687e-01
ENSG00000188807  5.328492e-03  3.161234025  5.232693e-02 9.588976e-01
ENSG00000171608  7.094923e-02  3.600417471  6.282114e-01 5.384802e-01
ENSG00000171603  3.306178e-02  7.507456408  5.380248e-01 5.977563e-01
ENSG00000178585  6.346380e-02  4.096458428  7.955617e-01 4.376034e-01
ENSG00000162441  1.186006e-01  4.190251149  1.529293e+00 1.451704e-01
ENSG00000173614  2.975761e-02  3.790237230  2.848469e-01 7.793121e-01
ENSG00000130939 -6.197711e-02  6.013665524 -1.037435e+00 3.145257e-01
ENSG00000054523 -4.123988e-02  6.790885629 -8.603956e-01 4.019228e-01
ENSG00000142657 -3.729739e-03  6.764910548 -7.057029e-02 9.445896e-01
ENSG00000160049  1.313065e-02  5.436360887  2.673031e-01 7.925542e-01
ENSG00000142655 -8.607047e-02  3.921860299 -1.144931e+00 2.686041e-01
ENSG00000120948  4.740066e-03  5.498744258  8.865993e-02 9.304213e-01
ENSG00000116649 -1.282801e-01  6.989287261 -1.721375e+00 1.039100e-01
ENSG00000171824 -7.211280e-02  5.208139078 -1.244451e+00 2.307527e-01
ENSG00000198793 -9.718115e-02  6.572268484 -1.652002e+00 1.174692e-01
ENSG00000171819 -2.522350e-02  5.005029463 -1.376544e-01 8.921824e-01
ENSG00000120942 -4.665394e-02  4.505427589 -6.996204e-01 4.939283e-01
ENSG00000116661  4.538212e-02  2.256655281  2.892704e-01 7.759842e-01
ENSG00000132879  5.047387e-02  2.851964046  5.140595e-01 6.140387e-01
ENSG00000116670 -1.620555e-02  3.776766362 -1.788251e-01 8.602564e-01
ENSG00000177674 -1.650027e-02  4.748151475 -2.329628e-01 8.186609e-01
ENSG00000177000 -1.954206e-02  4.306535766 -2.608867e-01 7.974140e-01
ENSG00000011021 -5.368589e-02  4.716053644 -7.572647e-01 4.595891e-01
ENSG00000116685 -2.715616e-02  5.360029702 -4.072493e-01 6.890691e-01
ENSG00000083444 -3.196610e-04  9.617689757 -4.644060e-03 9.963504e-01
ENSG00000116688 -2.886059e-02  6.632063082 -5.603383e-01 5.827914e-01
ENSG00000116691 -9.442851e-02  3.486834952 -1.371627e+00 1.885779e-01
ENSG00000048707 -4.387627e-02  5.830304323 -7.811816e-01 4.457803e-01
ENSG00000162496  7.132749e-03  3.119770104  4.998909e-02 9.607323e-01
ENSG00000162494  1.108371e-01  1.522400198  6.695634e-01 5.124145e-01
ENSG00000162493  6.301397e-02  9.669928769  9.404883e-01 3.605578e-01
ENSG00000116731  9.616667e-03  5.589398806  1.860587e-01 8.546711e-01
ENSG00000189337 -3.245446e-01  3.000052029 -2.734260e+00 1.442174e-02
ENSG00000171729 -1.172006e-02  3.118331547 -7.152052e-02 9.438448e-01
ENSG00000142634 -1.343972e-01  4.068304279 -1.177448e+00 2.557526e-01
ENSG00000132906  2.680318e-02  3.641839894  3.054571e-01 7.638449e-01
ENSG00000116138  7.087244e-02  5.209789620  1.186077e+00 2.524217e-01
ENSG00000197312  3.885225e-02  5.118656021  5.126870e-01 6.149777e-01
ENSG00000116786 -5.266448e-02  6.306994840 -1.100670e+00 2.868677e-01
ENSG00000162458  2.255180e-02  7.121657904  2.532404e-01 8.032164e-01
ENSG00000065526 -4.768490e-02  5.499653620 -9.010641e-01 3.805422e-01
ENSG00000116809 -1.349074e-01  4.245851773 -1.576710e+00 1.338746e-01
ENSG00000173641 -8.187012e-02  5.013884293 -6.026605e-01 5.549428e-01
ENSG00000142627 -1.223668e-01  6.565606623 -1.291357e+00 2.144107e-01
ENSG00000142632  8.106169e-02  2.972003499  6.217386e-01 5.426252e-01
ENSG00000037637  7.379134e-02  4.745003107  1.200514e+00 2.469228e-01
ENSG00000055070 -9.546725e-02  6.825257519 -2.032924e+00 5.850485e-02
ENSG00000157191 -1.143232e-02  6.110674810 -2.623481e-01 7.963064e-01
ENSG00000219481  2.727089e-02  4.648960829  3.788661e-01 7.096271e-01
ENSG00000215908  1.371333e-02  3.665056004  1.658364e-01 8.703044e-01
ENSG00000058453  4.242127e-02  4.313812210  3.765343e-01 7.113266e-01
ENSG00000117122  2.811569e-02  6.989385574  4.559562e-01 6.543761e-01
ENSG00000159363 -7.670726e-02  6.019552468 -8.977913e-01 3.822341e-01
ENSG00000117118  6.413403e-02  6.167713801  1.219173e+00 2.399526e-01
ENSG00000179051 -9.695514e-03  6.193488468 -1.541437e-01 8.793695e-01
ENSG00000074964 -9.096484e-02  3.574390645 -1.106968e+00 2.842143e-01
ENSG00000159423  9.813939e-02  2.894230519  7.727420e-01 4.506233e-01
ENSG00000169991 -1.991366e-02  4.732484074 -2.183019e-01 8.298759e-01
ENSG00000127481  2.077112e-02  9.073849311  2.827934e-01 7.808586e-01
ENSG00000127463 -6.445170e-02  6.630439259 -1.227360e+00 2.369424e-01
ENSG00000053372  4.049068e-02  4.612180635  5.715513e-01 5.753440e-01
ENSG00000053371  1.041692e-01  5.024884155  1.585805e+00 1.317951e-01
ENSG00000040487 -5.388565e-02  4.555068328 -5.689101e-01 5.770937e-01
ENSG00000077549  1.911891e-02  7.815775016  4.665090e-01 6.469624e-01
ENSG00000173436  5.501056e-02  3.042210288  4.691851e-01 6.450884e-01
ENSG00000158747  6.931981e-02  6.183331667  8.686460e-01 3.975227e-01
ENSG00000169914 -3.690127e-02  4.817885052 -3.367870e-01 7.405309e-01
ENSG00000188257  4.553099e-01  2.000223706  1.348188e+00 1.958489e-01
ENSG00000127472 -1.712184e-02  3.088517748 -1.427284e-01 8.882363e-01
ENSG00000162545  7.889504e-02  4.827178273  7.083895e-01 4.886093e-01
ENSG00000090432 -4.614923e-02  5.675075630 -7.593953e-01 4.583484e-01
ENSG00000158828 -1.351954e-01  4.494932010 -1.460992e+00 1.628334e-01
ENSG00000117242 -6.493812e-02  2.631331799 -5.686621e-01 5.772582e-01
ENSG00000244038 -5.918305e-02  8.697751526 -1.082698e+00 2.945399e-01
ENSG00000117245 -9.493758e-02  2.607635834 -6.368905e-01 5.329497e-01
ENSG00000189410  9.519159e-02  2.810261770  6.985668e-01 4.945696e-01
ENSG00000127483  5.857631e-02  7.082879913  1.112752e+00 2.817936e-01
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ENSG00000169515  2.224996e-02  6.217376588  3.047887e-01 7.643449e-01
ENSG00000182013  6.239513e-02  4.098389913  7.602489e-01 4.578519e-01
ENSG00000160014 -7.868095e-02  6.669841601 -1.704475e+00 1.070818e-01
ENSG00000197380  1.587623e-01  1.871194780  9.015094e-01 3.803124e-01
ENSG00000105287 -2.489662e-01  3.771143271 -2.879132e+00 1.066409e-02
ENSG00000090372 -8.270668e-02  5.820892491 -1.381259e+00 1.856535e-01
ENSG00000181027 -1.195456e-01  4.641894417 -1.388680e+00 1.834258e-01
ENSG00000105281 -3.723690e-02  7.857433925 -6.510603e-01 5.239882e-01
ENSG00000042753 -2.226620e-02  7.434923049 -4.589021e-01 6.523027e-01
ENSG00000160007 -3.407913e-02  6.288965066 -6.310425e-01 5.366727e-01
ENSG00000130751  1.409289e-02  1.595824281  5.983124e-02 9.530100e-01
ENSG00000130748  1.097251e-02  3.344774900  7.750277e-02 9.391574e-01
ENSG00000130749 -1.290957e-01  4.763281284 -1.351529e+00 1.947988e-01
ENSG00000142230 -5.880843e-04  6.729612621 -1.132797e-02 9.910979e-01
ENSG00000105327  7.031333e-03  3.801955028  5.948945e-02 9.532781e-01
ENSG00000105321 -1.064889e-01  4.678268012 -1.370359e+00 1.889656e-01
ENSG00000257704 -1.644363e-01  3.298874371 -1.328617e+00 2.020908e-01
ENSG00000134815 -9.119813e-02  3.693557527 -9.605780e-01 3.506557e-01
ENSG00000105419 -5.575113e-02  4.933703137 -6.898131e-01 4.999170e-01
ENSG00000105402 -3.193571e-02  5.408501710 -4.305786e-01 6.723567e-01
ENSG00000063169 -2.827645e-01  3.327719514 -2.806520e+00 1.241068e-02
ENSG00000024422 -7.134437e-02  8.032530303 -8.918349e-01 3.853262e-01
ENSG00000105373 -8.156329e-04  5.891610812 -1.502234e-02 9.881948e-01
ENSG00000178980  1.058327e-01  7.035800120  2.010036e+00 6.110025e-02
ENSG00000105499 -6.469636e-02  1.927616636 -3.620553e-01 7.219144e-01
ENSG00000105486 -3.025851e-02  3.002420359 -2.300626e-01 8.208763e-01
ENSG00000185453 -1.091958e-02  2.708174192 -9.898390e-02 9.223458e-01
ENSG00000105483  5.886405e-02  3.977034748  9.022870e-01 3.799113e-01
ENSG00000142227  3.248479e-02  5.980823546  3.840384e-01 7.058629e-01
ENSG00000105438 -2.198881e-02  8.088896974 -4.352763e-01 6.690123e-01
ENSG00000105464 -1.545601e-01  1.667123160 -1.274502e+00 2.201751e-01
ENSG00000105447 -1.333124e-01  4.746674892 -2.283183e+00 3.600696e-02
ENSG00000105443 -1.078480e-02  5.536496313 -1.192005e-01 9.065584e-01
ENSG00000063177 -4.304865e-02  8.145714965 -7.054668e-01 4.903783e-01
ENSG00000063176 -1.512043e-01  4.421560402 -1.782817e+00 9.305653e-02
ENSG00000105552  6.411307e-02  3.944928364  8.735954e-01 3.948983e-01
ENSG00000087076 -3.043453e-02  4.966516712 -3.145953e-01 7.570193e-01
ENSG00000087074 -1.825947e-01  6.783914463 -2.689127e+00 1.583329e-02
ENSG00000104805 -4.980369e-02  7.906149214 -6.925374e-01 4.982492e-01
ENSG00000087088 -2.152988e-02  6.436261320 -2.329278e-01 8.186876e-01
ENSG00000087086  6.255048e-02 12.058941043  9.356754e-01 3.629583e-01
ENSG00000104812 -2.575250e-02  5.554919935 -4.806532e-01 6.370856e-01
ENSG00000183207 -7.390550e-02  5.649854617 -1.057872e+00 3.053841e-01
ENSG00000104852 -6.378488e-02  6.570625396 -7.105688e-01 4.872927e-01
ENSG00000104863  6.425739e-02  2.860985462  5.522532e-01 5.881917e-01
ENSG00000177380 -1.492647e-01  2.904772987 -1.159850e+00 2.626488e-01
ENSG00000130529 -9.262552e-03  3.954710118 -7.685950e-02 9.396613e-01
ENSG00000074219 -3.053489e-02  4.784127661 -4.028138e-01 6.922657e-01
ENSG00000104872  8.441557e-02  5.215611657  1.207148e+00 2.444273e-01
ENSG00000161618 -2.769705e-02  4.073193668 -2.452751e-01 8.092735e-01
ENSG00000142541  2.843842e-02  8.798495572  5.079207e-01 6.182437e-01
ENSG00000142534 -4.444455e-02  9.214561396 -6.457921e-01 5.273101e-01
ENSG00000104870  5.003368e-02  5.305007871  6.433113e-01 5.288784e-01
ENSG00000142552 -1.613884e-01  6.302870351 -2.521273e+00 2.233512e-02
ENSG00000142546 -2.741847e-02  5.367518939 -4.338060e-01 6.700583e-01
ENSG00000126464 -1.263306e-01  4.885551572 -1.491764e+00 1.546669e-01
ENSG00000126458 -3.880913e-03  6.339176461 -7.433093e-02 9.416424e-01
ENSG00000126461 -1.997334e-01  6.133402435 -2.058226e+00 5.575231e-02
ENSG00000126456 -1.403812e-01  4.969957329 -2.268460e+00 3.706882e-02
ENSG00000126453 -2.204106e-01  2.842914353 -2.127428e+00 4.881585e-02
ENSG00000126457 -1.421547e-01  6.324574391 -2.581586e+00 1.975019e-02
ENSG00000196961 -1.039950e-01  6.862993870 -1.465106e+00 1.617213e-01
ENSG00000010361  1.053325e-01  2.746988061  8.052597e-01 4.321424e-01
ENSG00000104973 -2.247663e-01  4.644685303 -2.719239e+00 1.487751e-02
ENSG00000104960  1.434868e-02  5.126602512  2.068590e-01 8.386558e-01
ENSG00000039650 -6.621613e-02  4.318555072 -8.696405e-01 3.969945e-01
ENSG00000204673 -1.025748e-01  6.615684364 -1.457379e+00 1.638150e-01
ENSG00000104946 -8.609590e-02  5.142717077 -1.172642e+00 2.576221e-01
ENSG00000213024  1.202328e-02  5.178261322  2.132699e-01 8.337341e-01
ENSG00000169136 -9.710737e-02  3.340949893 -1.043520e+00 3.117835e-01
ENSG00000105053  1.229434e-01  4.303539969  1.380423e+00 1.859060e-01
ENSG00000142528  5.598441e-02  3.054946621  5.363498e-01 5.988873e-01
ENSG00000131408 -1.885685e-02  5.748430698 -2.472178e-01 8.077951e-01
ENSG00000062822 -3.852277e-02  3.000646471 -3.341149e-01 7.425095e-01
ENSG00000161671 -5.843566e-02  6.833897974 -8.781085e-01 3.925153e-01
ENSG00000161677 -6.169624e-02  4.863914065 -7.738741e-01 4.499718e-01
ENSG00000167747  1.569852e-02  4.345002868  1.868997e-01 8.540222e-01
ENSG00000142544  6.314276e-02  2.311663930  2.972649e-01 7.699810e-01
ENSG00000105379 -1.055500e-01  3.407808788 -9.624280e-01 3.497534e-01
ENSG00000105497  7.406711e-02  3.196139230  8.982416e-01 3.820010e-01
ENSG00000182310  2.020385e-02  2.485832085  1.722401e-01 8.653476e-01
ENSG00000198093 -1.781771e-01  2.053797321 -1.324042e+00 2.035723e-01
ENSG00000176024  1.229927e-01  2.592669391  1.236849e+00 2.334902e-01
ENSG00000256683 -3.022781e-02  2.455207926 -2.551277e-01 8.017831e-01
ENSG00000197619  3.954679e-01  2.482955439  2.791343e+00 1.280924e-02
ENSG00000142556  1.259079e-01  3.382865635  1.323104e+00 2.038772e-01
ENSG00000256087  1.209538e-01  4.021520586  1.110355e+00 2.827948e-01
ENSG00000197608  1.919544e-01  4.006239358  2.404003e+00 2.830598e-02
ENSG00000204611 -3.505352e-02  3.850670783 -4.274408e-01 6.745945e-01
ENSG00000105568 -8.331832e-02  7.439852649 -1.371001e+00 1.887690e-01
ENSG00000196214 -1.116932e-01  3.198031676 -1.383913e+00 1.848543e-01
ENSG00000198464  5.042845e-02  3.424444091  5.051079e-01 6.201750e-01
ENSG00000167554  9.467719e-02  2.135684048  7.410519e-01 4.690971e-01
ENSG00000221923 -1.041664e-01  2.348356875 -8.615520e-01 4.013042e-01
ENSG00000167555  5.609910e-02  2.377642494  4.735539e-01 6.420344e-01
ENSG00000167766  1.210421e-01  3.897495780  1.439299e+00 1.688013e-01
ENSG00000213020  4.247709e-02  2.480214607  4.089158e-01 6.878696e-01
ENSG00000189190  1.232563e-01  1.940346670  7.900108e-01 4.407485e-01
ENSG00000198538  1.790608e-01  3.912907898  1.897435e+00 7.544440e-02
ENSG00000204604  3.169256e-02  4.547968222  2.952149e-01 7.715189e-01
ENSG00000213793  1.233096e-01  3.335171849  1.182046e+00 2.539734e-01
ENSG00000180257  1.167095e-01  3.077122991  1.334408e+00 2.002275e-01
ENSG00000242779 -5.938592e-02  4.041796100 -8.114221e-01 4.286949e-01
ENSG00000170949  3.980759e-02  4.027401106  5.982795e-01 5.577923e-01
                 adj.P.Val           B       lfsr       lfdr     qvalue
ENSG00000225972 0.03206567  2.34201392 0.16927420 0.11421833 0.06162590
ENSG00000225630 0.22586000  0.13698082 0.25431420 0.18535011 0.14216112
ENSG00000237973 0.67698578 -3.63015398 0.45411333 0.31053360 0.26574415
ENSG00000248527 0.05680183  2.39713189 0.07918372 0.05784497 0.02672962
ENSG00000198744 0.94108198 -5.13705661 0.65051320 0.37692390 0.33407155
ENSG00000228794 0.99056607 -5.20588505 0.68370927 0.37895767 0.33637783
ENSG00000223764 0.98276879 -5.13143705 0.67822814 0.37449227 0.33078111
ENSG00000187634 0.82848167 -4.90575717 0.58861543 0.36487526 0.31773747
ENSG00000188976 0.69256556 -3.96440070 0.35066314 0.26235234 0.22219624
ENSG00000187961 0.81069335 -4.86665475 0.57296012 0.36151420 0.31373559
ENSG00000187608 0.88489224 -5.23444412 0.62597984 0.37171858 0.32683680
ENSG00000188157 0.69889082 -4.49291533 0.48377322 0.32801840 0.28028003
ENSG00000131591 0.95623844 -5.22197810 0.65631022 0.38061910 0.33823672
ENSG00000078808 0.89239880 -5.69364185 0.59689547 0.39204200 0.34751354
ENSG00000176022 0.98871281 -5.83157508 0.68580979 0.39335337 0.34842339
ENSG00000160087 0.84632247 -5.43392751 0.53728436 0.37823493 0.33565666
ENSG00000131584 0.73407810 -4.60344894 0.45579265 0.32026601 0.27438986
ENSG00000169972 0.78448036 -4.80327650 0.51652552 0.34928228 0.30076464
ENSG00000127054 0.69889082 -4.50512675 0.36498134 0.27870600 0.23616496
ENSG00000224051 0.88757226 -5.44158993 0.60211322 0.38099764 0.33864862
ENSG00000107404 0.83001904 -5.34181938 0.55853270 0.36450002 0.31728955
ENSG00000162576 0.90181821 -5.66435952 0.61809738 0.37898069 0.33641466
ENSG00000175756 0.93678307 -5.79425181 0.63503542 0.43080715 0.36203383
ENSG00000221978 0.82349008 -5.37680511 0.58113956 0.36411464 0.31683653
ENSG00000224870 0.91565222 -5.47119667 0.62007182 0.38512577 0.34256687
ENSG00000242485 0.97830792 -5.83829240 0.68256735 0.41967924 0.35939635
ENSG00000160072 0.95717112 -5.55065256 0.65457177 0.39884509 0.35141027
ENSG00000197785 0.93527929 -5.61276727 0.63245797 0.39186593 0.34741843
ENSG00000160075 0.92842091 -5.81444812 0.62586267 0.42657841 0.36114134
ENSG00000228594 0.93719317 -5.32116934 0.64616878 0.37879613 0.33620796
ENSG00000197530 0.69889082 -4.52126991 0.48645479 0.32930524 0.28154268
ENSG00000189409 0.96537609 -5.65570157 0.66241063 0.38467919 0.34219008
ENSG00000248333 0.56465058 -1.72627218 0.30669558 0.22598080 0.18918798
ENSG00000189339 0.75969524 -4.92806343 0.44811508 0.32811018 0.28038875
ENSG00000008130 0.90021819 -5.64735048 0.59586619 0.40995419 0.35637996
ENSG00000078369 0.95717112 -5.84271389 0.66811657 0.45783692 0.36569145
ENSG00000162585 0.83001904 -5.24701686 0.56682477 0.36552768 0.31866498
ENSG00000157933 0.87189376 -5.64055901 0.56920527 0.39773121 0.35084020
ENSG00000157916 0.93099810 -5.82233037 0.62906013 0.43424847 0.36270446
ENSG00000157911 0.96537609 -5.50870452 0.66203030 0.38569957 0.34299844
ENSG00000157881 0.96537609 -5.56767230 0.66376391 0.40709318 0.35521711
ENSG00000157870 0.77619856 -4.70746726 0.55067207 0.35461947 0.30583190
ENSG00000158109 0.73212605 -4.67055462 0.38039192 0.28952699 0.24595726
ENSG00000116213 0.86866914 -5.29391607 0.57699119 0.38071322 0.33835589
ENSG00000227372 0.96686686 -5.54605376 0.66459773 0.40387336 0.35383902
ENSG00000130764 0.84968600 -5.45344516 0.55085459 0.37706069 0.33422000
ENSG00000116198 0.84632247 -5.32760104 0.54962756 0.37312181 0.32881250
ENSG00000198912 0.97933520 -5.67855372 0.68208375 0.41103788 0.35685039
ENSG00000131697 0.97183826 -5.38541497 0.66832870 0.39534337 0.34960523
ENSG00000116251 0.72997233 -4.65189122 0.41306033 0.30287901 0.25824169
ENSG00000116237 0.97367105 -5.92485858 0.68374219 0.44453802 0.36440042
ENSG00000158292 0.91912614 -5.19494955 0.63509852 0.37756457 0.33487661
ENSG00000097021 0.96537609 -5.73393087 0.66540018 0.37783105 0.33519663
ENSG00000215788 0.97534428 -5.17054862 0.67372762 0.37279599 0.32825033
ENSG00000171680 0.95473561 -5.69442613 0.65660793 0.37862355 0.33601508
ENSG00000162408 0.69889082 -4.22768003 0.47025283 0.32258790 0.27606971
ENSG00000204859 0.93719317 -5.33605853 0.64278361 0.38219547 0.33981308
ENSG00000162413 0.74036206 -4.74038734 0.40104137 0.30038931 0.25636078
ENSG00000116273 0.90719414 -5.60697698 0.61012038 0.38978855 0.34610863
ENSG00000041988 0.83001904 -4.98931835 0.56376317 0.36532136 0.31841086
ENSG00000007923 0.69889082 -4.23631988 0.42084033 0.30079490 0.25678354
ENSG00000171735 0.98171416 -5.56891237 0.67701754 0.38276703 0.34038417
ENSG00000049245 0.72011795 -4.63158515 0.35381344 0.27662924 0.23491538
ENSG00000116288 0.78137975 -5.15031118 0.45307199 0.33879885 0.29029328
ENSG00000116285 0.97534428 -5.89704282 0.67286877 0.37517510 0.33173272
ENSG00000142599 0.06115857  2.13299373 0.09013278 0.06893422 0.03376372
ENSG00000074800 0.98290632 -5.87022072 0.69070817 0.42243817 0.36008862
ENSG00000142583 0.94585030 -5.09995681 0.66178601 0.37155792 0.32658438
ENSG00000180758 0.76530038 -4.55871938 0.52857867 0.34901972 0.30032730
ENSG00000228526 0.90651177 -5.22636355 0.64453852 0.37104536 0.32575537
ENSG00000049239 0.93246524 -5.77013890 0.63312836 0.38728507 0.34424890
ENSG00000171621 0.87134705 -5.63417123 0.58595005 0.38015288 0.33760539
ENSG00000171612 0.83124533 -4.92756988 0.58930821 0.36600538 0.31921600
ENSG00000188807 0.99221659 -5.39405399 0.68872651 0.38902994 0.34557739
ENSG00000171608 0.90699375 -5.33368045 0.62605074 0.37731483 0.33456922
ENSG00000171603 0.92493605 -5.80481052 0.62034137 0.40634949 0.35486978
ENSG00000178585 0.86996897 -5.32602896 0.58696046 0.37927739 0.33670091
ENSG00000162441 0.74383407 -4.62601612 0.47901736 0.33180894 0.28358061
ENSG00000173614 0.96537609 -5.50788485 0.66231551 0.38613191 0.34336385
ENSG00000130939 0.83001904 -5.40313727 0.52608120 0.36837766 0.32204040
ENSG00000054523 0.86440170 -5.59020538 0.55186576 0.39685569 0.35039764
ENSG00000142657 0.99029781 -5.94188985 0.70749516 0.43843702 0.36357064
ENSG00000160049 0.96686686 -5.81501673 0.67575863 0.44257571 0.36413639
ENSG00000142655 0.81069335 -5.00130500 0.52956689 0.35832345 0.30995150
ENSG00000120948 0.98897356 -5.85919184 0.70376965 0.43686348 0.36323225
ENSG00000116649 0.71043695 -4.60780900 0.44698427 0.31552153 0.27032041
ENSG00000171824 0.79438826 -5.10429118 0.48394171 0.34739504 0.29854620
ENSG00000198793 0.73635397 -4.70118158 0.41317056 0.30413484 0.25930552
ENSG00000171819 0.98214869 -5.73029663 0.67792663 0.37408932 0.33025150
ENSG00000120942 0.88899448 -5.47005133 0.59359788 0.39149007 0.34725780
ENSG00000116661 0.96537609 -5.18014138 0.66590123 0.37581002 0.33257653
ENSG00000132879 0.92962775 -5.20917782 0.63411664 0.38378318 0.34134845
ENSG00000116670 0.97830792 -5.51537735 0.67512351 0.39347738 0.34851736
ENSG00000177674 0.97191985 -5.70951037 0.67047503 0.40758635 0.35537660
ENSG00000177000 0.96804025 -5.62316440 0.66555048 0.40308271 0.35347146
ENSG00000011021 0.88101100 -5.46899058 0.58651353 0.38522863 0.34263053
ENSG00000116685 0.94632635 -5.76123093 0.64320996 0.40671652 0.35502282
ENSG00000083444 0.99857777 -5.85721824 0.70549747 0.41234918 0.35734661
ENSG00000116688 0.91918749 -5.79093253 0.61633568 0.41979523 0.35944712
ENSG00000116691 0.76530038 -4.69476708 0.48373852 0.33902437 0.29056200
ENSG00000048707 0.87423811 -5.60519516 0.57258438 0.39464672 0.34921400
ENSG00000162496 0.99221659 -5.37227850 0.68516963 0.37865527 0.33605225
ENSG00000162494 0.89675590 -4.96362034 0.63814946 0.37139855 0.32632999
ENSG00000162493 0.84703107 -5.43730576 0.55225684 0.37433605 0.33057372
ENSG00000116731 0.97777372 -5.85791027 0.68835093 0.43901160 0.36365970
ENSG00000189337 0.67698578 -2.90989058 0.46288689 0.31120735 0.26630093
ENSG00000171729 0.98999465 -5.39452574 0.68271023 0.37592548 0.33276405
ENSG00000142634 0.80744860 -4.99340359 0.56965153 0.36055667 0.31260139
ENSG00000132906 0.96235982 -5.47546140 0.65886243 0.39313996 0.34827643
ENSG00000116138 0.80569801 -5.17004778 0.49817892 0.35367099 0.30497227
ENSG00000197312 0.92976437 -5.68552571 0.62763327 0.39453610 0.34914975
ENSG00000116786 0.82094034 -5.35666830 0.49749848 0.36672572 0.32004033
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ENSG00000105287 0.67698578 -2.61953593 0.37956426 0.27046223 0.23003486
ENSG00000090372 0.76516643 -5.01513848 0.46277866 0.33356504 0.28502493
ENSG00000181027 0.76278573 -4.85944644 0.51275159 0.34516381 0.29658601
ENSG00000105281 0.90316863 -5.73321731 0.59847645 0.40409272 0.35394403
ENSG00000042753 0.93779060 -5.84409093 0.63838310 0.43353189 0.36257612
ENSG00000160007 0.90644519 -5.73712738 0.60187747 0.41005564 0.35642755
ENSG00000130751 0.99143000 -5.11467270 0.68258781 0.37144690 0.32637907
ENSG00000130748 0.98927865 -5.43636317 0.68290053 0.37878116 0.33618575
ENSG00000130749 0.76978634 -4.91873784 0.53104742 0.35016999 0.30176735
ENSG00000142230 0.99666051 -5.94598498 0.71858802 0.44096525 0.36392235
ENSG00000105327 0.99143000 -5.53505546 0.68599209 0.38363213 0.34120444
ENSG00000105321 0.76530038 -4.89292367 0.50090830 0.34306727 0.29490477
ENSG00000257704 0.77417022 -4.71852177 0.56403395 0.35664210 0.30805684
ENSG00000134815 0.84632247 -5.12257956 0.57694113 0.36862655 0.32236076
ENSG00000105419 0.89090722 -5.55194232 0.60321886 0.38408079 0.34162193
ENSG00000105402 0.94462262 -5.75141916 0.63991480 0.39883833 0.35139282
ENSG00000063169 0.67698578 -2.76969719 0.42259573 0.29259633 0.24952656
ENSG00000024422 0.86054711 -5.55048778 0.57294173 0.37399692 0.33012006
ENSG00000105373 0.99619402 -5.89458424 0.71532197 0.43558258 0.36298508
ENSG00000178980 0.69735521 -4.17443470 0.33293872 0.25468318 0.21494991
ENSG00000105499 0.95574052 -5.05812716 0.66233392 0.37345042 0.32928420
ENSG00000105486 0.97318371 -5.32972677 0.66940608 0.37981045 0.33722413
ENSG00000185453 0.98779094 -5.26985352 0.68264228 0.38580404 0.34309946
ENSG00000105483 0.85823678 -5.22522169 0.55709007 0.37798943 0.33536320
ENSG00000142227 0.95024002 -5.83751820 0.64800970 0.39316132 0.34828820
ENSG00000105438 0.94435167 -5.83916434 0.64191146 0.43051591 0.36198526
ENSG00000105464 0.78760513 -4.57368928 0.56666021 0.35804113 0.30962128
ENSG00000105447 0.67698578 -3.61106148 0.32089138 0.24293999 0.20556009
ENSG00000105443 0.98516819 -5.85984426 0.68261429 0.39410386 0.34886900
ENSG00000063177 0.88899448 -5.68991934 0.58960936 0.39585614 0.34986746
ENSG00000063176 0.69889082 -4.32298690 0.46412561 0.32085742 0.27462709
ENSG00000105552 0.86440170 -5.23578086 0.56969652 0.37688096 0.33398530
ENSG00000087076 0.96010270 -5.71443942 0.65825216 0.38862463 0.34525544
ENSG00000087074 0.67698578 -3.01843339 0.32355441 0.24040996 0.20432584
ENSG00000104805 0.89072108 -5.70132286 0.59771301 0.38842949 0.34513353
ENSG00000087088 0.97191985 -5.91118441 0.66822244 0.39186387 0.34741249
ENSG00000087086 0.84833949 -5.32120830 0.55292444 0.37475799 0.33118360
ENSG00000104812 0.93581910 -5.75984617 0.63165237 0.42152078 0.35987540
ENSG00000183207 0.82848167 -5.34360800 0.53595645 0.36471368 0.31752652
ENSG00000104852 0.88890285 -5.69784382 0.60541715 0.38004024 0.33745474
ENSG00000104863 0.92104438 -5.19222136 0.63525738 0.37836938 0.33576894
ENSG00000177380 0.80943331 -4.80690342 0.58261757 0.36216032 0.31449265
ENSG00000130529 0.98927865 -5.58459898 0.68409351 0.38298917 0.34059726
ENSG00000074219 0.94827284 -5.66350529 0.64432004 0.39849449 0.35119493
ENSG00000104872 0.80141844 -5.14118173 0.51182689 0.35297880 0.30443707
ENSG00000161618 0.97052078 -5.57639396 0.66710258 0.38395011 0.34150494
ENSG00000142541 0.93133261 -5.77709473 0.62589286 0.41569654 0.35836658
ENSG00000142534 0.90530498 -5.68149142 0.60381998 0.39312872 0.34825876
ENSG00000104870 0.90537408 -5.62422341 0.60852070 0.38766614 0.34453314
ENSG00000142552 0.67698578 -3.28619109 0.32087779 0.24024068 0.20395367
ENSG00000142546 0.94447145 -5.73811602 0.63881581 0.40960907 0.35617156
ENSG00000126464 0.74539301 -4.76875827 0.49762279 0.33834285 0.28968209
ENSG00000126458 0.98929462 -5.92827092 0.70753275 0.43987529 0.36379409
ENSG00000126461 0.69735521 -4.07937424 0.46414648 0.31707771 0.27137178
ENSG00000126456 0.67698578 -3.65459016 0.33782891 0.25283609 0.21380874
ENSG00000126453 0.69238680 -3.74676182 0.47170631 0.31941091 0.27361462
ENSG00000126457 0.67698578 -3.20368760 0.27188765 0.20967652 0.17202080
ENSG00000196961 0.74721455 -4.95415289 0.47400103 0.33246086 0.28414235
ENSG00000010361 0.86869189 -5.03540061 0.61572889 0.37115517 0.32593480
ENSG00000104973 0.67698578 -2.88360667 0.37712473 0.27023431 0.22981852
ENSG00000104960 0.97534428 -5.78678627 0.67486922 0.40969080 0.35621324
ENSG00000039650 0.86440170 -5.31231318 0.57280700 0.37626879 0.33325605
ENSG00000204673 0.74830569 -4.95931054 0.47384896 0.33271739 0.28439576
ENSG00000104946 0.80778642 -5.16791798 0.52276048 0.35614653 0.30758629
ENSG00000213024 0.97524880 -5.79194102 0.67973352 0.42840517 0.36158047
ENSG00000169136 0.83001904 -4.98435719 0.56489140 0.36489923 0.31778691
ENSG00000105053 0.76521922 -4.81765521 0.51842545 0.34669283 0.29791231
ENSG00000142528 0.92493605 -5.25296682 0.63335934 0.38140115 0.33903600
ENSG00000131408 0.97052078 -5.85714631 0.66738234 0.40218682 0.35297575
ENSG00000062822 0.95717112 -5.30321148 0.65793034 0.38227968 0.33990094
ENSG00000161671 0.86440170 -5.57426485 0.56258169 0.37923779 0.33667164
ENSG00000161677 0.87535545 -5.47086236 0.59013733 0.38041660 0.33789769
ENSG00000167747 0.97777372 -5.64209151 0.67480927 0.39737374 0.35064813
ENSG00000142544 0.96335224 -5.15130893 0.66885262 0.37188861 0.32703935
ENSG00000105379 0.84632247 -5.05733767 0.58826395 0.36789153 0.32152744
ENSG00000105497 0.85823678 -5.07351596 0.57423107 0.37314101 0.32885813
ENSG00000182310 0.97838568 -5.22421594 0.67473485 0.38336362 0.34092835
ENSG00000198093 0.77619856 -4.55946115 0.57317520 0.35812921 0.30966645
ENSG00000176024 0.79576594 -4.69101568 0.54881155 0.35644085 0.30782217
ENSG00000256683 0.96967652 -5.19224540 0.66634717 0.38238481 0.34002227
ENSG00000197619 0.67698578 -2.94129798 0.49452626 0.32350733 0.27667729
ENSG00000142556 0.77619856 -4.73007028 0.53380715 0.35148876 0.30311094
ENSG00000256087 0.81860856 -5.06133593 0.57196804 0.36260594 0.31502521
ENSG00000197608 0.67698578 -3.37503084 0.39110628 0.28002380 0.23707228
ENSG00000204611 0.94493176 -5.47921529 0.64156092 0.39348315 0.34852322
ENSG00000105568 0.76530038 -5.07043075 0.46660957 0.33508616 0.28657779
ENSG00000196214 0.76512406 -4.64396837 0.50436593 0.34337465 0.29514779
ENSG00000198464 0.93209148 -5.34080305 0.63568834 0.38347996 0.34106001
ENSG00000167554 0.88443557 -4.95457982 0.62044801 0.37280318 0.32828750
ENSG00000221923 0.86440170 -4.96365002 0.60559341 0.37041073 0.32470911
ENSG00000167555 0.93678307 -5.29907559 0.64398039 0.37943766 0.33689059
ENSG00000167766 0.75267407 -4.69487989 0.50309464 0.34128944 0.29321480
ENSG00000213020 0.94592528 -5.15793983 0.64799903 0.38430718 0.34179703
ENSG00000189190 0.87189376 -4.90974236 0.62642299 0.37014305 0.32431461
ENSG00000198538 0.69889082 -4.11187586 0.47275803 0.32237719 0.27577859
ENSG00000204604 0.96353871 -5.66262800 0.66135486 0.38503886 0.34249679
ENSG00000213793 0.80572737 -4.87206166 0.56003664 0.35944170 0.31120307
ENSG00000180257 0.77368432 -4.67435824 0.52164597 0.34878977 0.29994020
ENSG00000242779 0.86866914 -5.28892623 0.57944208 0.38083070 0.33850251
ENSG00000170949 0.91565222 -5.44170046 0.61095110 0.39766519 0.35080529
                    svalue
ENSG00000225972 0.10554713
ENSG00000225630 0.20075277
ENSG00000237973 0.37513704
ENSG00000248527 0.03661649
ENSG00000198744 0.53102010
ENSG00000228794 0.55694548
ENSG00000223764 0.55276926
ENSG00000187634 0.48251510
ENSG00000188976 0.29144004
ENSG00000187961 0.46988413
ENSG00000187608 0.51185988
ENSG00000188157 0.39835447
ENSG00000131591 0.53556710
ENSG00000078808 0.48949126
ENSG00000176022 0.55868543
ENSG00000160087 0.43968510
ENSG00000131584 0.37628647
ENSG00000169972 0.42296905
ENSG00000127054 0.30387583
ENSG00000224051 0.49329755
ENSG00000107404 0.45766729
ENSG00000162576 0.50579640
ENSG00000175756 0.51903955
ENSG00000221978 0.47681313
ENSG00000224870 0.50724464
ENSG00000242485 0.55612824
ENSG00000160072 0.53398351
ENSG00000197785 0.51664297
ENSG00000160075 0.51175484
ENSG00000228594 0.52733371
ENSG00000197530 0.40022461
ENSG00000189409 0.54023245
ENSG00000248333 0.25595522
ENSG00000189339 0.37030454
ENSG00000008130 0.48860178
ENSG00000078369 0.54482287
ENSG00000162585 0.46442613
ENSG00000157933 0.46662536
ENSG00000157916 0.51415464
ENSG00000157911 0.53981900
ENSG00000157881 0.54129038
ENSG00000157870 0.45097566
ENSG00000158109 0.31565327
ENSG00000116213 0.47350766
ENSG00000227372 0.54219456
ENSG00000130764 0.45113842
ENSG00000116198 0.45004839
ENSG00000198912 0.55565782
ENSG00000131697 0.54500902
ENSG00000116251 0.34427973
ENSG00000116237 0.55695884
ENSG00000158292 0.51910638
ENSG00000097021 0.54271701
ENSG00000215788 0.54893203
ENSG00000171680 0.53577878
ENSG00000162408 0.38753343
ENSG00000204859 0.52472802
ENSG00000162413 0.33378308
ENSG00000116273 0.49944356
ENSG00000041988 0.46199350
ENSG00000007923 0.35015969
ENSG00000171735 0.55169901
ENSG00000049245 0.29374974
ENSG00000116288 0.37453418
ENSG00000116285 0.54838424
ENSG00000142599 0.04553587
ENSG00000074800 0.56200726
ENSG00000142583 0.53965617
ENSG00000180758 0.43289546
ENSG00000228526 0.52602077
ENSG00000049239 0.51718699
ENSG00000171621 0.48035060
ENSG00000171612 0.48315106
ENSG00000188807 0.56059508
ENSG00000171608 0.51194733
ENSG00000171603 0.50733478
ENSG00000178585 0.48095401
ENSG00000162441 0.39482154
ENSG00000173614 0.54011448
ENSG00000130939 0.43103332
ENSG00000054523 0.45197603
ENSG00000142657 0.56788891
ENSG00000160049 0.55062072
ENSG00000142655 0.43358292
ENSG00000120948 0.56707020
ENSG00000116649 0.36924653
ENSG00000171824 0.39843630
ENSG00000198793 0.34441200
ENSG00000171819 0.55260519
ENSG00000120942 0.48649233
ENSG00000116661 0.54303588
ENSG00000132879 0.51815080
ENSG00000116670 0.55010634
ENSG00000177674 0.54663352
ENSG00000177000 0.54278951
ENSG00000011021 0.48073853
ENSG00000116685 0.52493866
ENSG00000083444 0.56747107
ENSG00000116688 0.50416668
ENSG00000116691 0.39827259
ENSG00000048707 0.46953407
ENSG00000162496 0.55831482
ENSG00000162494 0.52147803
ENSG00000162493 0.45243289
ENSG00000116731 0.56034544
ENSG00000189337 0.38159504
ENSG00000171729 0.55623557
ENSG00000142634 0.46705517
ENSG00000132906 0.53733146
ENSG00000116138 0.40914373
ENSG00000197312 0.51302788
ENSG00000116786 0.40865335
ENSG00000162458 0.54290547
ENSG00000065526 0.44716929
ENSG00000116809 0.40230548
ENSG00000173641 0.51980658
ENSG00000142627 0.43944651
ENSG00000142632 0.51677921
ENSG00000037637 0.40940717
ENSG00000055070 0.25340412
ENSG00000157191 0.55678498
ENSG00000219481 0.52866769
ENSG00000215908 0.55249568
ENSG00000058453 0.53284657
ENSG00000117122 0.51900612
ENSG00000159363 0.47343990
ENSG00000117118 0.39486356
ENSG00000179051 0.55871188
ENSG00000074964 0.44570427
ENSG00000159423 0.50470022
ENSG00000169991 0.54626432
ENSG00000127481 0.54024718
ENSG00000127463 0.39364124
ENSG00000053372 0.50449803
ENSG00000053371 0.36672433
ENSG00000040487 0.51201724
ENSG00000077549 0.52594029
ENSG00000173436 0.52574692
ENSG00000158747 0.47282834
ENSG00000169914 0.53602055
ENSG00000188257 0.52066951
ENSG00000127472 0.55231757
ENSG00000162545 0.50436920
ENSG00000090432 0.47539364
ENSG00000158828 0.42107820
ENSG00000117242 0.51701723
ENSG00000244038 0.41809826
ENSG00000117245 0.52020526
ENSG00000189410 0.51299310
ENSG00000127483 0.41120484
ENSG00000075151 0.40383976
ENSG00000117298 0.28329604
ENSG00000142794 0.48545706
ENSG00000162551 0.55767834
ENSG00000090686 0.56310233
ENSG00000142798 0.50112284
ENSG00000070831 0.54789183
ENSG00000162552 0.54879171
ENSG00000184677 0.56356050
ENSG00000133216 0.55134046
ENSG00000004487 0.27227846
ENSG00000169641 0.38465038
ENSG00000179546 0.50085982
ENSG00000125944 0.48447657
ENSG00000125945 0.47216753
ENSG00000088280 0.52627788
ENSG00000117318 0.56224192
ENSG00000142676 0.55725255
ENSG00000011007 0.44733698
ENSG00000057757 0.56861387
ENSG00000011009 0.30122357
ENSG00000117308 0.56488531
ENSG00000117305 0.44691714
ENSG00000179163 0.52605295
ENSG00000189266 0.29681282
ENSG00000188529 0.40555451
ENSG00000001460 0.51342732
ENSG00000001461 0.50566914
ENSG00000117602 0.54664770
ENSG00000133226 0.43764466
ENSG00000169504 0.43920752
ENSG00000117614 0.53098899
ENSG00000117616 0.45629832
ENSG00000183726 0.54134895
ENSG00000204178 0.36409311
ENSG00000157978 0.48910796
ENSG00000117643 0.44060480
ENSG00000162430 0.26318539
ENSG00000117640 0.56545106
ENSG00000182749 0.55770491
ENSG00000117632 0.48711075
ENSG00000158006 0.49258618
ENSG00000158008 0.41728215
ENSG00000158022 0.47698952
ENSG00000130695 0.52344453
ENSG00000142669 0.34368084
ENSG00000158062 0.48609960
ENSG00000117682 0.36263787
ENSG00000198830 0.51890579
ENSG00000117713 0.39137495
ENSG00000060642 0.54897411
ENSG00000204160 0.52563409
ENSG00000142751 0.46559143
ENSG00000198746 0.56432067
ENSG00000090273 0.37737667
ENSG00000253368 0.50866369
ENSG00000158246 0.50484703
ENSG00000090020 0.50762304
ENSG00000142784 0.44081170
ENSG00000186501 0.35078200
ENSG00000142733 0.54936628
ENSG00000158195 0.28475570
ENSG00000126705 0.39941477
ENSG00000126709 0.55464533
ENSG00000009780 0.55793057
ENSG00000117758 0.41689039
ENSG00000117751 0.51373936
ENSG00000117748 0.50939359
ENSG00000158156 0.55502378
ENSG00000158161 0.56663036
ENSG00000126698 0.46537382
ENSG00000130770 0.39637075
ENSG00000130766 0.56158984
ENSG00000130772 0.51638721
ENSG00000204138 0.45173351
ENSG00000180198 0.55555004
ENSG00000242125 0.55335614
ENSG00000180098 0.53199742
ENSG00000197989 0.55330164
ENSG00000120656 0.47303250
ENSG00000162419 0.36353622
ENSG00000198492 0.40899294
ENSG00000159023 0.41465947
ENSG00000253304 0.50411144
ENSG00000116350 0.45064910
ENSG00000116353 0.48439283
ENSG00000060656 0.46079500
ENSG00000162512 0.51662593
ENSG00000134644 0.14932735
ENSG00000060688 0.41298116
ENSG00000121766 0.50925148
ENSG00000121769 0.54535226
ENSG00000168528 0.50614160
ENSG00000162517 0.56737718
ENSG00000084636 0.50992499
ENSG00000121753 0.55666448
ENSG00000134668 0.49987938
ENSG00000184007 0.55701231
ENSG00000121774 0.56927132
ENSG00000121775 0.52624577
ENSG00000025800 0.56151151
ENSG00000084652 0.49199111
ENSG00000160050 0.44021990
ENSG00000160055 0.44914261
ENSG00000084623 0.55707909
ENSG00000220785 0.49874211
ENSG00000116478 0.22370405
ENSG00000175130 0.44433413
ENSG00000160058 0.42422088
ENSG00000160062 0.54029140
ENSG00000176261 0.40970820
ENSG00000162521 0.54650583
ENSG00000162520 0.52790690
ENSG00000162522 0.42180404
ENSG00000134684 0.41042160
ENSG00000116497 0.34321109
ENSG00000160097 0.49345513
ENSG00000116514 0.50550525
ENSG00000004455 0.55910830
ENSG00000142920 0.46454807
ENSG00000116525 0.54652002
ENSG00000160094 0.54202009
ENSG00000134686 0.41094425
ENSG00000121903 0.48811382
ENSG00000121904 0.53497569
ENSG00000163866 0.41985919
ENSG00000163867 0.35707325
ENSG00000197056 0.36178528
ENSG00000116560 0.41678342
ENSG00000146463 0.38589261
ENSG00000142687 0.51346199
ENSG00000020129 0.32870810
ENSG00000126067 0.42704037
ENSG00000142686 0.51115859
ENSG00000134698 0.47097317
ENSG00000092847 0.51546367
ENSG00000126070 0.25844089
ENSG00000116863 0.45059462
ENSG00000171812 0.55797036
ENSG00000054116 0.53576366
ENSG00000116871 0.45102994
ENSG00000054118 0.48121221
ENSG00000142694 0.52651855
ENSG00000196182 0.47512577
ENSG00000181817 0.56538518
ENSG00000116898 0.40337020
ENSG00000163874 0.42225113
ENSG00000163875 0.37855601
ENSG00000163877 0.54886188
ENSG00000134697 0.20331119
ENSG00000116922 0.34857463
ENSG00000196449 0.52566633
ENSG00000197982 0.50379852
ENSG00000188786 0.32055574
ENSG00000204084 0.48260004
ENSG00000183431 0.54749675
ENSG00000183386 0.55341061
ENSG00000183520 0.51717002
ENSG00000116954 0.42927802
ENSG00000214114 0.48104016
ENSG00000174574 0.50617789
ENSG00000168653 0.25864185
ENSG00000127603 0.45818065
ENSG00000090621 0.52706236
ENSG00000163909 0.49063525
ENSG00000084072 0.34650767
ENSG00000043514 0.53293903
ENSG00000168389 0.51038422
ENSG00000131236 0.39953669
ENSG00000131238 0.52433886
ENSG00000117000 0.53816960
ENSG00000084073 0.54654841
ENSG00000084070 0.53943397
ENSG00000066136 0.27005218
ENSG00000171793 0.44530613
ENSG00000010803 0.47775963
ENSG00000127124 0.44559075
ENSG00000198815 0.50198338
ENSG00000127125 0.32927059
ENSG00000171960 0.55256414
ENSG00000065978 0.49799865
ENSG00000117385 0.46496173
ENSG00000164010 0.31181708
ENSG00000164011 0.42834403
ENSG00000117394 0.48336228
ENSG00000117395 0.55496972
ENSG00000066322 0.53002092
ENSG00000159479 0.23290848
ENSG00000198198 0.50488370
ENSG00000142949 0.28179497
ENSG00000066135 0.13333187
ENSG00000117408 0.24800832
ENSG00000132768 0.52958177
ENSG00000117410 0.49959515
ENSG00000117411 0.55391352
ENSG00000196517 0.52800222
ENSG00000178028 0.42324100
ENSG00000117419 0.56371770
ENSG00000187147 0.50231817
ENSG00000126106 0.49475011
ENSG00000142937 0.45751294
ENSG00000173846 0.54410475
ENSG00000222009 0.52860441
ENSG00000070785 0.56530618
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ENSG00000105053 0.42472443
ENSG00000142528 0.51737360
ENSG00000131408 0.54424860
ENSG00000062822 0.53654902
ENSG00000161671 0.46089543
ENSG00000161677 0.48378386
ENSG00000167747 0.54972983
ENSG00000142544 0.54538083
ENSG00000105379 0.48213203
ENSG00000105497 0.47099626
ENSG00000182310 0.54965996
ENSG00000198093 0.47009355
ENSG00000176024 0.44952739
ENSG00000256683 0.54333983
ENSG00000197619 0.40648157
ENSG00000142556 0.43703919
ENSG00000256087 0.46894847
ENSG00000197608 0.32455100
ENSG00000204611 0.52391672
ENSG00000105568 0.38455759
ENSG00000196214 0.41363964
ENSG00000198464 0.51952358
ENSG00000167554 0.50747894
ENSG00000221923 0.49593726
ENSG00000167555 0.52555343
ENSG00000167766 0.41257681
ENSG00000213020 0.52887310
ENSG00000189190 0.51219190
ENSG00000198538 0.39002453
ENSG00000204604 0.53931537
ENSG00000213793 0.45876883
ENSG00000180257 0.42746552
ENSG00000242779 0.47537134
ENSG00000170949 0.49993618
 [ reached 'max' / getOption("max.print") -- omitted 448 rows ]

[[8]]
                        logFC      AveExpr             t     P.Value
ENSG00000225972  6.176263e-02  3.439734306  2.460221e-01 0.808784223
ENSG00000225630  1.872325e-01  5.259763521  1.759984e+00 0.097455791
ENSG00000237973  5.495285e-02  5.765427761  4.462037e-01 0.661412205
ENSG00000248527  2.219403e-01  7.291375670  1.934800e+00 0.070843374
ENSG00000198744  1.230114e-01  1.692163426  5.731332e-01 0.574498809
ENSG00000228794 -1.870802e-01  2.429990051 -1.329676e+00 0.202218143
ENSG00000223764  1.625400e-01  1.604113326  9.207808e-01 0.370800793
ENSG00000187634  1.887467e-01  2.774428967  1.471774e+00 0.160421536
ENSG00000188976  8.381312e-03  5.602324306  1.211967e-01 0.905039846
ENSG00000187961 -7.831098e-02  3.205023751 -6.338478e-01 0.535111410
ENSG00000187608 -2.904265e-01  3.515541854 -2.106990e+00 0.051202556
ENSG00000188157  7.494317e-02  8.438003633  7.163728e-01 0.484057157
ENSG00000131591  8.687687e-02  2.698849622  7.362383e-01 0.472211894
ENSG00000078808  2.877867e-02  8.404430472  4.099929e-01 0.687232519
ENSG00000176022  2.915388e-02  5.315643527  3.131972e-01 0.758164807
ENSG00000160087  3.440625e-02  5.574117382  5.931475e-01 0.561349870
ENSG00000131584  9.982131e-02  5.338644789  1.270116e+00 0.222151524
ENSG00000169972  4.576278e-02  3.649507997  5.415361e-01 0.595577525
ENSG00000127054  6.530279e-02  5.813712471  1.219928e+00 0.240118147
ENSG00000224051  1.070971e-01  4.433660580  1.255486e+00 0.227276990
ENSG00000107404 -5.319495e-04  5.541314411 -5.516923e-03 0.995666158
ENSG00000162576  4.302085e-02  5.643016003  4.104292e-01 0.686918938
ENSG00000175756  1.819987e-03  5.949578662  3.497059e-02 0.972534501
ENSG00000221978 -2.486562e-03  6.117640537 -2.055987e-02 0.983850231
ENSG00000224870  1.271493e-01  4.193043833  1.471516e+00 0.160490473
ENSG00000242485  8.835333e-02  5.474356677  1.456441e+00 0.164558372
ENSG00000160072 -6.491056e-02  4.020742816 -8.267821e-01 0.420484903
ENSG00000197785 -7.570493e-03  4.667370310 -8.825738e-02 0.930764152
ENSG00000160075 -3.282892e-02  6.698987873 -6.370295e-01 0.533089103
ENSG00000228594 -6.518548e-02  3.231082811 -5.384188e-01 0.597677908
ENSG00000197530  7.546450e-02  6.011139637  7.189284e-01 0.482523485
ENSG00000189409 -3.332827e-02  4.590321361 -3.035718e-01 0.765354682
ENSG00000248333  1.486426e-01  3.904469734  1.628646e+00 0.122858780
ENSG00000189339  6.419810e-02  5.329578573  1.103204e+00 0.286208516
ENSG00000008130 -2.761397e-04  5.472226379 -5.013078e-03 0.996061952
ENSG00000078369  9.286559e-03  8.804321589  2.098025e-01 0.836462300
ENSG00000162585  3.112726e-02  4.754428869  3.112766e-01 0.759597670
ENSG00000157933  7.476877e-02  6.562145698  1.431775e+00 0.171397761
ENSG00000157916  3.647914e-02  7.002652621  7.727153e-01 0.450922984
ENSG00000157911  8.804946e-02  3.826112744  7.994561e-01 0.435700634
ENSG00000157881 -5.312394e-02  4.048444809 -7.324617e-01 0.474450237
ENSG00000157870 -2.983027e-02  3.237377913 -2.582520e-01 0.799495355
ENSG00000158109  9.136394e-02  6.732297019  1.826454e+00 0.086443939
ENSG00000116213  1.171513e-01  4.048572327  1.681432e+00 0.112034634
ENSG00000227372 -3.824039e-02  3.931432132 -5.133947e-01 0.614671000
ENSG00000130764 -4.415521e-02  5.498222486 -6.757553e-01 0.508818126
ENSG00000116198 -4.474903e-02  4.799410870 -6.235362e-01 0.541694477
ENSG00000198912 -8.665235e-03  4.517142545 -1.232367e-01 0.903449983
ENSG00000131697  1.226924e-02  3.217207294  1.391234e-01 0.891083696
ENSG00000116251 -4.650169e-02  6.491595851 -7.070120e-01 0.489699462
ENSG00000116237 -4.503863e-03  7.144503644 -8.961698e-02 0.929700583
ENSG00000158292  8.940109e-02  2.850382649  7.298634e-01 0.475993900
ENSG00000097021 -1.007043e-01  4.963811963 -6.432177e-01 0.529168008
ENSG00000215788  7.744185e-02  2.224832337  3.826409e-01 0.707006745
ENSG00000171680  1.560785e-02  4.816276482  1.145879e-01 0.910193284
ENSG00000162408 -8.636697e-02  3.954485497 -8.833900e-01 0.390068410
ENSG00000204859  1.021136e-01  3.319571732  9.515179e-01 0.355454340
ENSG00000162413  5.962137e-02  6.835844141  1.042406e+00 0.312673940
ENSG00000116273 -3.728919e-03  5.018894856 -4.566340e-02 0.964141969
ENSG00000041988  9.028269e-02  3.387269004  9.599860e-01 0.351304564
ENSG00000007923  1.782601e-01  5.116929638  2.525817e+00 0.022438854
ENSG00000171735 -9.870396e-03  3.971476593 -7.831901e-02 0.938542583
ENSG00000049245 -3.980983e-02  6.747961733 -8.310134e-01 0.418159749
ENSG00000116288  1.485032e-02  7.469041111  2.832662e-01 0.780594501
ENSG00000116285  2.925353e-02  6.567378923  1.594182e-01 0.875328671
ENSG00000142599  1.686544e-01  6.882232369  1.923526e+00 0.072340171
ENSG00000074800 -1.022451e-03  9.240103588 -1.644896e-02 0.987079001
ENSG00000142583 -2.629372e-01  2.154021950 -1.273730e+00 0.220899711
ENSG00000180758 -7.150332e-02  2.520571933 -7.041632e-01 0.491424267
ENSG00000228526  3.185412e-01  3.111024724  1.970913e+00 0.066234150
ENSG00000049239  6.416371e-02  5.843277506  6.888154e-01 0.500777902
ENSG00000171621  5.223099e-02  7.640791271  6.130173e-01 0.548455313
ENSG00000171612 -1.181926e-01  2.962339532 -9.599845e-01 0.351305304
ENSG00000188807  4.888653e-03  3.161234025  4.718460e-02 0.962948345
ENSG00000171608  8.419872e-02  3.600417471  6.819705e-01 0.504982627
ENSG00000171603  1.069443e-02  7.507456408  1.643530e-01 0.871505618
ENSG00000178585 -7.107852e-02  4.096458428 -8.602410e-01 0.402325984
ENSG00000162441 -1.946506e-01  4.190251149 -2.689135e+00 0.016096380
ENSG00000173614 -4.137640e-02  3.790237230 -3.794068e-01 0.709359603
ENSG00000130939  2.257704e-02  6.013665524  3.583050e-01 0.724785026
ENSG00000054523 -5.432849e-03  6.790885629 -1.055497e-01 0.917247768
ENSG00000142657 -1.874556e-02  6.764910548 -3.397327e-01 0.738463714
ENSG00000160049 -3.750247e-03  5.436360887 -7.406615e-02 0.941873169
ENSG00000142655  2.382107e-02  3.921860299  3.006484e-01 0.767542864
ENSG00000120948 -2.663069e-02  5.498744258 -4.873603e-01 0.632593795
ENSG00000116649  3.387670e-02  6.989287261  4.136396e-01 0.684613368
ENSG00000171824  1.290262e-02  5.208139078  2.092803e-01 0.836863085
ENSG00000198793  4.952557e-02  6.572268484  7.498850e-01 0.464177030
ENSG00000171819  1.118929e-01  5.005029463  6.411570e-01 0.530471920
ENSG00000120942  8.250813e-02  4.505427589  1.223895e+00 0.238658335
ENSG00000116661  7.467479e-02  2.256655281  4.859740e-01 0.633554971
ENSG00000132879  7.225417e-02  2.851964046  7.613666e-01 0.457481888
ENSG00000116670 -1.178442e-01  3.776766362 -1.337515e+00 0.199704091
ENSG00000177674 -8.153765e-02  4.748151475 -1.156802e+00 0.264284285
ENSG00000177000  2.824296e-02  4.306535766  3.616651e-01 0.722320419
ENSG00000011021  7.472178e-02  4.716053644  1.077191e+00 0.297322551
ENSG00000116685  3.665168e-02  5.360029702  5.400711e-01 0.596564165
ENSG00000083444  3.603733e-03  9.617689757  4.989981e-02 0.960818057
ENSG00000116688  1.059868e-02  6.632063082  1.960183e-01 0.847056610
ENSG00000116691  7.838304e-02  3.486834952  1.078377e+00 0.296809282
ENSG00000048707  3.985402e-03  5.830304323  6.753264e-02 0.946991962
ENSG00000162496 -1.340868e-01  3.119770104 -9.806646e-01 0.341312806
ENSG00000162494 -3.205483e-02  1.522400198 -1.977083e-01 0.845756019
ENSG00000162493  5.447066e-02  9.669928769  7.658889e-01 0.454861252
ENSG00000116731  2.245938e-03  5.589398806  4.290529e-02 0.966306367
ENSG00000189337  2.521642e-01  3.000052029  1.862293e+00 0.080975079
ENSG00000171729  7.701102e-02  3.118331547  3.997281e-01 0.694626970
ENSG00000142634  8.482242e-02  4.068304279  6.997327e-01 0.494113831
ENSG00000132906  1.306717e-01  3.641839894  1.567142e+00 0.136586989
ENSG00000116138 -3.144961e-02  5.209789620 -4.904705e-01 0.630439823
ENSG00000197312  2.176824e-02  5.118656021  2.735176e-01 0.787944448
ENSG00000116786  7.964753e-02  6.306994840  1.712770e+00 0.106006014
ENSG00000162458  3.183951e-02  7.121657904  3.339116e-01 0.742770046
ENSG00000065526  7.070465e-02  5.499653620  1.327226e+00 0.203008950
ENSG00000116809 -3.513022e-02  4.245851773 -3.684963e-01 0.717319430
ENSG00000173641 -1.973187e-02  5.013884293 -1.324019e-01 0.896312402
ENSG00000142627  5.467213e-02  6.565606623  5.282723e-01 0.604539899
ENSG00000142632 -9.239383e-03  2.972003499 -7.023543e-02 0.944874113
ENSG00000037637  3.709594e-02  4.745003107  5.770910e-01 0.571885998
ENSG00000055070 -9.075619e-03  6.825257519 -1.691019e-01 0.867829690
ENSG00000157191 -1.666133e-02  6.110674810 -3.710203e-01 0.715474961
ENSG00000219481 -6.382972e-02  4.648960829 -8.607064e-01 0.402077088
ENSG00000215908 -3.271323e-02  3.665056004 -3.840780e-01 0.705962223
ENSG00000058453  6.300997e-02  4.313812210  5.511823e-01 0.589101519
ENSG00000117122  2.899479e-02  6.989385574  4.416354e-01 0.664646349
ENSG00000159363  1.181533e-01  6.019552468  1.371684e+00 0.189036929
ENSG00000117118  5.506892e-02  6.167713801  1.018152e+00 0.323711248
ENSG00000179051 -5.554788e-02  6.193488468 -8.773092e-01 0.393263952
ENSG00000074964  1.739129e-01  3.574390645  2.354332e+00 0.031621865
ENSG00000159423 -5.864000e-02  2.894230519 -4.661184e-01 0.647395278
ENSG00000169991 -1.491482e-01  4.732484074 -1.707677e+00 0.106966264
ENSG00000127481  8.141085e-02  9.073849311  1.078826e+00 0.296615112
ENSG00000127463  2.383229e-02  6.630439259  4.145766e-01 0.683941042
ENSG00000053372 -3.941211e-02  4.612180635 -5.372909e-01 0.598438787
ENSG00000053371 -9.111854e-02  5.024884155 -1.358845e+00 0.192990056
ENSG00000040487  3.509632e-02  4.555068328  3.688759e-01 0.717041857
ENSG00000077549 -1.984935e-03  7.815775016 -4.590870e-02 0.963949486
ENSG00000173436  7.998522e-02  3.042210288  6.936642e-01 0.497811718
ENSG00000158747 -1.546368e-02  6.183331667 -1.799608e-01 0.859436208
ENSG00000169914 -1.190611e-04  4.817885052 -9.655102e-04 0.999241535
ENSG00000188257 -1.015748e+00  2.000223706 -3.479092e+00 0.003085827
ENSG00000127472 -7.164670e-02  3.088517748 -5.894792e-01 0.563747875
ENSG00000162545 -4.754974e-02  4.827178273 -3.856234e-01 0.704839677
ENSG00000090432  7.699435e-02  5.675075630  1.293519e+00 0.214142052
ENSG00000158828  1.024357e-01  4.494932010  1.078652e+00 0.296690226
ENSG00000117242  1.580630e-01  2.631331799  1.369062e+00 0.189838932
ENSG00000244038  2.975871e-02  8.697751526  5.008726e-01 0.623261047
ENSG00000117245 -9.319224e-02  2.607635834 -5.419876e-01 0.595273628
ENSG00000189410 -2.063920e-01  2.810261770 -1.368601e+00 0.189980205
ENSG00000127483  1.437145e-02  7.082879913  2.592305e-01 0.798753504
ENSG00000075151  3.546962e-02  7.195981909  7.158994e-01 0.484341578
ENSG00000117298  9.525144e-02  7.753644680  1.605967e+00 0.127777448
ENSG00000142794  3.539304e-02  3.437321097  4.938970e-01 0.628070852
ENSG00000162551 -3.566063e-02  2.911729077 -2.591819e-01 0.798790389
ENSG00000090686 -5.071255e-02  6.011313564 -1.030635e+00 0.317996636
ENSG00000142798  3.902513e-02  9.621243365  3.232414e-01 0.750686445
ENSG00000070831 -5.848052e-03  7.015276370 -9.407600e-02 0.926213424
ENSG00000162552 -5.043302e-02  4.263306989 -1.935934e-01 0.848923532
ENSG00000184677 -9.993110e-03  4.911668448 -1.134131e-01 0.911109788
ENSG00000133216 -2.739220e-01  2.966685326 -1.754381e+00 0.098437959
ENSG00000004487  8.531261e-02  6.294359862  1.765353e+00 0.096522778
ENSG00000169641 -3.163436e-02  7.231379749 -5.791569e-01 0.570524612
ENSG00000179546 -1.336316e-01  2.315193798 -7.279231e-01 0.477148627
ENSG00000125944 -2.254414e-02  6.529112938 -4.368638e-01 0.668031655
ENSG00000125945 -2.596950e-02  3.921018354 -3.205582e-01 0.752681728
ENSG00000088280  1.261390e-02  3.296382364  1.336536e-01 0.895338273
ENSG00000117318 -6.497915e-02  5.930665385 -8.343879e-01 0.416311343
ENSG00000142676  8.349368e-02  8.453924701  1.542515e+00 0.142436898
ENSG00000011007 -6.701129e-02  6.399420217 -1.426726e+00 0.172825977
ENSG00000057757 -8.804400e-02  5.202976618 -1.590622e+00 0.131199920
ENSG00000011009 -2.294262e-02  4.923404734 -2.560998e-01 0.801127838
ENSG00000117308 -5.203826e-02  4.189851175 -6.628460e-01 0.516837865
ENSG00000117305 -7.695825e-02  4.884518302 -1.055495e+00 0.306831677
ENSG00000179163 -5.924203e-02  3.811079574 -6.212388e-01 0.543167205
ENSG00000189266 -1.752985e-02  4.351714351 -2.074795e-01 0.838245498
ENSG00000188529 -3.542616e-02  6.171229833 -4.586984e-01 0.652602201
ENSG00000001460 -6.189175e-02  2.291994164 -4.891114e-01 0.631380687
ENSG00000001461  1.045175e-02  6.677853599  1.519106e-01 0.881150903
ENSG00000117602  9.394632e-02  3.219033653  8.131957e-01 0.428006994
ENSG00000133226 -1.307819e-01  5.491583196 -2.208539e+00 0.042096430
ENSG00000169504 -2.894523e-02  9.454272243 -4.240509e-01 0.677158610
ENSG00000117614 -7.799517e-02  5.024299045 -1.343528e+00 0.197792544
ENSG00000117616 -1.490048e-01  4.588311643 -8.014723e-01 0.434566220
ENSG00000183726 -1.810232e-02  6.850214952 -3.487993e-01 0.731774402
ENSG00000204178  1.061011e-02  5.958824602  2.083255e-01 0.837595955
ENSG00000157978  4.848087e-02  6.068638613  5.574513e-01 0.584912002
ENSG00000117643  3.465349e-01  1.415338761  2.032798e+00 0.058961130
ENSG00000162430  6.606033e-02  5.957692750  7.471791e-01 0.465763563
ENSG00000117640  9.579516e-02  5.016308406  1.456146e+00 0.164638722
ENSG00000182749 -9.024843e-03  4.295597117 -1.422820e-01 0.888628346
ENSG00000117632 -1.508016e-01  5.651559854 -1.448236e+00 0.166808118
ENSG00000158006 -1.238231e-01  4.206717021 -1.613471e+00 0.126131654
ENSG00000158008 -1.292609e-01  4.859412186 -7.127231e-01 0.486252475
ENSG00000158022 -1.387909e-01  0.546043864 -5.704618e-01 0.576265869
ENSG00000130695  3.645126e-02  3.176271933  2.656096e-01 0.793922003
ENSG00000142669 -9.577565e-03  7.176776149 -8.361825e-02 0.934394192
ENSG00000158062 -7.476734e-02  2.455506246 -6.664251e-01 0.514607175
ENSG00000117682  3.673523e-02  6.112583345  5.280974e-01 0.604658540
ENSG00000198830  2.386691e-02  4.420262183  2.701871e-01 0.790460330
ENSG00000117713  3.389180e-03  6.324294109  5.318764e-02 0.958238917
ENSG00000060642  1.491551e-01  3.737334743  1.595927e+00 0.130007851
ENSG00000204160 -1.171676e-03  5.247200030 -1.970736e-02 0.984519785
ENSG00000142751  3.032838e-02  4.851611935  4.708404e-01 0.644091409
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ENSG00000105379 -5.705691e-02  3.407808788 -4.984034e-01 0.624961591
ENSG00000105497 -1.214110e-02  3.196139230 -1.424049e-01 0.888532824
ENSG00000182310  2.313231e-02  2.485832085  2.041609e-01 0.840794543
ENSG00000198093  1.398718e-01  2.053797321  9.871583e-01 0.338216577
ENSG00000176024 -1.111898e-01  2.592669391 -1.084779e+00 0.294048289
ENSG00000256683 -6.273315e-02  2.455207926 -5.195982e-01 0.610436635
ENSG00000197619 -2.298483e-01  2.482955439 -1.336106e+00 0.200153990
ENSG00000142556  6.786424e-02  3.382865635  6.848629e-01 0.503203353
ENSG00000256087 -1.596735e-01  4.021520586 -1.409120e+00 0.177882929
ENSG00000197608 -4.053469e-02  4.006239358 -4.194408e-01 0.680455341
ENSG00000204611 -2.783246e-02  3.850670783 -3.195359e-01 0.753442409
ENSG00000105568  1.005735e-02  7.439852649  1.502948e-01 0.882404967
ENSG00000196214  3.913874e-02  3.198031676  4.447906e-01 0.662411926
ENSG00000198464  1.415984e-01  3.424444091  1.522576e+00 0.147326319
ENSG00000167554  1.141215e-01  2.135684048  8.528381e-01 0.406298786
ENSG00000221923  2.812207e-02  2.348356875  1.950161e-01 0.847828086
ENSG00000167555 -2.686262e-02  2.377642494 -1.795900e-01 0.859722547
ENSG00000167766  2.701092e-02  3.897495780  3.015553e-01 0.766863776
ENSG00000213020 -2.353378e-02  2.480214607 -2.142747e-01 0.833031948
ENSG00000189190 -2.969432e-01  1.940346670 -1.888472e+00 0.077176927
ENSG00000198538 -5.845894e-02  3.912907898 -5.424518e-01 0.594961245
ENSG00000204604  9.122106e-02  4.547968222  8.194336e-01 0.424542802
ENSG00000213793 -1.863942e-01  3.335171849 -1.752916e+00 0.098696176
ENSG00000180257 -1.795365e-01  3.077122991 -2.112929e+00 0.050623695
ENSG00000242779 -3.323222e-02  4.041796100 -4.625081e-01 0.649926434
ENSG00000170949  4.436089e-02  4.027401106  6.614449e-01 0.517712572
                adj.P.Val         B lfsr lfdr qvalue svalue
ENSG00000225972 0.9998519 -4.909635    1    1      1      1
ENSG00000225630 0.9998519 -4.171629    1    1      1      1
ENSG00000237973 0.9998519 -5.098324    1    1      1      1
ENSG00000248527 0.9998519 -3.983218    1    1      1      1
ENSG00000198744 0.9998519 -4.660391    1    1      1      1
ENSG00000228794 0.9998519 -4.511513    1    1      1      1
ENSG00000223764 0.9998519 -4.643289    1    1      1      1
ENSG00000187634 0.9998519 -4.431887    1    1      1      1
ENSG00000188976 0.9998519 -5.198365    1    1      1      1
ENSG00000187961 0.9998519 -4.796490    1    1      1      1
ENSG00000187608 0.9998519 -4.002297    1    1      1      1
ENSG00000188157 0.9998519 -5.042677    1    1      1      1
ENSG00000131591 0.9998519 -4.730064    1    1      1      1
ENSG00000078808 0.9998519 -5.170130    1    1      1      1
ENSG00000176022 0.9998519 -5.148635    1    1      1      1
ENSG00000160087 0.9998519 -5.076239    1    1      1      1
ENSG00000131584 0.9998519 -4.628740    1    1      1      1
ENSG00000169972 0.9998519 -4.883326    1    1      1      1
ENSG00000127054 0.9998519 -4.690739    1    1      1      1
ENSG00000224051 0.9998519 -4.588148    1    1      1      1
ENSG00000107404 0.9998519 -5.195665    1    1      1      1
ENSG00000162576 0.9998519 -5.152089    1    1      1      1
ENSG00000175756 0.9998519 -5.228183    1    1      1      1
ENSG00000221978 0.9998519 -5.249706    1    1      1      1
ENSG00000224870 0.9998519 -4.421778    1    1      1      1
ENSG00000242485 0.9998519 -4.471485    1    1      1      1
ENSG00000160072 0.9998519 -4.813539    1    1      1      1
ENSG00000197785 0.9998519 -5.093674    1    1      1      1
ENSG00000160075 0.9998519 -5.103973    1    1      1      1
ENSG00000228594 0.9998519 -4.845830    1    1      1      1
ENSG00000197530 0.9998519 -5.047156    1    1      1      1
ENSG00000189409 0.9998519 -5.071853    1    1      1      1
ENSG00000248333 0.9998519 -4.300603    1    1      1      1
ENSG00000189339 0.9998519 -4.762896    1    1      1      1
ENSG00000008130 0.9998519 -5.197946    1    1      1      1
ENSG00000078369 0.9998519 -5.204507    1    1      1      1
ENSG00000162585 0.9998519 -5.070013    1    1      1      1
ENSG00000157933 0.9998519 -4.518389    1    1      1      1
ENSG00000157916 0.9998519 -5.034434    1    1      1      1
ENSG00000157911 0.9998519 -4.809225    1    1      1      1
ENSG00000157881 0.9998519 -4.856732    1    1      1      1
ENSG00000157870 0.9998519 -4.886505    1    1      1      1
ENSG00000158109 0.9998519 -4.106564    1    1      1      1
ENSG00000116213 0.9998519 -4.256262    1    1      1      1
ENSG00000227372 0.9998519 -4.935183    1    1      1      1
ENSG00000130764 0.9998519 -5.028791    1    1      1      1
ENSG00000116198 0.9998519 -4.983974    1    1      1      1
ENSG00000198912 0.9998519 -5.081007    1    1      1      1
ENSG00000131697 0.9998519 -4.903745    1    1      1      1
ENSG00000116251 0.9998519 -5.067163    1    1      1      1
ENSG00000116237 0.9998519 -5.259341    1    1      1      1
ENSG00000158292 0.9998519 -4.738763    1    1      1      1
ENSG00000097021 0.9998519 -4.973632    1    1      1      1
ENSG00000215788 0.9998519 -4.765982    1    1      1      1
ENSG00000171680 0.9998519 -5.126277    1    1      1      1
ENSG00000162408 0.9998519 -4.783479    1    1      1      1
ENSG00000204859 0.9998519 -4.695079    1    1      1      1
ENSG00000162413 0.9998519 -4.854090    1    1      1      1
ENSG00000116273 0.9998519 -5.141424    1    1      1      1
ENSG00000041988 0.9998519 -4.694566    1    1      1      1
ENSG00000007923 0.9998519 -3.332090    1    1      1      1
ENSG00000171735 0.9998519 -4.998909    1    1      1      1
ENSG00000049245 0.9998519 -4.997140    1    1      1      1
ENSG00000116288 0.9998519 -5.228697    1    1      1      1
ENSG00000116285 0.9998519 -5.225366    1    1      1      1
ENSG00000142599 0.9998519 -3.996220    1    1      1      1
ENSG00000074800 0.9998519 -5.205277    1    1      1      1
ENSG00000142583 0.9998519 -4.535331    1    1      1      1
ENSG00000180758 0.9998519 -4.721859    1    1      1      1
ENSG00000228526 0.9998519 -4.093088    1    1      1      1
ENSG00000049239 0.9998519 -5.058378    1    1      1      1
ENSG00000171621 0.9998519 -5.105582    1    1      1      1
ENSG00000171612 0.9998519 -4.672340    1    1      1      1
ENSG00000188807 0.9998519 -4.898803    1    1      1      1
ENSG00000171608 0.9998519 -4.816841    1    1      1      1
ENSG00000171603 0.9998519 -5.247625    1    1      1      1
ENSG00000178585 0.9998519 -4.800566    1    1      1      1
ENSG00000162441 0.9998519 -3.330768    1    1      1      1
ENSG00000173614 0.9998519 -4.935707    1    1      1      1
ENSG00000130939 0.9998519 -5.192278    1    1      1      1
ENSG00000054523 0.9998519 -5.257462    1    1      1      1
ENSG00000142657 0.9998519 -5.214245    1    1      1      1
ENSG00000160049 0.9998519 -5.192228    1    1      1      1
ENSG00000142655 0.9998519 -4.972468    1    1      1      1
ENSG00000120948 0.9998519 -5.113684    1    1      1      1
ENSG00000116649 0.9998519 -5.195862    1    1      1      1
ENSG00000171824 0.9998519 -5.157541    1    1      1      1
ENSG00000198793 0.9998519 -5.045543    1    1      1      1
ENSG00000171819 0.9998519 -5.036019    1    1      1      1
ENSG00000120942 0.9998519 -4.618787    1    1      1      1
ENSG00000116661 0.9998519 -4.773355    1    1      1      1
ENSG00000132879 0.9998519 -4.742945    1    1      1      1
ENSG00000116670 0.9998519 -4.506457    1    1      1      1
ENSG00000177674 0.9998519 -4.673781    1    1      1      1
ENSG00000177000 0.9998519 -5.022591    1    1      1      1
ENSG00000011021 0.9998519 -4.744434    1    1      1      1
ENSG00000116685 0.9998519 -5.080353    1    1      1      1
ENSG00000083444 0.9998519 -5.182388    1    1      1      1
ENSG00000116688 0.9998519 -5.245393    1    1      1      1
ENSG00000116691 0.9998519 -4.643700    1    1      1      1
ENSG00000048707 0.9998519 -5.230849    1    1      1      1
ENSG00000162496 0.9998519 -4.672928    1    1      1      1
ENSG00000162494 0.9998519 -4.767268    1    1      1      1
ENSG00000162493 0.9998519 -4.962204    1    1      1      1
ENSG00000116731 0.9998519 -5.214009    1    1      1      1
ENSG00000189337 0.9998519 -4.204716    1    1      1      1
ENSG00000171729 0.9998519 -4.824846    1    1      1      1
ENSG00000142634 0.9998519 -4.872785    1    1      1      1
ENSG00000132906 0.9998519 -4.351674    1    1      1      1
ENSG00000116138 0.9998519 -5.091308    1    1      1      1
ENSG00000197312 0.9998519 -5.130867    1    1      1      1
ENSG00000116786 0.9998519 -4.229826    1    1      1      1
ENSG00000162458 0.9998519 -5.215651    1    1      1      1
ENSG00000065526 0.9998519 -4.587435    1    1      1      1
ENSG00000116809 0.9998519 -4.991662    1    1      1      1
ENSG00000173641 0.9998519 -5.145312    1    1      1      1
ENSG00000142627 0.9998519 -5.142438    1    1      1      1
ENSG00000142632 0.9998519 -4.886161    1    1      1      1
ENSG00000037637 0.9998519 -5.008523    1    1      1      1
ENSG00000055070 0.9998519 -5.249759    1    1      1      1
ENSG00000157191 0.9998519 -5.189166    1    1      1      1
ENSG00000219481 0.9998519 -4.855551    1    1      1      1
ENSG00000215908 0.9998519 -4.927446    1    1      1      1
ENSG00000058453 0.9998519 -4.960708    1    1      1      1
ENSG00000117122 0.9998519 -5.185359    1    1      1      1
ENSG00000159363 0.9998519 -4.564681    1    1      1      1
ENSG00000117118 0.9998519 -4.860847    1    1      1      1
ENSG00000179051 0.9998519 -4.960145    1    1      1      1
ENSG00000074964 0.9998519 -3.737965    1    1      1      1
ENSG00000159423 0.9998519 -4.822624    1    1      1      1
ENSG00000169991 0.9998519 -4.222870    1    1      1      1
ENSG00000127481 0.9998519 -4.785047    1    1      1      1
ENSG00000127463 0.9998519 -5.193421    1    1      1      1
ENSG00000053372 0.9998519 -4.987426    1    1      1      1
ENSG00000053371 0.9998519 -4.541223    1    1      1      1
ENSG00000040487 0.9998519 -5.048971    1    1      1      1
ENSG00000077549 0.9998519 -5.252841    1    1      1      1
ENSG00000173436 0.9998519 -4.773366    1    1      1      1
ENSG00000158747 0.9998519 -5.237624    1    1      1      1
ENSG00000169914 0.9998519 -5.101077    1    1      1      1
ENSG00000188257 0.9998519 -3.683331    1    1      1      1
ENSG00000127472 0.9998519 -4.815946    1    1      1      1
ENSG00000162545 0.9998519 -5.071917    1    1      1      1
ENSG00000090432 0.9998519 -4.625093    1    1      1      1
ENSG00000158828 0.9998519 -4.714950    1    1      1      1
ENSG00000117242 0.9998519 -4.492768    1    1      1      1
ENSG00000244038 0.9998519 -5.129763    1    1      1      1
ENSG00000117245 0.9998519 -4.745515    1    1      1      1
ENSG00000189410 0.9998519 -4.492357    1    1      1      1
ENSG00000127483 0.9998519 -5.236547    1    1      1      1
ENSG00000075151 0.9998519 -5.066128    1    1      1      1
ENSG00000117298 0.9998519 -4.343584    1    1      1      1
ENSG00000142794 0.9998519 -4.876361    1    1      1      1
ENSG00000162551 0.9998519 -4.816587    1    1      1      1
ENSG00000090686 0.9998519 -4.849149    1    1      1      1
ENSG00000142798 0.9998519 -5.141672    1    1      1      1
ENSG00000070831 0.9998519 -5.258913    1    1      1      1
ENSG00000162552 0.9998519 -5.046798    1    1      1      1
ENSG00000184677 0.9998519 -5.134123    1    1      1      1
ENSG00000133216 0.9998519 -4.287518    1    1      1      1
ENSG00000004487 0.9998519 -4.173318    1    1      1      1
ENSG00000169641 0.9998519 -5.131414    1    1      1      1
ENSG00000179546 0.9998519 -4.681679    1    1      1      1
ENSG00000125944 0.9998519 -5.185284    1    1      1      1
ENSG00000125945 0.9998519 -4.970150    1    1      1      1
ENSG00000088280 0.9998519 -4.935593    1    1      1      1
ENSG00000117318 0.9998519 -4.968512    1    1      1      1
ENSG00000142676 0.9998519 -4.400098    1    1      1      1
ENSG00000011007 0.9998519 -4.520728    1    1      1      1
ENSG00000057757 0.9998519 -4.337443    1    1      1      1
ENSG00000011009 0.9998519 -5.100354    1    1      1      1
ENSG00000117308 0.9998519 -4.879249    1    1      1      1
ENSG00000117305 0.9998519 -4.755914    1    1      1      1
ENSG00000179163 0.9998519 -4.893001    1    1      1      1
ENSG00000189266 0.9998519 -5.048225    1    1      1      1
ENSG00000188529 0.9998519 -5.166838    1    1      1      1
ENSG00000001460 0.9998519 -4.742413    1    1      1      1
ENSG00000001461 0.9998519 -5.251885    1    1      1      1
ENSG00000117602 0.9998519 -4.741332    1    1      1      1
ENSG00000133226 0.9998519 -3.675588    1    1      1      1
ENSG00000169504 0.9998519 -5.127356    1    1      1      1
ENSG00000117614 0.9998519 -4.550770    1    1      1      1
ENSG00000117616 0.9998519 -4.889933    1    1      1      1
ENSG00000183726 0.9998519 -5.214320    1    1      1      1
ENSG00000204178 0.9998519 -5.219389    1    1      1      1
ENSG00000157978 0.9998519 -5.127064    1    1      1      1
ENSG00000117643 0.9998519 -4.314875    1    1      1      1
ENSG00000162430 0.9998519 -5.021086    1    1      1      1
ENSG00000117640 0.9998519 -4.455841    1    1      1      1
ENSG00000182749 0.9998519 -5.038869    1    1      1      1
ENSG00000117632 0.9998519 -4.471225    1    1      1      1
ENSG00000158006 0.9998519 -4.311080    1    1      1      1
ENSG00000158008 0.9998519 -4.868930    1    1      1      1
ENSG00000158022 0.9998519 -4.651713    1    1      1      1
ENSG00000130695 0.9998519 -4.873409    1    1      1      1
ENSG00000142669 0.9998519 -5.257322    1    1      1      1
ENSG00000158062 0.9998519 -4.723983    1    1      1      1
ENSG00000117682 0.9998519 -5.138738    1    1      1      1
ENSG00000198830 0.9998519 -5.054112    1    1      1      1
ENSG00000117713 0.9998519 -5.253256    1    1      1      1
ENSG00000060642 0.9998519 -4.327481    1    1      1      1
ENSG00000204160 0.9998519 -5.171870    1    1      1      1
ENSG00000142751 0.9998519 -5.050444    1    1      1      1
ENSG00000198746 0.9998519 -4.969453    1    1      1      1
ENSG00000090273 0.9998519 -5.209456    1    1      1      1
ENSG00000253368 0.9998519 -4.732099    1    1      1      1
ENSG00000158246 0.9998519 -5.061765    1    1      1      1
ENSG00000090020 0.9998519 -5.123582    1    1      1      1
ENSG00000142784 0.9998519 -4.232526    1    1      1      1
ENSG00000186501 0.9998519 -4.798186    1    1      1      1
ENSG00000142733 0.9998519 -5.166393    1    1      1      1
ENSG00000158195 0.9998519 -4.197277    1    1      1      1
ENSG00000126705 0.9998519 -4.999224    1    1      1      1
ENSG00000126709 0.9998519 -5.034116    1    1      1      1
ENSG00000009780 0.9998519 -4.796893    1    1      1      1
ENSG00000117758 0.9998519 -5.211900    1    1      1      1
ENSG00000117751 0.9998519 -4.310209    1    1      1      1
ENSG00000117748 0.9998519 -5.024765    1    1      1      1
ENSG00000158156 0.9998519 -4.871206    1    1      1      1
ENSG00000158161 0.9998519 -5.078143    1    1      1      1
ENSG00000126698 0.9998519 -5.246360    1    1      1      1
ENSG00000130770 0.9998519 -4.900803    1    1      1      1
ENSG00000130766 0.9998519 -5.198306    1    1      1      1
ENSG00000130772 0.9998519 -4.212217    1    1      1      1
ENSG00000204138 0.9998519 -5.117041    1    1      1      1
ENSG00000180198 0.9998519 -4.919368    1    1      1      1
ENSG00000242125 0.9998519 -4.835282    1    1      1      1
ENSG00000180098 0.9998519 -4.872306    1    1      1      1
ENSG00000197989 0.9998519 -4.792466    1    1      1      1
ENSG00000120656 0.9998519 -5.052084    1    1      1      1
ENSG00000162419 0.9998519 -5.010296    1    1      1      1
ENSG00000198492 0.9998519 -5.195498    1    1      1      1
ENSG00000159023 0.9998519 -5.117721    1    1      1      1
ENSG00000253304 0.9998519 -4.781898    1    1      1      1
ENSG00000116350 0.9998519 -5.185861    1    1      1      1
ENSG00000116353 0.9998519 -4.828309    1    1      1      1
ENSG00000060656 0.9998519 -3.995592    1    1      1      1
ENSG00000162512 0.9998519 -5.183314    1    1      1      1
ENSG00000134644 0.9998519 -3.700091    1    1      1      1
ENSG00000060688 0.9998519 -4.961914    1    1      1      1
ENSG00000121766 0.9998519 -4.815701    1    1      1      1
ENSG00000121769 0.9998519 -4.260925    1    1      1      1
ENSG00000168528 0.9998519 -5.112687    1    1      1      1
ENSG00000162517 0.9998519 -5.224068    1    1      1      1
ENSG00000084636 0.9998519 -4.768405    1    1      1      1
ENSG00000121753 0.9998519 -4.875616    1    1      1      1
ENSG00000134668 0.9998519 -4.824460    1    1      1      1
ENSG00000184007 0.9998519 -4.996692    1    1      1      1
ENSG00000121774 0.9998519 -5.189345    1    1      1      1
ENSG00000121775 0.9998519 -4.810272    1    1      1      1
ENSG00000025800 0.9998519 -5.253332    1    1      1      1
ENSG00000084652 0.9998519 -5.070649    1    1      1      1
ENSG00000160050 0.9998519 -4.688047    1    1      1      1
ENSG00000160055 0.9998519 -4.390790    1    1      1      1
ENSG00000084623 0.9998519 -5.237980    1    1      1      1
ENSG00000220785 0.9998519 -4.738295    1    1      1      1
ENSG00000116478 0.9998519 -4.989891    1    1      1      1
ENSG00000175130 0.9998519 -5.185703    1    1      1      1
ENSG00000160058 0.9998519 -4.962481    1    1      1      1
ENSG00000160062 0.9998519 -4.607277    1    1      1      1
ENSG00000176261 0.9998519 -4.909828    1    1      1      1
ENSG00000162521 0.9998519 -4.992035    1    1      1      1
ENSG00000162520 0.9998519 -5.155837    1    1      1      1
ENSG00000162522 0.9998519 -5.147366    1    1      1      1
ENSG00000134684 0.9998519 -5.226723    1    1      1      1
ENSG00000116497 0.9998519 -5.055319    1    1      1      1
ENSG00000160097 0.9998519 -4.811312    1    1      1      1
ENSG00000116514 0.9998519 -4.258970    1    1      1      1
ENSG00000004455 0.9998519 -5.109487    1    1      1      1
ENSG00000142920 0.9998519 -4.546764    1    1      1      1
ENSG00000116525 0.9998519 -4.651203    1    1      1      1
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ENSG00000256683 0.9998519 -4.751339    1    1      1      1
ENSG00000197619 0.9998519 -4.508172    1    1      1      1
ENSG00000142556 0.9998519 -4.809856    1    1      1      1
ENSG00000256087 0.9998519 -4.463165    1    1      1      1
ENSG00000197608 0.9998519 -4.958877    1    1      1      1
ENSG00000204611 0.9998519 -4.955632    1    1      1      1
ENSG00000105568 0.9998519 -5.251971    1    1      1      1
ENSG00000196214 0.9998519 -4.850862    1    1      1      1
ENSG00000198464 0.9998519 -4.384067    1    1      1      1
ENSG00000167554 0.9998519 -4.656716    1    1      1      1
ENSG00000221923 0.9998519 -4.764467    1    1      1      1
ENSG00000167555 0.9998519 -4.807032    1    1      1      1
ENSG00000167766 0.9998519 -4.982285    1    1      1      1
ENSG00000213020 0.9998519 -4.790860    1    1      1      1
ENSG00000189190 0.9998519 -4.340839    1    1      1      1
ENSG00000198538 0.9998519 -4.906530    1    1      1      1
ENSG00000204604 0.9998519 -4.859904    1    1      1      1
ENSG00000213793 0.9998519 -4.249787    1    1      1      1
ENSG00000180257 0.9998519 -4.044960    1    1      1      1
ENSG00000242779 0.9998519 -4.968664    1    1      1      1
ENSG00000170949 0.9998519 -4.891950    1    1      1      1
 [ reached 'max' / getOption("max.print") -- omitted 448 rows ]

[[9]]
                        logFC      AveExpr             t      P.Value
ENSG00000225972  5.568389e-01  3.439734306  3.628821e+00 0.0022211846
ENSG00000225630  2.480504e-01  5.259763521  2.201611e+00 0.0425328119
ENSG00000237973  2.281614e-01  5.765427761  1.988714e+00 0.0639123203
ENSG00000248527  2.958533e-01  7.291375670  2.510478e+00 0.0230392027
ENSG00000198744 -1.482055e-01  1.692163426 -1.102869e+00 0.2862127809
ENSG00000228794  1.484883e-01  2.429990051  9.566100e-01 0.3528352641
ENSG00000223764 -1.157460e-01  1.604113326 -6.839229e-01 0.5036986990
ENSG00000187634 -2.182665e-01  2.774428967 -1.895058e+00 0.0760900049
ENSG00000188976  3.516307e-02  5.602324306  4.734281e-01 0.6422300727
ENSG00000187961 -1.410553e-01  3.205023751 -1.070978e+00 0.2998899465
ENSG00000187608 -6.400174e-02  3.515541854 -4.213422e-01 0.6790473817
ENSG00000188157 -3.424727e-02  8.438003633 -2.953461e-01 0.7714845954
ENSG00000131591 -1.647638e-01  2.698849622 -1.326857e+00 0.2029717020
ENSG00000078808 -6.063881e-02  8.404430472 -8.021385e-01 0.4340927981
ENSG00000176022 -1.142071e-01  5.315643527 -1.170424e+00 0.2587755274
ENSG00000160087 -3.624387e-03  5.574117382 -5.660695e-02 0.9555512131
ENSG00000131584  5.406808e-03  5.338644789  5.996719e-02 0.9529159556
ENSG00000169972 -5.236603e-03  3.649507997 -5.647879e-02 0.9556517355
ENSG00000127054 -9.376932e-03  5.813712471 -1.532963e-01 0.8800595101
ENSG00000224051 -7.337425e-03  4.433660580 -7.541295e-02 0.9408104020
ENSG00000107404 -2.481812e-02  5.541314411 -2.366281e-01 0.8159139889
ENSG00000162576 -7.992954e-02  5.643016003 -6.984197e-01 0.4948279934
ENSG00000175756 -4.843825e-02  5.949578662 -8.752064e-01 0.3942640639
ENSG00000221978 -1.577052e-02  6.117640537 -1.195789e-01 0.9062883870
ENSG00000224870  1.855495e-03  4.193043833  1.862765e-02 0.9853658400
ENSG00000242485 -7.143208e-03  5.474356677 -1.025219e-01 0.9196018484
ENSG00000160072  8.170936e-02  4.020742816  9.752057e-01 0.3438089767
ENSG00000197785 -8.358559e-02  4.667370310 -9.343505e-01 0.3638540775
ENSG00000160075  2.133402e-02  6.698987873  3.759558e-01 0.7118317885
ENSG00000228594 -9.822173e-02  3.231082811 -7.283393e-01 0.4768121082
ENSG00000197530 -3.183417e-04  6.011139637 -2.739815e-03 0.9978474316
ENSG00000189409  3.124193e-03  4.590321361  2.550967e-02 0.9799603030
ENSG00000248333  1.630755e-01  3.904469734  1.632016e+00 0.1219767313
ENSG00000189339 -7.739241e-03  5.329578573 -1.166620e-01 0.9085632269
ENSG00000008130  4.869830e-02  5.472226379  8.229775e-01 0.4224808531
ENSG00000078369  1.446536e-02  8.804321589  2.978826e-01 0.7695824209
ENSG00000162585  1.140936e-03  4.754428869  1.057160e-02 0.9916944498
ENSG00000157933  1.816034e-02  6.562145698  3.003893e-01 0.7677041320
ENSG00000157916  9.026591e-03  7.002652621  1.713345e-01 0.8660844561
ENSG00000157911 -4.581290e-02  3.826112744 -3.829985e-01 0.7067041572
ENSG00000157881  1.530295e-02  4.048444809  1.916296e-01 0.8504157342
ENSG00000157870 -5.118455e-02  3.237377913 -4.060119e-01 0.6900510134
ENSG00000158109 -7.207735e-04  6.732297019 -1.198293e-02 0.9905856948
ENSG00000116213 -2.535484e-02  4.048572327 -3.090923e-01 0.7611945469
ENSG00000227372  6.714475e-03  3.931432132  7.939243e-02 0.9376937967
ENSG00000130764 -3.682471e-02  5.498222486 -5.171777e-01 0.6120273683
ENSG00000116198  8.515316e-02  4.799410870  1.126112e+00 0.2765387110
ENSG00000198912  4.518149e-02  4.517142545  5.902290e-01 0.5631876466
ENSG00000131697 -2.783416e-02  3.217207294 -2.876654e-01 0.7772534664
ENSG00000116251  2.659463e-02  6.491595851  3.670140e-01 0.7183627662
ENSG00000116237 -3.574337e-02  7.144503644 -6.579222e-01 0.5198365643
ENSG00000158292  9.792014e-02  2.850382649  7.152431e-01 0.4846491296
ENSG00000097021  5.090424e-02  4.963811963  2.989705e-01 0.7687670933
ENSG00000215788  1.973834e-01  2.224832337  9.805489e-01 0.3412454824
ENSG00000171680 -5.509493e-02  4.816276482 -3.869577e-01 0.7038278804
ENSG00000162408 -1.508504e-01  3.954485497 -1.509923e+00 0.1503371061
ENSG00000204859 -4.589097e-02  3.319571732 -3.843844e-01 0.7056968341
ENSG00000162413 -7.071694e-03  6.835844141 -1.096389e-01 0.9140436476
ENSG00000116273 -5.812859e-02  5.018894856 -6.599851e-01 0.5185455794
ENSG00000041988 -7.544867e-02  3.387269004 -7.235512e-01 0.4796685712
ENSG00000007923  1.902495e-02  5.116929638  2.107244e-01 0.8357323505
ENSG00000171735  1.377149e-01  3.971476593  1.036645e+00 0.3151414150
ENSG00000049245 -2.307095e-02  6.747961733 -4.333688e-01 0.6704670432
ENSG00000116288  4.113084e-02  7.469041111  7.274157e-01 0.4773623184
ENSG00000116285  1.695913e-01  6.567378923  8.741894e-01 0.3948013549
ENSG00000142599  2.368721e-01  6.882232369  2.694679e+00 0.0158269822
ENSG00000074800 -3.352141e-02  9.240103588 -4.970536e-01 0.6258350545
ENSG00000142583  7.581281e-02  2.154021950  3.052774e-01 0.7640457251
ENSG00000180758 -1.652714e-01  2.520571933 -1.572361e+00 0.1352084223
ENSG00000228526  1.087564e-01  3.111024724  5.227262e-01 0.6082464936
ENSG00000049239 -4.820168e-03  5.843277506 -4.666559e-02 0.9633506910
ENSG00000171621 -6.902721e-02  7.640791271 -7.578026e-01 0.4594609080
ENSG00000171612 -2.095542e-02  2.962339532 -1.511335e-01 0.8817380091
ENSG00000188807 -9.251968e-02  3.161234025 -8.279085e-01 0.4197626065
ENSG00000171608 -4.427091e-02  3.600417471 -3.433655e-01 0.7357430051
ENSG00000171603 -2.982980e-02  7.507456408 -4.239826e-01 0.6771596503
ENSG00000178585 -6.352589e-02  4.096458428 -7.171558e-01 0.4834998298
ENSG00000162441 -5.896161e-02  4.190251149 -6.252478e-01 0.5405243093
ENSG00000173614  1.092395e-01  3.790237230  9.669785e-01 0.3477823715
ENSG00000130939  4.018071e-02  6.013665524  5.880347e-01 0.5646243542
ENSG00000054523  3.108294e-02  6.790885629  5.581488e-01 0.5843815436
ENSG00000142657 -5.748510e-02  6.764910548 -9.806123e-01 0.3412151583
ENSG00000160049 -4.945019e-02  5.436360887 -9.137223e-01 0.3742736362
ENSG00000142655  6.009315e-03  3.921860299  6.900068e-02 0.9458343471
ENSG00000120948 -2.605766e-02  5.498744258 -4.369525e-01 0.6679193130
ENSG00000116649  8.593340e-02  6.989287261  9.866365e-01 0.3383412448
ENSG00000171824  4.382201e-02  5.208139078  6.544118e-01 0.5220375531
ENSG00000198793  1.767341e-02  6.572268484  2.425291e-01 0.8114166765
ENSG00000171819 -6.944477e-02  5.005029463 -3.662898e-01 0.7188927134
ENSG00000120942 -6.916908e-03  4.505427589 -9.170458e-02 0.9280581612
ENSG00000116661 -1.077987e-01  2.256655281 -6.295782e-01 0.5377567854
ENSG00000132879 -1.558534e-01  2.851964046 -1.545874e+00 0.1414619147
ENSG00000116670 -6.695176e-02  3.776766362 -6.858475e-01 0.5025156990
ENSG00000177674 -5.206426e-02  4.748151475 -6.484037e-01 0.5258167627
ENSG00000177000  1.610744e-02  4.306535766  1.860273e-01 0.8547348132
ENSG00000011021 -2.652164e-02  4.716053644 -3.328879e-01 0.7434917353
ENSG00000116685 -4.095967e-02  5.360029702 -5.577215e-01 0.5846665545
ENSG00000083444 -2.842011e-02  9.617689757 -3.604103e-01 0.7232005656
ENSG00000116688 -1.898548e-02  6.632063082 -3.221649e-01 0.7514514375
ENSG00000116691  1.453889e-02  3.486834952  1.727413e-01 0.8649964112
ENSG00000048707  7.056809e-02  5.830304323  1.132089e+00 0.2740905237
ENSG00000162496 -8.611232e-03  3.119770104 -5.484147e-02 0.9569360018
ENSG00000162494  1.294109e-01  1.522400198  7.094685e-01 0.4881289362
ENSG00000162493  3.681934e-02  9.669928769  4.792256e-01 0.6381886947
ENSG00000116731  6.070609e-02  5.589398806  1.090901e+00 0.2912903569
ENSG00000189337  2.396425e-01  3.000052029  1.483583e+00 0.1571306600
ENSG00000171729 -9.056275e-03  3.118331547 -4.502836e-02 0.9646355692
ENSG00000142634  9.531661e-03  4.068304279  6.907069e-02 0.9457794883
ENSG00000132906 -5.584211e-02  3.641839894 -5.840116e-01 0.5672633349
ENSG00000116138 -7.948625e-03  5.209789620 -1.132177e-01 0.9112503584
ENSG00000197312  2.051345e-02  5.118656021  2.374427e-01 0.8152927358
ENSG00000116786 -1.947760e-02  6.306994840 -3.521078e-01 0.7293000430
ENSG00000162458  5.693073e-02  7.121657904  5.566046e-01 0.5854118933
ENSG00000065526  3.576203e-02  5.499653620  5.907424e-01 0.5628518280
ENSG00000116809 -6.001521e-02  4.245851773 -5.767294e-01 0.5720566506
ENSG00000173641  1.440636e-01  5.013884293  8.763761e-01 0.3936467279
ENSG00000142627 -2.707284e-02  6.565606623 -2.399394e-01 0.8133895294
ENSG00000142632 -1.824483e-01  2.972003499 -1.343931e+00 0.1975075655
ENSG00000037637 -6.040867e-02  4.745003107 -8.667195e-01 0.3987624677
ENSG00000055070  3.830017e-02  6.825257519  6.609064e-01 0.5179696112
ENSG00000157191  4.634952e-02  6.110674810  9.645387e-01 0.3489667975
ENSG00000219481 -9.562639e-02  4.648960829 -1.210145e+00 0.2436004086
ENSG00000215908 -1.482044e-01  3.665056004 -1.710134e+00 0.1063378694
ENSG00000058453 -2.109248e-01  4.313812210 -1.845611e+00 0.0833220235
ENSG00000117122 -1.541653e-02  6.989385574 -2.148182e-01 0.8325922832
ENSG00000159363 -1.214343e-02  6.019552468 -1.234974e-01 0.9032338104
ENSG00000117118 -4.641077e-02  6.167713801 -7.754036e-01 0.4492826171
ENSG00000179051 -1.795170e-02  6.193488468 -2.550537e-01 0.8018941178
ENSG00000074964 -1.578633e-02  3.574390645 -1.648273e-01 0.8711208885
ENSG00000159423 -4.799860e-02  2.894230519 -3.530493e-01 0.7286074179
ENSG00000169991 -1.269431e-02  4.732484074 -1.268157e-01 0.9006483694
ENSG00000127481 -9.144598e-02  9.073849311 -1.127538e+00 0.2759529498
ENSG00000127463  3.804123e-03  6.630439259  6.044559e-02 0.9525408201
ENSG00000053372  4.343522e-02  4.612180635  5.518237e-01 0.5886078008
ENSG00000053371 -1.614463e-01  5.024884155 -2.478069e+00 0.0245958356
ENSG00000040487 -6.002672e-02  4.555068328 -5.765681e-01 0.5721630727
ENSG00000077549 -2.292133e-03  7.815775016 -4.834822e-02 0.9620302929
ENSG00000173436  3.936765e-02  3.042210288  3.056573e-01 0.7637616352
ENSG00000158747 -2.955313e-02  6.183331667 -3.181761e-01 0.7544198041
ENSG00000169914  8.194247e-02  4.817885052  6.257160e-01 0.5402247555
ENSG00000188257  1.970280e-01  2.000223706  4.843700e-01 0.6346124143
ENSG00000127472  1.759508e-01  3.088517748  1.315902e+00 0.2065408821
ENSG00000162545  3.323302e-02  4.827178273  2.503226e-01 0.8054875382
ENSG00000090432  1.955467e-02  5.675075630  2.868594e-01 0.7778596637
ENSG00000158828 -1.176944e-01  4.494932010 -1.146946e+00 0.2680765728
ENSG00000117242  1.126598e-01  2.631331799  9.398703e-01 0.3610999101
ENSG00000244038 -2.887474e-03  8.697751526 -4.410647e-02 0.9653591018
ENSG00000117245  8.055869e-02  2.607635834  4.627725e-01 0.6496882113
ENSG00000189410 -6.884761e-02  2.810261770 -4.286306e-01 0.6738419596
ENSG00000127483  2.562719e-02  7.082879913  4.243349e-01 0.6769079543
ENSG00000075151  1.829151e-02  7.195981909  3.332782e-01 0.7432025610
ENSG00000117298  1.424649e-02  7.753644680  2.046426e-01 0.8404026262
ENSG00000142794  4.876303e-02  3.437321097  6.135843e-01 0.5480169628
ENSG00000162551 -3.588406e-02  2.911729077 -2.852511e-01 0.7790696458
ENSG00000090686 -3.470577e-02  6.011313564 -6.331569e-01 0.5354756230
ENSG00000142798 -4.218359e-02  9.621243365 -3.250262e-01 0.7493246423
ENSG00000070831  7.794344e-02  7.015276370  1.198756e+00 0.2478799304
ENSG00000162552 -7.452306e-03  4.263306989 -2.832539e-02 0.9777489441
ENSG00000184677  8.591087e-02  4.911668448  9.148620e-01 0.3736927354
ENSG00000133216 -1.687950e-02  2.966685326 -9.533308e-02 0.9252205895
ENSG00000004487  7.608503e-02  6.294359862  1.396304e+00 0.1814793987
ENSG00000169641  2.074099e-02  7.231379749  3.456029e-01 0.7340921167
ENSG00000179546  2.692843e-01  2.315193798  1.719752e+00 0.1045379932
ENSG00000125944  1.394245e-02  6.529112938  2.464107e-01 0.8084621303
ENSG00000125945  4.885932e-02  3.921018354  5.620520e-01 0.5817812668
ENSG00000088280  7.756509e-03  3.296382364  7.239975e-02 0.9431709045
ENSG00000117318  1.325401e-02  5.930665385  1.539164e-01 0.8795783859
ENSG00000142676 -7.046566e-03  8.453924701 -1.116461e-01 0.9124768329
ENSG00000011007 -8.291039e-03  6.399420217 -1.523889e-01 0.8807636936
ENSG00000057757 -6.014348e-03  5.202976618 -9.382965e-02 0.9263961846
ENSG00000011009  1.107568e-01  4.923404734  1.192353e+00 0.2503112131
ENSG00000117308  9.270136e-04  4.189851175  1.130367e-02 0.9911193229
ENSG00000117305 -4.929918e-02  4.884518302 -6.094153e-01 0.5507086950
ENSG00000179163 -2.923209e-02  3.811079574 -2.873221e-01 0.7775116340
ENSG00000189266 -1.101519e-01  4.351714351 -1.255568e+00 0.2270965011
ENSG00000188529 -4.191615e-02  6.171229833 -5.013157e-01 0.6228984628
ENSG00000001460  2.106007e-02  2.291994164  1.449409e-01 0.8865470685
ENSG00000001461  4.419754e-03  6.677853599  5.918539e-02 0.9535290338
ENSG00000117602 -2.467725e-03  3.219033653 -1.910091e-02 0.9849940879
ENSG00000133226  3.818249e-02  5.491583196  5.248802e-01 0.6067817642
ENSG00000169504  4.096349e-02  9.454272243  5.555375e-01 0.5861244331
ENSG00000117614 -5.583178e-03  5.024299045 -8.345791e-02 0.9345109250
ENSG00000117616 -2.164614e-01  4.588311643 -1.090017e+00 0.2916681191
ENSG00000183726  2.568268e-02  6.850214952  4.540611e-01 0.6558143113
ENSG00000204178  9.578236e-03  5.958824602  1.727590e-01 0.8649827461
ENSG00000157978  9.726757e-03  6.068638613  1.027083e-01 0.9194562334
ENSG00000117643  1.314826e-01  1.415338761  6.487647e-01 0.5255892848
ENSG00000162430  1.624539e-01  5.957692750  1.819828e+00 0.0873296965
ENSG00000117640  7.258364e-02  5.016308406  9.739609e-01 0.3444081163
ENSG00000182749 -3.741271e-02  4.295597117 -5.619012e-01 0.5818816073
ENSG00000117632  3.004569e-02  5.651559854  2.608748e-01 0.7974791833
ENSG00000158006  3.853395e-02  4.206717021  4.505621e-01 0.6582820807
ENSG00000158008  1.640013e-01  4.859412186  9.920702e-01 0.3357636336
ENSG00000158022  1.785604e-01  0.546043864  9.735290e-01 0.3446161841
ENSG00000130695  1.947333e-01  3.176271933  1.421540e+00 0.1741418136
ENSG00000142669  1.157972e-01  7.176776149  9.581002e-01 0.3521059621
ENSG00000158062 -5.359913e-02  2.455506246 -4.335256e-01 0.6703554850
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ENSG00000131115  1.217557e-01  2.992248604  1.342591e+00 0.1979320013
ENSG00000062370  1.661639e-01  2.401433710  1.135116e+00 0.2728574165
ENSG00000278318  1.100744e-01  0.979126751  9.955224e-01 0.3341332358
ENSG00000167384 -5.768298e-02  2.427775316 -4.504933e-01 0.6583306597
ENSG00000073008 -2.540734e-02  6.628771200 -4.407457e-01 0.6652271444
ENSG00000279095  1.294931e-01  2.586428111  9.608594e-01 0.3507582734
ENSG00000069399 -2.937116e-01  3.339772580 -1.990509e+00 0.0636970934
ENSG00000130202  1.793722e-02  6.894434617  2.205000e-01 0.8282390435
ENSG00000130204 -2.617850e-02  4.659605433 -3.137135e-01 0.7577454706
ENSG00000130203 -8.735754e-02  3.143686136 -5.613005e-01 0.5822814315
ENSG00000104853  2.144874e-02  6.993213285  3.495798e-01 0.7311610179
ENSG00000104856  1.594755e-02  2.766145266  6.774756e-02 0.9468164420
ENSG00000104859  4.663128e-02  4.072995944  5.634198e-01 0.5808714587
ENSG00000142252  8.498335e-02  3.467358598  1.053091e+00 0.3077674134
ENSG00000007047  8.764139e-02  5.363544183  9.750390e-01 0.3438891566
ENSG00000104866 -1.865666e-02  4.825681576 -2.001084e-01 0.8438883812
ENSG00000007255 -8.821623e-02  2.891837829 -5.212710e-01 0.6092369834
ENSG00000189114  1.328735e-01  4.089487234  1.611355e+00 0.1264287508
ENSG00000104884  5.514125e-02  4.719206848  5.352265e-01 0.5997704638
ENSG00000104881  1.234178e-01  4.899760551  1.028675e+00 0.3187602209
ENSG00000012061 -6.168450e-03  5.266235979 -6.243172e-02 0.9509835120
ENSG00000125744  3.233026e-02  3.270864718  3.109129e-01 0.7598350986
ENSG00000125753  8.213893e-02  6.542329712  9.406083e-01 0.3607327892
ENSG00000125741 -4.730733e-03  5.027972167 -6.810521e-02 0.9465361336
ENSG00000125746  1.341885e-02  4.067216554  1.678011e-01 0.8688184735
ENSG00000125743  5.733625e-02  6.918742564  8.900031e-01 0.3865019233
ENSG00000011478 -2.145617e-02  5.400119293 -3.393661e-01 0.7386973566
ENSG00000177051 -6.730150e-02  2.991101820 -4.997501e-01 0.6239763577
ENSG00000177045 -1.840386e-01  3.224570072 -1.004026e+00 0.3301410801
ENSG00000104936 -9.720782e-02  5.370633599 -1.191131e+00 0.2507770758
ENSG00000185800 -1.842983e-02  5.023702953 -2.107597e-01 0.8357052564
ENSG00000125755 -1.491738e-02  6.003761254 -1.869028e-01 0.8540594805
ENSG00000170604  1.476949e-01  4.613920159  1.106261e+00 0.2847855958
ENSG00000176182  9.304074e-02  3.618458128  9.182651e-01 0.3719618185
ENSG00000188624 -2.782151e-01  2.451040156 -1.768300e+00 0.0958513733
ENSG00000204866 -8.144467e-02  6.246041858 -9.985133e-01 0.3327252128
ENSG00000124440 -1.084094e-01  3.202673522 -6.837254e-01 0.5038201764
ENSG00000011485  9.817904e-02  5.531932188  1.131625e+00 0.2742802719
ENSG00000169515 -1.028587e-01  6.217376588 -1.277295e+00 0.2195169966
ENSG00000182013 -4.298616e-02  4.098389913 -4.623312e-01 0.6499979190
ENSG00000160014  5.831655e-02  6.669841601  1.078520e+00 0.2966132480
ENSG00000197380 -2.414551e-01  1.871194780 -1.244745e+00 0.2309478805
ENSG00000105287  1.527956e-01  3.771143271  1.358132e+00 0.1930531671
ENSG00000090372 -2.761105e-02  5.820892491 -3.898897e-01 0.7017008280
ENSG00000181027 -2.004938e-03  4.641894417 -1.983439e-02 0.9844179401
ENSG00000105281 -3.987001e-02  7.857433925 -6.184029e-01 0.5449146950
ENSG00000042753  3.770535e-02  7.434923049  6.967074e-01 0.4958709890
ENSG00000160007 -4.164172e-02  6.288965066 -6.711819e-01 0.5115702935
ENSG00000130751  1.472370e-01  1.595824281  5.100818e-01 0.6168791940
ENSG00000130748 -3.397714e-01  3.344774900 -2.527163e+00 0.0222747084
ENSG00000130749  4.877079e-02  4.763281284  4.412703e-01 0.6648551972
ENSG00000142230 -6.233146e-03  6.729612621 -1.042039e-01 0.9182878372
ENSG00000105327 -2.626773e-03  3.801955028 -1.979141e-02 0.9844516958
ENSG00000105321  3.147291e-03  4.678268012  3.443240e-02 0.9729534090
ENSG00000257704 -2.439890e-02  3.298874371 -1.670060e-01 0.8694340050
ENSG00000134815  1.304393e-02  3.693557527  1.177074e-01 0.9077478201
ENSG00000105419 -4.715336e-02  4.933703137 -5.395509e-01 0.5968519242
ENSG00000105402  2.292760e-02  5.408501710  2.815937e-01 0.7818235104
ENSG00000063169  7.180203e-02  3.327719514  5.263433e-01 0.6057878557
ENSG00000024422  6.361948e-02  8.032530303  7.027797e-01 0.4921780440
ENSG00000105373 -5.330770e-02  5.891610812 -8.836865e-01 0.3898029783
ENSG00000178980 -2.836567e-02  7.035800120 -4.379193e-01 0.6672326499
ENSG00000105499  7.104226e-02  1.927616636  3.158118e-01 0.7561811723
ENSG00000105486 -1.956376e-01  3.002420359 -1.402772e+00 0.1795753098
ENSG00000185453  3.004659e-03  2.708174192  2.383848e-02 0.9812728672
ENSG00000105483 -6.392900e-02  3.977034748 -8.720157e-01 0.3959513272
ENSG00000142227 -2.672635e-02  5.980823546 -2.686313e-01 0.7916072772
ENSG00000105438  8.149159e-03  8.088896974  1.411038e-01 0.8895292133
ENSG00000105464  1.665739e-01  1.667123160  1.198520e+00 0.2479691741
ENSG00000105447  8.849718e-02  4.746674892  1.231046e+00 0.2358948127
ENSG00000105443 -4.681811e-02  5.536496313 -4.685045e-01 0.6456713745
ENSG00000063177 -2.568230e-02  8.145714965 -3.728292e-01 0.7141128553
ENSG00000063176  1.559305e-01  4.421560402  1.652299e+00 0.1177374257
ENSG00000105552  2.682129e-02  3.944928364  3.189702e-01 0.7538285712
ENSG00000087076 -8.126441e-02  4.966516712 -7.249327e-01 0.4788433397
ENSG00000087074  1.668933e-01  6.783914463  2.057871e+00 0.0560809862
ENSG00000104805  1.288592e-02  7.906149214  1.509509e-01 0.8818797371
ENSG00000087088 -5.738324e-02  6.436261320 -5.590632e-01 0.5837718383
ENSG00000087086 -5.174353e-02 12.058941043 -6.743642e-01 0.5095976452
ENSG00000104812  1.639293e-02  5.554919935  2.720587e-01 0.7890168004
ENSG00000183207  1.339974e-02  5.649854617  1.648994e-01 0.8710650630
ENSG00000104852  2.072569e-02  6.570625396  2.060596e-01 0.8393139315
ENSG00000104863 -1.486653e-01  2.860985462 -1.233137e+00 0.2351345255
ENSG00000177380 -6.346102e-02  2.904772987 -4.337635e-01 0.6701862575
ENSG00000130529 -1.745875e-02  3.954710118 -1.285178e-01 0.8993225503
ENSG00000074219  8.397291e-03  4.784127661  1.004123e-01 0.9212502510
ENSG00000104872 -8.868283e-02  5.215611657 -1.146155e+00 0.2683940162
ENSG00000161618 -1.422554e-01  4.073193668 -1.211530e+00 0.2430839128
ENSG00000142541 -3.167126e-02  8.798495572 -5.027931e-01 0.6218820518
ENSG00000142534  4.506815e-02  9.214561396  5.855027e-01 0.5662844624
ENSG00000104870 -1.394604e-01  5.305007871 -1.709065e+00 0.1065396226
ENSG00000142552  4.146683e-02  6.302870351  4.831424e-01 0.6354650338
ENSG00000142546 -2.035014e-03  5.367518939 -2.908462e-02 0.9771527063
ENSG00000126464 -2.481162e-02  4.885551572 -2.464497e-01 0.8084324925
ENSG00000126458  2.754993e-02  6.339176461  4.698978e-01 0.6446966861
ENSG00000126461  3.548075e-02  6.133402435  2.965623e-01 0.7705723624
ENSG00000126456  5.758663e-02  4.969957329  7.385553e-01 0.4707516847
ENSG00000126453  1.473793e-01  2.842914353  1.243673e+00 0.2313318654
ENSG00000126457  5.598592e-02  6.324574391  7.830561e-01 0.4449013126
ENSG00000196961  4.282691e-03  6.862993870  5.105123e-02 0.9599094261
ENSG00000010361 -2.502356e-01  2.746988061 -1.853043e+00 0.0821973999
ENSG00000104973  8.017698e-02  4.644685303  7.496785e-01 0.4642062792
ENSG00000104960 -4.567657e-02  5.126602512 -5.944174e-01 0.5604507845
ENSG00000039650  1.554283e-02  4.318555072  1.806198e-01 0.8589082078
ENSG00000204673  2.043320e-02  6.615684364  2.461301e-01 0.8086756462
ENSG00000104946  3.785559e-02  5.142717077  4.521744e-01 0.6571444655
ENSG00000213024  2.297654e-03  5.178261322  3.606361e-02 0.9716726724
ENSG00000169136  4.944395e-02  3.340949893  4.998240e-01 0.6239254770
ENSG00000105053 -1.119712e-01  4.303539969 -1.087254e+00 0.2928510442
ENSG00000142528  1.425050e-01  3.054946621  1.196725e+00 0.2486490870
ENSG00000131408 -1.255564e-01  5.748430698 -1.589804e+00 0.1312190774
ENSG00000062822 -1.903832e-02  3.000646471 -1.474212e-01 0.8846203247
ENSG00000161671 -7.449825e-02  6.833897974 -1.005200e+00 0.3295925841
ENSG00000161677 -7.438634e-02  4.863914065 -8.611031e-01 0.4017579336
ENSG00000167747 -2.988973e-02  4.345002868 -3.092779e-01 0.7610559347
ENSG00000142544 -1.554391e-01  2.311663930 -6.656117e-01 0.5150336550
ENSG00000105379  1.834916e-01  3.407808788  1.604636e+00 0.1279059325
ENSG00000105497 -1.576406e-02  3.196139230 -1.682965e-01 0.8684350783
ENSG00000182310  8.439719e-04  2.485832085  6.589452e-03 0.9948229507
ENSG00000198093  1.058498e-01  2.053797321  7.450462e-01 0.4669253634
ENSG00000176024 -7.241341e-02  2.592669391 -6.256319e-01 0.5402785580
ENSG00000256683  2.120898e-01  2.455207926  1.828549e+00 0.0859553618
ENSG00000197619 -1.148275e-01  2.482955439 -5.932591e-01 0.5612069708
ENSG00000142556  3.820800e-02  3.382865635  3.543064e-01 0.7276829855
ENSG00000256087 -3.406313e-02  4.021520586 -2.647523e-01 0.7945422120
ENSG00000197608 -1.579575e-01  4.006239358 -1.633831e+00 0.1215921836
ENSG00000204611  4.335509e-02  3.850670783  4.708450e-01 0.6440344701
ENSG00000105568  6.091729e-02  7.439852649  8.546230e-01 0.4052324063
ENSG00000196214  6.328970e-02  3.198031676  6.795799e-01 0.5063739669
ENSG00000198464 -1.185754e-01  3.424444091 -1.121719e+00 0.2783481664
ENSG00000167554  3.701018e-02  2.135684048  2.702501e-01 0.7903834483
ENSG00000221923  6.740501e-02  2.348356875  5.171583e-01 0.6120406042
ENSG00000167555  1.165429e-01  2.377642494  9.988522e-01 0.3325659337
ENSG00000167766  4.478686e-02  3.897495780  4.527314e-01 0.6567516665
ENSG00000213020 -1.131545e-01  2.480214607 -9.759210e-01 0.3434650150
ENSG00000189190 -7.818841e-03  1.940346670 -4.124230e-02 0.9676071963
ENSG00000198538 -5.175959e-02  3.912907898 -4.412022e-01 0.6649034437
ENSG00000204604 -1.401986e-01  4.547968222 -1.118208e+00 0.2798005761
ENSG00000213793  1.616135e-01  3.335171849  1.335723e+00 0.2001194635
ENSG00000180257 -1.176918e-02  3.077122991 -1.175510e-01 0.9078697762
ENSG00000242779  1.104585e-01  4.041796100  1.464984e+00 0.1620797823
ENSG00000170949 -9.444381e-02  4.027401106 -1.296540e+00 0.2129704014
                adj.P.Val          B lfsr lfdr qvalue svalue
ENSG00000225972 0.9997370 -2.5092096    1    1      1      1
ENSG00000225630 0.9997370 -3.7362668    1    1      1      1
ENSG00000237973 0.9997370 -3.9394002    1    1      1      1
ENSG00000248527 0.9997370 -3.3259548    1    1      1      1
ENSG00000198744 0.9997370 -4.5954422    1    1      1      1
ENSG00000228794 0.9997370 -4.6341922    1    1      1      1
ENSG00000223764 0.9997370 -4.7092965    1    1      1      1
ENSG00000187634 0.9997370 -4.1697680    1    1      1      1
ENSG00000188976 0.9997370 -5.0683421    1    1      1      1
ENSG00000187961 0.9997370 -4.6204218    1    1      1      1
ENSG00000187608 0.9997370 -4.8736044    1    1      1      1
ENSG00000188157 0.9997370 -5.1358067    1    1      1      1
ENSG00000131591 0.9997370 -4.5107391    1    1      1      1
ENSG00000078808 0.9997370 -4.9416765    1    1      1      1
ENSG00000176022 0.9997370 -4.6740054    1    1      1      1
ENSG00000160087 0.9997370 -5.1426109    1    1      1      1
ENSG00000131584 0.9997370 -5.1205818    1    1      1      1
ENSG00000169972 0.9997370 -4.9207971    1    1      1      1
ENSG00000127054 0.9997370 -5.1521933    1    1      1      1
ENSG00000224051 0.9997370 -5.0119591    1    1      1      1
ENSG00000107404 0.9997370 -5.1103210    1    1      1      1
ENSG00000162576 0.9997370 -4.9726825    1    1      1      1
ENSG00000175756 0.9997370 -4.8981685    1    1      1      1
ENSG00000221978 0.9997370 -5.1761646    1    1      1      1
ENSG00000224870 0.9997370 -4.9973793    1    1      1      1
ENSG00000242485 0.9997370 -5.1385863    1    1      1      1
ENSG00000160072 0.9997370 -4.7159543    1    1      1      1
ENSG00000197785 0.9997370 -4.7836178    1    1      1      1
ENSG00000160075 0.9997370 -5.1422018    1    1      1      1
ENSG00000228594 0.9997370 -4.7502292    1    1      1      1
ENSG00000197530 0.9999118 -5.1731461    1    1      1      1
ENSG00000189409 0.9997370 -5.0322293    1    1      1      1
ENSG00000248333 0.9997370 -4.3095059    1    1      1      1
ENSG00000189339 0.9997370 -5.1205794    1    1      1      1
ENSG00000008130 0.9997370 -4.9028526    1    1      1      1
ENSG00000078369 0.9997370 -5.1265268    1    1      1      1
ENSG00000162585 0.9997370 -5.0521160    1    1      1      1
ENSG00000157933 0.9997370 -5.1595651    1    1      1      1
ENSG00000157916 0.9997370 -5.1855341    1    1      1      1
ENSG00000157911 0.9997370 -4.9089414    1    1      1      1
ENSG00000157881 0.9997370 -4.9603274    1    1      1      1
ENSG00000157870 0.9997370 -4.8280841    1    1      1      1
ENSG00000158109 0.9997370 -5.1945494    1    1      1      1
ENSG00000116213 0.9997370 -4.9430588    1    1      1      1
ENSG00000227372 0.9997370 -4.9483443    1    1      1      1
ENSG00000130764 0.9997370 -5.0451881    1    1      1      1
ENSG00000116198 0.9997370 -4.6751931    1    1      1      1
ENSG00000198912 0.9997370 -4.9221847    1    1      1      1
ENSG00000131697 0.9997370 -4.8482952    1    1      1      1
ENSG00000116251 0.9997370 -5.1434585    1    1      1      1
ENSG00000116237 0.9997370 -5.0384090    1    1      1      1
ENSG00000158292 0.9997370 -4.7162044    1    1      1      1
ENSG00000097021 0.9997370 -5.0314141    1    1      1      1
ENSG00000215788 0.9997370 -4.6313572    1    1      1      1
ENSG00000171680 0.9997370 -5.0418523    1    1      1      1
ENSG00000162408 0.9997370 -4.3913628    1    1      1      1
ENSG00000204859 0.9997370 -4.8419603    1    1      1      1
ENSG00000162413 0.9997370 -5.1910786    1    1      1      1
ENSG00000116273 0.9997370 -4.9377750    1    1      1      1
ENSG00000041988 0.9997370 -4.7596314    1    1      1      1
ENSG00000007923 0.9997370 -5.0912003    1    1      1      1
ENSG00000171735 0.9997370 -4.6745103    1    1      1      1
ENSG00000049245 0.9997370 -5.1250677    1    1      1      1
ENSG00000116288 0.9997370 -5.0021928    1    1      1      1
ENSG00000116285 0.9997370 -4.9002955    1    1      1      1
ENSG00000142599 0.9997370 -3.1013738    1    1      1      1
ENSG00000074800 0.9997370 -5.0569462    1    1      1      1
ENSG00000142583 0.9997370 -4.7240057    1    1      1      1
ENSG00000180758 0.9997370 -4.4193087    1    1      1      1
ENSG00000228526 0.9997370 -4.7893534    1    1      1      1
ENSG00000049239 0.9997370 -5.1650225    1    1      1      1
ENSG00000171621 0.9997370 -4.9814668    1    1      1      1
ENSG00000171612 0.9997370 -4.8281845    1    1      1      1
ENSG00000188807 0.9997370 -4.7133688    1    1      1      1
ENSG00000171608 0.9997370 -4.8872051    1    1      1      1
ENSG00000171603 0.9997370 -5.1278879    1    1      1      1
ENSG00000178585 0.9997370 -4.8392552    1    1      1      1
ENSG00000162441 0.9997370 -4.8717331    1    1      1      1
ENSG00000173614 0.9997370 -4.7048547    1    1      1      1
ENSG00000130939 0.9997370 -5.0511739    1    1      1      1
ENSG00000054523 0.9997370 -5.0815400    1    1      1      1
ENSG00000142657 0.9997370 -4.8507830    1    1      1      1
ENSG00000160049 0.9997370 -4.8495967    1    1      1      1
ENSG00000142655 0.9997370 -4.9490734    1    1      1      1
ENSG00000120948 0.9997370 -5.0744940    1    1      1      1
ENSG00000116649 0.9997370 -4.8480551    1    1      1      1
ENSG00000171824 0.9997370 -4.9652967    1    1      1      1
ENSG00000198793 0.9997370 -5.1724347    1    1      1      1
ENSG00000171819 0.9997370 -5.0838040    1    1      1      1
ENSG00000120942 0.9997370 -5.0406527    1    1      1      1
ENSG00000116661 0.9997370 -4.7150251    1    1      1      1
ENSG00000132879 0.9997370 -4.4080488    1    1      1      1
ENSG00000116670 0.9997370 -4.8154947    1    1      1      1
ENSG00000177674 0.9997370 -4.9113797    1    1      1      1
ENSG00000177000 0.9997370 -4.9924405    1    1      1      1
ENSG00000011021 0.9997370 -5.0246554    1    1      1      1
ENSG00000116685 0.9997370 -5.0220079    1    1      1      1
ENSG00000083444 0.9997370 -5.0744856    1    1      1      1
ENSG00000116688 0.9997370 -5.1557675    1    1      1      1
ENSG00000116691 0.9997370 -4.8718496    1    1      1      1
ENSG00000048707 0.9997370 -4.7245828    1    1      1      1
ENSG00000162496 0.9997370 -4.8506984    1    1      1      1
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ENSG00000104960 0.9997370 -4.9830033    1    1      1      1
ENSG00000039650 0.9997370 -5.0004592    1    1      1      1
ENSG00000204673 0.9997370 -5.1715241    1    1      1      1
ENSG00000104946 0.9997370 -5.0328413    1    1      1      1
ENSG00000213024 0.9997370 -5.1063658    1    1      1      1
ENSG00000169136 0.9997370 -4.8481328    1    1      1      1
ENSG00000105053 0.9997370 -4.6664226    1    1      1      1
ENSG00000142528 0.9997370 -4.5642514    1    1      1      1
ENSG00000131408 0.9997370 -4.3350115    1    1      1      1
ENSG00000062822 0.9997370 -4.8311116    1    1      1      1
ENSG00000161671 0.9997370 -4.8352684    1    1      1      1
ENSG00000161677 0.9997370 -4.8372298    1    1      1      1
ENSG00000167747 0.9997370 -4.9779160    1    1      1      1
ENSG00000142544 0.9997370 -4.6988154    1    1      1      1
ENSG00000105379 0.9997370 -4.3457238    1    1      1      1
ENSG00000105497 0.9997370 -4.8602991    1    1      1      1
ENSG00000182310 0.9997370 -4.7886338    1    1      1      1
ENSG00000198093 0.9997370 -4.6790949    1    1      1      1
ENSG00000176024 0.9997370 -4.7221694    1    1      1      1
ENSG00000256683 0.9997370 -4.3065324    1    1      1      1
ENSG00000197619 0.9997370 -4.7215184    1    1      1      1
ENSG00000142556 0.9997370 -4.8635072    1    1      1      1
ENSG00000256087 0.9997370 -4.9457274    1    1      1      1
ENSG00000197608 0.9997370 -4.3030775    1    1      1      1
ENSG00000204611 0.9997370 -4.8935817    1    1      1      1
ENSG00000105568 0.9997370 -4.9319246    1    1      1      1
ENSG00000196214 0.9997370 -4.7688978    1    1      1      1
ENSG00000198464 0.9997370 -4.6141774    1    1      1      1
ENSG00000167554 0.9997370 -4.7510557    1    1      1      1
ENSG00000221923 0.9997370 -4.7533206    1    1      1      1
ENSG00000167555 0.9997370 -4.6703836    1    1      1      1
ENSG00000167766 0.9997370 -4.8982875    1    1      1      1
ENSG00000213020 0.9997370 -4.6291053    1    1      1      1
ENSG00000189190 0.9997370 -4.7222300    1    1      1      1
ENSG00000198538 0.9997370 -4.8950341    1    1      1      1
ENSG00000204604 0.9997370 -4.6471178    1    1      1      1
ENSG00000213793 0.9997370 -4.5016494    1    1      1      1
ENSG00000180257 0.9997370 -4.8536502    1    1      1      1
ENSG00000242779 0.9997370 -4.4221776    1    1      1      1
ENSG00000170949 0.9997370 -4.5307728    1    1      1      1
 [ reached 'max' / getOption("max.print") -- omitted 448 rows ]

[[10]]
                        logFC      AveExpr             t      P.Value
ENSG00000225972 -3.277380e-01  3.439734306 -1.119568e+00 0.2792039386
ENSG00000225630  4.387818e-02  5.259763521  3.106782e-01 0.7600022314
ENSG00000237973  2.549907e-02  5.765427761  1.618108e-01 0.8734534507
ENSG00000248527  1.832106e-02  7.291375670  1.167300e-01 0.9085072058
ENSG00000198744  1.224466e-01  1.692163426  1.143530e+00 0.2694167922
ENSG00000228794 -3.244804e-01  2.429990051 -1.909820e+00 0.0740049119
ENSG00000223764  4.344052e-01  1.604113326  2.324032e+00 0.0334223610
ENSG00000187634  2.465307e-01  2.774428967  1.563564e+00 0.1372195317
ENSG00000188976  1.180504e-02  5.602324306  1.370154e-01 0.8927050455
ENSG00000187961  1.844449e-01  3.205023751  1.224155e+00 0.2383787588
ENSG00000187608  2.455370e-01  3.515541854  1.363316e+00 0.1914093408
ENSG00000188157  1.592253e-01  8.438003633  1.271425e+00 0.2215083252
ENSG00000131591  1.847005e-01  2.698849622  1.283493e+00 0.2173549433
ENSG00000078808  2.915220e-02  8.404430472  3.343325e-01 0.7424128868
ENSG00000176022  9.196119e-02  5.315643527  8.041677e-01 0.4329295705
ENSG00000160087  3.857852e-02  5.574117382  5.295648e-01 0.6035875365
ENSG00000131584  8.535390e-02  5.338644789  8.397950e-01 0.4132315091
ENSG00000169972  4.707302e-02  3.649507997  4.418212e-01 0.6644527457
ENSG00000127054  6.847624e-02  5.813712471  1.009063e+00 0.3277619426
ENSG00000224051 -6.692329e-02  4.433660580 -5.999300e-01 0.5568424096
ENSG00000107404 -8.765204e-03  5.541314411 -7.217000e-02 0.9433490987
ENSG00000162576  5.561435e-02  5.643016003  4.292856e-01 0.6733634080
ENSG00000175756  9.931452e-02  5.949578662  1.630604e+00 0.1222371669
ENSG00000221978  1.760159e-01  6.117640537  1.227668e+00 0.2370915831
ENSG00000224870  3.664641e-02  4.193043833  3.172428e-01 0.7551066712
ENSG00000242485  7.892532e-02  5.474356677  1.007558e+00 0.3284625216
ENSG00000160072  8.799361e-02  4.020742816  8.878536e-01 0.3875967000
ENSG00000197785  8.665829e-02  4.667370310  8.175229e-01 0.4254767238
ENSG00000160075 -1.918509e-02  6.698987873 -2.948073e-01 0.7718811551
ENSG00000228594 -1.108694e-01  3.231082811 -7.615917e-01 0.4572355658
ENSG00000197530  2.317092e-01  6.011139637  1.920662e+00 0.0725326198
ENSG00000189409 -6.475021e-02  4.590321361 -4.958409e-01 0.6266581499
ENSG00000248333  1.166872e-02  3.904469734  9.516785e-02 0.9253473909
ENSG00000189339  6.090236e-02  5.329578573  8.205319e-01 0.4238089455
ENSG00000008130 -1.564213e-02  5.472226379 -2.260554e-01 0.8239824168
ENSG00000078369 -2.615406e-02  8.804321589 -4.752109e-01 0.6409731301
ENSG00000162585  1.229851e-01  4.754428869  1.006650e+00 0.3288860676
ENSG00000157933 -2.939486e-02  6.562145698 -4.270640e-01 0.6749479474
ENSG00000157916 -4.294066e-02  7.002652621 -7.262952e-01 0.4780091690
ENSG00000157911  1.160036e-01  3.826112744  8.331169e-01 0.4168789580
ENSG00000157881 -6.998944e-03  4.048444809 -7.528755e-02 0.9409067382
ENSG00000157870  2.441153e-01  3.237377913  1.851917e+00 0.0823290011
ENSG00000158109  1.206149e-02  6.732297019  1.762806e-01 0.8622557805
ENSG00000116213  6.477849e-02  4.048572327  6.928277e-01 0.4982188791
ENSG00000227372  2.769472e-02  3.931432132  2.946151e-01 0.7720253864
ENSG00000130764  2.495127e-02  5.498222486  3.029611e-01 0.7657707577
ENSG00000116198 -4.609591e-02  4.799410870 -5.078788e-01 0.6183752730
ENSG00000198912 -6.756070e-02  4.517142545 -7.860601e-01 0.4431655940
ENSG00000131697  1.063756e-01  3.217207294  9.824874e-01 0.3402894188
ENSG00000116251 -6.419227e-02  6.491595851 -7.900495e-01 0.4408975124
ENSG00000116237 -7.750642e-04  7.144503644 -1.235736e-02 0.9902912300
ENSG00000158292 -8.298186e-02  2.850382649 -5.299128e-01 0.6033516590
ENSG00000097021 -2.628471e-01  4.963811963 -1.379945e+00 0.1863304823
ENSG00000215788  2.535294e-01  2.224832337  1.035709e+00 0.3155340982
ENSG00000171680  2.068705e-01  4.816276482  1.263676e+00 0.2242081974
ENSG00000162408 -6.153082e-02  3.954485497 -4.969210e-01 0.6259128256
ENSG00000204859  2.243134e-01  3.319571732  1.740212e+00 0.1007578266
ENSG00000162413  3.356488e-02  6.835844141  4.589806e-01 0.6523391708
ENSG00000116273 -7.998857e-02  5.018894856 -7.916057e-01 0.4400147420
ENSG00000041988  1.294164e-01  3.387269004  1.100379e+00 0.2872311623
ENSG00000007923  6.874765e-02  5.116929638  6.688891e-01 0.5129750610
ENSG00000171735 -2.330170e-01  3.971476593 -1.587476e+00 0.1317063074
ENSG00000049245 -3.224875e-02  6.747961733 -5.320441e-01 0.6019080253
ENSG00000116288 -5.551827e-03  7.469041111 -8.471160e-02 0.9335275110
ENSG00000116285 -2.957899e-01  6.567378923 -1.357794e+00 0.1931202977
ENSG00000142599 -1.252892e-01  6.882232369 -1.079722e+00 0.2960608902
ENSG00000074800  4.663846e-03  9.240103588  6.058722e-02 0.9524282399
ENSG00000142583  6.170578e-02  2.154021950  2.525235e-01 0.8038088449
ENSG00000180758  6.598471e-02  2.520571933  5.203630e-01 0.6098410356
ENSG00000228526  3.770538e-01  3.111024724  1.843322e+00 0.0836329517
ENSG00000049239  3.708614e-03  5.843277506  3.136751e-02 0.9753592072
ENSG00000171621  8.220452e-02  7.640791271  7.779624e-01 0.4477917639
ENSG00000171612 -2.439989e-01  2.962339532 -1.642168e+00 0.1197994093
ENSG00000188807  1.005886e-01  3.161234025  7.945411e-01 0.4383526161
ENSG00000171608  4.375431e-03  3.600417471  2.755777e-02 0.9783510947
ENSG00000171603 -5.968075e-03  7.507456408 -7.341185e-02 0.9423761308
ENSG00000178585  1.071563e-03  4.096458428  1.006249e-02 0.9920941661
ENSG00000162441 -7.954777e-02  4.190251149 -7.533950e-01 0.4620097270
ENSG00000173614 -1.545128e-01  3.790237230 -1.177111e+00 0.2561370443
ENSG00000130939 -9.942158e-02  6.013665524 -1.325530e+00 0.2033640023
ENSG00000054523 -1.389765e-02  6.790885629 -2.154786e-01 0.8320805651
ENSG00000142657  1.162157e-02  6.764910548  1.681348e-01 0.8685559328
ENSG00000160049 -5.320256e-03  5.436360887 -8.390519e-02 0.9341587107
ENSG00000142655  1.615432e-02  3.921860299  1.622128e-01 0.8731419592
ENSG00000120948  2.572069e-02  5.498744258  3.750492e-01 0.7124829751
ENSG00000116649 -7.069905e-02  6.989287261 -7.043364e-01 0.4912135271
ENSG00000171824 -9.103144e-02  5.208139078 -1.230089e+00 0.2362078689
ENSG00000198793  1.023461e-01  6.572268484  1.278786e+00 0.2189673885
ENSG00000171819 -6.486469e-02  5.005029463 -3.072370e-01 0.7625727559
ENSG00000120942 -3.863839e-02  4.505427589 -4.369841e-01 0.6678850165
ENSG00000116661  9.912780e-02  2.256655281  5.598055e-01 0.5832615032
ENSG00000132879  1.836239e-01  2.851964046  1.696260e+00 0.1089425336
ENSG00000116670  1.474788e-02  3.776766362  1.284661e-01 0.8993596308
ENSG00000177674  2.975288e-02  4.748151475  3.280228e-01 0.7470908426
ENSG00000177000  2.224564e-02  4.306535766  2.254529e-01 0.8244431663
ENSG00000011021  1.467471e-01  4.716053644  1.795170e+00 0.0912819449
ENSG00000116685  9.505920e-02  5.360029702  1.148171e+00 0.2675512998
ENSG00000083444  9.383606e-03  9.617689757  1.049006e-01 0.9177410071
ENSG00000116688 -7.001938e-03  6.632063082 -1.034285e-01 0.9188910093
ENSG00000116691 -2.144418e-02  3.486834952 -2.233274e-01 0.8260692118
ENSG00000048707  2.122508e-02  5.830304323  2.884663e-01 0.7766438214
ENSG00000162496  1.278254e-01  3.119770104  8.578898e-01 0.4034529100
ENSG00000162494 -7.971858e-02  1.522400198 -4.217860e-01 0.6787186155
ENSG00000162493 -1.468760e-01  9.669928769 -1.786269e+00 0.0927615783
ENSG00000116731 -1.302542e-02  5.589398806 -1.991180e-01 0.8446452283
ENSG00000189337 -5.161060e-02  3.000052029 -2.758237e-01 0.7861668600
ENSG00000171729 -2.660954e-01  3.118331547 -1.134427e+00 0.2731041917
ENSG00000142634 -1.778852e-01  4.068304279 -1.184923e+00 0.2531203283
ENSG00000132906  3.131170e-02  3.641839894  2.783626e-01 0.7842515543
ENSG00000116138 -2.196291e-03  5.209789620 -2.709994e-02 0.9787106675
ENSG00000197312 -9.053344e-02  5.118656021 -9.226006e-01 0.3697369998
ENSG00000116786  2.230742e-02  6.306994840  3.546462e-01 0.7274238263
ENSG00000162458 -9.082764e-02  7.121657904 -7.740437e-01 0.4500412271
ENSG00000065526  5.870810e-02  5.499653620  8.455291e-01 0.4101162366
ENSG00000116809  1.715572e-01  4.245851773  1.543186e+00 0.1420705376
ENSG00000173641 -2.412153e-01  5.013884293 -1.313213e+00 0.2073872890
ENSG00000142627 -2.757001e-02  6.565606623 -2.112720e-01 0.8353068014
ENSG00000142632  1.176252e-01  2.972003499  7.355046e-01 0.4725350992
ENSG00000037637  5.420905e-02  4.745003107  6.772938e-01 0.5077660191
ENSG00000055070 -1.722197e-02  6.825257519 -2.579025e-01 0.7997259568
ENSG00000157191 -3.475802e-02  6.110674810 -6.208145e-01 0.5433480199
ENSG00000219481  7.691595e-02  4.648960829  8.306383e-01 0.4182380012
ENSG00000215908  2.240990e-01  3.665056004  2.418119e+00 0.0277140284
ENSG00000058453  1.111607e-01  4.313812210  7.790158e-01 0.4471882696
ENSG00000117122 -2.172596e-02  6.989385574 -2.629689e-01 0.7958858566
ENSG00000159363 -5.883096e-02  6.019552468 -5.181477e-01 0.6113512468
ENSG00000117118  3.942738e-03  6.167713801  5.690264e-02 0.9553178767
ENSG00000179051 -1.227257e-02  6.193488468 -1.520990e-01 0.8809847733
ENSG00000074964  8.047599e-02  3.574390645  7.526265e-01 0.4624588425
ENSG00000159423 -1.335244e-02  2.894230519 -8.442397e-02 0.9337526425
ENSG00000169991  1.070707e-01  4.732484074  9.302352e-01 0.3658889609
ENSG00000127481  1.806308e-01  9.073849311  2.107390e+00 0.0509875377
ENSG00000127463  6.819354e-02  6.630439259  9.698825e-01 0.3463471941
ENSG00000053372 -2.000249e-01  4.612180635 -2.526944e+00 0.0222599127
ENSG00000053371  1.116105e-01  5.024884155  1.338799e+00 0.1990999944
ENSG00000040487 -2.872966e-02  4.555068328 -2.412194e-01 0.8124080933
ENSG00000077549 -9.279992e-04  7.815775016 -1.707702e-02 0.9865834794
ENSG00000173436 -2.268036e-03  3.042210288 -1.544825e-02 0.9878630039
ENSG00000158747 -5.544785e-02  6.183331667 -5.215406e-01 0.6090389636
ENSG00000169914 -2.447767e-01  4.817885052 -1.687474e+00 0.1106459758
ENSG00000188257 -6.331697e-01  2.000223706 -1.347692e+00 0.1962822415
ENSG00000127472 -2.558437e-01  3.088517748 -2.069142e+00 0.0548560323
ENSG00000162545 -1.198480e-01  4.827178273 -7.776203e-01 0.4479878388
ENSG00000090432 -6.676847e-02  5.675075630 -8.733146e-01 0.3952378802
ENSG00000158828  1.547958e-01  4.494932010  1.333039e+00 0.2009422722
ENSG00000117242 -2.075025e-01  2.631331799 -1.433679e+00 0.1706610108
ENSG00000244038  7.492542e-02  8.697751526  1.035225e+00 0.3157529364
ENSG00000117245 -3.067769e-01  2.607635834 -1.505619e+00 0.1513908582
ENSG00000189410 -1.613539e-01  2.810261770 -8.352035e-01 0.4157370747
ENSG00000127483 -7.996778e-04  7.082879913 -1.157226e-02 0.9909080255
ENSG00000075151  1.077734e-02  7.195981909  1.715404e-01 0.8659208431
ENSG00000117298  6.875035e-02  7.753644680  8.865339e-01 0.3882861797
ENSG00000142794 -4.312569e-02  3.437321097 -4.750021e-01 0.6411187309
ENSG00000162551 -3.052693e-01  2.911729077 -2.009769e+00 0.0613934319
ENSG00000090686  1.094421e-01  6.011313564  1.904966e+00 0.0746726914
ENSG00000142798  1.937066e-01  9.621243365  1.359177e+00 0.1926906969
ENSG00000070831 -9.623057e-02  7.015276370 -1.308992e+00 0.2087804815
ENSG00000162552  2.992644e-01  4.263306989  9.806722e-01 0.3411571410
ENSG00000184677 -4.510988e-02  4.911668448 -4.081474e-01 0.6885028877
ENSG00000133216 -2.569996e-01  2.966685326 -1.223887e+00 0.2384772110
ENSG00000004487 -5.560091e-03  6.294359862 -8.425275e-02 0.9338866585
ENSG00000169641 -4.631114e-03  7.231379749 -6.710553e-02 0.9473179637
ENSG00000179546 -4.575490e-01  2.315193798 -2.422789e+00 0.0274560615
ENSG00000125944 -3.993140e-02  6.529112938 -6.220629e-01 0.5425470787
ENSG00000125945 -1.476692e-01  3.921018354 -1.531642e+00 0.1448819651
ENSG00000088280  9.325407e-02  3.296382364  8.181045e-01 0.4251540464
ENSG00000117318 -7.933025e-02  5.930665385 -8.159406e-01 0.4263553867
ENSG00000142676  1.626964e-03  8.453924701  2.260864e-02 0.9822382683
ENSG00000011007 -4.286526e-02  6.399420217 -6.975164e-01 0.4953578818
ENSG00000057757  1.838594e-02  5.202976618  2.476355e-01 0.8075240721
ENSG00000011009 -3.888521e-02  4.923404734 -3.473416e-01 0.7328009928
ENSG00000117308 -1.318776e-02  4.189851175 -1.309314e-01 0.8974398533
ENSG00000117305  1.918438e-02  4.884518302  2.064461e-01 0.8390117322
ENSG00000179163 -2.987708e-02  3.811079574 -2.508365e-01 0.8050905661
ENSG00000189266  2.327062e-02  4.351714351  2.201347e-01 0.8285131276
ENSG00000188529 -8.679733e-03  6.171229833 -8.963670e-02 0.9296734946
ENSG00000001460 -4.147248e-02  2.291994164 -2.622042e-01 0.7964650741
ENSG00000001461  1.022899e-01  6.677853599  1.243930e+00 0.2312037401
ENSG00000117602 -9.183140e-02  3.219033653 -6.224523e-01 0.5422973615
ENSG00000133226 -1.015264e-01  5.491583196 -1.271340e+00 0.2215380157
ENSG00000169504 -1.075799e-01  9.454272243 -1.319239e+00 0.2054112525
ENSG00000117614  1.858173e-02  5.024299045  2.446937e-01 0.8097623997
ENSG00000117616  2.465993e-01  4.588311643  1.078609e+00 0.2965426015
ENSG00000183726 -6.968132e-02  6.850214952 -1.109122e+00 0.2835528313
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ENSG00000105771 -5.757679e-02  5.116711790 -7.157755e-01 0.4843082747
ENSG00000167637  5.573709e-02  2.592650824  3.344342e-01 0.7423375347
ENSG00000176222  9.781446e-02  2.219045231  6.209171e-01 0.5432822004
ENSG00000124459 -1.286326e-01  4.346980811 -1.165673e+00 0.2606031244
ENSG00000159885 -1.368875e-01  2.185741583 -6.771111e-01 0.5078789345
ENSG00000267680  1.344843e-01  2.660724199  6.397939e-01 0.5312407781
ENSG00000256294  2.133755e-01  2.692183696  1.342841e+00 0.1978151999
ENSG00000263002 -7.752551e-03  3.408531106 -5.509178e-02 0.9567382774
ENSG00000167380 -3.635381e-02  4.441687498 -3.128610e-01 0.7583732052
ENSG00000131115 -7.576191e-02  2.992248604 -6.858461e-01 0.5024968220
ENSG00000062370 -2.650206e-01  2.401433710 -1.625987e+00 0.1232223446
ENSG00000278318 -5.474694e-02  0.979126751 -3.515432e-01 0.7297062601
ENSG00000167384 -1.699152e-02  2.427775316 -1.156794e-01 0.9093267413
ENSG00000073008  1.893016e-02  6.628771200  2.856663e-01 0.7787498466
ENSG00000279095 -1.367362e-01  2.586428111 -8.373273e-01 0.4145769231
ENSG00000069399  2.243657e-01  3.339772580  1.244133e+00 0.2311311954
ENSG00000130202  8.144095e-03  6.894434617  8.694185e-02 0.9317820675
ENSG00000130204  4.848829e-02  4.659605433  4.986595e-01 0.6247141093
ENSG00000130203  3.678519e-02  3.143686136  2.524371e-01 0.8038744328
ENSG00000104853  1.303879e-02  6.993213285  1.861168e-01 0.8546610494
ENSG00000104856 -3.831161e-01  2.766145266 -1.436633e+00 0.1698316541
ENSG00000104859  1.409590e-01  4.072995944  1.570107e+00 0.1356918907
ENSG00000142252  1.019089e-02  3.467358598  1.036610e-01 0.9187093796
ENSG00000007047 -1.184098e-02  5.363544183 -1.130267e-01 0.9113965563
ENSG00000104866 -5.392457e-02  4.825681576 -5.170619e-01 0.6120921227
ENSG00000007255  1.954525e-01  2.891837829  1.058187e+00 0.3054764879
ENSG00000189114 -1.151954e-01  4.089487234 -1.240124e+00 0.2325716079
ENSG00000104884  1.187611e-01  4.719206848  1.008581e+00 0.3279865409
ENSG00000104881 -1.337673e-01  4.899760551 -9.717497e-01 0.3454451181
ENSG00000012061 -8.597015e-02  5.266235979 -7.732254e-01 0.4505118648
ENSG00000125744 -7.492260e-02  3.270864718 -6.369286e-01 0.5330589964
ENSG00000125753 -1.609291e-02  6.542329712 -1.567041e-01 0.8774121003
ENSG00000125741 -2.467992e-02  5.027972167 -3.135251e-01 0.7578778304
ENSG00000125746  9.437056e-02  4.067216554  1.059069e+00 0.3050865146
ENSG00000125743 -3.514446e-02  6.918742564 -4.708524e-01 0.6440164549
ENSG00000011478  5.236088e-02  5.400119293  7.207339e-01 0.4813331169
ENSG00000177051  8.952057e-02  2.991101820  5.807444e-01 0.5693949488
ENSG00000177045  1.947096e-01  3.224570072  9.496953e-01 0.3562048064
ENSG00000104936  1.454273e-01  5.370633599  1.618438e+00 0.1248476832
ENSG00000185800  1.408824e-01  5.023702953  1.502045e+00 0.1523038096
ENSG00000125755  6.717909e-02  6.003761254  7.488772e-01 0.4646540229
ENSG00000170604  1.592845e-01  4.613920159  1.039190e+00 0.3139612078
ENSG00000176182 -2.289643e-02  3.618458128 -1.942006e-01 0.8484303366
ENSG00000188624  1.659760e-01  2.451040156  1.031175e+00 0.3175912566
ENSG00000204866  9.159702e-02  6.246041858  8.415701e-01 0.4122655173
ENSG00000124440  5.036017e-02  3.202673522  3.139441e-01 0.7575653187
ENSG00000011485 -2.833955e-02  5.531932188 -2.765974e-01 0.7855830416
ENSG00000169515  1.096493e-01  6.217376588  1.170429e+00 0.2587389448
ENSG00000182013 -3.177155e-02  4.098389913 -3.067811e-01 0.7629135105
ENSG00000160014 -2.096768e-02  6.669841601 -3.299011e-01 0.7456972067
ENSG00000197380  2.225981e-01  1.871194780  1.049319e+00 0.3094160919
ENSG00000105287 -2.734326e-02  3.771143271 -2.002283e-01 0.8437911183
ENSG00000090372  1.043451e-01  5.820892491  1.353744e+00 0.1943830892
ENSG00000181027  8.606983e-02  4.641894417  7.582393e-01 0.4591845042
ENSG00000105281  2.258486e-02  7.857433925  3.049605e-01 0.7642747629
ENSG00000042753 -8.745044e-02  7.434923049 -1.485266e+00 0.1566500733
ENSG00000160007  1.164105e-01  6.288965066  1.758704e+00 0.0974777246
ENSG00000130751  3.171574e-01  1.595824281  9.227578e-01 0.3696574761
ENSG00000130748  1.944654e-01  3.344774900  1.113315e+00 0.2818014210
ENSG00000130749 -6.445858e-03  4.763281284 -5.024835e-02 0.9605381009
ENSG00000142230  3.015652e-02  6.729612621  4.405512e-01 0.6653531763
ENSG00000105327 -1.078361e-01  3.801955028 -7.274651e-01 0.4773116971
ENSG00000105321 -5.222859e-02  4.678268012 -4.930562e-01 0.6285816290
ENSG00000257704  7.368938e-02  3.298874371  4.275494e-01 0.6746015994
ENSG00000134815 -8.975968e-02  3.693557527 -7.092436e-01 0.4882442455
ENSG00000105419  9.264518e-02  4.933703137  8.732407e-01 0.3952769651
ENSG00000105402 -1.801221e-02  5.408501710 -1.944297e-01 0.8482538892
ENSG00000063169  9.312185e-02  3.327719514  6.164679e-01 0.5461417907
ENSG00000024422 -1.074176e-01  8.032530303 -1.052516e+00 0.3079916024
ENSG00000105373  3.934381e-02  5.891610812  5.685257e-01 0.5774657123
ENSG00000178980  4.357890e-02  7.035800120  5.948610e-01 0.5601445578
ENSG00000105499 -1.353301e-01  1.927616636 -5.545816e-01 0.5867476205
ENSG00000105486  3.216725e-01  3.002420359  2.156160e+00 0.0464174529
ENSG00000185453  6.024243e-03  2.708174192  4.238559e-02 0.9667087267
ENSG00000105483  5.003227e-02  3.977034748  5.945839e-01 0.5603253369
ENSG00000142227 -1.207036e-01  5.980823546 -1.086408e+00 0.2931815438
ENSG00000105438 -2.439681e-02  8.088896974 -3.719482e-01 0.7147461915
ENSG00000105464 -6.666496e-02  1.667123160 -4.596780e-01 0.6518489096
ENSG00000105447  2.014532e-02  4.746674892  2.339796e-01 0.8179286627
ENSG00000105443  1.891405e-01  5.536496313  1.799223e+00 0.0906151666
ENSG00000063177  4.652233e-02  8.145714965  5.970486e-01 0.5587182177
ENSG00000063176 -7.116563e-02  4.421560402 -6.117432e-01 0.5491874528
ENSG00000105552 -6.228920e-02  3.944928364 -6.444664e-01 0.5282832416
ENSG00000087076  7.661095e-02  4.966516712  6.146570e-01 0.5473080665
ENSG00000087074 -1.118468e-01  6.783914463 -1.113708e+00 0.2816375655
ENSG00000104805  2.359245e-02  7.906149214  2.417690e-01 0.8119893673
ENSG00000087088  1.854511e-01  6.436261320  1.703599e+00 0.1075369036
ENSG00000087086 -1.783942e-02 12.058941043 -1.995424e-01 0.8443186759
ENSG00000104812 -2.427601e-02  5.554919935 -3.489470e-01 0.7316179819
ENSG00000183207  1.464538e-02  5.649854617  1.553912e-01 0.8784304006
ENSG00000104852  1.813349e-01  6.570625396  1.723934e+00 0.1037245015
ENSG00000104863  1.201307e-01  2.860985462  8.021078e-01 0.4340863707
ENSG00000177380  2.183231e-01  2.904772987  1.369109e+00 0.1896274102
ENSG00000130529  2.572452e-01  3.954710118  1.732844e+00 0.1020913030
ENSG00000074219  1.271830e-01  4.784127661  1.383773e+00 0.1851768788
ENSG00000104872  1.751072e-01  5.215611657  2.170693e+00 0.0451303038
ENSG00000161618  1.481556e-01  4.073193668  1.065806e+00 0.3021208871
ENSG00000142541  1.789075e-02  8.798495572  2.477174e-01 0.8074617981
ENSG00000142534 -7.710931e-03  9.214561396 -8.718372e-02 0.9315927934
ENSG00000104870  1.640233e-01  5.305007871  1.801707e+00 0.0902086298
ENSG00000142552 -3.538809e-03  6.302870351 -3.689466e-02 0.9710192816
ENSG00000142546 -2.047081e-02  5.367518939 -2.525271e-01 0.8038060691
ENSG00000126464 -1.435503e-02  4.885551572 -1.252932e-01 0.9018313293
ENSG00000126458  8.917152e-03  6.339176461  1.324386e-01 0.8962665404
ENSG00000126461  4.108364e-02  6.133402435  3.012632e-01 0.7670418470
ENSG00000126456  1.096632e-02  4.969957329  1.190062e-01 0.9067319853
ENSG00000126453 -7.784346e-02  2.842914353 -5.337345e-01 0.6007642835
ENSG00000126457  3.414127e-02  6.324574391  4.118300e-01 0.6858552745
ENSG00000196961 -5.102633e-03  6.862993870 -5.341483e-02 0.9580537770
ENSG00000010361  1.122530e-01  2.746988061  7.154410e-01 0.4845093813
ENSG00000104973 -3.806907e-02  4.644685303 -3.090924e-01 0.7611864342
ENSG00000104960  1.685454e-02  5.126602512  1.894867e-01 0.8520623766
ENSG00000039650  8.671324e-02  4.318555072  8.970854e-01 0.3827962406
ENSG00000204673 -3.680779e-02  6.615684364 -3.900367e-01 0.7015839095
ENSG00000104946 -2.118848e-02  5.142717077 -2.252678e-01 0.8245847805
ENSG00000213024  1.397892e-02  5.178261322  1.913159e-01 0.8506525728
ENSG00000169136  8.407525e-02  3.340949893  7.148678e-01 0.4848540867
ENSG00000105053 -2.906776e-02  4.303539969 -2.426794e-01 0.8112959731
ENSG00000142528 -1.941874e-01  3.054946621 -1.440362e+00 0.1687898734
ENSG00000131408  1.037758e-01  5.748430698  1.120144e+00 0.2789658588
ENSG00000062822  1.739026e-01  3.000646471  1.240221e+00 0.2325366421
ENSG00000161671  8.853830e-02  6.833897974  1.048826e+00 0.3096365095
ENSG00000161677  3.905649e-02  4.863914065  3.851825e-01 0.7051066815
ENSG00000167747  3.577830e-02  4.345002868  3.103793e-01 0.7602253431
ENSG00000142544  1.513900e-02  2.311663930  5.344171e-02 0.9580326962
ENSG00000105379 -9.722658e-02  3.407808788 -6.854290e-01 0.5027530136
ENSG00000105497  1.549598e-02  3.196139230  1.437699e-01 0.8874533081
ENSG00000182310  1.221541e-01  2.485832085  8.899042e-01 0.3865269089
ENSG00000198093  6.575128e-02  2.053797321  3.615157e-01 0.7223803359
ENSG00000176024  6.615802e-02  2.592669391  5.140809e-01 0.6141283600
ENSG00000256683 -1.441979e-01  2.455207926 -9.548070e-01 0.3536905538
ENSG00000197619 -1.970638e-01  2.482955439 -9.067413e-01 0.3778181259
ENSG00000142556 -3.436417e-02  3.382865635 -2.752261e-01 0.7866179512
ENSG00000256087  1.776714e-01  4.021520586  1.236307e+00 0.2339495815
ENSG00000197608  1.910518e-01  4.006239358  1.680380e+00 0.1120380152
ENSG00000204611 -1.131742e-01  3.850670783 -1.058708e+00 0.3052461497
ENSG00000105568 -7.184858e-02  7.439852649 -8.807919e-01 0.3912956943
ENSG00000196214  6.158756e-02  3.198031676  5.591960e-01 0.5836677083
ENSG00000198464  1.567247e-01  3.424444091  1.347899e+00 0.1962170982
ENSG00000167554  1.089879e-01  2.135684048  6.392768e-01 0.5315686360
ENSG00000221923  1.545944e-01  2.348356875  9.017044e-01 0.3804094616
ENSG00000167555  1.713247e-01  2.377642494  1.003703e+00 0.3302619354
ENSG00000167766  4.129026e-02  3.897495780  3.665583e-01 0.7186865036
ENSG00000213020 -2.282532e-02  2.480214607 -1.642882e-01 0.8715342049
ENSG00000189190 -8.382258e-02  1.940346670 -4.050247e-01 0.6907512372
ENSG00000198538 -1.497041e-01  3.912907898 -1.151390e+00 0.2662628166
ENSG00000204604  1.278701e-01  4.547968222  9.475637e-01 0.3572568822
ENSG00000213793 -1.615988e-01  3.335171849 -1.209234e+00 0.2439052333
ENSG00000180257  1.379998e-02  3.077122991  1.186289e-01 0.9070261704
ENSG00000242779 -3.505471e-04  4.041796100 -4.157299e-03 0.9967336700
ENSG00000170949  1.457758e-01  4.027401106  1.884510e+00 0.0775463574
                adj.P.Val         B lfsr lfdr qvalue svalue
ENSG00000225972 0.9999646 -4.595449    1    1      1      1
ENSG00000225630 0.9999646 -5.011192    1    1      1      1
ENSG00000237973 0.9999646 -5.004684    1    1      1      1
ENSG00000248527 0.9999646 -5.101894    1    1      1      1
ENSG00000198744 0.9999646 -4.596857    1    1      1      1
ENSG00000228794 0.9999646 -4.346166    1    1      1      1
ENSG00000223764 0.9999646 -4.227623    1    1      1      1
ENSG00000187634 0.9999646 -4.425951    1    1      1      1
ENSG00000188976 0.9999646 -5.048674    1    1      1      1
ENSG00000187961 0.9999646 -4.551635    1    1      1      1
ENSG00000187608 0.9999646 -4.492677    1    1      1      1
ENSG00000188157 0.9999646 -4.584098    1    1      1      1
ENSG00000131591 0.9999646 -4.533704    1    1      1      1
ENSG00000078808 0.9999646 -5.048836    1    1      1      1
ENSG00000176022 0.9999646 -4.840285    1    1      1      1
ENSG00000160087 0.9999646 -4.967619    1    1      1      1
ENSG00000131584 0.9999646 -4.820951    1    1      1      1
ENSG00000169972 0.9999646 -4.814989    1    1      1      1
ENSG00000127054 0.9999646 -4.754552    1    1      1      1
ENSG00000224051 0.9999646 -4.842719    1    1      1      1
ENSG00000107404 0.9999646 -5.041991    1    1      1      1
ENSG00000162576 0.9999646 -5.010642    1    1      1      1
ENSG00000175756 0.9999646 -4.292288    1    1      1      1
ENSG00000221978 0.9999646 -4.618407    1    1      1      1
ENSG00000224870 0.9999646 -4.897242    1    1      1      1
ENSG00000242485 0.9999646 -4.742616    1    1      1      1
ENSG00000160072 0.9999646 -4.711100    1    1      1      1
ENSG00000197785 0.9999646 -4.782350    1    1      1      1
ENSG00000160075 0.9999646 -5.076499    1    1      1      1
ENSG00000228594 0.9999646 -4.720258    1    1      1      1
ENSG00000197530 0.9999646 -4.027009    1    1      1      1
ENSG00000189409 0.9999646 -4.923704    1    1      1      1
ENSG00000248333 0.9999646 -4.885063    1    1      1      1
ENSG00000189339 0.9999646 -4.838697    1    1      1      1
ENSG00000008130 0.9999646 -5.033040    1    1      1      1
ENSG00000078369 0.9999646 -5.001930    1    1      1      1
ENSG00000162585 0.9999646 -4.697024    1    1      1      1
ENSG00000157933 0.9999646 -5.043665    1    1      1      1
ENSG00000157916 0.9999646 -4.931966    1    1      1      1
ENSG00000157911 0.9999646 -4.722710    1    1      1      1
ENSG00000157881 0.9999646 -4.897185    1    1      1      1
ENSG00000157870 0.9999646 -4.267583    1    1      1      1
ENSG00000158109 0.9999646 -5.095355    1    1      1      1
ENSG00000116213 0.9999646 -4.786763    1    1      1      1
ENSG00000227372 0.9999646 -4.877718    1    1      1      1
ENSG00000130764 0.9999646 -5.018903    1    1      1      1
ENSG00000116198 0.9999646 -4.907229    1    1      1      1
ENSG00000198912 0.9999646 -4.795137    1    1      1      1
ENSG00000131697 0.9999646 -4.641070    1    1      1      1
ENSG00000116251 0.9999646 -4.898687    1    1      1      1
ENSG00000116237 0.9999646 -5.108040    1    1      1      1
ENSG00000158292 0.9999646 -4.724366    1    1      1      1
ENSG00000097021 0.9999646 -4.479725    1    1      1      1
ENSG00000215788 0.9999646 -4.602288    1    1      1      1
ENSG00000171680 0.9999646 -4.557001    1    1      1      1
ENSG00000162408 0.9999646 -4.835509    1    1      1      1
ENSG00000204859 0.9999646 -4.317992    1    1      1      1
ENSG00000162413 0.9999646 -5.035995    1    1      1      1
ENSG00000116273 0.9999646 -4.820439    1    1      1      1
ENSG00000041988 0.9999646 -4.600853    1    1      1      1
ENSG00000007923 0.9999646 -4.888945    1    1      1      1
ENSG00000171735 0.9999646 -4.360991    1    1      1      1
ENSG00000049245 0.9999646 -5.010992    1    1      1      1
ENSG00000116288 0.9999646 -5.103873    1    1      1      1
ENSG00000116285 0.9999646 -4.517222    1    1      1      1
ENSG00000142599 0.9999646 -4.727613    1    1      1      1
ENSG00000074800 0.9999646 -5.061763    1    1      1      1
ENSG00000142583 0.9999646 -4.726798    1    1      1      1
ENSG00000180758 0.9999646 -4.710577    1    1      1      1
ENSG00000228526 0.9999646 -4.267636    1    1      1      1
ENSG00000049239 0.9999646 -5.084346    1    1      1      1
ENSG00000171621 0.9999646 -4.899347    1    1      1      1
ENSG00000171612 0.9999646 -4.384893    1    1      1      1
ENSG00000188807 0.9999646 -4.697743    1    1      1      1
ENSG00000171608 0.9999646 -4.832188    1    1      1      1
ENSG00000171603 0.9999646 -5.102654    1    1      1      1
ENSG00000178585 0.9999646 -4.898320    1    1      1      1
ENSG00000162441 0.9999646 -4.782462    1    1      1      1
ENSG00000173614 0.9999646 -4.578451    1    1      1      1
ENSG00000130939 0.9999646 -4.543618    1    1      1      1
ENSG00000054523 0.9999646 -5.091141    1    1      1      1
ENSG00000142657 0.9999646 -5.096390    1    1      1      1
ENSG00000160049 0.9999646 -5.047509    1    1      1      1
ENSG00000142655 0.9999646 -4.879099    1    1      1      1
ENSG00000120948 0.9999646 -5.010151    1    1      1      1
ENSG00000116649 0.9999646 -4.942417    1    1      1      1
ENSG00000171824 0.9999646 -4.591953    1    1      1      1
ENSG00000198793 0.9999646 -4.585973    1    1      1      1
ENSG00000171819 0.9999646 -5.032077    1    1      1      1
ENSG00000120942 0.9999646 -4.903628    1    1      1      1
ENSG00000116661 0.9999646 -4.719439    1    1      1      1
ENSG00000132879 0.9999646 -4.356587    1    1      1      1
ENSG00000116670 0.9999646 -4.862850    1    1      1      1
ENSG00000177674 0.9999646 -4.946124    1    1      1      1
ENSG00000177000 0.9999646 -4.925394    1    1      1      1
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ENSG00000279095 0.9999646 -4.650817    1    1      1      1
ENSG00000069399 0.9999646 -4.544131    1    1      1      1
ENSG00000130202 0.9999646 -5.105077    1    1      1      1
ENSG00000130204 0.9999646 -4.894075    1    1      1      1
ENSG00000130203 0.9999646 -4.857722    1    1      1      1
ENSG00000104853 0.9999646 -5.096289    1    1      1      1
ENSG00000104856 0.9999646 -4.494097    1    1      1      1
ENSG00000104859 0.9999646 -4.363331    1    1      1      1
ENSG00000142252 0.9999646 -4.830589    1    1      1      1
ENSG00000007047 0.9999646 -5.037570    1    1      1      1
ENSG00000104866 0.9999646 -4.907536    1    1      1      1
ENSG00000007255 0.9999646 -4.612117    1    1      1      1
ENSG00000189114 0.9999646 -4.555387    1    1      1      1
ENSG00000104884 0.9999646 -4.702589    1    1      1      1
ENSG00000104881 0.9999646 -4.732160    1    1      1      1
ENSG00000012061 0.9999646 -4.850692    1    1      1      1
ENSG00000125744 0.9999646 -4.736969    1    1      1      1
ENSG00000125753 0.9999646 -5.088685    1    1      1      1
ENSG00000125741 0.9999646 -4.987963    1    1      1      1
ENSG00000125746 0.9999646 -4.640657    1    1      1      1
ENSG00000125743 0.9999646 -5.031906    1    1      1      1
ENSG00000011478 0.9999646 -4.886999    1    1      1      1
ENSG00000177051 0.9999646 -4.730789    1    1      1      1
ENSG00000177045 0.9999646 -4.660911    1    1      1      1
ENSG00000104936 0.9999646 -4.303248    1    1      1      1
ENSG00000185800 0.9999646 -4.395750    1    1      1      1
ENSG00000125755 0.9999646 -4.906435    1    1      1      1
ENSG00000170604 0.9999646 -4.681281    1    1      1      1
ENSG00000176182 0.9999646 -4.856020    1    1      1      1
ENSG00000188624 0.9999646 -4.647797    1    1      1      1
ENSG00000204866 0.9999646 -4.772412    1    1      1      1
ENSG00000124440 0.9999646 -4.824813    1    1      1      1
ENSG00000011485 0.9999646 -5.026350    1    1      1      1
ENSG00000169515 0.9999646 -4.662672    1    1      1      1
ENSG00000182013 0.9999646 -4.909430    1    1      1      1
ENSG00000160014 0.9999646 -5.069066    1    1      1      1
ENSG00000197380 0.9999646 -4.597114    1    1      1      1
ENSG00000105287 0.9999646 -4.853841    1    1      1      1
ENSG00000090372 0.9999646 -4.518596    1    1      1      1
ENSG00000181027 0.9999646 -4.815458    1    1      1      1
ENSG00000105281 0.9999646 -5.068658    1    1      1      1
ENSG00000042753 0.9999646 -4.419481    1    1      1      1
ENSG00000160007 0.9999646 -4.175418    1    1      1      1
ENSG00000130751 0.9999646 -4.611065    1    1      1      1
ENSG00000130748 0.9999646 -4.595796    1    1      1      1
ENSG00000130749 0.9999646 -4.984692    1    1      1      1
ENSG00000142230 0.9999646 -5.041650    1    1      1      1
ENSG00000105327 0.9999646 -4.752570    1    1      1      1
ENSG00000105321 0.9999646 -4.892753    1    1      1      1
ENSG00000257704 0.9999646 -4.772759    1    1      1      1
ENSG00000134815 0.9999646 -4.746582    1    1      1      1
ENSG00000105419 0.9999646 -4.769008    1    1      1      1
ENSG00000105402 0.9999646 -5.044910    1    1      1      1
ENSG00000063169 0.9999646 -4.752507    1    1      1      1
ENSG00000024422 0.9999646 -4.740058    1    1      1      1
ENSG00000105373 0.9999646 -4.977955    1    1      1      1
ENSG00000178980 0.9999646 -4.988648    1    1      1      1
ENSG00000105499 0.9999646 -4.665050    1    1      1      1
ENSG00000105486 0.9999646 -4.145383    1    1      1      1
ENSG00000185453 0.9999646 -4.753576    1    1      1      1
ENSG00000105483 0.9999646 -4.820765    1    1      1      1
ENSG00000142227 0.9999646 -4.710374    1    1      1      1
ENSG00000105438 0.9999646 -5.048668    1    1      1      1
ENSG00000105464 0.9999646 -4.685779    1    1      1      1
ENSG00000105447 0.9999646 -4.956845    1    1      1      1
ENSG00000105443 0.9999646 -4.147946    1    1      1      1
ENSG00000063177 0.9999646 -4.977081    1    1      1      1
ENSG00000063176 0.9999646 -4.849960    1    1      1      1
ENSG00000105552 0.9999646 -4.785406    1    1      1      1
ENSG00000087076 0.9999646 -4.896921    1    1      1      1
ENSG00000087074 0.9999646 -4.703935    1    1      1      1
ENSG00000104805 0.9999646 -5.075906    1    1      1      1
ENSG00000087088 0.9999646 -4.226260    1    1      1      1
ENSG00000087086 0.9999646 -4.945200    1    1      1      1
ENSG00000104812 0.9999646 -5.015275    1    1      1      1
ENSG00000183207 0.9999646 -5.047929    1    1      1      1
ENSG00000104852 0.9999646 -4.207392    1    1      1      1
ENSG00000104863 0.9999646 -4.670470    1    1      1      1
ENSG00000177380 0.9999646 -4.498748    1    1      1      1
ENSG00000130529 0.9999646 -4.273387    1    1      1      1
ENSG00000074219 0.9999646 -4.478135    1    1      1      1
ENSG00000104872 0.9999646 -3.826956    1    1      1      1
ENSG00000161618 0.9999646 -4.644284    1    1      1      1
ENSG00000142541 0.9999646 -5.051982    1    1      1      1
ENSG00000142534 0.9999646 -5.056548    1    1      1      1
ENSG00000104870 0.9999646 -4.145836    1    1      1      1
ENSG00000142552 0.9999646 -5.066332    1    1      1      1
ENSG00000142546 0.9999646 -5.008096    1    1      1      1
ENSG00000126464 0.9999646 -4.986199    1    1      1      1
ENSG00000126458 0.9999646 -5.093369    1    1      1      1
ENSG00000126461 0.9999646 -5.063386    1    1      1      1
ENSG00000126456 0.9999646 -4.988679    1    1      1      1
ENSG00000126453 0.9999646 -4.726466    1    1      1      1
ENSG00000126457 0.9999646 -5.039957    1    1      1      1
ENSG00000196961 0.9999646 -5.106536    1    1      1      1
ENSG00000010361 0.9999646 -4.698921    1    1      1      1
ENSG00000104973 0.9999646 -4.944868    1    1      1      1
ENSG00000104960 0.9999646 -5.007519    1    1      1      1
ENSG00000039650 0.9999646 -4.733069    1    1      1      1
ENSG00000204673 0.9999646 -5.054122    1    1      1      1
ENSG00000104946 0.9999646 -5.015809    1    1      1      1
ENSG00000213024 0.9999646 -5.013378    1    1      1      1
ENSG00000169136 0.9999646 -4.732669    1    1      1      1
ENSG00000105053 0.9999646 -4.918333    1    1      1      1
ENSG00000142528 0.9999646 -4.471427    1    1      1      1
ENSG00000131408 0.9999646 -4.683306    1    1      1      1
ENSG00000062822 0.9999646 -4.545749    1    1      1      1
ENSG00000161671 0.9999646 -4.749504    1    1      1      1
ENSG00000161677 0.9999646 -4.945371    1    1      1      1
ENSG00000167747 0.9999646 -4.895900    1    1      1      1
ENSG00000142544 0.9999646 -4.718691    1    1      1      1
ENSG00000105379 0.9999646 -4.741089    1    1      1      1
ENSG00000105497 0.9999646 -4.809188    1    1      1      1
ENSG00000182310 0.9999646 -4.647299    1    1      1      1
ENSG00000198093 0.9999646 -4.689173    1    1      1      1
ENSG00000176024 0.9999646 -4.718310    1    1      1      1
ENSG00000256683 0.9999646 -4.621113    1    1      1      1
ENSG00000197619 0.9999646 -4.635054    1    1      1      1
ENSG00000142556 0.9999646 -4.817349    1    1      1      1
ENSG00000256087 0.9999646 -4.553309    1    1      1      1
ENSG00000197608 0.9999646 -4.300895    1    1      1      1
ENSG00000204611 0.9999646 -4.632714    1    1      1      1
ENSG00000105568 0.9999646 -4.851016    1    1      1      1
ENSG00000196214 0.9999646 -4.752216    1    1      1      1
ENSG00000198464 0.9999646 -4.495731    1    1      1      1
ENSG00000167554 0.9999646 -4.664998    1    1      1      1
ENSG00000221923 0.9999646 -4.628869    1    1      1      1
ENSG00000167555 0.9999646 -4.617677    1    1      1      1
ENSG00000167766 0.9999646 -4.859239    1    1      1      1
ENSG00000213020 0.9999646 -4.730353    1    1      1      1
ENSG00000189190 0.9999646 -4.686472    1    1      1      1
ENSG00000198538 0.9999646 -4.593603    1    1      1      1
ENSG00000204604 0.9999646 -4.721688    1    1      1      1
ENSG00000213793 0.9999646 -4.558579    1    1      1      1
ENSG00000180257 0.9999646 -4.798446    1    1      1      1
ENSG00000242779 0.9999646 -4.950105    1    1      1      1
ENSG00000170949 0.9999646 -4.159036    1    1      1      1
 [ reached 'max' / getOption("max.print") -- omitted 448 rows ]

[[11]]
                        logFC      AveExpr             t      P.Value
ENSG00000225972 -2.062813e-01  3.439734306 -7.968613e-01 4.371140e-01
ENSG00000225630 -1.579456e-01  5.259763521 -1.093937e+00 2.900637e-01
ENSG00000237973 -3.427893e-01  5.765427761 -2.597438e+00 1.935984e-02
ENSG00000248527 -2.431981e-01  7.291375670 -1.593777e+00 1.304067e-01
ENSG00000198744  1.223492e-01  1.692163426  8.843696e-01 3.894998e-01
ENSG00000228794 -2.844346e-02  2.429990051 -1.503906e-01 8.823226e-01
ENSG00000223764 -1.484227e-02  1.604113326 -6.415398e-02 9.496366e-01
ENSG00000187634  1.562791e-01  2.774428967  9.623578e-01 3.500878e-01
ENSG00000188976  3.485969e-02  5.602324306  3.950751e-01 6.979673e-01
ENSG00000187961  2.745835e-01  3.205023751  1.890268e+00 7.684332e-02
ENSG00000187608  2.403950e-01  3.515541854  1.339219e+00 1.990819e-01
ENSG00000188157  1.991143e-01  8.438003633  1.564796e+00 1.370523e-01
ENSG00000131591  2.147105e-01  2.698849622  1.439257e+00 1.692175e-01
ENSG00000078808  9.709187e-02  8.404430472  1.115342e+00 2.810591e-01
ENSG00000176022  1.746320e-01  5.315643527  1.541749e+00 1.425394e-01
ENSG00000160087 -1.207632e-02  5.574117382 -1.602312e-01 8.746900e-01
ENSG00000131584  1.331853e-01  5.338644789  1.304019e+00 2.105455e-01
ENSG00000169972  4.608736e-02  3.649507997  4.204368e-01 6.797188e-01
ENSG00000127054  6.799109e-02  5.813712471  9.730258e-01 3.449192e-01
ENSG00000224051 -1.500716e-02  4.433660580 -1.312551e-01 8.971980e-01
ENSG00000107404  1.264389e-01  5.541314411  1.068110e+00 3.012095e-01
ENSG00000162576  1.824176e-01  5.643016003  1.420777e+00 1.744404e-01
ENSG00000175756  5.616559e-02  5.949578662  8.638322e-01 4.003540e-01
ENSG00000221978  1.444939e-01  6.117640537  9.423921e-01 3.599050e-01
ENSG00000224870  6.974735e-02  4.193043833  5.940572e-01 5.607208e-01
ENSG00000242485 -3.466007e-02  5.474356677 -4.207007e-01 6.795299e-01
ENSG00000160072  3.952831e-02  4.020742816  3.834583e-01 7.063911e-01
ENSG00000197785  1.072823e-01  4.667370310  1.011342e+00 3.267963e-01
ENSG00000160075 -1.644480e-02  6.698987873 -2.466040e-01 8.083283e-01
ENSG00000228594  1.733650e-01  3.231082811  1.114502e+00 2.814087e-01
ENSG00000197530  2.172745e-01  6.011139637  1.711841e+00 1.060981e-01
ENSG00000189409  1.116679e-01  4.590321361  7.977088e-01 4.366359e-01
ENSG00000248333 -2.602572e-02  3.904469734 -2.056393e-01 8.396477e-01
ENSG00000189339  5.616034e-02  5.329578573  7.279983e-01 4.770593e-01
ENSG00000008130  2.895002e-02  5.472226379  4.119645e-01 6.857927e-01
ENSG00000078369  2.403209e-03  8.804321589  4.229427e-02 9.667837e-01
ENSG00000162585  1.535415e-01  4.754428869  1.263038e+00 2.245434e-01
ENSG00000157933 -3.745027e-02  6.562145698 -5.307189e-01 6.028507e-01
ENSG00000157916 -7.806702e-02  7.002652621 -1.327706e+00 2.027750e-01
ENSG00000157911  5.888193e-02  3.826112744  4.137943e-01 6.844789e-01
ENSG00000157881  2.593368e-02  4.048444809  2.769122e-01 7.853676e-01
ENSG00000157870  2.238842e-01  3.237377913  1.588170e+00 1.316706e-01
ENSG00000158109  1.664388e-02  6.732297019  2.352622e-01 8.169685e-01
ENSG00000116213  3.431137e-03  4.048572327  3.549222e-02 9.721231e-01
ENSG00000227372  9.149413e-02  3.931432132  9.579270e-01 3.522502e-01
ENSG00000130764  1.625488e-01  5.498222486  2.177867e+00 4.460721e-02
ENSG00000116198 -5.681042e-02  4.799410870 -6.222722e-01 5.424673e-01
ENSG00000198912 -1.107634e-02  4.517142545 -1.223188e-01 9.041588e-01
ENSG00000131697  4.797675e-02  3.217207294  4.191936e-01 6.806086e-01
ENSG00000116251 -4.252725e-02  6.491595851 -4.980316e-01 6.251891e-01
ENSG00000116237  3.212812e-02  7.144503644  5.008113e-01 6.232743e-01
ENSG00000158292 -1.728661e-01  2.850382649 -1.125811e+00 2.767316e-01
ENSG00000097021  5.457077e-03  4.963811963  2.799774e-02 9.780077e-01
ENSG00000215788  1.737910e-01  2.224832337  6.489362e-01 5.255198e-01
ENSG00000171680  3.203473e-01  4.816276482  2.040350e+00 5.805110e-02
ENSG00000162408  8.281877e-02  3.954485497  6.489471e-01 5.255130e-01
ENSG00000204859 -3.108271e-02  3.319571732 -2.195793e-01 8.289557e-01
ENSG00000162413  6.246043e-02  6.835844141  8.400598e-01 4.131640e-01
ENSG00000116273 -7.902624e-03  5.018894856 -7.630722e-02 9.401139e-01
ENSG00000041988 -5.386233e-02  3.387269004 -4.396118e-01 6.660561e-01
ENSG00000007923 -5.460850e-02  5.116929638 -5.139708e-01 6.142473e-01
ENSG00000171735 -1.517858e-01  3.971476593 -9.808430e-01 3.411658e-01
ENSG00000049245  2.999591e-02  6.747961733  4.816067e-01 6.365597e-01
ENSG00000116288 -1.650136e-02  7.469041111 -2.450949e-01 8.094764e-01
ENSG00000116285 -2.754736e-01  6.567378923 -1.255495e+00 2.271977e-01
ENSG00000142599 -1.661645e-01  6.882232369 -1.401565e+00 1.800090e-01
ENSG00000074800  9.274522e-02  9.240103588  1.208209e+00 2.443972e-01
ENSG00000142583  2.165000e-01  2.154021950  8.203568e-01 4.239806e-01
ENSG00000180758  2.165517e-01  2.520571933  1.767494e+00 9.607110e-02
ENSG00000228526 -4.938165e-02  3.111024724 -1.996043e-01 8.442868e-01
ENSG00000049239 -5.765884e-02  5.843277506 -4.756816e-01 6.406848e-01
ENSG00000171621  2.272511e-02  7.640791271  2.095401e-01 8.366525e-01
ENSG00000171612 -1.134130e-01  2.962339532 -6.975571e-01 4.953953e-01
ENSG00000188807  2.346959e-01  3.161234025  1.933039e+00 7.099765e-02
ENSG00000171608  7.876737e-02  3.600417471  5.128284e-01 6.150285e-01
ENSG00000171603  3.596870e-02  7.507456408  4.353551e-01 6.690789e-01
ENSG00000178585  9.512618e-02  4.096458428  9.043520e-01 3.791290e-01
ENSG00000162441  7.914428e-02  4.190251149  7.273992e-01 4.774162e-01
ENSG00000173614 -2.406453e-01  3.790237230 -1.936910e+00 7.048870e-02
ENSG00000130939  3.674584e-03  6.013665524  4.519394e-02 9.645080e-01
ENSG00000054523 -5.625434e-02  6.790885629 -8.750233e-01 3.944149e-01
ENSG00000142657  1.052333e-01  6.764910548  1.602771e+00 1.284008e-01
ENSG00000160049 -7.310957e-03  5.436360887 -1.126768e-01 9.116783e-01
ENSG00000142655  1.114166e-01  3.921860299  1.134266e+00 2.732729e-01
ENSG00000120948  1.098877e-01  5.498744258  1.686245e+00 1.110072e-01
ENSG00000116649 -1.138305e-02  6.989287261 -1.072394e-01 9.159227e-01
ENSG00000171824 -4.234751e-03  5.208139078 -5.313637e-02 9.582763e-01
ENSG00000198793  4.970222e-02  6.572268484  5.858498e-01 5.660911e-01
ENSG00000171819  6.654346e-02  5.005029463  2.697175e-01 7.908005e-01
ENSG00000120942 -2.073617e-02  4.505427589 -2.299473e-01 8.210259e-01
ENSG00000116661  2.134860e-01  2.256655281  1.077116e+00 2.972879e-01
ENSG00000132879  2.329408e-01  2.851964046  2.041235e+00 5.795390e-02
ENSG00000116670  1.108101e-01  3.776766362  9.698012e-01 3.464759e-01
ENSG00000177674  1.351131e-01  4.748151475  1.558888e+00 1.384415e-01
ENSG00000177000  7.838023e-03  4.306535766  7.717380e-02 9.394353e-01
ENSG00000011021  9.680887e-02  4.716053644  1.050136e+00 3.091481e-01
ENSG00000116685  1.317739e-01  5.360029702  1.603308e+00 1.282820e-01
ENSG00000083444  3.309219e-02  9.617689757  3.609613e-01 7.228163e-01
ENSG00000116688  2.288649e-02  6.632063082  3.311507e-01 7.447973e-01
ENSG00000116691 -3.500758e-02  3.486834952 -3.673943e-01 7.181048e-01
ENSG00000048707 -7.478023e-02  5.830304323 -1.015833e+00 3.247172e-01
ENSG00000162496  2.015462e-01  3.119770104  1.231733e+00 2.357191e-01
ENSG00000162494 -4.337203e-01  1.522400198 -2.113296e+00 5.051703e-02
ENSG00000162493 -1.497727e-01  9.669928769 -1.796606e+00 9.116406e-02
ENSG00000116731 -3.217469e-02  5.589398806 -4.778187e-01 6.391955e-01
ENSG00000189337 -4.081795e-02  3.000052029 -2.165741e-01 8.312579e-01
ENSG00000171729 -4.462739e-02  3.118331547 -1.966620e-01 8.465506e-01
ENSG00000142634 -7.707314e-02  4.068304279 -4.931798e-01 6.285379e-01
ENSG00000132906  5.436244e-02  3.641839894  4.727015e-01 6.427642e-01
ENSG00000116138  2.720895e-02  5.209789620  3.268065e-01 7.480202e-01
ENSG00000197312 -2.031277e-01  5.118656021 -2.281105e+00 3.647043e-02
ENSG00000116786  3.087438e-02  6.306994840  4.780756e-01 6.390166e-01
ENSG00000162458 -2.453747e-02  7.121657904 -2.024929e-01 8.420656e-01
ENSG00000065526 -7.504949e-02  5.499653620 -1.077556e+00 2.970974e-01
ENSG00000116809  2.433063e-01  4.245851773  2.310111e+00 3.444633e-02
ENSG00000173641 -2.406624e-01  5.013884293 -1.300586e+00 2.116908e-01
ENSG00000142627  6.711312e-02  6.565606623  5.063833e-01 6.194444e-01
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ENSG00000278318 -1.684600e-01  0.979126751 -1.361725e+00 1.920177e-01
ENSG00000167384  3.926050e-02  2.427775316  2.563626e-01 8.009146e-01
ENSG00000073008  2.668956e-02  6.628771200  3.935653e-01 6.990598e-01
ENSG00000279095 -1.377288e-02  2.586428111 -8.185373e-02 9.357710e-01
ENSG00000069399  5.218814e-01  3.339772580  3.496282e+00 2.959279e-03
ENSG00000130202  1.947879e-02  6.894434617  2.036381e-01 8.411853e-01
ENSG00000130204  6.834098e-02  4.659605433  6.938279e-01 4.976695e-01
ENSG00000130203  7.903727e-02  3.143686136  4.709800e-01 6.439669e-01
ENSG00000104853  1.574920e-02  6.993213285  2.173698e-01 8.306482e-01
ENSG00000104856 -1.940087e-01  2.766145266 -7.580625e-01 4.593558e-01
ENSG00000104859  4.343074e-02  4.072995944  4.367418e-01 6.680935e-01
ENSG00000142252 -1.065522e-02  3.467358598 -1.073147e-01 9.158639e-01
ENSG00000007047  3.111919e-02  5.363544183  2.866603e-01 7.780249e-01
ENSG00000104866  1.019097e-01  4.825681576  9.735966e-01 3.446441e-01
ENSG00000007255  2.445507e-01  2.891837829  1.235907e+00 2.342045e-01
ENSG00000189114 -5.704716e-02  4.089487234 -5.670577e-01 5.784882e-01
ENSG00000104884  4.275923e-02  4.719206848  3.438843e-01 7.353790e-01
ENSG00000104881  5.662244e-03  4.899760551  3.879544e-02 9.695300e-01
ENSG00000012061 -1.472379e-01  5.266235979 -1.327058e+00 2.029846e-01
ENSG00000125744  1.757760e-03  3.270864718  1.459496e-02 9.885345e-01
ENSG00000125753 -2.284557e-02  6.542329712 -2.161108e-01 8.316130e-01
ENSG00000125741 -1.833352e-02  5.027972167 -2.225790e-01 8.266594e-01
ENSG00000125746  6.842313e-03  4.067216554  7.331907e-02 9.424545e-01
ENSG00000125743 -1.048878e-01  6.918742564 -1.430776e+00 1.715982e-01
ENSG00000011478  6.496225e-02  5.400119293  8.672543e-01 3.985316e-01
ENSG00000177051  4.391583e-02  2.991101820  2.723665e-01 7.887989e-01
ENSG00000177045  3.783068e-01  3.224570072  1.817333e+00 8.780610e-02
ENSG00000104936  1.736511e-01  5.370633599  1.890349e+00 7.683183e-02
ENSG00000185800  1.274370e-01  5.023702953  1.287245e+00 2.161892e-01
ENSG00000125755  1.315033e-01  6.003761254  1.481377e+00 1.577925e-01
ENSG00000170604  7.002524e-02  4.613920159  4.246050e-01 6.767388e-01
ENSG00000176182  5.751388e-02  3.618458128  4.654277e-01 6.478525e-01
ENSG00000188624  2.838200e-01  2.451040156  1.952247e+00 6.850469e-02
ENSG00000204866  9.176680e-02  6.246041858  9.012372e-01 3.807332e-01
ENSG00000124440 -7.731658e-02  3.202673522 -4.294210e-01 6.733025e-01
ENSG00000011485 -1.567618e-01  5.531932188 -1.583280e+00 1.327816e-01
ENSG00000169515  1.319402e-01  6.217376588  1.401880e+00 1.799166e-01
ENSG00000182013  1.258815e-03  4.098389913  1.134540e-02 9.910871e-01
ENSG00000160014  1.825858e-02  6.669841601  2.782166e-01 7.843839e-01
ENSG00000197380  3.156457e-01  1.871194780  1.352938e+00 1.947514e-01
ENSG00000105287 -9.882031e-02  3.771143271 -7.234789e-01 4.797556e-01
ENSG00000090372  6.043316e-02  5.820892491  7.338612e-01 4.735750e-01
ENSG00000181027  9.075127e-02  4.641894417  7.702409e-01 4.523005e-01
ENSG00000105281  2.615462e-02  7.857433925  3.428357e-01 7.361529e-01
ENSG00000042753 -3.200671e-02  7.434923049 -4.998863e-01 6.239111e-01
ENSG00000160007  1.904094e-02  6.288965066  2.591721e-01 7.987837e-01
ENSG00000130751  2.750847e-01  1.595824281  8.689163e-01 3.976486e-01
ENSG00000130748  3.371120e-01  3.344774900  1.988065e+00 6.406535e-02
ENSG00000130749 -3.351755e-02  4.763281284 -2.527368e-01 8.036668e-01
ENSG00000142230 -1.959728e-02  6.729612621 -2.802756e-01 7.828318e-01
ENSG00000105327  1.948407e-01  3.801955028  1.327619e+00 2.028032e-01
ENSG00000105321  9.387848e-02  4.678268012  8.880875e-01 3.875561e-01
ENSG00000257704  1.485598e-01  3.298874371  8.717602e-01 3.961406e-01
ENSG00000134815  9.793041e-02  3.693557527  7.737966e-01 4.502533e-01
ENSG00000105419  1.944899e-01  4.933703137  1.996036e+00 6.311348e-02
ENSG00000105402 -3.509999e-03  5.408501710 -3.599910e-02 9.717252e-01
ENSG00000063169  6.269048e-02  3.327719514  3.947098e-01 6.982316e-01
ENSG00000024422 -7.058970e-02  8.032530303 -6.576690e-01 5.200344e-01
ENSG00000105373  9.528716e-04  5.891610812  1.324959e-02 9.895913e-01
ENSG00000178980  4.503409e-03  7.035800120  5.853140e-02 9.540449e-01
ENSG00000105499 -2.196779e-03  1.927616636 -9.154586e-03 9.928082e-01
ENSG00000105486  2.832343e-01  3.002420359  1.747426e+00 9.958705e-02
ENSG00000185453  1.826445e-01  2.708174192  1.323504e+00 2.041366e-01
ENSG00000105483  5.904341e-02  3.977034748  6.747993e-01 5.093687e-01
ENSG00000142227 -4.478493e-02  5.980823546 -3.865146e-01 7.041710e-01
ENSG00000105438 -1.672522e-02  8.088896974 -2.481210e-01 8.071746e-01
ENSG00000105464 -2.178903e-02  1.667123160 -1.321007e-01 8.965398e-01
ENSG00000105447 -5.163345e-02  4.746674892 -5.958021e-01 5.595825e-01
ENSG00000105443  1.791365e-01  5.536496313  1.612353e+00 1.262927e-01
ENSG00000063177  5.168998e-02  8.145714965  6.410970e-01 5.304714e-01
ENSG00000063176 -1.556378e-02  4.421560402 -1.280323e-01 8.997074e-01
ENSG00000105552  4.843294e-02  3.944928364  4.968249e-01 6.260212e-01
ENSG00000087076 -1.094911e-03  4.966516712 -8.451363e-03 9.933606e-01
ENSG00000087074 -2.556687e-02  6.783914463 -2.374844e-01 8.152737e-01
ENSG00000104805  7.910012e-02  7.906149214  8.134207e-01 4.278312e-01
ENSG00000087088  2.694500e-01  6.436261320  2.631115e+00 1.807554e-02
ENSG00000087086  8.911156e-02 12.058941043  1.001463e+00 3.314032e-01
ENSG00000104812  8.524824e-02  5.554919935  1.250744e+00 2.288818e-01
ENSG00000183207  2.280460e-02  5.649854617  2.376776e-01 8.151264e-01
ENSG00000104852  1.865624e-01  6.570625396  1.694944e+00 1.093171e-01
ENSG00000104863  2.243790e-01  2.860985462  1.560019e+00 1.381748e-01
ENSG00000177380  3.934315e-01  2.904772987  2.598878e+00 1.930318e-02
ENSG00000130529  6.986503e-02  3.954710118  4.319463e-01 6.715037e-01
ENSG00000074219  1.556818e-01  4.784127661  1.677648e+00 1.126994e-01
ENSG00000104872  3.348059e-02  5.215611657  3.531052e-01 7.285857e-01
ENSG00000161618  1.158232e-01  4.073193668  7.863066e-01 4.430965e-01
ENSG00000142541 -1.261682e-02  8.798495572 -1.695704e-01 8.674582e-01
ENSG00000142534 -5.516253e-02  9.214561396 -6.082012e-01 5.515298e-01
ENSG00000104870  1.031474e-01  5.305007871  1.009117e+00 3.278300e-01
ENSG00000142552 -3.033763e-03  6.302870351 -3.088083e-02 9.757438e-01
ENSG00000142546 -1.125937e-01  5.367518939 -1.439740e+00 1.690827e-01
ENSG00000126464  1.038345e-01  4.885551572  8.993223e-01 3.817217e-01
ENSG00000126458  5.559530e-02  6.339176461  8.201837e-01 4.240764e-01
ENSG00000126461  1.550978e-01  6.133402435  1.131039e+00 2.745890e-01
ENSG00000126456  5.262915e-02  4.969957329  5.675008e-01 5.781943e-01
ENSG00000126453 -1.278543e-01  2.842914353 -8.727072e-01 3.956392e-01
ENSG00000126457 -1.391611e-02  6.324574391 -1.617754e-01 8.734935e-01
ENSG00000196961  6.403957e-02  6.862993870  6.539684e-01 5.223549e-01
ENSG00000010361  6.642158e-02  2.746988061  3.875413e-01 7.034258e-01
ENSG00000104973 -5.332447e-02  4.644685303 -4.168653e-01 6.822764e-01
ENSG00000104960  9.642665e-02  5.126602512  1.088247e+00 2.924927e-01
ENSG00000039650  1.929541e-02  4.318555072  1.886367e-01 8.527325e-01
ENSG00000204673  1.000342e-01  6.615684364  1.051337e+00 3.086132e-01
ENSG00000104946  9.933460e-02  5.142717077  1.033027e+00 3.168450e-01
ENSG00000213024  9.349429e-02  5.178261322  1.314441e+00 2.070979e-01
ENSG00000169136  1.685658e-01  3.340949893  1.425770e+00 1.730164e-01
ENSG00000105053 -3.043226e-02  4.303539969 -2.459593e-01 8.088187e-01
ENSG00000142528 -9.568706e-02  3.054946621 -6.894014e-01 5.003770e-01
ENSG00000131408  2.374984e-01  5.748430698  2.944010e+00 9.472148e-03
ENSG00000062822  1.964351e-01  3.000646471  1.347694e+00 1.963976e-01
ENSG00000161671  1.251079e-01  6.833897974  1.479401e+00 1.583137e-01
ENSG00000161677  1.503106e-01  4.863914065  1.524760e+00 1.467014e-01
ENSG00000167747  1.143297e-01  4.345002868  1.036649e+00 3.152041e-01
ENSG00000142544  3.381991e-01  2.311663930  1.231436e+00 2.358271e-01
ENSG00000105379 -6.932273e-02  3.407808788 -4.713594e-01 6.437017e-01
ENSG00000105497  5.674069e-03  3.196139230  5.059379e-02 9.602710e-01
ENSG00000182310  8.230159e-02  2.485832085  5.365572e-01 5.989026e-01
ENSG00000198093 -2.410902e-01  2.053797321 -1.412125e+00 1.769304e-01
ENSG00000176024  1.943566e-01  2.592669391  1.535314e+00 1.441040e-01
ENSG00000256683 -2.641410e-01  2.455207926 -1.890706e+00 7.678125e-02
ENSG00000197619 -8.191555e-02  2.482955439 -3.576203e-01 7.252678e-01
ENSG00000142556 -7.822893e-02  3.382865635 -6.097679e-01 5.505167e-01
ENSG00000256087  6.244081e-02  4.021520586  4.102505e-01 6.870242e-01
ENSG00000197608  1.715010e-01  4.006239358  1.458626e+00 1.638816e-01
ENSG00000204611 -4.440526e-02  3.850670783 -4.041174e-01 6.914384e-01
ENSG00000105568  3.437991e-02  7.439852649  4.027451e-01 6.924276e-01
ENSG00000196214 -6.490260e-02  3.198031676 -5.822126e-01 5.684796e-01
ENSG00000198464  5.043357e-02  3.424444091  3.825927e-01 7.070204e-01
ENSG00000167554 -1.246502e-01  2.135684048 -7.470227e-01 4.658094e-01
ENSG00000221923 -2.376670e-01  2.348356875 -1.592612e+00 1.306685e-01
ENSG00000167555 -3.769011e-02  2.377642494 -2.399521e-01 8.133927e-01
ENSG00000167766 -6.935445e-02  3.897495780 -5.937140e-01 5.609448e-01
ENSG00000213020  1.754035e-02  2.480214607  1.258655e-01 9.013952e-01
ENSG00000189190  3.256262e-01  1.940346670  1.678098e+00 1.126103e-01
ENSG00000198538 -1.131020e-01  3.912907898 -8.410969e-01 4.125997e-01
ENSG00000204604 -1.068317e-01  4.547968222 -7.686167e-01 4.532376e-01
ENSG00000213793  2.348110e-02  3.335171849  1.669429e-01 8.694916e-01
ENSG00000180257  4.601416e-02  3.077122991  3.851676e-01 7.051491e-01
ENSG00000242779 -9.536143e-02  4.041796100 -1.050610e+00 3.089368e-01
ENSG00000170949  6.085996e-02  4.027401106  6.968147e-01 4.958475e-01
                adj.P.Val          B      lfsr      lfdr    qvalue
ENSG00000225972 0.9988697 -4.7556698 0.9999658 0.9999532 0.9998023
ENSG00000225630 0.9988697 -4.6751535 0.9999632 0.9999565 0.9998240
ENSG00000237973 0.9988697 -3.4275354 0.9997019 0.9996975 0.9978198
ENSG00000248527 0.9988697 -4.3248057 0.9999284 0.9999224 0.9996087
ENSG00000198744 0.9988697 -4.6636194 0.9999722 0.9999652 0.9998687
ENSG00000228794 0.9988697 -4.7249782 0.9999826 0.9999686 0.9998850
ENSG00000223764 0.9988697 -4.7079583 0.9999812 0.9999640 0.9998627
ENSG00000187634 0.9988697 -4.6364752 0.9999661 0.9999582 0.9998324
ENSG00000188976 0.9988697 -4.9998747 0.9999892 0.9999834 0.9999356
ENSG00000187961 0.9988697 -4.2671574 0.9998938 0.9998885 0.9994126
ENSG00000187608 0.9988697 -4.5023427 0.9999458 0.9999383 0.9997128
ENSG00000188157 0.9988697 -4.3484778 0.9999361 0.9999311 0.9996671
ENSG00000131591 0.9988697 -4.4859956 0.9999419 0.9999358 0.9996995
ENSG00000078808 0.9988697 -4.6876281 0.9999756 0.9999716 0.9998974
ENSG00000176022 0.9988697 -4.3658485 0.9999430 0.9999384 0.9997134
ENSG00000160087 0.9988697 -5.0391015 0.9999926 0.9999868 0.9999425
ENSG00000131584 0.9988697 -4.5403688 0.9999631 0.9999587 0.9998353
ENSG00000169972 0.9988697 -4.8124697 0.9999863 0.9999792 0.9999242
ENSG00000127054 0.9988697 -4.7699176 0.9999837 0.9999803 0.9999270
ENSG00000224051 0.9988697 -4.9307464 0.9999890 0.9999801 0.9999265
ENSG00000107404 0.9988697 -4.7000345 0.9999694 0.9999639 0.9998617
ENSG00000162576 0.9988697 -4.4611026 0.9999477 0.9999424 0.9997377
ENSG00000175756 0.9988697 -4.8321211 0.9999867 0.9999834 0.9999356
ENSG00000221978 0.9988697 -4.7971345 0.9999680 0.9999605 0.9998452
ENSG00000224870 0.9988697 -4.8248243 0.9999826 0.9999757 0.9999132
ENSG00000242485 0.9988697 -4.9845914 0.9999897 0.9999844 0.9999378
ENSG00000160072 0.9988697 -4.8541580 0.9999876 0.9999808 0.9999283
ENSG00000197785 0.9988697 -4.6907996 0.9999742 0.9999691 0.9998874
ENSG00000160075 0.9988697 -5.0734495 0.9999929 0.9999881 0.9999442
ENSG00000228594 0.9988697 -4.5928390 0.9999605 0.9999534 0.9998034
ENSG00000197530 0.9988697 -4.2220070 0.9999209 0.9999160 0.9995753
ENSG00000189409 0.9988697 -4.7866573 0.9999746 0.9999672 0.9998784
ENSG00000248333 0.9988697 -4.8700517 0.9999871 0.9999778 0.9999194
ENSG00000189339 0.9988697 -4.8682518 0.9999866 0.9999824 0.9999329
ENSG00000008130 0.9988697 -4.9869846 0.9999913 0.9999867 0.9999423
ENSG00000078369 0.9988697 -5.0607060 0.9999949 0.9999902 0.9999455
ENSG00000162585 0.9988697 -4.5524658 0.9999595 0.9999542 0.9998081
ENSG00000157933 0.9988697 -4.9996716 0.9999901 0.9999858 0.9999409
ENSG00000157916 0.9988697 -4.5443906 0.9999778 0.9999753 0.9999116
ENSG00000157911 0.9988697 -4.8310285 0.9999827 0.9999735 0.9999051
ENSG00000157881 0.9988697 -4.8755390 0.9999898 0.9999831 0.9999348
ENSG00000157870 0.9988697 -4.4015611 0.9999306 0.9999251 0.9996241
ENSG00000158109 0.9988697 -5.0752671 0.9999925 0.9999874 0.9999435
ENSG00000116213 0.9988697 -4.8935121 0.9999914 0.9999833 0.9999352
ENSG00000227372 0.9988697 -4.6773456 0.9999782 0.9999735 0.9999051
ENSG00000130764 0.9988697 -3.8083848 0.9998855 0.9998829 0.9993784
ENSG00000116198 0.9988697 -4.8679113 0.9999859 0.9999807 0.9999281
ENSG00000198912 0.9988697 -4.9416971 0.9999914 0.9999842 0.9999375
ENSG00000131697 0.9988697 -4.7710856 0.9999857 0.9999784 0.9999213
ENSG00000116251 0.9988697 -5.0099443 0.9999884 0.9999832 0.9999349
ENSG00000116237 0.9988697 -5.0120439 0.9999913 0.9999873 0.9999434
ENSG00000158292 0.9988697 -4.5836408 0.9999603 0.9999533 0.9998028
ENSG00000097021 0.9988697 -4.9866317 0.9999838 0.9999682 0.9998830
ENSG00000215788 0.9988697 -4.6685682 0.9999693 0.9999555 0.9998170
ENSG00000171680 0.9988697 -3.9861524 0.9998716 0.9998660 0.9992556
ENSG00000162408 0.9988697 -4.7879552 0.9999800 0.9999728 0.9999025
ENSG00000204859 0.9988697 -4.8040514 0.9999855 0.9999752 0.9999113
ENSG00000162413 0.9988697 -4.8648307 0.9999853 0.9999814 0.9999302
ENSG00000116273 0.9988697 -4.9959511 0.9999905 0.9999820 0.9999319
ENSG00000041988 0.9988697 -4.7812317 0.9999845 0.9999767 0.9999162
ENSG00000007923 0.9988697 -4.9323407 0.9999854 0.9999789 0.9999233
ENSG00000171735 0.9988697 -4.6699700 0.9999663 0.9999589 0.9998359
ENSG00000049245 0.9988697 -5.0168864 0.9999917 0.9999878 0.9999439
ENSG00000116288 0.9988697 -5.0734283 0.9999928 0.9999880 0.9999441
ENSG00000116285 0.9988697 -4.5923458 0.9999496 0.9999403 0.9997230
ENSG00000142599 0.9988697 -4.4858616 0.9999519 0.9999469 0.9997634
ENSG00000074800 0.9988697 -4.6131120 0.9999755 0.9999721 0.9998997
ENSG00000142583 0.9988697 -4.6419235 0.9999650 0.9999524 0.9997973
ENSG00000180758 0.9988697 -4.3886672 0.9999155 0.9999109 0.9995442
ENSG00000228526 0.9988697 -4.7832151 0.9999786 0.9999620 0.9998528
ENSG00000049239 0.9988697 -4.9922368 0.9999841 0.9999765 0.9999157
ENSG00000171621 0.9988697 -5.0738506 0.9999889 0.9999808 0.9999286
ENSG00000171612 0.9988697 -4.7002333 0.9999745 0.9999656 0.9998703
ENSG00000188807 0.9988697 -4.2439117 0.9998913 0.9998869 0.9993999
ENSG00000171608 0.9988697 -4.7890797 0.9999797 0.9999704 0.9998927
ENSG00000171603 0.9988697 -5.0301047 0.9999895 0.9999842 0.9999374
ENSG00000178585 0.9988697 -4.7075975 0.9999776 0.9999723 0.9999006
ENSG00000162441 0.9988697 -4.7826072 0.9999812 0.9999753 0.9999117
ENSG00000173614 0.9988697 -4.1595827 0.9998897 0.9998852 0.9993921
ENSG00000130939 0.9988697 -5.0766280 0.9999927 0.9999859 0.9999411
ENSG00000054523 0.9988697 -4.8458515 0.9999867 0.9999835 0.9999356
ENSG00000142657 0.9988697 -4.3169658 0.9999623 0.9999597 0.9998410
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 [ reached 'max' / getOption("max.print") -- omitted 448 rows ]

[[12]]
                        logFC      AveExpr             t      P.Value
ENSG00000225972  7.184465e-01  3.439734306  2.8001391126 1.251162e-02
ENSG00000225630  2.556881e-01  5.259763521  1.2223723556 2.386482e-01
ENSG00000237973  2.828234e-01  5.765427761  1.6259618988 1.227989e-01
ENSG00000248527  3.654397e-01  7.291375670  1.9013020942 7.477469e-02
ENSG00000198744 -5.229600e-01  1.692163426 -0.8593654016 4.023849e-01
ENSG00000228794 -2.685819e-01  2.429990051 -1.0338345789 3.160481e-01
ENSG00000223764  2.208487e-01  1.604113326  0.7712055339 4.514291e-01
ENSG00000187634  6.335468e-03  2.774428967  0.0300042754 9.764216e-01
ENSG00000188976  1.274186e-01  5.602324306  1.1194965135 2.788736e-01
ENSG00000187961 -3.543970e-02  3.205023751 -0.1666425949 8.696652e-01
ENSG00000187608  4.903646e-01  3.515541854  2.1357284599 4.792241e-02
ENSG00000188157  3.308109e-01  8.438003633  2.0758993695 5.377924e-02
ENSG00000131591  4.499033e-02  2.698849622  0.2011298545 8.430421e-01
ENSG00000078808  8.432083e-02  8.404430472  0.7227303209 4.799100e-01
ENSG00000176022  4.939323e-02  5.315643527  0.3071623660 7.625415e-01
ENSG00000160087 -7.974216e-02  5.574117382 -0.7984740044 4.358763e-01
ENSG00000131584 -5.567335e-02  5.338644789 -0.4008365059 6.936551e-01
ENSG00000169972  6.293699e-02  3.649507997  0.4091599618 6.876555e-01
ENSG00000127054  9.054267e-02  5.813712471  0.9521302323 3.546965e-01
ENSG00000224051 -2.071206e-01  4.433660580 -1.4275433201 1.719741e-01
ENSG00000107404 -1.823149e-01  5.541314411 -1.1145099983 2.809448e-01
ENSG00000162576  2.803710e-01  5.643016003  1.5406326361 1.422607e-01
ENSG00000175756  1.317532e-01  5.949578662  1.5268767773 1.456289e-01
ENSG00000221978 -7.399060e-02  6.117640537 -0.3712595649 7.151423e-01
ENSG00000224870  2.265221e-01  4.193043833  1.3685521289 1.893858e-01
ENSG00000242485 -1.280256e-02  5.474356677 -0.1099774378 9.137465e-01
ENSG00000160072  5.058305e-02  4.020742816  0.3769759928 7.109694e-01
ENSG00000197785  2.044551e-01  4.667370310  1.4273714962 1.720229e-01
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ENSG00000189409  2.040662e-01  4.590321361  0.9020854080 3.799209e-01
ENSG00000248333  2.270171e-01  3.904469734  1.3366989051 1.993624e-01
ENSG00000189339  1.413689e-01  5.329578573  1.3445282597 1.968721e-01
ENSG00000008130  1.088553e-01  5.472226379  1.1385243216 2.710744e-01
ENSG00000078369 -4.362756e-02  8.804321589 -0.5870694216 5.650609e-01
ENSG00000162585  3.055515e-01  4.754428869  1.8767886959 7.824737e-02
ENSG00000157933 -1.848720e-02  6.562145698 -0.1939462501 8.485726e-01
ENSG00000157916 -5.716210e-02  7.002652621 -0.7174188555 4.830947e-01
ENSG00000157911  3.941156e-01  3.826112744  1.9737660941 6.529972e-02
ENSG00000157881 -9.662778e-02  4.048444809 -0.7434438056 4.676107e-01
ENSG00000157870  2.428724e-01  3.237377913  1.2051351790 2.450589e-01
ENSG00000158109 -3.366371e-02  6.732297019 -0.3663029637 7.187681e-01
ENSG00000116213 -1.738557e-01  4.048572327 -1.3394446752 1.984862e-01
ENSG00000227372  2.488627e-01  3.931432132  1.8972027486 7.534569e-02
ENSG00000130764  1.045934e-01  5.498222486  0.9471229030 3.571673e-01
ENSG00000116198 -1.298676e-02  4.799410870 -0.0996167987 9.218423e-01
ENSG00000198912 -9.647284e-03  4.517142545 -0.0729526323 9.427161e-01
ENSG00000131697  1.417354e-01  3.217207294  0.8582032120 4.030080e-01
ENSG00000116251 -1.031630e-01  6.491595851 -0.9393659784 3.610181e-01
ENSG00000116237 -7.959071e-03  7.144503644 -0.0937558268 9.264260e-01
ENSG00000158292 -1.961635e-01  2.850382649 -0.9229606187 3.692556e-01
ENSG00000097021 -5.519796e-01  4.963811963 -2.2234430020 4.038836e-02
ENSG00000215788  2.417255e-02  2.224832337  0.0725830818 9.430057e-01
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ENSG00000105552 -6.529473e-03  3.944928364 -0.0480206572 9.622731e-01
ENSG00000087076  3.437643e-01  4.966516712  1.8021309202 8.972129e-02
ENSG00000087074  9.128512e-02  6.783914463  0.6463904241 5.268674e-01
ENSG00000104805  2.641010e-01  7.906149214  2.1604833728 4.567478e-02
ENSG00000087088  4.018566e-01  6.436261320  3.0272931359 7.759584e-03
ENSG00000087086 -6.791740e-02 12.058941043 -0.5727145479 5.745178e-01
ENSG00000104812  2.672014e-02  5.554919935  0.2798586152 7.830450e-01
ENSG00000183207  2.875467e-01  5.649854617  2.4982004637 2.331801e-02
ENSG00000104852  2.224702e-01  6.570625396  1.5363974644 1.432907e-01
ENSG00000104863  2.277814e-01  2.860985462  1.1139952763 2.811592e-01
ENSG00000177380  4.676903e-01  2.904772987  2.1191607351 4.948289e-02
ENSG00000130529  2.306270e-01  3.954710118  1.0848888579 2.934835e-01
ENSG00000074219  1.507523e-01  4.784127661  1.1019861142 2.861970e-01
ENSG00000104872  2.613332e-02  5.215611657  0.2045203064 8.404347e-01
ENSG00000161618  2.319206e-01  4.073193668  1.1072261966 2.839907e-01
ENSG00000142541 -1.915731e-02  8.798495572 -0.1984053625 8.451386e-01
ENSG00000142534  1.266387e-02  9.214561396  0.1076294283 9.155804e-01
ENSG00000104870  9.263790e-02  5.305007871  0.6016043849 5.555693e-01
ENSG00000142552  2.243315e-01  6.302870351  1.7322587227 1.017736e-01
ENSG00000142546 -7.712513e-02  5.367518939 -0.7088273702 4.882725e-01
ENSG00000126464  2.449246e-01  4.885551572  1.5884029428 1.310675e-01
ENSG00000126458  1.213896e-01  6.339176461  1.3568604418 1.930001e-01
ENSG00000126461  3.119709e-01  6.133402435  1.7744030239 9.434569e-02
ENSG00000126456 -4.148368e-02  4.969957329 -0.3292476428 7.460882e-01
ENSG00000126453  3.254994e-01  2.842914353  1.5525405126 1.393979e-01
ENSG00000126457  2.024895e-01  6.324574391  1.9526993009 6.793655e-02
ENSG00000196961 -1.711452e-03  6.862993870 -0.0131837141 9.896385e-01
ENSG00000010361 -8.066968e-02  2.746988061 -0.3023642626 7.661319e-01
ENSG00000104973  2.196117e-01  4.644685303  1.2662763170 2.229043e-01
ENSG00000104960 -1.368297e-01  5.126602512 -1.1518172889 2.657235e-01
ENSG00000039650  8.751353e-02  4.318555072  0.6100494758 5.500938e-01
ENSG00000204673  9.174503e-03  6.615684364  0.0706565027 9.445158e-01
ENSG00000104946  1.307383e-01  5.142717077  0.9604039715 3.506399e-01
ENSG00000213024  1.995840e-01  5.178261322  2.1265035006 4.878563e-02
ENSG00000169136  7.572827e-02  3.340949893  0.4455191823 6.617029e-01
ENSG00000105053 -2.539656e-01  4.303539969 -1.5614722482 1.372826e-01
ENSG00000142528 -3.490665e-01  3.054946621 -1.9556175047 6.756567e-02
ENSG00000131408  4.872805e-02  5.748430698  0.3607373775 7.228476e-01
ENSG00000062822  2.085180e-01  3.000646471  0.9445441059 3.584443e-01
ENSG00000161671  1.177293e-01  6.833897974  1.0062823076 3.287307e-01
ENSG00000161677  6.615302e-02  4.863914065  0.4616201275 6.503483e-01
ENSG00000167747  3.262302e-01  4.345002868  2.1978468355 4.246543e-02
ENSG00000142544 -3.897445e-01  2.311663930 -1.1286290596 2.751097e-01
ENSG00000105379  4.859891e-01  3.407808788  2.5050506877 2.299550e-02
ENSG00000105497 -5.838850e-02  3.196139230 -0.3740864830 7.130775e-01
ENSG00000182310 -2.593904e-01  2.485832085 -1.2287513513 2.363087e-01
ENSG00000198093  5.671649e-03  2.053797321  0.0238733526 9.812384e-01
ENSG00000176024  2.980020e-01  2.592669391  1.5071694063 1.505703e-01
ENSG00000256683 -5.969336e-02  2.455207926 -0.2890043651 7.761579e-01
ENSG00000197619 -5.004519e-01  2.482955439 -1.7566795810 9.740971e-02
ENSG00000142556 -2.520392e-01  3.382865635 -1.5004707955 1.522814e-01
ENSG00000256087  2.120414e-02  4.021520586  0.1043190301 9.181668e-01
ENSG00000197608 -1.221912e-01  4.006239358 -0.7686735287 4.528904e-01
ENSG00000204611 -3.422084e-02  3.850670783 -0.2205059071 8.281676e-01
ENSG00000105568 -5.877229e-02  7.439852649 -0.5115358990 6.157162e-01
ENSG00000196214  1.235480e-02  3.198031676  0.0775892201 9.390828e-01
ENSG00000198464  1.429722e-01  3.424444091  0.6752681163 5.088076e-01
ENSG00000167554 -1.154861e-01  2.135684048 -0.5110118475 6.160751e-01
ENSG00000221923 -5.245455e-02  2.348356875 -0.2626557304 7.960495e-01
ENSG00000167555  7.763522e-02  2.377642494  0.4369497287 6.677813e-01
ENSG00000167766 -1.817830e-01  3.897495780 -1.2011242386 2.465694e-01
ENSG00000213020 -2.996482e-01  2.480214607 -1.6567896748 1.163485e-01
ENSG00000189190 -2.221219e-01  1.940346670 -0.7115353091 4.866370e-01
ENSG00000198538 -4.692054e-01  3.912907898 -3.1100459100 6.510659e-03
ENSG00000204604 -4.543573e-01  4.547968222 -2.5962737522 1.908463e-02
ENSG00000213793  3.078365e-03  3.335171849  0.0147161016 9.884342e-01
ENSG00000180257  4.690308e-02  3.077122991  0.2714432135 7.893986e-01
ENSG00000242779  1.413781e-01  4.041796100  0.9173995881 3.720768e-01
ENSG00000170949 -1.351516e-01  4.027401106 -1.1524697923 2.654629e-01
                 adj.P.Val            B       lfsr       lfdr     qvalue
ENSG00000225972 0.26566844 -2.811634180 0.34294207 0.23286468 0.16590909
ENSG00000225630 0.59716344 -5.262658421 0.47127226 0.30863104 0.22149938
ENSG00000237973 0.46970095 -4.945008947 0.37416772 0.26405722 0.18752946
ENSG00000248527 0.39269205 -4.543288323 0.35164260 0.24661995 0.17570223
ENSG00000198744 0.72643952 -4.685566237 0.60754260 0.32503398 0.23515046
ENSG00000228794 0.66332047 -4.952216675 0.52521097 0.32223398 0.23270062
ENSG00000223764 0.75477320 -5.152258636 0.57004720 0.33309297 0.24263121
ENSG00000187634 0.99258781 -5.648976678 0.67912164 0.36783559 0.27069201
ENSG00000188976 0.63417333 -5.488506024 0.44660151 0.33359137 0.24313161
ENSG00000187961 0.95807156 -5.589417820 0.65651047 0.36599756 0.26953670
ENSG00000187608 0.34342418 -3.807810638 0.36502261 0.24885781 0.17737194
ENSG00000188157 0.35588244 -4.237349097 0.28519858 0.21024153 0.15008883
ENSG00000131591 0.94793460 -5.407838491 0.64990896 0.36171334 0.26644988
ENSG00000078808 0.77097034 -5.913319881 0.55401735 0.39319322 0.28596600
ENSG00000176022 0.91353877 -6.014000684 0.63810056 0.38855570 0.28357517
ENSG00000160087 0.74588038 -5.784007201 0.54373792 0.40470807 0.29138902
ENSG00000131584 0.88065557 -6.001352490 0.62399704 0.40156934 0.29008618
ENSG00000169972 0.87758815 -5.610139098 0.61825566 0.38840055 0.28349399
ENSG00000127054 0.69358924 -5.674061660 0.50284155 0.38485786 0.28169366
ENSG00000224051 0.52573776 -4.963655615 0.38539786 0.27950201 0.19996040
ENSG00000107404 0.63624467 -5.501373217 0.46527915 0.31894816 0.22984869
ENSG00000162576 0.49388180 -4.960638962 0.39658794 0.27536714 0.19685839
ENSG00000175756 0.49806960 -5.039924718 0.33093710 0.26930468 0.19184965
ENSG00000221978 0.89271021 -6.109805150 0.62178555 0.36563982 0.26933644
ENSG00000224870 0.55039120 -4.961768533 0.41420155 0.29000994 0.20653834
ENSG00000242485 0.97423037 -6.074375302 0.69996496 0.44317955 0.30639655
ENSG00000160072 0.89115768 -5.764547224 0.63112428 0.40789481 0.29275153
ENSG00000197785 0.52573776 -4.998957043 0.38391631 0.27924332 0.19975354
ENSG00000160075 0.69358924 -5.746713587 0.51047314 0.39753683 0.28824812
ENSG00000228594 0.85361625 -5.427134289 0.60442697 0.35069741 0.25773904
ENSG00000197530 0.25132751 -2.695650661 0.18425650 0.14023029 0.10235014
ENSG00000189409 0.71193424 -5.423982409 0.53303576 0.33129904 0.24096844
ENSG00000248333 0.56051941 -4.930765589 0.42380675 0.29416855 0.21007796
ENSG00000189339 0.55733835 -5.187783273 0.38302296 0.29651362 0.21168820
ENSG00000008130 0.62597585 -5.445256382 0.44582557 0.34661307 0.25443209
ENSG00000078369 0.81908803 -5.979644665 0.64062916 0.49715910 0.31887540
ENSG00000162585 0.39914564 -4.371080963 0.31988171 0.23254302 0.16538973
ENSG00000157933 0.94978834 -6.171464821 0.70230911 0.47973355 0.31604778
ENSG00000157916 0.77382556 -5.943213263 0.59378191 0.46085958 0.31160988
ENSG00000157911 0.38024891 -4.073259012 0.35062886 0.24471796 0.17393276
ENSG00000157881 0.76521452 -5.548866842 0.54482467 0.37745166 0.27695319
ENSG00000157870 0.60417021 -4.934407552 0.46964210 0.30961742 0.22250024
ENSG00000158109 0.89490844 -6.128992352 0.66726485 0.47606056 0.31525290
ENSG00000116213 0.55965483 -4.982421644 0.39451598 0.29147309 0.20763421
ENSG00000227372 0.39269205 -4.195979524 0.27514612 0.20988432 0.14981067
ENSG00000130764 0.69500361 -5.645456847 0.49530487 0.36617441 0.26965106
ENSG00000116198 0.97692090 -5.963050356 0.69266383 0.42405933 0.29956416
ENSG00000198912 0.98481888 -5.865619473 0.69695742 0.42220962 0.29874243
ENSG00000131697 0.72678724 -5.240281195 0.52101164 0.34571446 0.25396717
ENSG00000116251 0.69663021 -5.752756512 0.49769597 0.36811126 0.27087695
ENSG00000116237 0.97859893 -6.196770603 0.73676185 0.50870385 0.32042404
ENSG00000158292 0.70384826 -5.131073033 0.52448722 0.33121524 0.24087726
ENSG00000097021 0.32987396 -3.870254971 0.37552032 0.25260908 0.17997798
ENSG00000215788 0.98481888 -5.413270733 0.66295199 0.34252285 0.25086785
ENSG00000171680 0.38208466 -4.284075212 0.37104734 0.25409168 0.18086188
ENSG00000162408 0.69500361 -5.383833768 0.50275512 0.33628428 0.24566412
ENSG00000204859 0.98632203 -5.609827132 0.67605242 0.37415531 0.27485814
ENSG00000162413 0.98898908 -6.195976766 0.72627517 0.47263224 0.31443666
ENSG00000116273 0.21524191 -1.855287142 0.08462013 0.06869951 0.05028796
ENSG00000041988 0.92773182 -5.573328938 0.64311178 0.37971740 0.27842547
ENSG00000007923 0.42515412 -4.562936738 0.31133409 0.23188933 0.16486526
ENSG00000171735 0.40866560 -4.317158730 0.36902030 0.25544149 0.18162337
ENSG00000049245 0.54804802 -5.286180348 0.38433046 0.31484176 0.22697041
ENSG00000116288 0.35927605 -4.289690445 0.18806619 0.15830947 0.11373995
ENSG00000116285 0.23582775 -2.493050901 0.33941997 0.22988632 0.16356181
ENSG00000142599 0.66406651 -5.660467921 0.48049903 0.32933872 0.23924114
ENSG00000074800 0.90413032 -6.067651643 0.66027044 0.45242530 0.30940751
ENSG00000142583 0.40005100 -4.056463996 0.50840521 0.30289765 0.21746661
ENSG00000180758 0.77821104 -5.174238545 0.55805026 0.35098278 0.25798859
ENSG00000228526 0.95098674 -5.536404098 0.64957230 0.34121002 0.24992011
ENSG00000049239 0.89447571 -6.050923656 0.62364913 0.37629629 0.27615025
ENSG00000171621 0.57442208 -5.391708522 0.41643635 0.29806750 0.21355111
ENSG00000171612 0.31280683 -3.468280763 0.32037322 0.22497025 0.16034510
ENSG00000188807 0.84769608 -5.444454486 0.59817099 0.36267587 0.26720604
ENSG00000171608 0.27584994 -3.028128017 0.22646210 0.16893635 0.12062179
ENSG00000171603 0.83443248 -6.052990134 0.60370265 0.42126783 0.29829730
ENSG00000178585 0.60093827 -5.167335049 0.42871691 0.30981508 0.22271631
ENSG00000162441 0.76961954 -5.549663665 0.54894560 0.35956697 0.26479111
ENSG00000173614 0.65647144 -5.244225803 0.48846354 0.32332443 0.23343130
ENSG00000130939 0.94387324 -6.122361684 0.68296499 0.44966245 0.30848869
ENSG00000054523 0.80658335 -5.998662721 0.60262246 0.45132674 0.30905120
ENSG00000142657 0.99067516 -6.188330266 0.73194879 0.47946464 0.31595000
ENSG00000160049 0.76039660 -5.781212125 0.56634232 0.43034043 0.30178587
ENSG00000142655 0.69935878 -5.344764074 0.49745613 0.34721592 0.25502384
ENSG00000120948 0.97537808 -6.082089031 0.71910702 0.47934686 0.31590114
ENSG00000116649 0.69091971 -5.745627244 0.49076901 0.34676354 0.25460837
ENSG00000171824 0.82725227 -5.866458391 0.60022667 0.42238075 0.29879810
ENSG00000198793 0.21963505 -2.210478347 0.06632143 0.05529048 0.04060240
ENSG00000171819 0.99618400 -5.852752435 0.66760469 0.33797721 0.24702798
ENSG00000120942 0.95162373 -5.897220473 0.67595069 0.42400495 0.29950842
ENSG00000116661 0.88952032 -5.166526845 0.62762660 0.33786656 0.24692495
ENSG00000132879 0.96370037 -5.406446745 0.66150927 0.37217252 0.27367079
ENSG00000116670 0.61792731 -5.090703703 0.45372157 0.31422033 0.22634649
ENSG00000177674 0.85361625 -5.795114619 0.60740978 0.40164295 0.29012676
ENSG00000177000 0.35507150 -3.971936398 0.25598566 0.19413210 0.13854107
ENSG00000011021 0.56154982 -5.088712943 0.39527035 0.29253153 0.20876570
ENSG00000116685 0.77611637 -5.823379045 0.55672686 0.39463198 0.28669530
ENSG00000083444 0.70435311 -5.679442611 0.50026082 0.35994845 0.26508614
ENSG00000116688 0.47228290 -4.965721643 0.30498337 0.24857292 0.17705900
ENSG00000116691 0.73636870 -5.336382056 0.52281295 0.36458813 0.26861985
ENSG00000048707 0.47676743 -4.914912576 0.31016653 0.24683969 0.17586066
ENSG00000162496 0.28293909 -3.167875268 0.37917887 0.25145451 0.17902502
ENSG00000162494 0.31957167 -3.551912015 0.40456411 0.26447507 0.18782056
ENSG00000162493 0.24178609 -2.598564737 0.08070306 0.06714778 0.04960734
ENSG00000116731 0.97920572 -6.092200192 0.72851242 0.49170551 0.31808075
ENSG00000189337 0.87852712 -5.433327033 0.61848371 0.34715995 0.25496004
ENSG00000171729 0.18094608 -0.430514870 0.23465191 0.16714629 0.11929151
ENSG00000142634 0.42027405 -4.378642670 0.37849945 0.26032333 0.18478434
ENSG00000132906 0.86169372 -5.622926916 0.60699683 0.38315260 0.28067798
ENSG00000116138 0.42149250 -4.557884197 0.26892745 0.21214616 0.15115964
ENSG00000197312 0.31280683 -3.708018953 0.18344266 0.14528215 0.10557990
ENSG00000116786 0.81884484 -6.001312762 0.62032035 0.46656211 0.31287629
ENSG00000162458 0.54143000 -5.277021917 0.40734364 0.28726864 0.20472963
ENSG00000065526 0.85213411 -5.984323131 0.63093941 0.45274090 0.30949679
ENSG00000116809 0.45664755 -4.584576074 0.34755828 0.25235900 0.17979427
ENSG00000173641 0.27347285 -3.099194774 0.31474413 0.21915553 0.15592873
ENSG00000142627 0.49986288 -5.093826975 0.38871270 0.27391622 0.19557825
ENSG00000142632 0.81791069 -5.368135325 0.58829727 0.34461130 0.25288596
ENSG00000037637 0.80956857 -5.761307088 0.58111193 0.40814406 0.29292885
ENSG00000055070 0.71767250 -5.808589814 0.53095182 0.40959614 0.29365124
ENSG00000157191 0.77006832 -5.893939596 0.59584528 0.46566209 0.31268948
ENSG00000219481 0.36756717 -4.121327374 0.24440630 0.18916615 0.13496482
ENSG00000215908 0.72390732 -5.362074285 0.51579290 0.34947738 0.25670354
ENSG00000058453 0.91276080 -5.827349861 0.63281470 0.36774746 0.27064933
ENSG00000117122 0.94990717 -6.182621749 0.68243794 0.44002816 0.30528182
ENSG00000159363 0.28484236 -3.375551343 0.17580315 0.13728231 0.10013252
ENSG00000117118 0.54867738 -5.255078769 0.37650892 0.30051763 0.21558393
ENSG00000179051 0.99618400 -6.172760243 0.72343714 0.45231880 0.30934803
ENSG00000074964 0.86893803 -5.583680229 0.61091405 0.38279625 0.28039253
ENSG00000159423 0.71771239 -5.164331671 0.53687952 0.33252387 0.24209196
ENSG00000169991 0.48093015 -4.810816489 0.35724990 0.25984710 0.18451584
ENSG00000127481 0.77411883 -5.886022671 0.55162289 0.38097083 0.27926091
ENSG00000127463 0.27053117 -3.096747872 0.08833188 0.07456192 0.05462475
ENSG00000053372 0.56661718 -5.118606160 0.39455122 0.29598615 0.21123326
ENSG00000053371 0.98802587 -5.998528213 0.70333561 0.43079682 0.30188502
ENSG00000040487 0.86405352 -5.792428000 0.60683691 0.37433352 0.27498355
ENSG00000077549 0.80829939 -5.997935147 0.63087556 0.49301307 0.31830320
ENSG00000173436 0.79598958 -5.326940283 0.57114777 0.34759691 0.25535818
ENSG00000158747 0.37602535 -4.368421019 0.26997757 0.20410547 0.14487365
ENSG00000169914 0.18094608 -0.453151420 0.13024005 0.10002341 0.07395577
ENSG00000188257 0.93823109 -5.326714386 0.64955615 0.32913714 0.23901842
ENSG00000127472 0.99005434 -5.428941557 0.66923747 0.35155154 0.25859394
ENSG00000162545 0.32987396 -3.880059009 0.30981434 0.22085969 0.15709658
ENSG00000090432 0.86860908 -6.009455467 0.63166067 0.43732679 0.30440540
ENSG00000158828 0.93691842 -5.868264751 0.64952234 0.38406543 0.28131477
ENSG00000117242 0.99649705 -5.485053549 0.68551219 0.37443599 0.27509491
ENSG00000244038 0.31749404 -3.838244847 0.14866559 0.12349087 0.09059200
ENSG00000117245 0.67127263 -5.057227315 0.53032027 0.32338804 0.23354953
ENSG00000189410 0.58737944 -4.864998402 0.48869568 0.30958841 0.22243531
ENSG00000127483 0.89115768 -6.128863585 0.66377413 0.47366456 0.31469160
ENSG00000075151 0.64597041 -5.625705294 0.47561314 0.37893244 0.27798605
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ENSG00000130203 0.82129087 -5.193150998 0.60288387 0.33576753 0.24515882
ENSG00000104853 0.75146694 -5.897698864 0.55624248 0.41979382 0.29776985
ENSG00000104856 0.32884776 -3.584193062 0.42574133 0.27331224 0.19503872
ENSG00000104859 0.56154982 -5.000642631 0.39694045 0.29303075 0.20918015
ENSG00000142252 0.64597041 -5.104916367 0.46078489 0.32801691 0.23806626
ENSG00000007047 0.82513756 -5.890683572 0.58500458 0.38226186 0.28001130
ENSG00000104866 0.95372045 -5.926811419 0.66709780 0.40101062 0.28978839
ENSG00000007255 0.41381320 -4.132300348 0.46952716 0.29252041 0.20874126
ENSG00000189114 0.78944973 -5.542751421 0.55862226 0.37100182 0.27280083
ENSG00000104884 0.60503624 -5.255493713 0.45207973 0.30908151 0.22191411
ENSG00000104881 0.68575250 -5.530322073 0.50989826 0.32899682 0.23885102
ENSG00000012061 0.49124118 -4.927303239 0.36362827 0.26423287 0.18770415
ENSG00000125744 0.37979049 -4.027359248 0.28381451 0.21176896 0.15096169
ENSG00000125753 0.77969396 -5.940065110 0.55372133 0.37500831 0.27545630
ENSG00000125741 0.76961954 -5.729760840 0.55493608 0.39725390 0.28808635
ENSG00000125746 0.53817450 -4.918828717 0.37552538 0.28266183 0.20206245
ENSG00000125743 0.65133616 -5.634327721 0.46498937 0.35702701 0.26281120
ENSG00000011478 0.96388483 -6.061278672 0.70309838 0.46403501 0.31231724
ENSG00000177051 0.58287839 -4.857357613 0.46511610 0.30552598 0.21949640
ENSG00000177045 0.38882935 -4.033215540 0.47002138 0.29162105 0.20780753
ENSG00000104936 0.63024644 -5.443125749 0.45097778 0.32121814 0.23178476
ENSG00000185800 0.50837584 -4.981497488 0.36228815 0.26986284 0.19237830
ENSG00000125755 0.65593183 -5.602565455 0.46467049 0.33838671 0.24740487
ENSG00000170604 0.25493762 -2.612675997 0.25658897 0.18536010 0.13262762
ENSG00000176182 0.74750399 -5.362162485 0.53749581 0.34817934 0.25575484
ENSG00000188624 0.30176382 -3.366522897 0.32982789 0.22888976 0.16303043
ENSG00000204866 0.48661974 -5.019250373 0.32574781 0.25235043 0.17976362
ENSG00000124440 0.68529922 -5.125079446 0.53259820 0.32545384 0.23551746
ENSG00000011485 0.80453401 -5.882846860 0.56910262 0.38066829 0.27900097
ENSG00000169515 0.40474646 -4.589390062 0.27918549 0.21351340 0.15214273
ENSG00000182013 0.89836392 -5.705827728 0.62716894 0.38250018 0.28025651
ENSG00000160014 0.77707023 -5.939820052 0.58634183 0.44788639 0.30795818
ENSG00000197380 0.85361625 -5.141287513 0.61586577 0.33654806 0.24594152
ENSG00000105287 0.92773182 -5.699665518 0.64175565 0.37442960 0.27508100
ENSG00000090372 0.62048750 -5.479085649 0.43766290 0.32979086 0.23961109
ENSG00000181027 0.53536855 -4.994815108 0.40510297 0.28557791 0.20371597
ENSG00000105281 0.81831591 -6.018369313 0.60137265 0.43574918 0.30380441
ENSG00000042753 0.98819762 -6.199178539 0.74423663 0.50947718 0.32053392
ENSG00000160007 0.42509514 -4.690749934 0.26139565 0.21120434 0.15052579
ENSG00000130751 0.92759331 -5.283404398 0.64162898 0.33662306 0.24597614
ENSG00000130748 0.90528824 -5.586247561 0.62911482 0.35267033 0.25938046
ENSG00000130749 0.61195142 -5.275202823 0.46312381 0.31126149 0.22385405
ENSG00000142230 0.57491636 -5.394377955 0.40162208 0.31777653 0.22903175
ENSG00000105327 0.88458125 -5.623595898 0.61807683 0.35819229 0.26363331
ENSG00000105321 0.67372469 -5.482145743 0.48107338 0.33950092 0.24845856
ENSG00000257704 0.85519578 -5.545256765 0.60443925 0.35316206 0.25976469
ENSG00000134815 0.86694105 -5.629002337 0.60836534 0.37313802 0.27428612
ENSG00000105419 0.81911316 -5.890778961 0.58273288 0.39151700 0.28518230
ENSG00000105402 0.59809494 -5.321404432 0.42504495 0.30928643 0.22219684
ENSG00000063169 0.57350009 -4.844799006 0.46809383 0.30427354 0.21856376
ENSG00000024422 0.92804612 -6.155496675 0.65182204 0.40463949 0.29133464
ENSG00000105373 0.87390829 -6.031829796 0.64318879 0.45202675 0.30930345
ENSG00000178980 0.79114363 -5.971601395 0.58019411 0.42717387 0.30057258
ENSG00000105499 0.54036688 -4.529648653 0.52103345 0.31093066 0.22361876
ENSG00000105486 0.33745490 -3.698023765 0.37101623 0.25116720 0.17871493
ENSG00000185453 0.74438339 -5.135104299 0.54428678 0.34021658 0.24911624
ENSG00000105483 0.94277730 -5.742714870 0.66875259 0.42245027 0.29882594
ENSG00000142227 0.28155783 -3.323542657 0.18908601 0.14578564 0.10589654
ENSG00000105438 0.88065557 -6.104697339 0.66237298 0.47878518 0.31577091
ENSG00000105464 0.99059018 -5.100138806 0.66998181 0.35126014 0.25828404
ENSG00000105447 0.58033904 -5.169949038 0.40608188 0.30481788 0.21887536
ENSG00000105443 0.98854939 -6.100168355 0.68911133 0.39769855 0.28832903
ENSG00000063177 0.96853104 -6.178718962 0.70424059 0.46042166 0.31150297
ENSG00000063176 0.27676433 -3.066286433 0.21134028 0.15964410 0.11473074
ENSG00000105552 0.99031689 -5.767821062 0.69981328 0.41815012 0.29717452
ENSG00000087076 0.42069941 -4.451720129 0.36399844 0.25433516 0.18098387
ENSG00000087074 0.80122618 -5.976336933 0.56689034 0.37914746 0.27812335
ENSG00000104805 0.34031358 -4.110289377 0.21702813 0.16972156 0.12111532
ENSG00000087088 0.23582775 -2.510491401 0.14111244 0.11055130 0.08230795
ENSG00000087086 0.82198279 -5.810103182 0.59171806 0.40897936 0.29336488
ENSG00000104812 0.92350265 -6.068011678 0.68298545 0.47461454 0.31491555
ENSG00000183207 0.29139151 -3.446182002 0.15834797 0.12643862 0.09313444
ENSG00000104852 0.49502563 -5.075211413 0.36200833 0.26474301 0.18828377
ENSG00000104863 0.63630102 -4.963894664 0.48727886 0.31722930 0.22858063
ENSG00000177380 0.34740394 -3.768407902 0.35724819 0.24550444 0.17438688
ENSG00000130529 0.64547845 -5.257938568 0.49645425 0.31942510 0.23033574
ENSG00000074219 0.64115934 -5.363966516 0.45591775 0.32567249 0.23571008
ENSG00000104872 0.94622497 -6.006654339 0.67227807 0.42432171 0.29964783
ENSG00000161618 0.63948646 -5.221924014 0.49104937 0.31774319 0.22899083
ENSG00000142541 0.94871165 -6.138702174 0.69989079 0.47681452 0.31541406
ENSG00000142534 0.97460353 -6.131209076 0.69949947 0.44130653 0.30575881
ENSG00000104870 0.81459087 -5.836708486 0.57620750 0.37447742 0.27513664
ENSG00000142552 0.43827357 -4.684835040 0.30539513 0.23168328 0.16468984
ENSG00000142546 0.77779740 -5.814202413 0.56195557 0.40503517 0.29147060
ENSG00000126464 0.48093015 -4.794251429 0.36084714 0.26107970 0.18526120
ENSG00000126458 0.55285760 -5.285436398 0.38179970 0.30562562 0.21954064
ENSG00000126461 0.42697260 -4.692183839 0.35168382 0.24988640 0.17787202
ENSG00000126456 0.90554926 -5.950015394 0.64583637 0.42034218 0.29799169
ENSG00000126453 0.49106722 -4.475514897 0.41892701 0.28196243 0.20170578
ENSG00000126457 0.38208466 -4.436626989 0.23021761 0.18453161 0.13201185
ENSG00000196961 0.99618400 -6.199455944 0.71025697 0.42564349 0.29999751
ENSG00000010361 0.91450874 -5.343093197 0.63371124 0.34948659 0.25673504
ENSG00000104973 0.58095605 -5.146191582 0.44020222 0.30215002 0.21688049
ENSG00000104960 0.62048750 -5.397377068 0.43822148 0.32511108 0.23524714
ENSG00000039650 0.81293140 -5.669033117 0.57512262 0.38093897 0.27920622
ENSG00000204673 0.98481888 -6.188164508 0.69883431 0.42515854 0.29985744
ENSG00000104946 0.69038380 -5.537506831 0.49061560 0.34550107 0.25382266
ENSG00000213024 0.34666438 -4.034650402 0.18482050 0.15171161 0.10970733
ENSG00000169136 0.86694105 -5.545872815 0.60860463 0.37585232 0.27595587
ENSG00000105053 0.48940210 -4.742408135 0.37442586 0.26713970 0.19019303
ENSG00000142528 0.38208466 -4.025112226 0.32777884 0.23436236 0.16690361
ENSG00000131408 0.89696978 -6.038733407 0.63439855 0.40798304 0.29279247
ENSG00000062822 0.69525958 -5.102705513 0.52390635 0.32901422 0.23890686
ENSG00000161671 0.67252627 -5.695898381 0.47757438 0.35051530 0.25758281
ENSG00000161677 0.86103521 -5.853096105 0.60906603 0.39332732 0.28603355
ENSG00000167747 0.33356118 -3.811520004 0.25192904 0.18947902 0.13533508
ENSG00000142544 0.62972388 -4.885230293 0.54272883 0.31914292 0.23005191
ENSG00000105379 0.29093102 -3.208998839 0.28611073 0.20499914 0.14580341
ENSG00000105497 0.89182273 -5.523261212 0.62524433 0.38871869 0.28362929
ENSG00000182310 0.59450947 -4.775945227 0.47135993 0.30824930 0.22123660
ENSG00000198093 0.99390605 -5.329819735 0.67610436 0.35928100 0.26458424
ENSG00000176024 0.50270018 -4.478829843 0.41600453 0.28275108 0.20208796
ENSG00000256683 0.91985493 -5.375002950 0.63615142 0.36558108 0.26932214
ENSG00000197619 0.43065565 -4.224277921 0.44933393 0.28707062 0.20462852
ENSG00000142556 0.50392263 -4.663895747 0.39089152 0.27562084 0.19699100
ENSG00000256087 0.97547951 -5.824009838 0.66818898 0.37047872 0.27243441
ENSG00000197608 0.75580548 -5.565835441 0.53932660 0.35677428 0.26266128
ENSG00000204611 0.94169406 -5.753170738 0.65711710 0.39607551 0.28739749
ENSG00000105568 0.84458859 -6.067375840 0.60919091 0.42028568 0.29796395
ENSG00000196214 0.98309232 -5.596423211 0.68372808 0.39601445 0.28734343
ENSG00000198464 0.79114363 -5.346940716 0.56810329 0.34717854 0.25499195
ENSG00000167554 0.84485914 -5.240671068 0.59868863 0.35190448 0.25890285
ENSG00000221923 0.92882009 -5.476911285 0.64123316 0.36898440 0.27141653
ENSG00000167555 0.86964743 -5.650781868 0.60991517 0.37224501 0.27368479
ENSG00000167766 0.60503624 -5.122101686 0.43966762 0.30966547 0.22256510
ENSG00000213020 0.45919634 -4.342213705 0.37603105 0.26356540 0.18709160
ENSG00000189190 0.77652304 -5.038778646 0.58320957 0.33345864 0.24300676
ENSG00000198538 0.22842433 -2.207392926 0.16940152 0.12945808 0.09506982
ENSG00000204604 0.28099750 -3.143221399 0.24938336 0.18316453 0.13105479
ENSG00000213793 0.99618400 -5.577384768 0.68194692 0.36862547 0.27118943
ENSG00000180257 0.92601320 -5.499323929 0.64289078 0.38213236 0.27997040
ENSG00000242779 0.70563184 -5.255754767 0.50492236 0.34325870 0.25159449
ENSG00000170949 0.62036937 -5.184497036 0.43781949 0.32579398 0.23586388
                    svalue
ENSG00000225972 0.23383858
ENSG00000225630 0.31965143
ENSG00000237973 0.25472719
ENSG00000248527 0.23983742
ENSG00000198744 0.40986842
ENSG00000228794 0.35498840
ENSG00000223764 0.38470169
ENSG00000187634 0.45779705
ENSG00000188976 0.30302568
ENSG00000187961 0.44346523
ENSG00000187608 0.24906596
ENSG00000188157 0.19736340
ENSG00000131591 0.43904836
ENSG00000078808 0.37444584
ENSG00000176022 0.43087243
ENSG00000160087 0.36747577
ENSG00000131584 0.42111288
ENSG00000169972 0.41745440
ENSG00000127054 0.34031347
ENSG00000224051 0.26256076
ENSG00000107404 0.31523797
ENSG00000162576 0.26927183
ENSG00000175756 0.22578160
ENSG00000221978 0.41994688
ENSG00000224870 0.28124252
ENSG00000242485 0.46741231
ENSG00000160072 0.42562621
ENSG00000197785 0.26139838
ENSG00000160075 0.34552348
ENSG00000228594 0.40766833
ENSG00000197530 0.13208750
ENSG00000189409 0.36022606
ENSG00000248333 0.28804016
ENSG00000189339 0.26085634
ENSG00000008130 0.30256191
ENSG00000078369 0.43247370
ENSG00000162585 0.21873388
ENSG00000157933 0.46816201
ENSG00000157916 0.40119743
ENSG00000157911 0.23882845
ENSG00000157881 0.36820525
ENSG00000157870 0.31850518
ENSG00000158109 0.45058184
ENSG00000116213 0.26805217
ENSG00000227372 0.18972963
ENSG00000130764 0.33613239
ENSG00000116198 0.46449963
ENSG00000198912 0.46624343
ENSG00000131697 0.35194095
ENSG00000116251 0.33759383
ENSG00000116237 0.47723079
ENSG00000158292 0.35462431
ENSG00000097021 0.25588081
ENSG00000215788 0.44751223
ENSG00000171680 0.25305215
ENSG00000162408 0.34025023
ENSG00000204859 0.45603111
ENSG00000162413 0.47532443
ENSG00000116273 0.06248463
ENSG00000041988 0.43419082
ENSG00000007923 0.21408983
ENSG00000171735 0.25180423
ENSG00000049245 0.26164802
ENSG00000116288 0.13485439
ENSG00000116285 0.23190775
ENSG00000142599 0.32562713
ENSG00000074800 0.44573088
ENSG00000142583 0.34408921
ENSG00000180758 0.37664720
ENSG00000228526 0.43880684
ENSG00000049239 0.42088485
ENSG00000171621 0.28244238
ENSG00000171612 0.21893558
ENSG00000188807 0.40395560
ENSG00000171608 0.15781654
ENSG00000171603 0.40730038
ENSG00000178585 0.29169179
ENSG00000162441 0.37081850
ENSG00000173614 0.33119119
ENSG00000130939 0.45988484
ENSG00000054523 0.40669614
ENSG00000142657 0.47643178
ENSG00000160049 0.38212000
ENSG00000142655 0.33743541
ENSG00000120948 0.47362803
ENSG00000116649 0.33296560
ENSG00000171824 0.40540679
ENSG00000198793 0.04759237
ENSG00000171819 0.45081682
ENSG00000120942 0.45593798
ENSG00000116661 0.42326075
ENSG00000132879 0.44649174
ENSG00000116670 0.30765750
ENSG00000177674 0.40979009
ENSG00000177000 0.17715210
ENSG00000011021 0.26862140
ENSG00000116685 0.37584727
ENSG00000083444 0.33907956
ENSG00000116688 0.21003369
ENSG00000116691 0.35337803
ENSG00000048707 0.21307055
ENSG00000162496 0.25829619
ENSG00000162494 0.27484811
ENSG00000162493 0.05971603
ENSG00000116731 0.47574109
ENSG00000189337 0.41763299
ENSG00000171729 0.16431770
ENSG00000142634 0.25774754
ENSG00000132906 0.40945044
ENSG00000116138 0.18565017
ENSG00000197312 0.13116538
ENSG00000116786 0.41898259
ENSG00000162458 0.27662801
ENSG00000065526 0.42560112
ENSG00000116809 0.23665191
ENSG00000173641 0.21571026
ENSG00000142627 0.26486540
ENSG00000142632 0.39745487
ENSG00000037637 0.39225604
ENSG00000055070 0.35875832
ENSG00000157191 0.40249931
ENSG00000219481 0.17027898
ENSG00000215908 0.34871045
ENSG00000058453 0.42680403
ENSG00000117122 0.45974580
ENSG00000159363 0.12553041
ENSG00000117118 0.25668715
ENSG00000179051 0.47466712
ENSG00000074964 0.41228712
ENSG00000159423 0.36322343
ENSG00000169991 0.24337731
ENSG00000127481 0.37286868
ENSG00000127463 0.06454038
ENSG00000053372 0.26809289
ENSG00000053371 0.46860815
ENSG00000040487 0.40934588
ENSG00000077549 0.42550079
ENSG00000173436 0.38562147
ENSG00000158747 0.18612777
ENSG00000169914 0.09540710
ENSG00000188257 0.43878268
ENSG00000127472 0.45170947
ENSG00000162545 0.21296811
ENSG00000090432 0.42592720
ENSG00000158828 0.43873436
ENSG00000117242 0.46129799
ENSG00000244038 0.10875333
ENSG00000117245 0.35836812
ENSG00000189410 0.33138548
ENSG00000127483 0.44808081
ENSG00000075151 0.32216822
ENSG00000117298 0.38792063
ENSG00000142794 0.46190011
ENSG00000162551 0.41401897
ENSG00000090686 0.24206480
ENSG00000142798 0.18996239
ENSG00000070831 0.46699098
ENSG00000162552 0.31482589
ENSG00000184677 0.46368687
ENSG00000133216 0.37872665
ENSG00000004487 0.38913159
ENSG00000169641 0.45182682
ENSG00000179546 0.30547385
ENSG00000125944 0.32273720
ENSG00000125945 0.29632063
ENSG00000088280 0.34886481
ENSG00000117318 0.42078350
ENSG00000142676 0.31914633
ENSG00000011007 0.38059627
ENSG00000057757 0.39042159
ENSG00000011009 0.37847063
ENSG00000117308 0.46778692
ENSG00000117305 0.38358139
ENSG00000179163 0.39983890
ENSG00000189266 0.11494881
ENSG00000188529 0.15241580
ENSG00000001460 0.38152855
ENSG00000001461 0.04413959
ENSG00000117602 0.12971264
ENSG00000133226 0.39250181
ENSG00000169504 0.09475027
ENSG00000117614 0.41179424
ENSG00000117616 0.36633579
ENSG00000183726 0.34799955
ENSG00000204178 0.47413441
ENSG00000157978 0.08379366
ENSG00000117643 0.43822670
ENSG00000162430 0.34697971
ENSG00000117640 0.18338534
ENSG00000182749 0.47481281
ENSG00000117632 0.33860550
ENSG00000158006 0.43764568
ENSG00000158008 0.21646952
ENSG00000158022 0.39876917
ENSG00000130695 0.26519304
ENSG00000142669 0.46120534
ENSG00000158062 0.41373505
ENSG00000117682 0.05511682
ENSG00000198830 0.30891942
ENSG00000117713 0.15646307
ENSG00000060642 0.38090732
ENSG00000204160 0.34997462
ENSG00000142751 0.47221651
ENSG00000198746 0.37755997
ENSG00000090273 0.21439389
ENSG00000253368 0.23942564
ENSG00000158246 0.31585426
ENSG00000090020 0.36129821
ENSG00000142784 0.45334858
ENSG00000186501 0.41329592
ENSG00000142733 0.33885838
ENSG00000158195 0.45177989
ENSG00000126705 0.24571204
ENSG00000126709 0.40363829
ENSG00000009780 0.44665809
ENSG00000117758 0.30434160
ENSG00000117751 0.43062564
ENSG00000117748 0.47486139
ENSG00000158156 0.19254801
ENSG00000158161 0.21817933
ENSG00000126698 0.44786769
ENSG00000130770 0.06742359
ENSG00000130766 0.35279814
ENSG00000130772 0.39370019
ENSG00000204138 0.30769264
ENSG00000180198 0.29450897
ENSG00000242125 0.44250927
ENSG00000180098 0.37450306
ENSG00000197989 0.29061793
ENSG00000120656 0.33977584
ENSG00000162419 0.44651551
ENSG00000198492 0.43343137
ENSG00000159023 0.40666985
ENSG00000253304 0.35755568
ENSG00000116350 0.35334756
ENSG00000116353 0.33089934
ENSG00000060656 0.31830224
ENSG00000162512 0.14974376
ENSG00000134644 0.36466547
ENSG00000060688 0.34975906
ENSG00000121766 0.45967629
ENSG00000121769 0.33222506
ENSG00000168528 0.37861290
ENSG00000162517 0.20320958
ENSG00000084636 0.44763072
ENSG00000121753 0.32263694
ENSG00000134668 0.29139625
ENSG00000184007 0.28751331
ENSG00000121774 0.30395125
ENSG00000121775 0.21260963
ENSG00000025800 0.43960308
ENSG00000084652 0.11465237
ENSG00000160050 0.35129649
ENSG00000160055 0.46470874
ENSG00000084623 0.47793731
ENSG00000220785 0.45201452
ENSG00000116478 0.45037023
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ENSG00000125744 0.19620774
ENSG00000125753 0.37421680
ENSG00000125741 0.37498926
ENSG00000125746 0.25592334
ENSG00000125743 0.31489468
ENSG00000011478 0.46851421
ENSG00000177051 0.31506644
ENSG00000177045 0.31887654
ENSG00000104936 0.30600318
ENSG00000185800 0.24704518
ENSG00000125755 0.31468823
ENSG00000170604 0.17783857
ENSG00000176182 0.36360654
ENSG00000188624 0.22499762
ENSG00000204866 0.22243055
ENSG00000124440 0.35983768
ENSG00000011485 0.38380583
ENSG00000169515 0.19283279
ENSG00000182013 0.42303360
ENSG00000160014 0.39605482
ENSG00000197380 0.41594645
ENSG00000105287 0.43328420
ENSG00000090372 0.29772875
ENSG00000181027 0.27516503
ENSG00000105281 0.40598595
ENSG00000042753 0.47809043
ENSG00000160007 0.18109176
ENSG00000130751 0.43313694
ENSG00000130748 0.42424395
ENSG00000130749 0.31337652
ENSG00000142230 0.27281562
ENSG00000105327 0.41732676
ENSG00000105321 0.32605655
ENSG00000257704 0.40772086
ENSG00000134815 0.41046823
ENSG00000105419 0.39364587
ENSG00000105402 0.28897650
ENSG00000063169 0.31748978
ENSG00000024422 0.44039747
ENSG00000105373 0.43436205
ENSG00000178980 0.39157217
ENSG00000105499 0.35200225
ENSG00000105486 0.25296615
ENSG00000185453 0.36779693
ENSG00000105483 0.45131020
ENSG00000142227 0.13509652
ENSG00000105438 0.44725141
ENSG00000105464 0.45227237
ENSG00000105447 0.27571937
ENSG00000105443 0.46287456
ENSG00000063177 0.46907782
ENSG00000063176 0.14807456
ENSG00000105552 0.46727193
ENSG00000087076 0.24827745
ENSG00000087074 0.38248593
ENSG00000104805 0.15197325
ENSG00000087088 0.10325969
ENSG00000087086 0.39975881
ENSG00000104812 0.45990804
ENSG00000183207 0.11475146
ENSG00000104852 0.24664651
ENSG00000104863 0.33038001
ENSG00000177380 0.24333221
ENSG00000130529 0.33654598
ENSG00000074219 0.30898944
ENSG00000104872 0.45372262
ENSG00000161618 0.33319051
ENSG00000142541 0.46731874
ENSG00000142534 0.46703781
ENSG00000104870 0.38935126
ENSG00000142552 0.21029198
ENSG00000142546 0.37926621
ENSG00000126464 0.24593475
ENSG00000126458 0.25985156
ENSG00000126461 0.23988309
ENSG00000126456 0.43640882
ENSG00000126453 0.28444000
ENSG00000126457 0.16122438
ENSG00000196961 0.47119561
ENSG00000010361 0.42757843
ENSG00000104973 0.29963277
ENSG00000104960 0.29812507
ENSG00000039650 0.38863672
ENSG00000204673 0.46680375
ENSG00000104946 0.33280480
ENSG00000213024 0.13266553
ENSG00000169136 0.41062452
ENSG00000105053 0.25489877
ENSG00000142528 0.22371811
ENSG00000131408 0.42825065
ENSG00000062822 0.35419937
ENSG00000161671 0.32367066
ENSG00000161677 0.41098885
ENSG00000167747 0.17507315
ENSG00000142544 0.36695000
ENSG00000105379 0.19774779
ENSG00000105497 0.42197303
ENSG00000182310 0.31971872
ENSG00000198093 0.45612418
ENSG00000176024 0.28221040
ENSG00000256683 0.42976155
ENSG00000197619 0.30494370
ENSG00000142556 0.26592964
ENSG00000256087 0.45114570
ENSG00000197608 0.36487087
ENSG00000204611 0.44379948
ENSG00000105568 0.41106689
ENSG00000196214 0.46044108
ENSG00000198464 0.38324476
ENSG00000167554 0.40424630
ENSG00000221923 0.43303875
ENSG00000167555 0.41161252
ENSG00000167766 0.29916760
ENSG00000213020 0.25622093
ENSG00000189190 0.39391747
ENSG00000198538 0.12150177
ENSG00000204604 0.17336585
ENSG00000213793 0.45939809
ENSG00000180257 0.43406844
ENSG00000242779 0.34154498
ENSG00000170949 0.29794504
 [ reached 'max' / getOption("max.print") -- omitted 448 rows ]

#visualize what the permutations look like (what the scrambled labels look like)
for(time in 1:6){
     print(permuted_results[[time]])
}

          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3  Unstrain 10.0
19160_3_S 19160_3_S   NA19160    M         3    Strain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2    Strain 10.0
18856_2_S 18856_2_S   NA18856    M         2  Unstrain  9.6
19160_3_U 19160_3_U   NA19160    M         3  Unstrain 10.0
18855_2_U 18855_2_U   NA18855    F         2    Strain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1  Unstrain  9.9
18856_1_S 18856_1_S   NA18856    M         1  Unstrain  8.5
19160_1_S 19160_1_S   NA19160    M         1    Strain  9.9
19160_2_U 19160_2_U   NA19160    M         2    Strain 10.0
18855_1_U 18855_1_U   NA18855    F         1    Strain 10.0
18856_3_S 18856_3_S   NA18856    M         3    Strain  9.6
18856_2_U 18856_2_U   NA18856    M         2    Strain  9.5
18855_3_U 18855_3_U   NA18855    F         3  Unstrain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3    Strain 10.0
19160_3_S 19160_3_S   NA19160    M         3    Strain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2  Unstrain 10.0
18856_2_S 18856_2_S   NA18856    M         2    Strain  9.6
19160_3_U 19160_3_U   NA19160    M         3    Strain 10.0
18855_2_U 18855_2_U   NA18855    F         2    Strain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1    Strain  9.9
18856_1_S 18856_1_S   NA18856    M         1    Strain  8.5
19160_1_S 19160_1_S   NA19160    M         1  Unstrain  9.9
19160_2_U 19160_2_U   NA19160    M         2  Unstrain 10.0
18855_1_U 18855_1_U   NA18855    F         1    Strain 10.0
18856_3_S 18856_3_S   NA18856    M         3  Unstrain  9.6
18856_2_U 18856_2_U   NA18856    M         2  Unstrain  9.5
18855_3_U 18855_3_U   NA18855    F         3  Unstrain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3    Strain 10.0
19160_3_S 19160_3_S   NA19160    M         3    Strain 10.0
18856_3_U 18856_3_U   NA18856    M         3    Strain 10.0
18856_1_U 18856_1_U   NA18856    M         1    Strain  9.9
18855_2_S 18855_2_S   NA18855    F         2  Unstrain 10.0
18856_2_S 18856_2_S   NA18856    M         2  Unstrain  9.6
19160_3_U 19160_3_U   NA19160    M         3  Unstrain 10.0
18855_2_U 18855_2_U   NA18855    F         2    Strain 10.0
19160_2_S 19160_2_S   NA19160    M         2  Unstrain 10.0
18855_1_S 18855_1_S   NA18855    F         1    Strain  9.9
18856_1_S 18856_1_S   NA18856    M         1    Strain  8.5
19160_1_S 19160_1_S   NA19160    M         1    Strain  9.9
19160_2_U 19160_2_U   NA19160    M         2  Unstrain 10.0
18855_1_U 18855_1_U   NA18855    F         1  Unstrain 10.0
18856_3_S 18856_3_S   NA18856    M         3  Unstrain  9.6
18856_2_U 18856_2_U   NA18856    M         2  Unstrain  9.5
18855_3_U 18855_3_U   NA18855    F         3    Strain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3  Unstrain 10.0
19160_3_S 19160_3_S   NA19160    M         3  Unstrain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2    Strain 10.0
18856_2_S 18856_2_S   NA18856    M         2  Unstrain  9.6
19160_3_U 19160_3_U   NA19160    M         3    Strain 10.0
18855_2_U 18855_2_U   NA18855    F         2    Strain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1    Strain  9.9
18856_1_S 18856_1_S   NA18856    M         1    Strain  8.5
19160_1_S 19160_1_S   NA19160    M         1  Unstrain  9.9
19160_2_U 19160_2_U   NA19160    M         2  Unstrain 10.0
18855_1_U 18855_1_U   NA18855    F         1    Strain 10.0
18856_3_S 18856_3_S   NA18856    M         3    Strain  9.6
18856_2_U 18856_2_U   NA18856    M         2  Unstrain  9.5
18855_3_U 18855_3_U   NA18855    F         3    Strain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3  Unstrain 10.0
19160_3_S 19160_3_S   NA19160    M         3  Unstrain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2  Unstrain 10.0
18856_2_S 18856_2_S   NA18856    M         2    Strain  9.6
19160_3_U 19160_3_U   NA19160    M         3    Strain 10.0
18855_2_U 18855_2_U   NA18855    F         2  Unstrain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1  Unstrain  9.9
18856_1_S 18856_1_S   NA18856    M         1  Unstrain  8.5
19160_1_S 19160_1_S   NA19160    M         1    Strain  9.9
19160_2_U 19160_2_U   NA19160    M         2    Strain 10.0
18855_1_U 18855_1_U   NA18855    F         1    Strain 10.0
18856_3_S 18856_3_S   NA18856    M         3    Strain  9.6
18856_2_U 18856_2_U   NA18856    M         2    Strain  9.5
18855_3_U 18855_3_U   NA18855    F         3    Strain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295
          Sample_ID Individual Sex Replicate treatment  RIN
18855_3_S 18855_3_S   NA18855    F         3  Unstrain 10.0
19160_3_S 19160_3_S   NA19160    M         3    Strain 10.0
18856_3_U 18856_3_U   NA18856    M         3  Unstrain 10.0
18856_1_U 18856_1_U   NA18856    M         1  Unstrain  9.9
18855_2_S 18855_2_S   NA18855    F         2  Unstrain 10.0
18856_2_S 18856_2_S   NA18856    M         2    Strain  9.6
19160_3_U 19160_3_U   NA19160    M         3    Strain 10.0
18855_2_U 18855_2_U   NA18855    F         2  Unstrain 10.0
19160_2_S 19160_2_S   NA19160    M         2    Strain 10.0
18855_1_S 18855_1_S   NA18855    F         1  Unstrain  9.9
18856_1_S 18856_1_S   NA18856    M         1    Strain  8.5
19160_1_S 19160_1_S   NA19160    M         1    Strain  9.9
19160_2_U 19160_2_U   NA19160    M         2    Strain 10.0
18855_1_U 18855_1_U   NA18855    F         1  Unstrain 10.0
18856_3_S 18856_3_S   NA18856    M         3    Strain  9.6
18856_2_U 18856_2_U   NA18856    M         2  Unstrain  9.5
18855_3_U 18855_3_U   NA18855    F         3    Strain 10.0
          LibraryPrepBatch  LibSize       W_1        W_2
18855_3_S                2 15419569 0.6403178 -1.0334196
19160_3_S                2 15177653 0.4887528 -1.3355831
18856_3_U                2 13722909 0.9502388 -0.7892404
18856_1_U                1 18647599 1.2228123 -1.4496449
18855_2_S                1 18256163 0.8233400 -0.6748150
18856_2_S                1 16782764 0.0515988 -1.2784836
19160_3_U                2 19839604 0.3406102 -1.4859733
18855_2_U                1 18618691 0.7609177 -0.8596946
19160_2_S                1 16622407 0.4247172 -1.4414851
18855_1_S                1 19712744 0.7356719 -1.4499412
18856_1_S                1 13571439 1.1409773 -1.1686123
19160_1_S                1 20979958 0.5909682 -1.9538068
19160_2_U                1 20924281 0.1295380 -1.8537818
18855_1_U                1 20146697 0.7569979 -1.3228202
18856_3_S                2 15807863 0.8205467 -0.8981659
18856_2_U                1 15142152 0.4572116 -1.0041098
18855_3_U                2 18157918 0.5909283 -1.1455295

for (permutation in 7:12){
     results <- permuted_results[[permutation]]
     
     # k-s test making use of ranked based on p-values
     genes <- results$qvalue
     names(genes) <- rownames(results)

     selection <- function(allScore){ return(allScore < 0.05)} # function that returns TRUE/FALSE for p-values<0.05
     allGO2genes <- annFUN.org(whichOnto="BP", feasibleGenes=NULL, mapping="org.Hs.eg.db", ID="ensembl")
     GOdata <- new("topGOdata",
       ontology="BP",
       allGenes=genes,
       annot=annFUN.GO2genes,
       GO2genes=allGO2genes,
       geneSel=selection,
       nodeSize=10)

     results.ks <- runTest(GOdata, algorithm="classic", statistic="ks")
     goEnrichment <- GenTable(GOdata, KS=results.ks, orderBy="KS", topNodes=20)
     goEnrichment <- goEnrichment %>% 
          mutate(KS = ifelse(grepl("<", KS), 1e-30, KS))
     goEnrichment$KS <- as.numeric(goEnrichment$KS)
     goEnrichment <- goEnrichment[goEnrichment$KS<0.05,]
     goEnrichment <- goEnrichment[,c("GO.ID","Term","KS")]
     goEnrichment$Term <- gsub(" [a-z]*\\.\\.\\.$", "", goEnrichment$Term)
     goEnrichment$Term <- gsub("\\.\\.\\.$", "", goEnrichment$Term)
     goEnrichment$Term <- paste(goEnrichment$GO.ID, goEnrichment$Term, sep=", ")
     goEnrichment$Term <- factor(goEnrichment$Term, levels=rev(goEnrichment$Term))
     goEnrichment$KS <- as.numeric(goEnrichment$KS)

     plot <- ggplot(goEnrichment, aes(x=Term, y=-log10(KS))) +
         stat_summary(geom = "bar", fun = mean, position = "dodge") +
         xlab("Biological process") +
         ylab("Enrichment") +
         ggtitle("Title") +
         scale_y_continuous(breaks = round(seq(0, max(-log10(goEnrichment$KS)), by = 2), 1)) +
         theme_bw(base_size=24) +
         theme(
             legend.position='none',
             legend.background=element_rect(),
             plot.title=element_text(angle=0, size=24, face="bold", vjust=1),
             axis.text.x=element_text(angle=0, size=18, face="bold", hjust=1.10),
             axis.text.y=element_text(angle=0, size=18, face="bold", vjust=0.5),
             axis.title=element_text(size=24, face="bold"),
          legend.key=element_blank(),     #removes the border
          legend.key.size=unit(1, "cm"),      #Sets overall area/size of the legend
          legend.text=element_text(size=18),  #Text size
          title=element_text(size=18)) +
          guides(colour=guide_legend(override.aes=list(size=2.5))) +
          coord_flip()

     print(plot)
}

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

Past versions of “ks test permuted-1.png”

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

Past versions of “ks test permuted-2.png”

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

Past versions of “ks test permuted-3.png”

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

Past versions of “ks test permuted-4.png”

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

Past versions of “ks test permuted-5.png”

Past versions of “ks test permuted-6.png”

for (permutation in 7:12){
     results <- permuted_results[[permutation]]
     
     # k-s test making use of ranked based on p-values
     genes <- results$qvalue
     names(genes) <- rownames(results)

     selection <- function(allScore){ return(allScore < 0.05)} # function that returns TRUE/FALSE for p-values<0.05
     allGO2genes <- annFUN.org(whichOnto="BP", feasibleGenes=NULL, mapping="org.Hs.eg.db", ID="ensembl")
     GOdata <- new("topGOdata",
       ontology="BP",
       allGenes=genes,
       annot=annFUN.GO2genes,
       GO2genes=allGO2genes,
       geneSel=selection,
       nodeSize=10)

     results.ks <- runTest(GOdata, algorithm="classic", statistic="ks")
     goEnrichment <- GenTable(GOdata, KS=results.ks, orderBy="KS", topNodes=20)
     goEnrichment <- goEnrichment %>% 
          mutate(KS = ifelse(grepl("<", KS), 1e-30, KS))
     goEnrichment$KS <- as.numeric(goEnrichment$KS)
     goEnrichment <- goEnrichment[goEnrichment$KS<0.05,]
     goEnrichment <- goEnrichment[,c("GO.ID","Term","KS")]
     goEnrichment$Term <- gsub(" [a-z]*\\.\\.\\.$", "", goEnrichment$Term)
     goEnrichment$Term <- gsub("\\.\\.\\.$", "", goEnrichment$Term)
     goEnrichment$Term <- paste(goEnrichment$GO.ID, goEnrichment$Term, sep=", ")
     goEnrichment$Term <- factor(goEnrichment$Term, levels=rev(goEnrichment$Term))
     goEnrichment$KS <- as.numeric(goEnrichment$KS)

     print(goEnrichment$Term)
}

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

 [1] GO:0010469, regulation of signaling receptor       
 [2] GO:0048729, tissue morphogenesis                   
 [3] GO:0051270, regulation of cellular component       
 [4] GO:0007186, G protein-coupled receptor signaling   
 [5] GO:0009653, anatomical structure morphogenesis     
 [6] GO:0006928, movement of cell or subcellular        
 [7] GO:0035107, appendage morphogenesis                
 [8] GO:0035108, limb morphogenesis                     
 [9] GO:0002009, morphogenesis of an epithelium         
[10] GO:0042330, taxis                                  
[11] GO:0040011, locomotion                             
[12] GO:0035295, tube development                       
[13] GO:0042035, regulation of cytokine biosynthetic    
[14] GO:0006935, chemotaxis                             
[15] GO:0060541, respiratory system development         
[16] GO:0050819, negative regulation of coagulation     
[17] GO:0060562, epithelial tube morphogenesis          
[18] GO:0032501, multicellular organismal process       
[19] GO:0150076, neuroinflammatory response             
[20] GO:0048646, anatomical structure formation involved
20 Levels: GO:0048646, anatomical structure formation involved ...

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

 [1] GO:0010591, regulation of lamellipodium assembly  
 [2] GO:0043038, amino acid activation                 
 [3] GO:0043039, tRNA aminoacylation                   
 [4] GO:0003230, cardiac atrium development            
 [5] GO:0006418, tRNA aminoacylation for protein       
 [6] GO:0010592, positive regulation of lamellipodium  
 [7] GO:0032635, interleukin-6 production              
 [8] GO:0043489, RNA stabilization                     
 [9] GO:0021536, diencephalon development              
[10] GO:0003209, cardiac atrium morphogenesis          
[11] GO:0003283, atrial septum development             
[12] GO:0006928, movement of cell or subcellular       
[13] GO:0060021, roof of mouth development             
[14] GO:0050919, negative chemotaxis                   
[15] GO:0048255, mRNA stabilization                    
[16] GO:0032781, positive regulation of ATPase activity
[17] GO:0045669, positive regulation of osteoblast     
[18] GO:0061029, eyelid development in camera-type eye 
[19] GO:0043486, histone exchange                      
[20] GO:0007156, homophilic cell adhesion via plasma   
20 Levels: GO:0007156, homophilic cell adhesion via plasma ...

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

 [1] GO:0010591, regulation of lamellipodium assembly  
 [2] GO:0043038, amino acid activation                 
 [3] GO:0043039, tRNA aminoacylation                   
 [4] GO:0003230, cardiac atrium development            
 [5] GO:0006418, tRNA aminoacylation for protein       
 [6] GO:0010592, positive regulation of lamellipodium  
 [7] GO:0032635, interleukin-6 production              
 [8] GO:0043489, RNA stabilization                     
 [9] GO:0021536, diencephalon development              
[10] GO:0003209, cardiac atrium morphogenesis          
[11] GO:0003283, atrial septum development             
[12] GO:0006928, movement of cell or subcellular       
[13] GO:0060021, roof of mouth development             
[14] GO:0050919, negative chemotaxis                   
[15] GO:0048255, mRNA stabilization                    
[16] GO:0032781, positive regulation of ATPase activity
[17] GO:0045669, positive regulation of osteoblast     
[18] GO:0061029, eyelid development in camera-type eye 
[19] GO:0043486, histone exchange                      
[20] GO:0007156, homophilic cell adhesion via plasma   
20 Levels: GO:0007156, homophilic cell adhesion via plasma ...

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

 [1] GO:0010591, regulation of lamellipodium assembly  
 [2] GO:0043038, amino acid activation                 
 [3] GO:0043039, tRNA aminoacylation                   
 [4] GO:0003230, cardiac atrium development            
 [5] GO:0006418, tRNA aminoacylation for protein       
 [6] GO:0010592, positive regulation of lamellipodium  
 [7] GO:0032635, interleukin-6 production              
 [8] GO:0043489, RNA stabilization                     
 [9] GO:0021536, diencephalon development              
[10] GO:0003209, cardiac atrium morphogenesis          
[11] GO:0003283, atrial septum development             
[12] GO:0006928, movement of cell or subcellular       
[13] GO:0060021, roof of mouth development             
[14] GO:0050919, negative chemotaxis                   
[15] GO:0048255, mRNA stabilization                    
[16] GO:0032781, positive regulation of ATPase activity
[17] GO:0045669, positive regulation of osteoblast     
[18] GO:0061029, eyelid development in camera-type eye 
[19] GO:0043486, histone exchange                      
[20] GO:0007156, homophilic cell adhesion via plasma   
20 Levels: GO:0007156, homophilic cell adhesion via plasma ...

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

 [1] GO:0010469, regulation of signaling receptor    
 [2] GO:0007186, G protein-coupled receptor signaling
 [3] GO:0072359, circulatory system development      
 [4] GO:0048568, embryonic organ development         
 [5] GO:0030198, extracellular matrix organization   
 [6] GO:0072001, renal system development            
 [7] GO:0003008, system process                      
 [8] GO:0001944, vasculature development             
 [9] GO:0001655, urogenital system development       
[10] GO:0006935, chemotaxis                          
[11] GO:0043062, extracellular structure organization
[12] GO:0001822, kidney development                  
[13] GO:0042330, taxis                               
[14] GO:0040011, locomotion                          
[15] GO:0035295, tube development                    
[16] GO:0072358, cardiovascular system development   
[17] GO:0072006, nephron development                 
[18] GO:0035239, tube morphogenesis                  
[19] GO:0032501, multicellular organismal process    
[20] GO:0001568, blood vessel development            
20 Levels: GO:0001568, blood vessel development ...

Building most specific GOs .....

    ( 9770 GO terms found. )

Build GO DAG topology ..........

    ( 13850 GO terms and 32624 relations. )

Annotating nodes ...............

    ( 9172 genes annotated to the GO terms. )

             -- Classic Algorithm -- 

         the algorithm is scoring 5173 nontrivial nodes
         parameters: 
             test statistic: ks
             score order: increasing

 [1] GO:0035295, tube development                       
 [2] GO:0072359, circulatory system development         
 [3] GO:0009653, anatomical structure morphogenesis     
 [4] GO:0035239, tube morphogenesis                     
 [5] GO:0032502, developmental process                  
 [6] GO:0008283, cell proliferation                     
 [7] GO:0023052, signaling                              
 [8] GO:0001944, vasculature development                
 [9] GO:0007275, multicellular organism development     
[10] GO:0048856, anatomical structure development       
[11] GO:0048646, anatomical structure formation involved
[12] GO:0030334, regulation of cell migration           
[13] GO:0051270, regulation of cellular component       
[14] GO:0072358, cardiovascular system development      
[15] GO:0001568, blood vessel development               
[16] GO:0007154, cell communication                     
[17] GO:0040012, regulation of locomotion               
[18] GO:0042127, regulation of cell proliferation       
[19] GO:0008015, blood circulation                      
[20] GO:0016477, cell migration                         
20 Levels: GO:0016477, cell migration ... GO:0035295, tube development

Session information

sessionInfo()

R version 3.6.1 (2019-07-05)
Platform: x86_64-pc-linux-gnu (64-bit)
Running under: Scientific Linux 7.4 (Nitrogen)

Matrix products: default
BLAS/LAPACK: /software/openblas-0.2.19-el7-x86_64/lib/libopenblas_haswellp-r0.2.19.so

locale:
 [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
 [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
 [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
 [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
 [9] LC_ADDRESS=C               LC_TELEPHONE=C            
[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       

attached base packages:
 [1] stats4    parallel  grid      stats     graphics  grDevices utils    
 [8] datasets  methods   base     

other attached packages:
 [1] org.Hs.eg.db_3.8.2          topGO_2.36.0               
 [3] SparseM_1.78                GO.db_3.8.2                
 [5] AnnotationDbi_1.46.0        graph_1.62.0               
 [7] RUVSeq_1.18.0               EDASeq_2.18.0              
 [9] ShortRead_1.42.0            GenomicAlignments_1.20.1   
[11] SummarizedExperiment_1.14.1 DelayedArray_0.10.0        
[13] matrixStats_0.57.0          Rsamtools_2.0.0            
[15] GenomicRanges_1.36.1        GenomeInfoDb_1.20.0        
[17] Biostrings_2.52.0           XVector_0.24.0             
[19] IRanges_2.18.3              S4Vectors_0.22.1           
[21] BiocParallel_1.18.1         Biobase_2.44.0             
[23] BiocGenerics_0.30.0         VennDiagram_1.6.20         
[25] futile.logger_1.4.3         cowplot_1.1.0              
[27] ggplot2_3.3.2               ashr_2.2-47                
[29] tidyr_1.1.2                 dplyr_1.0.2                
[31] edgeR_3.26.5                plyr_1.8.6                 
[33] limma_3.40.6               

loaded via a namespace (and not attached):
  [1] colorspace_1.4-1       hwriter_1.3.2          ellipsis_0.3.1        
  [4] rprojroot_1.3-2        htmlTable_1.13.1       base64enc_0.1-3       
  [7] fs_1.3.1               rstudioapi_0.11        farver_2.0.3          
 [10] bit64_0.9-7            splines_3.6.1          R.methodsS3_1.8.1     
 [13] DESeq_1.36.0           geneplotter_1.62.0     knitr_1.23            
 [16] Formula_1.2-3          workflowr_1.6.2        annotate_1.62.0       
 [19] cluster_2.1.0          R.oo_1.24.0            compiler_3.6.1        
 [22] httr_1.4.2             backports_1.1.10       Matrix_1.2-18         
 [25] later_1.1.0.1          formatR_1.7            acepack_1.4.1         
 [28] htmltools_0.5.0        prettyunits_1.1.1      tools_3.6.1           
 [31] gtable_0.3.0           glue_1.4.2             GenomeInfoDbData_1.2.1
 [34] Rcpp_1.0.5             vctrs_0.3.4            rtracklayer_1.44.0    
 [37] xfun_0.8               stringr_1.4.0          lifecycle_0.2.0       
 [40] irlba_2.3.3            statmod_1.4.32         XML_3.98-1.20         
 [43] zlibbioc_1.30.0        MASS_7.3-52            scales_1.1.1          
 [46] aroma.light_3.14.0     hms_0.5.3              promises_1.1.1        
 [49] lambda.r_1.2.4         RColorBrewer_1.1-2     yaml_2.2.1            
 [52] gridExtra_2.3          memoise_1.1.0          rpart_4.1-15          
 [55] biomaRt_2.40.1         latticeExtra_0.6-28    stringi_1.4.6         
 [58] RSQLite_2.1.1          SQUAREM_2020.4         genefilter_1.66.0     
 [61] checkmate_1.9.4        GenomicFeatures_1.36.3 truncnorm_1.0-8       
 [64] rlang_0.4.8            pkgconfig_2.0.3        bitops_1.0-6          
 [67] evaluate_0.14          lattice_0.20-41        invgamma_1.1          
 [70] purrr_0.3.4            htmlwidgets_1.5.2      labeling_0.3          
 [73] bit_4.0.4              tidyselect_1.1.0       magrittr_1.5          
 [76] R6_2.4.1               Hmisc_4.2-0            generics_0.0.2        
 [79] DBI_1.1.0              foreign_0.8-71         pillar_1.4.6          
 [82] whisker_0.3-2          withr_2.3.0            nnet_7.3-12           
 [85] survival_2.44-1.1      RCurl_1.98-1.1         mixsqp_0.3-43         
 [88] tibble_3.0.4           crayon_1.3.4           futile.options_1.0.1  
 [91] rmarkdown_1.13         progress_1.2.2         locfit_1.5-9.1        
 [94] data.table_1.13.0      blob_1.2.0             git2r_0.26.1          
 [97] etrunct_0.1            digest_0.6.25          xtable_1.8-4          
[100] httpuv_1.5.1           R.utils_2.9.0          munsell_0.5.0